Motif ID: HLF.p2

Z-value: 2.749


Transcription factors associated with HLF.p2:

Gene SymbolEntrez IDGene Name
HLF 3131 hepatic leukemia factor



Activity profile for motif HLF.p2.

activity profile for motif HLF.p2


Sorted Z-values histogram for motif HLF.p2

Sorted Z-values for motif HLF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HLF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_113601608 9.650 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr2_+_113601616 6.142 IL1RN
interleukin 1 receptor antagonist
chr16_+_70646008 5.988 NM_001126102
NM_005143
HP

haptoglobin

chr9_+_116125123 5.768 NM_000607
ORM1
orosomucoid 1
chr9_+_116131889 5.350 NM_000608
ORM2
orosomucoid 2
chr16_+_70654625 4.768 NM_020995
HPR
haptoglobin-related protein
chr22_+_49272078 4.275 NM_017584
MIOX
myo-inositol oxygenase
chr2_-_73723001 3.991 NM_003960
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr1_+_149221122 3.931 NM_003568
ANXA9
annexin A9
chr3_+_120984246 3.757 NM_022002
NR1I2
nuclear receptor subfamily 1, group I, member 2
chr1_-_177106702 3.669 NM_004673
ANGPTL1
angiopoietin-like 1
chr17_-_31352643 3.667 CCL14-CCL15
CCL15
CCL14-CCL15 read-through transcript
chemokine (C-C motif) ligand 15
chr9_-_129752687 3.650 NM_203305
FAM102A
family with sequence similarity 102, member A
chr19_+_40465249 3.528 NM_021175
HAMP
hepcidin antimicrobial peptide
chr10_+_85994788 3.524 NM_001012720
NM_001012722
NM_002921
RGR


retinal G protein coupled receptor


chr3_+_187917791 3.483 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr17_-_31352720 3.377 CCL14-CCL15
CCL14-CCL15 read-through transcript
chr2_-_32344192 3.237 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr14_-_69333624 3.236 NM_003049
SLC10A1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr3_-_49701085 3.122 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr6_-_30151526 2.994 NM_170769
NM_025236
RNF39

ring finger protein 39

chr3_-_121883647 2.980 HGD
homogentisate 1,2-dioxygenase
chr17_-_17426416 2.930 PEMT
phosphatidylethanolamine N-methyltransferase
chr5_-_138746840 2.821 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr16_+_55963899 2.768 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr10_-_52315436 2.687 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr2_+_108360798 2.644 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr10_-_82039158 2.561 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr12_-_120591938 2.557 NM_173855
MORN3
MORN repeat containing 3
chr3_+_187813538 2.539 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr20_+_4614796 2.504 NM_000311
NM_001080121
NM_001080122
NM_183079
NM_001080123
PRNP




prion protein




chr6_+_131936057 2.455 NM_000045
ARG1
arginase, liver
chr5_-_138746917 2.425 NM_005847
NM_152685
SLC23A1

solute carrier family 23 (nucleobase transporters), member 1

chr4_+_187424336 2.424 F11
coagulation factor XI
chr9_+_102987137 2.382 NM_017753
LPPR1
lipid phosphate phosphatase-related protein type 1
chr20_+_61842880 2.382 SLC2A4RG
SLC2A4 regulator
chr13_-_45577144 2.381 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr17_-_36346240 2.336 KRT23
keratin 23 (histone deacetylase inducible)
chr1_-_228916486 2.325 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr12_-_121767272 2.309 NM_006018
GPR109B
G protein-coupled receptor 109B
chr10_-_95350949 2.304 NM_006744
RBP4
retinol binding protein 4, plasma
chr12_-_28016182 2.293 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr17_-_17426469 2.293 NM_007169
PEMT
phosphatidylethanolamine N-methyltransferase
chr2_+_3683660 2.289 NM_018436
ALLC
allantoicase
chr9_+_676640 2.264


