Motif ID: PBX1.p2

Z-value: 1.652


Transcription factors associated with PBX1.p2:

Gene SymbolEntrez IDGene Name
PBX1 5087 pre-B-cell leukemia homeobox 1



Activity profile for motif PBX1.p2.

activity profile for motif PBX1.p2


Sorted Z-values histogram for motif PBX1.p2

Sorted Z-values for motif PBX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PBX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_27108826 3.948 NM_006735
HOXA2
homeobox A2
chr2_-_189752575 3.289 NM_000393
COL5A2
collagen, type V, alpha 2
chr21_+_29439768 2.619 C21orf7
chromosome 21 open reading frame 7
chr11_+_113671744 2.467 NM_006169
NNMT
nicotinamide N-methyltransferase
chr5_-_58607673 1.852 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr18_+_30427279 1.695 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr21_-_35174742 1.663 RUNX1
runt-related transcription factor 1
chr3_-_21767819 1.554 NM_024697
ZNF385D
zinc finger protein 385D
chr10_+_63092724 1.466 NM_173554
C10orf107
chromosome 10 open reading frame 107
chr12_+_21570457 1.458 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr12_+_77782719 1.428 SYT1
synaptotagmin I
chr5_+_15553288 1.419 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr4_+_86968069 1.417 ARHGAP24
Rho GTPase activating protein 24
chr1_-_147665783 1.390 HIST2H2BF
histone cluster 2, H2bf
chr6_-_26125939 1.331 NM_005325
HIST1H1A
histone cluster 1, H1a
chr2_+_44249565 1.317 PPM1B
protein phosphatase, Mg2+/Mn2+ dependent, 1B
chr10_+_69539255 1.282 NM_032578
MYPN
myopalladin
chr13_-_60887210 1.233 PCDH20
protocadherin 20
chr8_+_107807415 1.224 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr13_+_38159172 1.200 NM_207361
FREM2
FRAS1 related extracellular matrix protein 2
chr10_+_50557689 1.159 NM_001042427
NM_182554
C10orf53

chromosome 10 open reading frame 53

chr7_+_29569913 1.118 NM_175887
PRR15
proline rich 15
chr16_+_15503623 1.115 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr8_+_69027277 1.090 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr17_+_72380323 1.057 NM_198955
MGAT5B
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr5_-_89741233 1.055 NM_004365
CETN3
centrin, EF-hand protein, 3
chr1_+_162795328 1.047 NM_002585
PBX1
pre-B-cell leukemia homeobox 1
chr11_-_102174032 1.036 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr2_-_192767844 1.025 NM_016192
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr11_-_102174102 1.005 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr18_+_42780784 0.979 NM_031303
KATNAL2
katanin p60 subunit A-like 2
chr11_+_95163457 0.963 CEP57
centrosomal protein 57kDa
chr4_-_118226119 0.947 NM_152402
TRAM1L1
translocation associated membrane protein 1-like 1
chr4_-_48477021 0.947 FRYL
FRY-like
chr5_-_171814026 0.935 NM_001017995
SH3PXD2B
SH3 and PX domains 2B
chr5_+_3649167 0.915 NM_024337
IRX1
iroquois homeobox 1
chr3_+_173951163 0.891 ECT2
epithelial cell transforming sequence 2 oncogene
chr5_-_22248630 0.871 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr4_+_77575276 0.865 NM_020859
SHROOM3
shroom family member 3
chr9_-_83494198 0.862 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr5_+_162797149 0.862 NM_004060
NM_199246
CCNG1

cyclin G1

chr8_+_69026895 0.861 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr16_+_81218074 0.847 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr2_+_44249487 0.822 NM_001033556
NM_001033557
NM_002706
NM_177968
NM_177969
PPM1B




protein phosphatase, Mg2+/Mn2+ dependent, 1B




chr17_+_56884560 0.808 TBX4
T-box 4
chr8_+_69027166 0.788 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr8_+_69027143 0.760 NM_024870
NM_025170
PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

