Motif ID: NR1H4.p2

Z-value: 3.855


Transcription factors associated with NR1H4.p2:

Gene SymbolEntrez IDGene Name
NR1H4 9971 nuclear receptor subfamily 1, group H, member 4



Activity profile for motif NR1H4.p2.

activity profile for motif NR1H4.p2


Sorted Z-values histogram for motif NR1H4.p2

Sorted Z-values for motif NR1H4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR1H4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_7474128 7.510 SHBG
sex hormone-binding globulin
chr6_+_31731647 7.166 NM_019101
APOM
apolipoprotein M
chr6_+_31731667 7.013 APOM
apolipoprotein M
chr3_-_127719283 6.854 NM_001165974
NM_144639
UROC1

urocanase domain containing 1

chr12_-_7172641 6.794 NM_031491
RBP5
retinol binding protein 5, cellular
chr17_+_7474177 6.777 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr11_-_116168316 6.617 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr3_+_52803823 6.546 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr1_-_27113018 5.833 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr20_-_3097070 5.335 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr3_-_50315983 4.987 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr1_-_150070849 4.927 NM_005060
RORC
RAR-related orphan receptor C
chr22_+_43451600 4.863 PRR5
proline rich 5 (renal)
chr17_-_71352017 4.674 UNC13D
unc-13 homolog D (C. elegans)
chr1_+_93830169 4.522 LOC100129046
hypothetical LOC100129046
chr2_-_73723001 4.501 NM_003960
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr1_+_93830106 4.483 LOC100129046
hypothetical LOC100129046
chr22_+_43451351 4.438 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr22_+_23329113 4.434 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr2_+_108271526 4.399 NM_001056
NM_176825
SULT1C2

sulfotransferase family, cytosolic, 1C, member 2

chr17_-_71352090 4.396 UNC13D
unc-13 homolog D (C. elegans)
chr19_+_55398680 4.326 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chr10_-_101831579 4.115 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr16_+_65552600 4.023 NM_001185177
NM_024922
CES3

carboxylesterase 3

chr17_-_71352182 3.920 NM_199242
UNC13D
unc-13 homolog D (C. elegans)
chr15_+_63124760 3.903 NM_178859
OSTBETA
organic solute transporter beta
chr12_+_107797985 3.685 NM_001917
DAO
D-amino-acid oxidase
chr17_+_18796202 3.486 NM_001042450
NM_152351
SLC5A10

solute carrier family 5 (sodium/glucose cotransporter), member 10

chr12_+_56299959 3.397 NM_133489
SLC26A10
solute carrier family 26, member 10
chr1_+_152560179 3.362 NM_080429
AQP10
aquaporin 10
chr1_-_25619863 3.314 NM_020485
NM_138616
NM_138617
NM_138618
RHCE



