Motif ID: RXRG_dimer.p3

Z-value: 0.967


Transcription factors associated with RXRG_dimer.p3:

Gene SymbolEntrez IDGene Name
NR1H2 7376 nuclear receptor subfamily 1, group H, member 2
PPARA 5465 peroxisome proliferator-activated receptor alpha
PPARG 5468 peroxisome proliferator-activated receptor gamma
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma



Activity profile for motif RXRG_dimer.p3.

activity profile for motif RXRG_dimer.p3


Sorted Z-values histogram for motif RXRG_dimer.p3

Sorted Z-values for motif RXRG_dimer.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRG_dimer.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_44308224 1.764 NM_001014831
NM_001014832
NM_001014834
NM_001014835
NM_005884
PAK4




p21 protein (Cdc42/Rac)-activated kinase 4




chr18_-_50004458 1.764 MBD2
methyl-CpG binding domain protein 2
chr3_-_49289285 1.451 NM_198562
C3orf62
chromosome 3 open reading frame 62
chr2_+_206732859 1.387 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr6_+_142510094 1.295 NM_016485
VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr6_+_142510075 1.264 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr7_+_142790047 1.173 ZYX
zyxin
chr2_+_206732562 1.171 NM_001037663
NM_001959
NM_021121
EEF1B2


eukaryotic translation elongation factor 1 beta 2


chr6_+_142510108 1.168 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr2_+_219141761 1.166 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr2_+_206732575 1.148 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr2_-_206732348 1.112 NM_005006
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr16_+_79829794 1.070 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr4_+_30331289 1.051 PCDH7
protocadherin 7
chr14_-_94693359 1.036 DICER1
dicer 1, ribonuclease type III
chr6_+_142510034 1.021 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr12_+_65949414 1.016 CAND1
cullin-associated and neddylation-dissociated 1
chr18_-_50004770 0.989 MBD2
methyl-CpG binding domain protein 2
chr1_-_101263867 0.972 NM_001077394
NM_001077395
NM_015958
DPH5


DPH5 homolog (S. cerevisiae)


chr1_-_154147787 0.960 NM_006912
RIT1
Ras-like without CAAX 1
chr1_-_154147687 0.956 RIT1
Ras-like without CAAX 1
chr3_-_114947330 0.955 NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr12_+_65949631 0.952 CAND1
cullin-associated and neddylation-dissociated 1
chr4_+_30330963 0.949 NM_001173523
NM_002589
NM_032456
NM_032457
PCDH7



protocadherin 7



chr12_+_65949327 0.949 NM_018448
CAND1
cullin-associated and neddylation-dissociated 1
chr9_+_88086932 0.883


chr1_+_101263989 0.860


chr2_+_138438277 0.854 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr2_-_219141199 0.790 NM_020935
USP37
ubiquitin specific peptidase 37
chr3_+_151747204 0.784 NM_032025
EIF2A
eukaryotic translation initiation factor 2A, 65kDa
chr11_+_85690900 0.752 NM_016401
C11orf73
chromosome 11 open reading frame 73
chr12_-_6995988 0.750 NM_005768
LPCAT3
lysophosphatidylcholine acyltransferase 3
chr9_-_138277467 0.745 NM_181701
QSOX2
quiescin Q6 sulfhydryl oxidase 2
chr3_-_49424322 0.734 RHOA
ras homolog gene family, member A
chr3_+_151747266 0.730 EIF2A
eukaryotic translation initiation factor 2A, 65kDa
chr6_+_144040751 0.713 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr2_-_27966715 0.709 NM_022128
RBKS
ribokinase
chr1_+_43628186 0.708 C1orf84
chromosome 1 open reading frame 84
chr1_+_61320213 0.697 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr9_+_103335983 0.685 RNF20
ring finger protein 20
chr6_-_146326918 0.676 NM_001042683
NM_173082
SHPRH

SNF2 histone linker PHD RING helicase

chr4_-_4594620 0.673 STX18
syntaxin 18
chr9_+_114182216 0.653 HSDL2
hydroxysteroid dehydrogenase like 2
chr5_+_80292313 0.651 NM_006909
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr11_+_118374071 0.632 CCDC84
coiled-coil domain containing 84
chr12_-_93991235 0.610 NM_001032287
NM_001127362
NM_003297
NR2C1


nuclear receptor subfamily 2, group C, member 1


chr3_-_52287297 0.604 WDR82
WD repeat domain 82
chr2_+_219141546 0.601 RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr3_+_185538998 0.598 FAM131A
family with sequence similarity 131, member A
chr5_+_92944680 0.580 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr20_-_7869068 0.579 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr19_+_50086482 0.577 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr7_+_142789476 0.573 ZYX
zyxin
chr1_+_196148241 0.571 NM_001014434
LHX9
LIM homeobox 9
chr12_+_48422220 0.570 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr2_+_161725172 0.557 TANK
TRAF family member-associated NFKB activator
chr7_-_106991941 0.554 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chr17_+_35532994 0.554 MSL1
male-specific lethal 1 homolog (Drosophila)
chr19_+_41980248 0.552 LOC284408
hypothetical LOC284408
chr12_-_117295095 0.544 NM_016281
TAOK3
TAO kinase 3
chr20_+_43943254 0.540 NM_080603
ZSWIM1
zinc finger, SWIM-type containing 1
chr6_+_143813472 0.540 NM_003630
PEX3
peroxisomal biogenesis factor 3
chr1_-_6684426 0.540 DNAJC11
DnaJ (Hsp40) homolog, subfamily C, member 11
chr6_-_146326863 0.529 SHPRH
SNF2 histone linker PHD RING helicase
chr9_+_114182009 0.520 NM_001195822
NM_032303
HSDL2

