Motif ID: GLI1..3.p2

Z-value: 1.317


Transcription factors associated with GLI1..3.p2:

Gene SymbolEntrez IDGene Name
GLI1 2735 glioma-associated oncogene homolog 1 (zinc finger protein)
GLI2 2736 GLI-Kruppel family member GLI2
GLI3 2737 GLI-Kruppel family member GLI3



Activity profile for motif GLI1..3.p2.

activity profile for motif GLI1..3.p2


Sorted Z-values histogram for motif GLI1..3.p2

Sorted Z-values for motif GLI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GLI1..3.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_32892705 2.775 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr11_-_60880799 2.118 NM_001161452
CYBASC3
cytochrome b, ascorbate dependent 3
chr11_-_72057755 1.966 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr18_+_75825563 1.797 NM_001136180
HSBP1L1
heat shock factor binding protein 1-like 1
chr16_+_48865521 1.733 ADCY7
adenylate cyclase 7
chr1_+_154389945 1.569 NM_001193300
NM_022367
NM_001193302
SEMA4A


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A


chr5_+_175725050 1.531 NM_173664
ARL10
ADP-ribosylation factor-like 10
chr2_-_231498184 1.490 NM_005683
GPR55
G protein-coupled receptor 55
chr17_-_3407780 1.448 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr12_-_56422120 1.437 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr16_-_66827449 1.430 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr1_-_16411690 1.352 NM_153213
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr19_+_38485583 1.338 LOC80054
hypothetical LOC80054
chr2_-_26058831 1.316 KIF3C
kinesin family member 3C
chr1_+_151147646 1.291 NM_005547
IVL
involucrin
chrX_-_1615999 1.284 NM_178129
P2RY8
CRLF2
purinergic receptor P2Y, G-protein coupled, 8
cytokine receptor-like factor 2
chr6_+_44076281 1.254 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr18_-_17434811 1.241 ESCO1
establishment of cohesion 1 homolog 1 (S. cerevisiae)
chr1_-_55039458 1.171 NM_001114108
NM_017904
TTC22

tetratricopeptide repeat domain 22

chr1_-_38285033 1.165 NM_002699
POU3F1
POU class 3 homeobox 1
chr19_+_3129735 1.160 NM_003775
S1PR4
sphingosine-1-phosphate receptor 4
chr19_-_15436333 1.153 NM_022904
RASAL3
RAS protein activator like 3
chr16_-_3049336 1.152


chr17_-_3408038 1.139 NM_145068
TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr7_+_87095640 1.124 NM_001134405
NM_001134406
NM_138290
RUNDC3B


RUN domain containing 3B


chr8_+_21937533 1.103 NPM2
nucleophosmin/nucleoplasmin 2
chr17_-_37181626 1.096


chr19_-_48976852 1.096 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr22_-_49317408 1.076 ODF3B
outer dense fiber of sperm tails 3B
chr16_+_66236512 1.041 NM_001013838
RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr1_-_11909042 1.034 NM_138346
KIAA2013
KIAA2013
chr11_+_9736408 1.031 LOC283104
hypothetical LOC283104
chr19_-_48977247 1.029 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr1_+_40715465 1.017 ZNF642
zinc finger protein 642
chr19_+_2240996 1.008


chr16_+_66236559 1.002 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr3_+_49566901 1.000 NM_003458
BSN
bassoon (presynaptic cytomatrix protein)
chr1_-_209818675 0.988 NM_021194
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr16_+_56134077 0.970 NM_153837
GPR114
G protein-coupled receptor 114
chr3_-_27385856 0.964 NM_199347
NEK10
NIMA (never in mitosis gene a)- related kinase 10
chr17_+_7283412 0.961 NM_004112
FGF11
fibroblast growth factor 11
chr2_+_96355661 0.958 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chr16_+_56134037 0.951 GPR114
G protein-coupled receptor 114
chr14_-_106330781 0.949 IGHV5-78
immunoglobulin heavy variable 5-78 pseudogene
chr4_-_140696740 0.945 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr16_+_1979959 0.930 NM_004209
SYNGR3
synaptogyrin 3
chr19_+_40431678 0.923 LSR
lipolysis stimulated lipoprotein receptor
chrX_+_49013424 0.919 PPP1R3F
protein phosphatase 1, regulatory (inhibitor) subunit 3F
chr2_+_137239583 0.905 THSD7B
thrombospondin, type I, domain containing 7B
chr11_+_65815911 0.899 TMEM151A
transmembrane protein 151A
chr12_+_6915698 0.895