RHD
Rh blood group, CcEe antigens



Rh blood group, D antigen
chr6_-_29635680 3.257 NM_006398
UBD
ubiquitin D
chr8_+_145692916 3.255 NM_032902
PPP1R16A
protein phosphatase 1, regulatory (inhibitor) subunit 16A
chrX_+_7147471 3.236 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr12_+_68028407 3.180 LYZ
lysozyme
chr20_-_43889339 3.155 NM_003279
TNNC2
troponin C type 2 (fast)
chr19_-_56585603 3.104 NM_001193623
LOC147646
hypothetical protein LOC147646
chr19_+_15644885 3.068 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr22_+_19651446 3.061 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr1_+_25471470 3.050 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr6_+_24465109 3.018 NM_181337
KAAG1
kidney associated antigen 1
chr11_-_64459910 3.014 NM_130769
GPHA2
glycoprotein hormone alpha 2
chr17_-_43390108 3.012 NM_024320
PRR15L
proline rich 15-like
chr17_-_71535076 2.969 NM_001988
EVPL
envoplakin
chr19_-_17377383 2.942 NM_004335
BST2
bone marrow stromal cell antigen 2
chr2_+_27225362 2.934 NM_175769
TCF23
transcription factor 23
chr1_+_148496792 2.919 NM_012113
CA14
carbonic anhydrase XIV
chr20_+_61839931 2.916 LIME1
Lck interacting transmembrane adaptor 1
chr10_-_95350949 2.881 NM_006744
RBP4
retinol binding protein 4, plasma
chr19_+_810673 2.854 CFD
complement factor D (adipsin)
chr1_+_32489426 2.830 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr17_-_42250961 2.676 NM_030753
WNT3
wingless-type MMTV integration site family, member 3
chr2_+_218929822 2.661 NM_198559
C2orf62
chromosome 2 open reading frame 62
chr1_+_15941503 2.631 NM_001013641
TMEM82
transmembrane protein 82
chr19_-_63556632 2.591 NM_130786
A1BG
alpha-1-B glycoprotein
chr10_+_685887 2.576 C10orf108
chromosome 10 open reading frame 108
chr6_+_167456230 2.569 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr19_-_54350457 2.518 NM_002152
HRC
histidine rich calcium binding protein
chr11_+_72660894 2.487 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr8_-_37576515 2.467 LOC157860
hypothetical protein LOC157860
chr12_+_56802 2.451 NM_015232
IQSEC3
IQ motif and Sec7 domain 3
chr17_+_1612031 2.323 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr19_+_810658 2.304 NM_001928
CFD
complement factor D (adipsin)
chr17_-_7023283 2.277 ASGR1
asialoglycoprotein receptor 1
chr16_+_1979959 2.265 NM_004209
SYNGR3
synaptogyrin 3
chr16_+_24765052 2.256 NM_052944
SLC5A11
solute carrier family 5 (sodium/glucose cotransporter), member 11
chr17_+_1612092 2.255 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_+_1611983 2.254 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr21_+_41663853 2.249 MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr17_-_71534906 2.226 EVPL
envoplakin
chr17_+_75319476 2.204 NM_178543
ENPP7
ectonucleotide pyrophosphatase/phosphodiesterase 7
chr17_-_15463742 2.201 NM_006382
CDRT1
CMT1A duplicated region transcript 1
chr1_-_11029737 2.200 NM_006610
NM_139208
MASP2

mannan-binding lectin serine peptidase 2

chr17_+_1612056 2.190 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr5_-_149772469 2.163 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr6_-_29635456 2.151 UBD
ubiquitin D
chr17_-_9880598 2.134 GAS7
growth arrest-specific 7
chr1_+_149221122 2.124 NM_003568
ANXA9
annexin A9
chr19_-_15451203 2.119 NM_052890
PGLYRP2
peptidoglycan recognition protein 2
chr4_-_100359353 2.106 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr1_+_32512298 2.104 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr1_-_47468029 2.101 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr3_-_180460372 2.093 NM_171829
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr2_-_178645718 2.064 NM_016953
PDE11A
phosphodiesterase 11A
chr17_+_2627099 2.042 RAP1GAP2
RAP1 GTPase activating protein 2
chr1_-_180622083 2.042 GLUL
glutamate-ammonia ligase
chr11_-_64368616 2.021 NM_017525
CDC42BPG
CDC42 binding protein kinase gamma (DMPK-like)
chr1_+_559618 2.020


chr12_-_56422120 1.997 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr1_-_172153024 1.968 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr17_-_9880729 1.967 NM_201432
GAS7
growth arrest-specific 7
chr4_-_176970407 1.954 GPM6A
glycoprotein M6A
chr4_-_176970372 1.949 GPM6A
glycoprotein M6A
chr13_-_99422163 1.921 NM_033132
ZIC5
Zic family member 5 (odd-paired homolog, Drosophila)
chrX_-_118711350 1.881 NM_015129
NM_145799
NM_145800
NM_145802
SEPT6



