Motif ID: SMAD1..7,9.p2

Z-value: 1.168


Transcription factors associated with SMAD1..7,9.p2:

Gene SymbolEntrez IDGene Name
SMAD1 4086 SMAD family member 1
SMAD2 4087 SMAD family member 2
SMAD3 4088 SMAD family member 3
SMAD4 4089 SMAD family member 4
SMAD5 4090 SMAD family member 5
SMAD6 4091 SMAD family member 6
SMAD7 4092 SMAD family member 7
SMAD9 4093 SMAD family member 9



Activity profile for motif SMAD1..7,9.p2.

activity profile for motif SMAD1..7,9.p2


Sorted Z-values histogram for motif SMAD1..7,9.p2

Sorted Z-values for motif SMAD1..7,9.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1..7,9.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_30151526 4.307 NM_170769
NM_025236
RNF39

ring finger protein 39

chr15_-_40236061 2.533 NM_213600
PLA2G4F
phospholipase A2, group IVF
chr19_+_40299058 2.456 FXYD3
FXYD domain containing ion transport regulator 3
chr19_-_48976852 2.453 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr19_-_17275083 2.340 NM_024527
ABHD8
abhydrolase domain containing 8
chr1_-_43523825 2.278 NM_182517
NM_001164829
C1orf210

chromosome 1 open reading frame 210

chr11_+_66580884 2.187 RHOD
ras homolog gene family, member D
chr16_+_82959626 2.186 NM_014861
ATP2C2
ATPase, Ca++ transporting, type 2C, member 2
chr1_+_232416618 2.164 SLC35F3
solute carrier family 35, member F3
chr12_-_121780835 2.097 NM_032554
GPR81
G protein-coupled receptor 81
chr1_-_26553168 2.034 NM_001039775
AIM1L
absent in melanoma 1-like
chr1_-_6368324 1.977 NM_181864
ACOT7
acyl-CoA thioesterase 7
chr1_+_144439069 1.945 NM_002614
PDZK1
PDZ domain containing 1
chr2_-_108972100 1.899 NM_022336
EDAR
ectodysplasin A receptor
chr9_+_139239464 1.894 NM_199001
C9orf169
chromosome 9 open reading frame 169
chr11_-_65860450 1.878 NM_004292
RIN1
Ras and Rab interactor 1
chrX_+_152682772 1.856 NM_001163257
NM_005393
PLXNB3

plexin B3

chr22_+_23221114 1.842 NM_016327
UPB1
ureidopropionase, beta
chr19_-_48977247 1.841 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr17_-_67628523 1.825 FLJ37644
hypothetical LOC400618
chr8_+_22493928 1.789 NM_176871
NM_198042
PDLIM2

PDZ and LIM domain 2 (mystique)

chr8_-_143864933 1.710 NM_003695
LY6D
lymphocyte antigen 6 complex, locus D
chr9_-_139010805 1.703 NM_004669
CLIC3
chloride intracellular channel 3
chr15_+_31390454 1.690 NM_001036
RYR3
ryanodine receptor 3
chr19_+_45973139 1.677 NM_006533
MIA
melanoma inhibitory activity
chr17_+_19377732 1.634 NM_018242
SLC47A1
solute carrier family 47, member 1
chr1_+_20751518 1.632 NM_207334
FAM43B
family with sequence similarity 43, member B
chr10_-_98021144 1.561 NM_001114094
NM_013314
BLNK