chr14_+_20493467 2.121 NM_002934
RNASE2
ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
chr22_+_33792125 2.053 NM_001008494
ISX
intestine-specific homeobox
chr1_-_62557655 2.022 NM_181712
KANK4
KN motif and ankyrin repeat domains 4
chr11_-_66431910 2.021 NM_022172
PC
pyruvate carboxylase
chr8_-_145187553 2.014 NM_017570
OPLAH
5-oxoprolinase (ATP-hydrolysing)
chr6_-_30188845 2.004 NM_007028
TRIM31
tripartite motif containing 31
chr17_-_31353196 2.001 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr6_+_32003180 1.999 NM_000063
NM_001145903
C2

complement component 2

chr3_+_187813553 1.984 AHSG
alpha-2-HS-glycoprotein
chr20_+_41621079 1.944 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr1_-_228916470 1.941 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr11_-_116168316 1.938 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr3_-_12561962 1.911 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr16_-_54424517 1.906 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr10_+_70650064 1.889 NM_025130
HKDC1
hexokinase domain containing 1
chr12_-_1791146 1.868 CACNA2D4
calcium channel, voltage-dependent, alpha 2/delta subunit 4
chr3_+_46591048 1.832 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr6_+_32003380 1.813 C2
complement component 2
chr11_-_6418705 1.809 NM_000613
HPX
hemopexin
chr20_+_16676997 1.745 NM_020157
OTOR
otoraplin
chr18_+_75967902 1.705 NM_014913
ADNP2
ADNP homeobox 2
chr16_+_30391550 1.696 ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr7_+_45899621 1.692


chr16_-_54424473 1.686 CES1
carboxylesterase 1
chr2_+_161980865 1.657 NM_006593
TBR1
T-box, brain, 1
chr3_+_187866464 1.653 NM_000412
HRG
histidine-rich glycoprotein
chr20_+_41621119 1.599 SGK2
serum/glucocorticoid regulated kinase 2
chr16_+_30391460 1.595 NM_001114380
NM_002209
ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

chr10_+_114123765 1.592 ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_+_205328834 1.586 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr2_+_64540843 1.576 HSPC159
galectin-related protein
chr19_-_4491078 1.563 LRG1
leucine-rich alpha-2-glycoprotein 1
chr22_+_23309717 1.558 NM_013430
GGT1
gamma-glutamyltransferase 1
chr1_-_228916559 1.545 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr8_-_27524744 1.538 NM_203339
CLU
clusterin
chr5_+_73145098 1.497 RGNEF
190 kDa guanine nucleotide exchange factor
chr6_-_24491498 1.442 NM_001195610
DCDC2
doublecortin domain containing 2
chr2_+_161981046 1.430 TBR1
T-box, brain, 1
chr14_-_22354457 1.419 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr11_+_62893836 1.416 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr1_-_62557559 1.400 KANK4
KN motif and ankyrin repeat domains 4
chr9_-_106705867 1.379 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr2_+_218954995 1.365 NM_000578
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr17_+_11442472 1.357 NM_001372
DNAH9
dynein, axonemal, heavy chain 9
chr3_-_172227152 1.357 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr16_+_30391609 1.308


chr12_-_121753795 1.304 NM_177551
GPR109A
G protein-coupled receptor 109A
chr8_-_6722848 1.300 NM_005218
DEFB1
defensin, beta 1
chr19_-_59295882 1.298 NM_130771
NM_133168
NM_133169
NM_206818
OSCAR



osteoclast associated, immunoglobulin-like receptor



chr20_+_23419765 1.273 NM_005492
CST8
cystatin 8 (cystatin-related epididymal specific)
chr19_-_4491024 1.270 NM_052972
LRG1
leucine-rich alpha-2-glycoprotein 1
chr19_-_52308848 1.250 NM_015168
ZC3H4
zinc finger CCCH-type containing 4
chr14_-_94053933 1.224 NM_173850
SERPINA12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
chr19_+_53801811 1.217 NM_133498
SPACA4
sperm acrosome associated 4
chr4_+_71235259 1.206 NM_033122
CABS1
calcium-binding protein, spermatid-specific 1
chr14_-_22354389 1.201 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr2_+_113119985 1.195 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr17_-_71352017 1.180 UNC13D
unc-13 homolog D (C. elegans)
chr17_-_77824849 1.172 NM_001893
NM_139062
CSNK1D