septin 6



chrX_+_106336517 1.861 NM_001169154
NM_173494
CXorf41

chromosome X open reading frame 41

chr16_-_73012740 1.837 NM_001011880
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chrX_-_153903963 1.828 NM_000132
F8
coagulation factor VIII, procoagulant component
chr4_-_69852090 1.822 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr22_+_23309717 1.816 NM_013430
GGT1
gamma-glutamyltransferase 1
chr11_-_6418705 1.803 NM_000613
HPX
hemopexin
chr7_+_26298136 1.791 SNX10
sorting nexin 10
chr14_-_22825148 1.790 NM_020834
HOMEZ
homeobox and leucine zipper encoding
chr1_-_2129031 1.789 NM_001146310
C1orf86
chromosome 1 open reading frame 86
chr3_-_52463070 1.784 NM_003280
TNNC1
troponin C type 1 (slow)
chr3_-_49701085 1.782 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr16_+_56259657 1.776 NM_170776
GPR97
G protein-coupled receptor 97
chr16_+_25135783 1.770 NM_001169
AQP8
aquaporin 8
chr13_+_49658016 1.736


chrX_-_106336199 1.734 NM_017681
NUP62CL
nucleoporin 62kDa C-terminal like
chr3_-_129777618 1.731 NM_007354
C3orf27
chromosome 3 open reading frame 27
chr20_-_61933012 1.721 ZBTB46
zinc finger and BTB domain containing 46
chr11_+_74539679 1.715 NM_001145212
NM_007256
SLCO2B1

solute carrier organic anion transporter family, member 2B1

chr14_-_23968570 1.715 NM_001039771
CBLN3
cerebellin 3 precursor
chr17_+_18588050 1.688 NM_031456
FBXW10
CDRT1
F-box and WD repeat domain containing 10
CMT1A duplicated region transcript 1
chr1_+_85819004 1.678 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr7_+_128099581 1.672 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chrX_-_70755023 1.634 NM_001142797
NM_001504
CXCR3

chemokine (C-X-C motif) receptor 3

chr9_+_35663852 1.622 NM_001216
CA9
carbonic anhydrase IX
chr19_+_977555 1.622 CNN2
calponin 2
chrX_+_151617900 1.586 NM_005363
NM_175868
MAGEA6

melanoma antigen family A, 6

chr16_-_1783653 1.586 NM_001146006
NM_004970
IGFALS

insulin-like growth factor binding protein, acid labile subunit

chr16_+_8722068 1.579 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr17_+_75776193 1.577 NM_052819
CARD14
caspase recruitment domain family, member 14
chr17_-_7023378 1.573 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chrX_-_132947290 1.573 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chrX_-_106033202 1.562 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chrX_-_151653756 1.558 NM_001166386
NM_001166387
NM_005367
MAGEA12


melanoma antigen family A, 12


chr17_-_53764867 1.556


chr12_+_52105131 1.553 AMHR2
anti-Mullerian hormone receptor, type II
chr4_-_40212670 1.541 NM_019027
RBM47
RNA binding motif protein 47
chr18_-_26935883 1.539 NM_004949
NM_024422
DSC2

desmocollin 2

chr7_+_100037817 1.522 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr2_+_176724358 1.486 NM_014621
HOXD4
homeobox D4
chr11_-_113082233 1.482 NM_030770
TMPRSS5
transmembrane protease, serine 5
chr11_+_118561375 1.472 NM_001168468
NM_024791
PDZD3

PDZ domain containing 3

chr9_-_116305273 1.457 NM_001083885
DFNB31
deafness, autosomal recessive 31
chr1_+_11749385 1.444 C1orf167
chromosome 1 open reading frame 167
chr16_-_1369613 1.426 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like

chr1_+_45046740 1.419 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr7_+_44045202 1.407 FLJ35390
hypothetical LOC255031
chr7_-_149669622 1.400 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr17_+_18221803 1.394 NM_001145127
EVPLL
envoplakin-like
chr16_+_70654625 1.387 NM_020995
HPR
haptoglobin-related protein
chr1_+_6537924 1.386 NM_138697
NM_177540
TAS1R1

taste receptor, type 1, member 1

chr17_+_61729306 1.385 NM_002737
PRKCA
protein kinase C, alpha
chr12_+_68459015 1.385 NM_001024647
RAB3IP
RAB3A interacting protein (rabin3)
chr19_-_47724365 1.383 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001712
CEACAM1




carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)