B-cell linker

chr17_+_69941430 1.546 NM_018653
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr17_+_72795567 1.524 NM_001113492
SEPT9
septin 9
chr16_+_65579988 1.502 NM_173815
CES4A
carboxylesterase 4A
chr22_+_29848923 1.455 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr7_+_147667461 1.441 CNTNAP2
contactin associated protein-like 2
chr19_-_56204615 1.426 NM_012315
KLK9
kallikrein-related peptidase 9
chr19_-_54258935 1.421 NM_006179
NTF4
neurotrophin 4
chr2_+_101981888 1.384 NM_173343
IL1R2
interleukin 1 receptor, type II
chr21_+_38550739 1.383 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr1_-_24342158 1.374 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr7_+_72883128 1.358 NM_001305
CLDN4
claudin 4
chr16_-_31054563 1.353 NM_002773
PRSS8
protease, serine, 8
chr9_+_35663852 1.345 NM_001216
CA9
carbonic anhydrase IX
chr6_+_35373572 1.323 NM_022047
DEF6
differentially expressed in FDCP 6 homolog (mouse)
chr3_+_9919295 1.319 NM_153483
IL17RE
interleukin 17 receptor E
chr17_-_36346240 1.307 KRT23
keratin 23 (histone deacetylase inducible)
chr15_+_75074483 1.269 NM_003978
PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr1_-_39180036 1.259 NM_017821
RHBDL2
rhomboid, veinlet-like 2 (Drosophila)
chrX_-_48213545 1.257 NM_033518
SLC38A5
solute carrier family 38, member 5
chr8_-_57395207 1.255 SDR16C5
short chain dehydrogenase/reductase family 16C, member 5
chr15_-_64644758 1.237 NM_207338
LCTL
lactase-like
chr20_-_57948653 1.232 NM_006242
PPP1R3D
protein phosphatase 1, regulatory (inhibitor) subunit 3D
chrX_-_84521320 1.227 POF1B
premature ovarian failure, 1B
chr20_-_32363268 1.227 NM_001161766
AHCY
adenosylhomocysteinase
chr16_-_56389176 1.216 NM_001130099
KIFC3
kinesin family member C3
chr14_-_94053933 1.208 NM_173850
SERPINA12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
chr15_+_75074793 1.206 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr14_-_23107106 1.205 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr6_+_152053323 1.198 NM_001122742
ESR1
estrogen receptor 1
chr1_+_3558958 1.193 NM_005427
TP73
tumor protein p73
chr2_-_232499202 1.190 NM_024409
NPPC
natriuretic peptide C
chr8_-_144726064 1.182 NM_001100878
C8orf73
chromosome 8 open reading frame 73
chrX_-_10761729 1.178 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr17_-_35911340 1.177 NM_032865
TNS4
tensin 4
chr19_+_40465249 1.172 NM_021175
HAMP
hepcidin antimicrobial peptide
chr17_+_12633504 1.166 NM_014859
ARHGAP44
Rho GTPase activating protein 44
chr16_-_21919928 1.163 NM_173806
PDZD9
PDZ domain containing 9
chr2_-_101370291 1.148 CREG2
cellular repressor of E1A-stimulated genes 2
chr9_-_34652629 1.142 NM_006664
CCL27
chemokine (C-C motif) ligand 27
chr1_+_154389945 1.140 NM_001193300
NM_022367
NM_001193302
SEMA4A


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A


chr17_+_67628749 1.126 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr22_+_18330049 1.117 NM_007310
COMT
catechol-O-methyltransferase
chr11_+_45900731 1.110 GYLTL1B
glycosyltransferase-like 1B
chr12_+_55896844 1.104 NM_007224
NXPH4
neurexophilin 4
chr2_-_108972048 1.103 EDAR
ectodysplasin A receptor
chr10_-_102880892 1.100 NM_001085398
TLX1NB
TLX1 neighbor
chr16_-_29817841 1.095 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr15_-_50869379 1.092 NM_004498
ONECUT1
one cut homeobox 1
chr16_+_22732982 1.091 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr6_-_24466258 1.086 NM_016356
DCDC2
doublecortin domain containing 2
chr11_+_122901543 1.084 GRAMD1B
GRAM domain containing 1B
chr3_-_127382093 1.083 NM_012190
ALDH1L1
aldehyde dehydrogenase 1 family, member L1
chr3_+_112934016 1.082 NM_001134437
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr3_-_127382051 1.080 ALDH1L1
aldehyde dehydrogenase 1 family, member L1
chr14_+_20608179 1.074 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr15_+_75074743 1.073 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr5_-_58370693 1.052 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr1_+_36409277 1.042 MAP7D1
MAP7 domain containing 1
chr17_+_1574782 1.042 NM_001163809
WDR81
WD repeat domain 81
chr3_-_52463070 1.041 NM_003280
TNNC1
troponin C type 1 (slow)
chrX_-_48213508 1.040 SLC38A5
solute carrier family 38, member 5
chr17_+_69939130 1.039 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr7_-_1562272 1.036 NM_001097620
TMEM184A
transmembrane protein 184A
chr11_-_116692128 1.029 NM_012104
NM_138971
NM_138972
NM_138973
BACE1



beta-site APP-cleaving enzyme 1



chr17_-_40858775 1.024 NM_199282
ARHGAP27
Rho GTPase activating protein 27
chr5_+_131437383 1.017 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr22_-_41372620 1.009 CYB5R3
cytochrome b5 reductase 3
chr11_+_93394025 1.006 NM_001098672
HEPHL1
hephaestin-like 1
chr19_+_45807909 1.002


chr11_+_66580861 1.001 NM_014578
RHOD
ras homolog gene family, member D
chr17_+_39741306 0.997 NM_001144825
NM_001144826
NM_006695
RUNDC3A