chr5_+_176717553 0.893


chr19_+_16296632 0.887 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr19_+_811615 0.882 CFD
complement factor D (adipsin)
chr4_-_176970895 0.874 GPM6A
glycoprotein M6A
chr11_-_404975 0.865 NM_001135054
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr5_-_1647617 0.864 SDHAP3
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 3
chr2_+_220200530 0.861 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chr3_+_3816079 0.828 NM_020873
LRRN1
leucine rich repeat neuronal 1
chr11_-_118055564 0.814 NM_007180
TREH
trehalase (brush-border membrane glycoprotein)
chr1_-_209818576 0.809 SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr16_-_73366200 0.802 NM_024306
FA2H
fatty acid 2-hydroxylase
chr6_+_31647854 0.800 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr17_-_3766441 0.796 P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr16_+_29581783 0.789 NM_001030288
SPN
sialophorin
chr22_+_45401321 0.787 NM_015124
GRAMD4
GRAM domain containing 4
chr16_+_54247852 0.786 NM_001043
NM_001172504
SLC6A2

solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2

chr11_+_65815940 0.783 NM_153266
TMEM151A
transmembrane protein 151A
chr19_+_16296734 0.780 KLF2
Kruppel-like factor 2 (lung)
chrX_-_7855764 0.776 NM_001142389
NM_001172672
PNPLA4

patatin-like phospholipase domain containing 4

chr15_+_38923914 0.776 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr2_-_242096673 0.768 NM_006374
STK25
serine/threonine kinase 25
chr13_-_40138607 0.768 NM_002015
FOXO1
forkhead box O1
chr1_-_158815850 0.753 CD84
CD84 molecule
chr12_-_53064723 0.753 NM_015481
ZNF385A
zinc finger protein 385A
chr18_-_17434655 0.752 NM_052911
ESCO1
establishment of cohesion 1 homolog 1 (S. cerevisiae)
chr11_-_75056761 0.749 MAP6
microtubule-associated protein 6
chr19_+_50109903 0.747 APOC1
apolipoprotein C-I
chr19_-_10900086 0.747 NM_024029
YIPF2
Yip1 domain family, member 2
chr8_-_134653194 0.745 NM_003033
NM_173344
ST3GAL1

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

chr20_+_61655934 0.743


chr19_-_43800374 0.739 NM_001042600
NM_007181
MAP4K1

mitogen-activated protein kinase kinase kinase kinase 1

chr16_+_55950195 0.739 NM_002990
CCL22
chemokine (C-C motif) ligand 22
chr6_+_47774247 0.735 NM_153838
GPR115
G protein-coupled receptor 115
chr22_-_44751671 0.732 NM_058238
WNT7B
wingless-type MMTV integration site family, member 7B
chr7_-_960534 0.729 ADAP1
ArfGAP with dual PH domains 1
chr4_+_8251818 0.726 NM_018986
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr1_-_45081190 0.725 NM_001166292
NM_003738
PTCH2

patched 2

chr11_+_22171150 0.721 NM_001142649
NM_213599
ANO5

anoctamin 5

chr4_-_176970372 0.720 GPM6A
glycoprotein M6A
chr16_-_73365975 0.717 FA2H
fatty acid 2-hydroxylase
chr14_+_76717835 0.715 NM_020431
TMEM63C
transmembrane protein 63C
chr14_+_92188546 0.715 RIN3
Ras and Rab interactor 3
chr1_-_6343306 0.713 NM_181865
ACOT7
acyl-CoA thioesterase 7
chr20_+_30103642 0.712 NM_001172129
NM_001172130
NM_001172131
NM_001172132
NM_001172133
NM_002110
HCK





hemopoietic cell kinase





chr18_+_58143499 0.710 NM_003839
TNFRSF11A
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
chr2_+_19932101 0.703 FLJ12334
hypothetical LOC400946
chr19_-_53832381 0.703 NM_001352
DBP
D site of albumin promoter (albumin D-box) binding protein
chr20_-_44612619 0.703 NM_080721
C20orf123
chromosome 20 open reading frame 123
chr3_+_50272648 0.700


chr18_+_13208777 0.698 NM_181481
NM_181482
C18orf1

chromosome 18 open reading frame 1

chr16_+_2461500 0.696 NM_006181
NTN3
netrin 3
chr1_+_148090804 0.696 NM_021059
NM_001005464
HIST2H3C
HIST2H3A
histone cluster 2, H3c
histone cluster 2, H3a
chr3_+_47004457 0.693 NBEAL2
neurobeachin-like 2
chr6_+_3009120 0.692 RIPK1
receptor (TNFRSF)-interacting serine-threonine kinase 1
chr2_-_242096592 0.689 STK25
serine/threonine kinase 25
chr4_-_176970407 0.685 GPM6A
glycoprotein M6A
chr4_-_957269 0.680 DGKQ
diacylglycerol kinase, theta 110kDa
chr5_-_156935283 0.677