casein kinase 1, delta

chr11_+_76516957 1.171 NM_000260
NM_001127179
NM_001127180
MYO7A


myosin VIIA


chr20_+_54533191 1.145 NM_001012971
C20orf106
C20orf107
chromosome 20 open reading frame 106
chromosome 20 open reading frame 107
chr22_-_27787793 1.143 NM_015370
C22orf31
chromosome 22 open reading frame 31
chr2_+_65517316 1.142 FLJ16124
FLJ16124 protein
chr19_-_59568483 1.114 NM_002287
NM_021706
LAIR1

leukocyte-associated immunoglobulin-like receptor 1

chr8_-_101384633 1.066 NM_015435
RNF19A
ring finger protein 19A
chrX_-_15530112 1.061 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr3_-_58175437 1.056 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr2_+_219453487 1.048 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr3_+_187813405 1.047 AHSG
alpha-2-HS-glycoprotein
chr9_-_98421894 1.037 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr3_-_172227223 1.030 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr4_-_77147625 1.020 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr16_+_9093035 1.015 NM_014117
C16orf72
chromosome 16 open reading frame 72
chr20_+_2030527 0.976 NM_080836
STK35
serine/threonine kinase 35
chr19_-_411995 0.967 NM_012435
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr10_-_104587069 0.966 NM_000102
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr1_-_176205970 0.963 SEC16B
SEC16 homolog B (S. cerevisiae)
chr6_-_2785682 0.955 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr4_+_155703581 0.950 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr20_+_43531806 0.937 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr4_+_39084867 0.933 NM_175737
KLB
klotho beta
chr14_+_102458745 0.931 NM_030943
AMN
amnionless homolog (mouse)
chr9_+_674193 0.913


chr6_+_17501589 0.898 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr13_+_96726415 0.896 MBNL2
muscleblind-like 2 (Drosophila)
chr7_+_80145461 0.888 CD36
CD36 molecule (thrombospondin receptor)
chrX_-_15242589 0.867 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr10_+_89257569 0.862 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr2_-_31491102 0.838 NM_000379
XDH
xanthine dehydrogenase
chr14_-_21074875 0.832 NM_005407
SALL2
sal-like 2 (Drosophila)
chr19_+_53951155 0.828 NM_019113
FGF21
fibroblast growth factor 21
chr6_-_64087806 0.827 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr20_+_61967122 0.822 TPD52L2
tumor protein D52-like 2
chr8_+_124263932 0.820 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr20_+_31613800 0.818 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr12_-_115803614 0.803 NM_003806
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr10_+_114123828 0.797 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr3_+_123526700 0.780 NM_005213
CSTA
cystatin A (stefin A)
chr7_-_15568099 0.777 NM_001004320
AGMO
alkylglycerol monooxygenase
chr5_+_140227951 0.776 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr2_-_110319828 0.774 NPHP1
nephronophthisis 1 (juvenile)
chr14_+_74964261 0.770 NM_001135047
JDP2
Jun dimerization protein 2
chr1_+_57093030 0.754 NM_000562
C8A
complement component 8, alpha polypeptide
chr20_+_61967078 0.753 TPD52L2
tumor protein D52-like 2
chr8_+_124264054 0.751 FAM83A
family with sequence similarity 83, member A
chr2_-_31491057 0.751 XDH
xanthine dehydrogenase
chr20_+_61967094 0.751 TPD52L2
tumor protein D52-like 2
chr2_+_161981138 0.740 TBR1
T-box, brain, 1
chr4_+_71418886 0.739 NM_212557
AMTN
amelotin
chr16_-_3485421 0.732 NM_001080524
C16orf90
chromosome 16 open reading frame 90
chr15_+_38673509 0.729 CASC5
cancer susceptibility candidate 5
chr8_+_21972804 0.726 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr2_+_201464884 0.723 NM_001142356
NIF3L1
NIF3 NGG1 interacting factor 3-like 1 (S. pombe)
chr17_+_39280041 0.720 NM_001168322
NM_001168323
NM_001168324
NM_145273
CD300LG