RUN domain containing 3A


chr20_-_45418818 0.995 NM_012408
NM_183047
NM_183048
ZMYND8


zinc finger, MYND-type containing 8


chr20_-_35586366 0.973 NM_001167823
BLCAP
bladder cancer associated protein
chr21_+_44818033 0.972 NM_198687
KRTAP10-4
keratin associated protein 10-4
chr7_+_54577512 0.972 NM_182546
VSTM2A
V-set and transmembrane domain containing 2A
chr9_+_135276940 0.960 NM_139025
NM_139026
NM_139027
ADAMTS13


ADAM metallopeptidase with thrombospondin type 1 motif, 13


chr3_+_127725851 0.959 NM_152889
CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr16_-_45339605 0.953 NM_182493
MYLK3
myosin light chain kinase 3
chr22_-_41372920 0.951 NM_001129819
NM_001171661
NM_007326
CYB5R3


cytochrome b5 reductase 3


chr3_+_9919511 0.949 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr10_-_125841840 0.944 NM_014863
NM_015892
CHST15

carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15

chr22_+_36365629 0.943 NM_018957
SH3BP1
SH3-domain binding protein 1
chr2_-_219633481 0.941 NM_002181
IHH
Indian hedgehog
chr16_+_88467518 0.941 TCF25
transcription factor 25 (basic helix-loop-helix)
chr17_-_36719030 0.933 NM_001146182
KRTAP16-1
keratin associated protein 16-1
chr12_-_51200347 0.930 NM_000424
KRT5
keratin 5
chr1_-_181826633 0.923 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr16_+_23221091 0.920 NM_000336
SCNN1B
sodium channel, nonvoltage-gated 1, beta
chr2_+_137239583 0.918 THSD7B
thrombospondin, type I, domain containing 7B
chr3_+_144165470 0.912 U2SURP
U2 snRNP-associated SURP domain containing
chr17_+_69939806 0.907 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr16_-_31054321 0.903 PRSS8
protease, serine, 8
chr12_+_54910086 0.903 NM_173596
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr2_+_171381317 0.890 NM_000817
NM_013445
GAD1

glutamate decarboxylase 1 (brain, 67kDa)

chr3_+_89239363 0.888 NM_005233
NM_182644
EPHA3

EPH receptor A3

chr10_+_102881050 0.886 NM_001195517
NM_005521
TLX1

T-cell leukemia homeobox 1

chr17_-_73867748 0.882 NM_003955
SOCS3
suppressor of cytokine signaling 3
chr8_-_26780645 0.881


chr8_-_26780665 0.880 ADRA1A
adrenergic, alpha-1A-, receptor
chr19_+_3659358 0.879 TJP3
tight junction protein 3 (zona occludens 3)
chr3_+_134947788 0.873 TF
transferrin
chr16_-_29818334 0.870 SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr12_+_115481568 0.869 NM_001085481
MAP1LC3B2
microtubule-associated protein 1 light chain 3 beta 2
chr1_+_4614528 0.869 AJAP1
adherens junctions associated protein 1
chr2_+_242400702 0.866 NM_001167599
NM_001167602
NM_080741
NEU4


sialidase 4


chr14_-_49543987 0.860 NM_001012706
C14orf182
chromosome 14 open reading frame 182
chrX_-_132376660 0.855 NM_001448
GPC4
glypican 4
chr7_-_156494741 0.855 NM_001165255
MNX1
motor neuron and pancreas homeobox 1
chr1_+_27062215 0.853 NM_006142
SFN
stratifin
chr17_-_17421050 0.849 PEMT
phosphatidylethanolamine N-methyltransferase
chr11_+_1812115 0.848 NM_138567
SYT8
synaptotagmin VIII
chr1_-_10779291 0.846 NM_001079843
NM_017766
CASZ1