chr20_-_42457717 0.674


chr5_-_1165106 0.673 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr16_+_30952350 0.672 STX4
syntaxin 4
chr5_+_176717449 0.671 NM_006480
RGS14
regulator of G-protein signaling 14
chr17_-_74231240 0.667 CYTH1
cytohesin 1
chr17_+_4795128 0.667 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr17_-_71272811 0.666 NM_000154
GALK1
galactokinase 1
chr7_+_149699185 0.659 NM_014374
REPIN1
replication initiator 1
chr16_-_11588525 0.656 LITAF
lipopolysaccharide-induced TNF factor
chr17_+_45008473 0.651 NXPH3
neurexophilin 3
chr1_+_34993234 0.641 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr7_+_99809068 0.639 PILRA
paired immunoglobin-like type 2 receptor alpha
chr2_-_6923215 0.639 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr11_+_112763722 0.639 NM_178510
ANKK1
ankyrin repeat and kinase domain containing 1
chr1_-_6341553 0.638 NM_181866
ACOT7
acyl-CoA thioesterase 7
chr17_-_37181636 0.637 JUP
junction plakoglobin
chr16_+_56259657 0.635 NM_170776
GPR97
G protein-coupled receptor 97
chr11_+_75157450 0.632 DGAT2
diacylglycerol O-acyltransferase 2
chr11_-_30564338 0.629 NM_001145399
MPPED2
metallophosphoesterase domain containing 2
chr12_+_110328126 0.629 NM_005475
SH2B3
SH2B adaptor protein 3
chr17_-_34607257 0.624 NM_000723
NM_199247
NM_199248
CACNB1


calcium channel, voltage-dependent, beta 1 subunit


chr2_+_46623325 0.622 NM_012249
RHOQ
ras homolog gene family, member Q
chr9_+_130258256 0.620 ODF2
outer dense fiber of sperm tails 2
chr12_-_6668680 0.619 ZNF384
zinc finger protein 384
chr20_+_61654816 0.619 NM_024059
C20orf195
chromosome 20 open reading frame 195
chr14_-_106352471 0.618


chr7_-_148212336 0.616 NM_004456
NM_152998
EZH2

enhancer of zeste homolog 2 (Drosophila)

chr19_+_3087026 0.614 NM_002068
GNA15
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chr1_+_153513810 0.614 NM_020897
HCN3
hyperpolarization activated cyclic nucleotide-gated potassium channel 3
chr17_+_73738985 0.613 NM_001145529
TMEM235
transmembrane protein 235
chr22_-_49317873 0.611 NM_001014440
ODF3B
outer dense fiber of sperm tails 3B
chr20_+_31783426 0.610 NM_032819
ZNF341
zinc finger protein 341
chr5_-_156935317 0.608 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr19_+_10900502 0.605 C19orf52
chromosome 19 open reading frame 52
chr12_-_101835026 0.602 PAH
phenylalanine hydroxylase
chr1_+_199259664 0.601


chrX_+_48427103 0.599 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr9_-_138757175 0.599 NM_001001712
LCN10
lipocalin 10
chr13_-_24643620 0.598 FAM123A
family with sequence similarity 123A
chr17_-_45617899 0.595 COL1A1
collagen, type I, alpha 1
chr15_-_76720598 0.595 NM_000750
CHRNB4
cholinergic receptor, nicotinic, beta 4
chr7_+_72883128 0.592 NM_001305
CLDN4
claudin 4
chr2_-_85490984 0.591 CAPG
capping protein (actin filament), gelsolin-like
chr4_+_100957003 0.590 NM_014395
DAPP1
dual adaptor of phosphotyrosine and 3-phosphoinositides
chr4_-_176971175 0.589 NM_201591
GPM6A
glycoprotein M6A
chr11_-_118405288 0.587 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr19_+_63670148 0.586 NM_014347
ZNF324
zinc finger protein 324
chr19_-_11477689 0.586 NM_138783
ZNF653
zinc finger protein 653
chr10_+_8137356 0.585 GATA3
GATA binding protein 3
chr16_-_10184111 0.584 NM_000833
GRIN2A
glutamate receptor, ionotropic, N-methyl D-aspartate 2A
chr1_-_39929654 0.581 NM_016257
HPCAL4
hippocalcin like 4
chr7_-_99518294 0.579 ZNF3
zinc finger protein 3
chr11_+_65311142 0.579 OVOL1
ovo-like 1(Drosophila)
chr20_-_43974092 0.579 NM_006227
NM_182676
PLTP