CD300 molecule-like family member g



chr16_-_5055920 0.717 C16orf89
chromosome 16 open reading frame 89
chr3_+_123385219 0.700 NM_000388
CASR
calcium-sensing receptor
chr1_-_228916958 0.690 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr21_-_42659671 0.684 NM_003225
TFF1
trefoil factor 1
chr20_+_61967033 0.666 NM_003288
NM_199359
NM_199360
NM_199361
NM_199362
NM_199363
TPD52L2





tumor protein D52-like 2





chr6_+_150731720 0.664 NM_001164694
NM_001164695
NM_203395
IYD


iodotyrosine deiodinase


chr7_-_37923040 0.663 NM_003014
SFRP4
secreted frizzled-related protein 4
chr1_-_202449659 0.655 NM_198447
GOLT1A
golgi transport 1A
chr12_-_103846186 0.654 NM_032148
SLC41A2
solute carrier family 41, member 2
chr14_-_23754977 0.652 NM_138476
MDP1
magnesium-dependent phosphatase 1
chr3_-_150422474 0.648 NM_000096
CP
ceruloplasmin (ferroxidase)
chr11_+_62813947 0.635 NM_001039752
SLC22A10
solute carrier family 22, member 10
chr17_-_61655915 0.634 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr20_+_47328575 0.633 NCRNA00275
non-protein coding RNA 275
chr6_+_144654565 0.627 NM_007124
UTRN
utrophin
chr14_+_28311740 0.622 C14orf23
chromosome 14 open reading frame 23
chr11_-_76862197 0.620 NM_001128620
NM_002576
PAK1

p21 protein (Cdc42/Rac)-activated kinase 1

chr7_-_111216180 0.618 DOCK4
dedicator of cytokinesis 4
chr6_-_52217185 0.618 NM_052872
IL17F
interleukin 17F
chr8_+_26569709 0.607 DPYSL2
dihydropyrimidinase-like 2
chr14_-_22354851 0.607 NM_001126105
NM_003982
SLC7A7

solute carrier family 7 (cationic amino acid transporter, y+ system), member 7

chr19_+_40541327 0.605 NM_005304
FFAR3
free fatty acid receptor 3
chr3_+_63928459 0.605 NM_001128149
ATXN7
ataxin 7
chr16_+_9093072 0.602 C16orf72
chromosome 16 open reading frame 72
chr2_+_228386800 0.589 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr6_+_131190237 0.582 NM_001195597
LOC285733
hypothetical LOC285733
chr17_+_31455332 0.577 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr20_+_23290844 0.572 GZF1
GDNF-inducible zinc finger protein 1
chr4_-_23500706 0.565 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr19_+_810658 0.562 NM_001928
CFD
complement factor D (adipsin)
chr12_+_16391342 0.559 NM_145792
MGST1
microsomal glutathione S-transferase 1
chr20_-_43177137 0.558 NM_145652
WFDC5
WAP four-disulfide core domain 5
chr6_+_31690957 0.556 NM_004847
NM_001623
AIF1

allograft inflammatory factor 1

chr14_+_31868229 0.555 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr19_+_50663089 0.552 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr20_+_47328585 0.544 NCRNA00275
non-protein coding RNA 275
chr5_+_150380173 0.544 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr16_-_66614599 0.544 DDX28
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
chr19_-_4853878 0.542 NM_001080523
ARRDC5
arrestin domain containing 5
chr12_-_86947276 0.535 NM_152589
C12orf50
chromosome 12 open reading frame 50
chr6_+_32048077 0.532 STK19
serine/threonine kinase 19

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.31 2.18e-03 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.03 1.19e-04 GO:0005615 extracellular space
1.82 6.65e-04 GO:0044421 extracellular region part
1.51 2.30e-03 GO:0005576 extracellular region
7.95 4.89e-03 GO:0034364 high-density lipoprotein particle
6.23 8.67e-03 GO:0032994 protein-lipid complex
6.23 8.67e-03 GO:0034358 plasma lipoprotein particle

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.03 1.92e-02 GO:0061135 endopeptidase regulator activity
2.97 4.07e-02 GO:0004866 endopeptidase inhibitor activity