castor zinc finger 1

chr12_+_52689062 0.841 NM_022658
HOXC8
homeobox C8
chr8_-_6722848 0.841 NM_005218
DEFB1
defensin, beta 1
chr3_+_134947940 0.832 TF
transferrin
chr18_+_586997 0.831 NM_014410
CLUL1
clusterin-like 1 (retinal)
chr1_-_112333192 0.827 NM_004980
NM_172198
KCND3

potassium voltage-gated channel, Shal-related subfamily, member 3

chr9_-_115880281 0.825 AMBP
alpha-1-microglobulin/bikunin precursor
chr3_+_134947894 0.825 TF
transferrin
chr3_+_89239494 0.825 EPHA3
EPH receptor A3
chr17_+_1574583 0.824 NM_001163811
WDR81
WD repeat domain 81
chr3_+_141136896 0.822 CLSTN2
calsyntenin 2
chr4_-_78038025 0.820 NM_001029870
ANKRD56
ankyrin repeat domain 56
chr17_-_34607257 0.817 NM_000723
NM_199247
NM_199248
CACNB1


calcium channel, voltage-dependent, beta 1 subunit


chr19_+_702108 0.816 NM_173481
C19orf21
chromosome 19 open reading frame 21
chr1_-_6341553 0.812 NM_181866
ACOT7
acyl-CoA thioesterase 7
chr19_-_56164628 0.811 NM_002774
KLK6
kallikrein-related peptidase 6
chr2_+_102169864 0.808 NM_003854
IL1RL2
interleukin 1 receptor-like 2
chr12_+_106236281 0.808 NM_001018072
BTBD11
BTB (POZ) domain containing 11
chr20_-_62081434 0.806 NM_080621
SAMD10
sterile alpha motif domain containing 10
chr17_+_4621924 0.805 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr16_-_73858179 0.802 NM_001170716
BCAR1
breast cancer anti-estrogen resistance 1
chr22_+_43451600 0.801 PRR5
proline rich 5 (renal)
chr18_+_19706979 0.798 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr16_-_3246587 0.796 NM_000243
NM_001198536
MEFV

Mediterranean fever

chr8_+_63323739 0.794 NKAIN3
Na+/K+ transporting ATPase interacting 3
chr16_-_88295595 0.794 NM_152339
SPATA2L
spermatogenesis associated 2-like
chr2_+_171381626 0.790 GAD1
glutamate decarboxylase 1 (brain, 67kDa)
chr1_+_15935395 0.787 NM_207348
SLC25A34
solute carrier family 25, member 34
chr19_-_11550576 0.787 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr3_-_50324815 0.786 NM_153281
HYAL1
hyaluronoglucosaminidase 1
chr1_-_28392966 0.785 NM_001164722
NM_001164721
PTAFR

platelet-activating factor receptor

chr11_-_34491878 0.784 NM_001422
ELF5
E74-like factor 5 (ets domain transcription factor)
chr17_+_7199178 0.784 NM_198154
TMEM95
transmembrane protein 95
chr1_+_44171578 0.779 NM_001136215
NM_057090
NM_057091
ARTN


artemin


chr5_-_22889487 0.779 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr9_+_139241838 0.776 NM_001190228
LOC643596
hypothetical LOC643596
chr21_-_41140908 0.766 NM_001389
DSCAM
Down syndrome cell adhesion molecule
chr4_-_187713512 0.762 NM_005958
MTNR1A
melatonin receptor 1A
chr19_-_59295882 0.759 NM_130771
NM_133168
NM_133169
NM_206818
OSCAR



osteoclast associated, immunoglobulin-like receptor



chr7_-_100331417 0.758 NM_000665
NM_015831
ACHE

acetylcholinesterase

chr2_+_233112680 0.758 NM_005199
CHRNG
cholinergic receptor, nicotinic, gamma
chr1_+_26220852 0.757 NM_004455
EXTL1
exostoses (multiple)-like 1
chr2_-_101370355 0.756 NM_153836
CREG2
cellular repressor of E1A-stimulated genes 2
chr15_+_38923470 0.756 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr17_-_47590975 0.754 CA10
carbonic anhydrase X
chr21_+_38550533 0.749 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr22_+_36365393 0.747