phospholipid transfer protein

chr7_-_102044374 0.578 RASA4
RAS p21 protein activator 4
chr10_+_85944383 0.578 NM_001171971
NM_033100
CDHR1

cadherin-related family member 1

chr14_-_50631407 0.578 TRIM9
tripartite motif containing 9
chr10_+_71060008 0.578 NM_145306
C10orf35
chromosome 10 open reading frame 35
chr5_+_150206277 0.577 NM_001145805
IRGM
immunity-related GTPase family, M
chr9_+_130258100 0.574 NM_153432
NM_153435
NM_153439
ODF2


outer dense fiber of sperm tails 2


chr16_+_30952382 0.574 NM_004604
STX4
syntaxin 4
chr17_-_17340219 0.574 NM_016084
RASD1
RAS, dexamethasone-induced 1
chr12_+_45896511 0.573 FAM113B
family with sequence similarity 113, member B
chr10_+_99488223 0.572 NM_001002261
ZFYVE27
zinc finger, FYVE domain containing 27
chr17_-_53920699 0.569 NM_001080439
HSF5
heat shock transcription factor family member 5
chr12_-_53064565 0.569 ZNF385A
zinc finger protein 385A
chr15_+_37660568 0.568 NM_003246
THBS1
thrombospondin 1
chr6_-_133126278 0.566 NM_078488
VNN2
vanin 2
chr3_-_120761092 0.566 NM_005191
CD80
CD80 molecule
chr6_+_33280396 0.565 NM_014234
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr20_+_44180355 0.563 CD40
CD40 molecule, TNF receptor superfamily member 5
chr2_+_172658453 0.559 NM_001038493
NM_178120
DLX1

distal-less homeobox 1

chr13_-_19665100 0.556 NM_004004
GJB2
gap junction protein, beta 2, 26kDa
chr1_-_210939727 0.554


chr7_+_73826244 0.553 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr3_-_53055078 0.552 NM_001005158
NM_016329
SFMBT1

Scm-like with four mbt domains 1

chr3_-_159306214 0.548


chr7_-_127833231 0.546 NM_001142573
NM_001142574
NM_001142575
IMPDH1


IMP (inosine 5'-monophosphate) dehydrogenase 1


chr19_+_482737 0.546 CDC34
cell division cycle 34 homolog (S. cerevisiae)
chr12_+_6517600 0.544


chr9_+_130258247 0.543 ODF2
outer dense fiber of sperm tails 2
chr2_-_26058941 0.540 NM_002254
KIF3C
kinesin family member 3C
chr1_-_111544820 0.538 DENND2D
DENN/MADD domain containing 2D
chr20_+_44180296 0.538 NM_001250
NM_152854
CD40

CD40 molecule, TNF receptor superfamily member 5

chr8_+_21938299 0.537 NM_182795
NPM2
nucleophosmin/nucleoplasmin 2
chr19_-_38485281 0.534 CEBPA
CCAAT/enhancer binding protein (C/EBP), alpha
chrX_+_106336517 0.531 NM_001169154
NM_173494
CXorf41

chromosome X open reading frame 41

chr13_-_19665036 0.531 GJB2
gap junction protein, beta 2, 26kDa
chr11_-_83071084 0.531 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr12_-_101396459 0.530 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr18_+_2896178 0.528 EMILIN2
elastin microfibril interfacer 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.30 5.80e-04 GO:0048583 regulation of response to stimulus
1.36 5.91e-04 GO:0009966 regulation of signal transduction
1.32 1.20e-03 GO:0023051 regulation of signaling
1.11 1.54e-03 GO:0065007 biological regulation
1.44 1.65e-03 GO:0009611 response to wounding
1.59 3.79e-03 GO:0007596 blood coagulation
1.59 3.79e-03 GO:0050817 coagulation
1.58 5.21e-03 GO:0007599 hemostasis
1.52 7.45e-03 GO:0042060 wound healing
1.52 1.08e-02 GO:0050878 regulation of body fluid levels
1.63 2.02e-02 GO:0051056 regulation of small GTPase mediated signal transduction
1.21 2.29e-02 GO:0048518 positive regulation of biological process
1.24 4.44e-02 GO:0048869 cellular developmental process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.69 6.55e-03 GO:0005083 small GTPase regulator activity
3.54 2.93e-02 GO:0042169 SH2 domain binding
1.68 3.18e-02 GO:0005096 GTPase activator activity
1.40 3.74e-02 GO:0043565 sequence-specific DNA binding
1.32 3.92e-02 GO:0001071 nucleic acid binding transcription factor activity
1.32 3.92e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.48 4.62e-02 GO:0030695 GTPase regulator activity