chrX_-_92815222 0.755 NM_004538
NAP1L3
nucleosome assembly protein 1-like 3
chr4_-_48477038 0.750 NM_015030
FRYL
FRY-like
chrX_+_92815667 0.748 NM_001171109
NM_001171110
NM_001171111
NM_173698
FAM133A



family with sequence similarity 133, member A



chr9_+_112470871 0.745 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr14_+_51025604 0.741 NM_001042481
FRMD6
FERM domain containing 6
chr5_+_15553539 0.735 FBXL7
F-box and leucine-rich repeat protein 7
chr12_+_79995927 0.732 NM_024560
ACSS3
acyl-CoA synthetase short-chain family member 3
chr5_+_90711887 0.731 LOC100129716
hypothetical LOC100129716
chr3_-_130641460 0.730 MBD4
methyl-CpG binding domain protein 4
chr18_+_45342398 0.728 NM_006033
LIPG
lipase, endothelial
chr22_+_27468018 0.728 NM_172002
HSCB
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr5_-_171813960 0.722 SH3PXD2B
SH3 and PX domains 2B
chr16_+_81218142 0.710 CDH13
cadherin 13, H-cadherin (heart)
chr6_-_25679197 0.689


chr8_-_23768242 0.685 NM_003155
STC1
stanniocalcin 1
chr4_-_177950658 0.673 NM_005429
VEGFC
vascular endothelial growth factor C
chr2_-_183439515 0.661 NM_001463
FRZB
frizzled-related protein
chr13_-_60887655 0.661 NM_022843
PCDH20
protocadherin 20
chr2_-_219614481 0.656 NM_152389
NM_194302
CCDC108

coiled-coil domain containing 108

chr8_-_25371708 0.652 KCTD9
potassium channel tetramerisation domain containing 9
chr22_-_37211467 0.650 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr3_-_130641365 0.648 MBD4
methyl-CpG binding domain protein 4
chr8_-_25371663 0.647 KCTD9
potassium channel tetramerisation domain containing 9
chr18_+_58005494 0.645 NM_020854
KIAA1468
KIAA1468
chr4_-_111777956 0.644 NM_153426
NM_153427
PITX2

paired-like homeodomain 2

chr3_+_171621721 0.635 NM_001185056
CLDN11
claudin 11
chr15_-_91417362 0.633 NM_001166286
RGMA
RGM domain family, member A
chr11_-_129803515 0.630 ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chr3_+_130641639 0.626 NM_018262
NM_052985
NM_052989
NM_052990
IFT122



intraflagellar transport 122 homolog (Chlamydomonas)