chr12_-_49878216 0.746 NM_002702
POU6F1
POU class 6 homeobox 1
chr12_+_56406296 0.742 LOC100130776
hypothetical LOC100130776
chr2_+_37425240 0.739 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr1_+_15964045 0.739 NM_001024216
FBLIM1
filamin binding LIM protein 1
chr18_-_45630154 0.737 MYO5B
myosin VB
chr12_-_51153788 0.736 NM_173086
KRT6C
keratin 6C
chr3_+_134947573 0.736 NM_001063
TF
transferrin
chr8_-_8276598 0.735 NM_001080826
SGK223
homolog of rat pragma of Rnd2
chr2_-_85490997 0.729 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr22_+_31527678 0.729 TIMP3
TIMP metallopeptidase inhibitor 3
chr22_+_38720881 0.728 NM_138435
FAM83F
family with sequence similarity 83, member F
chr12_-_101835026 0.727 PAH
phenylalanine hydroxylase
chr2_+_17585462 0.716 VSNL1
visinin-like 1
chr8_+_123863075 0.713 NM_014943
ZHX2
zinc fingers and homeoboxes 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.46 1.10e-06 GO:0051239 regulation of multicellular organismal process
1.23 7.71e-06 GO:0023052 signaling
1.40 1.40e-05 GO:0007399 nervous system development
1.26 5.91e-05 GO:0048731 system development
1.50 1.41e-04 GO:0048699 generation of neurons
1.48 1.48e-04 GO:0022008 neurogenesis
1.23 2.07e-04 GO:0007165 signal transduction
1.22 2.14e-04 GO:0007275 multicellular organismal development
1.23 2.30e-04 GO:0048856 anatomical structure development
1.56 2.51e-04 GO:0045595 regulation of cell differentiation
1.47 2.70e-04 GO:0050793 regulation of developmental process
1.35 7.71e-04 GO:0009653 anatomical structure morphogenesis
1.28 1.10e-03 GO:0065008 regulation of biological quality
1.45 1.18e-03 GO:0009611 response to wounding
1.49 1.42e-03 GO:2000026 regulation of multicellular organismal development
1.28 2.13e-03 GO:0030154 cell differentiation
1.41 2.37e-03 GO:0007154 cell communication
1.19 2.50e-03 GO:0032502 developmental process
1.76 2.76e-03 GO:0060284 regulation of cell development
1.11 2.77e-03 GO:0065007 biological regulation
1.34 4.53e-03 GO:0035556 intracellular signal transduction
1.48 8.10e-03 GO:0030182 neuron differentiation
1.26 8.39e-03 GO:0048869 cellular developmental process
1.52 8.42e-03 GO:0042060 wound healing
1.82 1.03e-02 GO:0050767 regulation of neurogenesis
1.71 1.36e-02 GO:0007610 behavior
1.14 1.76e-02 GO:0032501 multicellular organismal process
1.51 2.08e-02 GO:0050878 regulation of body fluid levels
2.12 2.24e-02 GO:0030802 regulation of cyclic nucleotide biosynthetic process
2.12 2.24e-02 GO:0030808 regulation of nucleotide biosynthetic process
1.40 2.32e-02 GO:0009888 tissue development
2.17 2.43e-02 GO:0030817 regulation of cAMP biosynthetic process
2.15 3.02e-02 GO:0030814 regulation of cAMP metabolic process
1.53 3.25e-02 GO:0007599 hemostasis
1.38 3.30e-02 GO:0048468 cell development
2.07 4.13e-02 GO:0030799 regulation of cyclic nucleotide metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.20 3.77e-06 GO:0071944 cell periphery
1.20 5.92e-06 GO:0005886 plasma membrane
1.13 1.18e-05 GO:0016020 membrane
1.29 1.32e-05 GO:0044459 plasma membrane part
1.51 9.74e-04 GO:0030054 cell junction
1.12 2.64e-03 GO:0044425 membrane part
1.93 3.72e-03 GO:0070161 anchoring junction
1.31 6.02e-03 GO:0005887 integral to plasma membrane
1.31 7.29e-03 GO:0031226 intrinsic to plasma membrane
1.85 3.94e-02 GO:0005912 adherens junction

Nothing significant found in function category.