chr20_-_22512893 1.375 FOXA2
forkhead box A2
chr17_-_7036490 1.370


chr9_-_115880366 1.369 AMBP
alpha-1-microglobulin/bikunin precursor
chr11_-_64268126 1.361 NM_001098671
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr19_+_11211282 1.359 NM_018687
LOC55908
hepatocellular carcinoma-associated gene TD26
chr5_-_35266305 1.353 PRLR
prolactin receptor
chr12_-_120591938 1.338 NM_173855
MORN3
MORN repeat containing 3
chr17_+_37942034 1.331


chr20_-_3592045 1.330 NM_022139
NM_145762
GFRA4

GDNF family receptor alpha 4

chrX_+_151633730 1.320 NM_005361
NM_175742
NM_175743
MAGEA2


melanoma antigen family A, 2


chr7_-_100078270 1.320 TFR2
transferrin receptor 2
chr19_+_4180494 1.319 NM_005755
EBI3
Epstein-Barr virus induced 3
chr19_-_18246166 1.317 NM_001145304
NM_001145305
NM_025249
KIAA1683


KIAA1683


chr16_-_28425632 1.316 NM_145659
IL27
interleukin 27
chr4_+_74500748 1.313 ALB
albumin
chr20_+_61967094 1.312 TPD52L2
tumor protein D52-like 2
chr19_+_977608 1.311 CNN2
calponin 2
chr22_-_22304486 1.306 NM_016449
C22orf43
chromosome 22 open reading frame 43
chr14_-_22825072 1.300 HOMEZ
homeobox and leucine zipper encoding
chr7_+_45899080 1.296 IGFBP1
insulin-like growth factor binding protein 1
chr22_-_23665312 1.292 NM_001001663
TMEM211
transmembrane protein 211
chr4_+_74497998 1.290 ALB
albumin
chr20_+_57027703 1.271 NM_030773
TUBB1
tubulin, beta 1
chr3_+_134947940 1.266 TF
transferrin
chr20_+_61967122 1.260 TPD52L2
tumor protein D52-like 2
chr6_+_43373972 1.260 NM_006672
NM_153320
SLC22A7

solute carrier family 22 (organic anion transporter), member 7

chr19_-_56567602 1.258 NM_005601
NKG7
natural killer cell group 7 sequence
chr6_+_35812836 1.255 NM_145028
C6orf81
chromosome 6 open reading frame 81
chr20_+_61967078 1.250 TPD52L2
tumor protein D52-like 2
chr7_-_100077072 1.240 NM_003227
TFR2
transferrin receptor 2
chr14_+_23095028 1.232 NM_001126339
NM_024328
THTPA

thiamine triphosphatase

chr7_-_44547382 1.230 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr12_-_21439637 1.229 NM_134431
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr9_+_130231027 1.222 CERCAM
cerebral endothelial cell adhesion molecule
chr19_-_53081326 1.214 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr17_-_78599695 1.210 B3GNTL1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
chr20_-_54534387 1.205 NM_080615
GCNT7
glucosaminyl (N-acetyl) transferase family member 7
chr5_+_137447479 1.201 NM_058244
WNT8A
wingless-type MMTV integration site family, member 8A
chr17_+_69950782 1.200 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr12_-_120781002 1.197 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr6_+_44234525 1.191 NM_007058
CAPN11
calpain 11
chrX_+_65152004 1.186


chr16_+_22011362 1.182 NM_173615
VWA3A
von Willebrand factor A domain containing 3A
chr11_-_5232480 1.178 NM_000184
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr17_-_76720342 1.176 AATK
apoptosis-associated tyrosine kinase
chr17_-_43283529 1.175 SP6
Sp6 transcription factor
chr19_+_40321584 1.164 FXYD1
FXYD domain containing ion transport regulator 1
chr1_+_158603480 1.163 NM_005598
NHLH1
nescient helix loop helix 1
chr1_-_159459814 1.163 APOA2
apolipoprotein A-II
chr19_+_40321567 1.152 NM_021902
FXYD1
FXYD domain containing ion transport regulator 1
chr16_+_23754772 1.145 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr17_+_9686572 1.145 GLP2R
glucagon-like peptide 2 receptor

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.32 1.52e-02 GO:0010038 response to metal ion
1.98 3.37e-02 GO:0010035 response to inorganic substance

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.87 9.34e-03 GO:0003823 antigen binding
3.76 2.76e-02 GO:0051087 chaperone binding