chr11_-_85115105 0.626 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr17_-_36074812 0.616 NM_152349
KRT222
keratin 222
chr2_+_166034402 0.615 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr17_-_36436979 0.609 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr9_+_73716189 0.602 NM_182505
C9orf85
chromosome 9 open reading frame 85
chr8_-_108579270 0.601 NM_001146
ANGPT1
angiopoietin 1
chr6_-_26232109 0.599 NM_003526
HIST1H2BG
HIST1H2BC
histone cluster 1, H2bg
histone cluster 1, H2bc
chr6_-_166960496 0.596 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr3_-_130641539 0.586 NM_003925
MBD4
methyl-CpG binding domain protein 4
chr3_-_113495763 0.576 NM_183061
SLC9A10
solute carrier family 9, member 10
chr3_+_138063764 0.573 NCK1
NCK adaptor protein 1
chr1_+_117404432 0.571 TTF2
transcription termination factor, RNA polymerase II
chr13_-_109236897 0.564 NM_003749
IRS2
insulin receptor substrate 2
chr15_-_91417312 0.562 RGMA
RGM domain family, member A
chr2_-_162808123 0.558 NM_004460
FAP
fibroblast activation protein, alpha
chr9_+_91115924 0.548 NM_001827
CKS2
CDC28 protein kinase regulatory subunit 2
chr11_+_95163256 0.541 NM_014679
CEP57
centrosomal protein 57kDa
chr20_+_11846536 0.541 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr18_+_58005519 0.541 KIAA1468
KIAA1468
chr7_-_155297576 0.532 NM_000193
SHH
sonic hedgehog
chr2_-_192767494 0.524 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr3_+_138063697 0.524 NM_006153
NCK1
NCK adaptor protein 1
chr12_-_90097384 0.505 NM_133503
DCN
decorin
chr14_-_22722680 0.503 NM_012244
SLC7A8
solute carrier family 7 (amino acid transporter, L-type), member 8
chr3_+_174598937 0.503 NM_014932
NLGN1
neuroligin 1
chr4_-_186537145 0.503 NM_018409
LRP2BP
LRP2 binding protein
chr14_+_73621408 0.497 NM_001024674
LIN52
lin-52 homolog (C. elegans)
chr10_+_124310170 0.494 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr3_+_130641765 0.492 IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chrX_-_107568211 0.486 NM_033641
COL4A6
collagen, type IV, alpha 6
chr14_+_75197303 0.483 NM_015072
TTLL5
tubulin tyrosine ligase-like family, member 5
chr5_-_75048965 0.483 NM_001099271
POC5
POC5 centriolar protein homolog (Chlamydomonas)
chr3_-_33456881 0.480 NM_001128161
UBP1
upstream binding protein 1 (LBP-1a)
chr14_+_75197409 0.478 TTLL5
tubulin tyrosine ligase-like family, member 5
chr5_-_94442941 0.476 MCTP1
multiple C2 domains, transmembrane 1
chr17_+_43328514 0.475 NM_003110
SP2
Sp2 transcription factor
chr2_-_218843039 0.475 AAMP
angio-associated, migratory cell protein
chr6_+_26232351 0.471 NM_003512
HIST1H2AC
histone cluster 1, H2ac
chr2_+_176680251 0.466 NM_021192
HOXD11
homeobox D11
chr1_-_148050534 0.462 NM_001024599
NM_001161334
HIST2H2BF

histone cluster 2, H2bf

chr1_-_226712140 0.462 NM_033445
HIST3H2A
histone cluster 3, H2a
chr7_-_135083906 0.459 NM_205855
FAM180A
family with sequence similarity 180, member A
chr1_+_148603613 0.458 NM_015203
RPRD2
regulation of nuclear pre-mRNA domain containing 2
chrX_+_46581418 0.457 RP2
retinitis pigmentosa 2 (X-linked recessive)
chr19_-_50912429 0.456


chr2_+_71534260 0.455 NM_001130976
NM_001130977
NM_001130978
NM_001130979
NM_001130980
NM_001130981
NM_003494
DYSF






dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)






chr15_-_32875040 0.451 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr5_+_147562531 0.450 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr11_+_113436438 0.447 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr15_+_41597097 0.446 NM_002373
MAP1A
microtubule-associated protein 1A
chr16_+_65868913 0.446 NM_015432
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr5_-_16795336 0.445 MYO10
myosin X
chr13_+_94052022 0.439 NM_180989
GPR180
G protein-coupled receptor 180
chr17_+_43480674 0.434 NM_003204
NFE2L1
nuclear factor (erythroid-derived 2)-like 1
chr3_+_130641779 0.429 IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chr8_-_130868315 0.424 NM_031415
GSDMC
gasdermin C
chrX_-_103288263 0.422 NM_001012755
MCART6
mitochondrial carrier triple repeat 6
chr3_+_123036719 0.422 NM_018456
EAF2
ELL associated factor 2
chr17_+_43539909 0.419 NM_152244
NM_013323
SNX11

sorting nexin 11

chr10_+_63331401 0.416 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr12_+_77782648 0.416 SYT1
synaptotagmin I
chr6_+_26333361 0.415 NM_003532
HIST1H3E
histone cluster 1, H3e
chr13_-_32757835 0.410 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr13_-_47510033 0.410 SUCLA2
succinate-CoA ligase, ADP-forming, beta subunit
chr7_-_95063738 0.408 NM_002612
PDK4
pyruvate dehydrogenase kinase, isozyme 4
chr14_+_36200867 0.408 PAX9
paired box 9
chr1_+_170656450 0.404 NM_139240
C1orf105
chromosome 1 open reading frame 105
chr9_-_37455250 0.394 ZBTB5
zinc finger and BTB domain containing 5
chrX_-_10548458 0.386 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr16_+_24459173 0.385 RBBP6
retinoblastoma binding protein 6
chr2_-_218843109 0.385 NM_001087
AAMP
angio-associated, migratory cell protein
chr17_+_43540124 0.384 SNX11
sorting nexin 11
chr3_+_130641828 0.381 IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chr19_+_14501413 0.379 TECR
trans-2,3-enoyl-CoA reductase
chr10_+_17310263 0.377 NM_003380
VIM
vimentin
chr4_+_87734489 0.369 NM_006264
NM_080683
NM_080684
NM_080685
PTPN13



protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)



chr8_+_6553278 0.367 NM_018361
AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr8_+_6553322 0.366 AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr14_-_57834558 0.366 FLJ31306
hypothetical LOC379025
chr14_+_95071136 0.363 GLRX5
glutaredoxin 5
chr13_+_96726197 0.362 MBNL2
muscleblind-like 2 (Drosophila)
chr12_-_8993460 0.360 M6PR
mannose-6-phosphate receptor (cation dependent)
chr8_-_102034272 0.360 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr12_+_21545965 0.357 NM_016072
GOLT1B
golgi transport 1B
chr12_+_103677388 0.353 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr11_+_6904167 0.352 NM_013250
ZNF215
zinc finger protein 215
chr3_+_157343444 0.352 NM_003471
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr14_-_90596665 0.349 NM_004755
NM_182398
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr9_-_98421894 0.349 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr3_+_182900081 0.349 SOX2OT
SOX2 overlapping transcript (non-protein coding)
chr5_+_145807059 0.349 NM_001040006
NM_006706
TCERG1

transcription elongation regulator 1

chr5_+_44844724 0.347 NM_016640
MRPS30
mitochondrial ribosomal protein S30
chr14_+_75197345 0.346 TTLL5
tubulin tyrosine ligase-like family, member 5
chr12_-_21545751 0.344 NM_002907
NM_032941
RECQL

RecQ protein-like (DNA helicase Q1-like)

chr11_+_13646822 0.342 FAR1
fatty acyl CoA reductase 1
chr12_-_54409710 0.341 CD63
CD63 molecule
chr1_-_148124738 0.341 NM_003528
HIST2H2BE
histone cluster 2, H2be
chr17_+_43480724 0.340 NFE2L1
nuclear factor (erythroid-derived 2)-like 1
chr7_+_133982070 0.340 NM_001724
NM_199186
BPGM

2,3-bisphosphoglycerate mutase

chr5_+_43639069 0.337 NNT
nicotinamide nucleotide transhydrogenase
chr12_+_97433462 0.334 NM_001032283
NM_001032284
NM_003276
TMPO


thymopoietin


chr3_-_161766055 0.333 NM_002268
KPNA4
karyopherin alpha 4 (importin alpha 3)
chr2_-_108972048 0.327 EDAR
ectodysplasin A receptor
chr5_+_43638973 0.325 NM_182977
NNT
nicotinamide nucleotide transhydrogenase
chr1_-_171442937 0.324 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr16_+_3433606 0.321 NM_001083601
NAT15
N-acetyltransferase 15 (GCN5-related, putative)
chr1_+_148125090 0.319 NM_003517
HIST2H2AC
histone cluster 2, H2ac
chr14_-_22722658 0.319 SLC7A8
solute carrier family 7 (amino acid transporter, L-type), member 8
chr3_-_79899748 0.319 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr21_-_31012965 0.318 NM_001164435
KRTAP21-3
keratin associated protein 21-3
chr14_+_99017485 0.318 NM_001099402
CCNK
cyclin K
chr5_+_131437383 0.318 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr6_-_26379567 0.317 NM_003534
HIST1H3G
histone cluster 1, H3g
chr12_+_21546012 0.317 GOLT1B
golgi transport 1B
chr19_-_63092099 0.316 NM_001144989
ZNF814
zinc finger protein 814
chr22_+_28164571 0.311 NM_021026
RFPL1
ret finger protein-like 1
chr12_+_64982542 0.310 NM_033647
HELB
helicase (DNA) B
chr17_+_71174993 0.309 NM_013260
SAP30BP
SAP30 binding protein
chr8_-_25371858 0.308 NM_017634
KCTD9
potassium channel tetramerisation domain containing 9
chr4_+_81325447 0.308 NM_020226
PRDM8
PR domain containing 8
chr1_-_118273728 0.307 NM_001135589
NM_017686
GDAP2

ganglioside induced differentiation associated protein 2

chr6_+_26153590 0.305 NM_003531
HIST1H3C
histone cluster 1, H3c
chr11_+_13646727 0.305 NM_032228
FAR1
fatty acyl CoA reductase 1
chr19_+_46461897 0.304 NM_007040
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.68 3.90e-08 GO:0065004 protein-DNA complex assembly
5.38 1.21e-07 GO:0071824 protein-DNA complex subunit organization
5.95 1.34e-07 GO:0006334 nucleosome assembly
4.84 1.69e-07 GO:0006333 chromatin assembly or disassembly
5.64 3.66e-07 GO:0031497 chromatin assembly
5.37 9.34e-07 GO:0034728 nucleosome organization
4.75 1.49e-06 GO:0006323 DNA packaging
3.00 3.20e-06 GO:0034622 cellular macromolecular complex assembly
4.08 2.78e-05 GO:0071103 DNA conformation change
2.56 2.86e-05 GO:0034621 cellular macromolecular complex subunit organization
2.03 1.96e-03 GO:0071844 cellular component assembly at cellular level
1.45 7.91e-03 GO:0071842 cellular component organization at cellular level
2.24 1.07e-02 GO:0006325 chromatin organization
1.42 1.76e-02 GO:0071841 cellular component organization or biogenesis at cellular level
1.95 1.92e-02 GO:0065003 macromolecular complex assembly
1.85 2.04e-02 GO:0043933 macromolecular complex subunit organization
2.01 2.25e-02 GO:0051276 chromosome organization
1.35 2.77e-02 GO:0071840 cellular component organization or biogenesis
1.35 4.21e-02 GO:0016043 cellular component organization
1.55 4.59e-02 GO:0006996 organelle organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.22 1.05e-08 GO:0043229 intracellular organelle
1.22 1.43e-08 GO:0043226 organelle
7.13 9.51e-08 GO:0000786 nucleosome
1.16 4.55e-07 GO:0044424 intracellular part
1.15 8.28e-07 GO:0005622 intracellular
1.32 1.22e-05 GO:0005634 nucleus
4.85 1.47e-05 GO:0032993 protein-DNA complex
1.19 9.83e-05 GO:0043231 intracellular membrane-bounded organelle
1.19 1.13e-04 GO:0043227 membrane-bounded organelle
1.44 7.83e-04 GO:0043228 non-membrane-bounded organelle
1.44 7.83e-04 GO:0043232 intracellular non-membrane-bounded organelle
2.85 9.34e-04 GO:0000785 chromatin
1.25 1.90e-03 GO:0044446 intracellular organelle part
1.25 2.64e-03 GO:0044422 organelle part
2.19 2.83e-03 GO:0044427 chromosomal part
2.04 4.27e-03 GO:0005694 chromosome

Nothing significant found in function category.