hydroxysteroid dehydrogenase like 2

chr20_+_37024383 0.516 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr1_+_43628136 0.515 NM_001012961
C1orf84
chromosome 1 open reading frame 84
chr3_-_151746821 0.514 SERP1
stress-associated endoplasmic reticulum protein 1
chr22_+_40195058 0.509 NM_001098
ACO2
aconitase 2, mitochondrial
chr2_+_220007943 0.503 NM_005876
SPEG
SPEG complex locus
chr22_+_28493351 0.502 NM_001003684
NM_013387
UQCR10

ubiquinol-cytochrome c reductase, complex III subunit X

chr10_-_21854616 0.501 NM_207371
C10orf140
chromosome 10 open reading frame 140
chr4_+_109761170 0.500 NM_000995
NM_033625
RPL34

ribosomal protein L34

chr2_+_73294852 0.497 NM_006062
SMYD5
SMYD family member 5
chr4_-_4594591 0.490 STX18
syntaxin 18
chr11_+_118374051 0.484 NM_198489
CCDC84
coiled-coil domain containing 84
chr2_+_198073358 0.483 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr2_-_27457088 0.477 NM_144631
ZNF513
zinc finger protein 513
chr9_+_103335964 0.475 RNF20
ring finger protein 20
chr12_+_67489063 0.466 MDM2
Mdm2 p53 binding protein homolog (mouse)
chr20_+_19981157 0.425 NM_015585
C20orf26
chromosome 20 open reading frame 26
chr3_-_114947681 0.422 NM_025146
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr13_+_20612709 0.415 SAP18
Sin3A-associated protein, 18kDa
chr8_-_81104938 0.414 NM_014018
MRPS28
mitochondrial ribosomal protein S28
chr3_-_151746970 0.409 NM_014445
SERP1
stress-associated endoplasmic reticulum protein 1
chr12_+_94776901 0.408 SNRPF
small nuclear ribonucleoprotein polypeptide F
chr12_-_117294933 0.407 TAOK3
TAO kinase 3
chr3_+_46423682 0.405 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr20_-_19981005 0.401 CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr19_+_44082458 0.394 NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr1_-_43628060 0.389 NM_052877
NM_201542
MED8

mediator complex subunit 8

chr10_-_118887801 0.387 NM_001112704
NM_199131
VAX1

ventral anterior homeobox 1

chr3_-_49424361 0.387 RHOA
ras homolog gene family, member A
chr21_+_44256630 0.386 NM_003274
TRAPPC10
trafficking protein particle complex 10
chr9_+_139633272 0.380 EHMT1
euchromatic histone-lysine N-methyltransferase 1
chr19_+_50086357 0.378 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr1_-_79244948 0.376 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr5_+_1854493 0.373 NM_004553
NDUFS6
NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
chr1_-_158579653 0.373 COPA
coatomer protein complex, subunit alpha
chr6_+_30702586 0.371 NM_024909
NM_001031722
NM_001190724
ATAT1


alpha tubulin acetyltransferase 1


chr6_-_32034607 0.371 NM_002904
RDBP
RD RNA binding protein
chr19_+_50086362 0.370 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr7_+_120415958 0.370 NM_024913
C7orf58
chromosome 7 open reading frame 58
chr2_-_175754366 0.363 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr12_-_52407470 0.363 NM_001143682
NM_020898
CALCOCO1

calcium binding and coiled-coil domain 1

chr18_-_44730706 0.360 SMAD7
SMAD family member 7
chr3_-_49424380 0.359 RHOA
ras homolog gene family, member A
chr1_-_158579583 0.358


chr10_-_119795663 0.355 NM_014904
RAB11FIP2
RAB11 family interacting protein 2 (class I)
chr18_+_45594326 0.355


chr6_-_146327238 0.353 SHPRH
SNF2 histone linker PHD RING helicase
chr1_-_95311031 0.346 NM_144988
ALG14
asparagine-linked glycosylation 14 homolog (S. cerevisiae)
chr19_+_44082410 0.346 NM_001001716
NM_002503
NFKBIB

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta

chr3_-_49424506 0.341 RHOA
ras homolog gene family, member A
chr6_-_146327155 0.337 SHPRH
SNF2 histone linker PHD RING helicase
chr1_-_43628035 0.330 MED8
mediator complex subunit 8
chr3_-_49424529 0.326 NM_001664
RHOA
ras homolog gene family, member A
chr2_+_108604111 0.320 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr14_-_74713086 0.318 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr1_-_158579680 0.318 COPA
coatomer protein complex, subunit alpha
chr3_-_151746924 0.314 SERP1
stress-associated endoplasmic reticulum protein 1
chr14_-_74713062 0.312 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr1_-_43691932 0.309 HYI
hydroxypyruvate isomerase (putative)
chr1_-_32632601 0.298 NM_001143888
NM_001143889
NM_001143890
NM_018045
BSDC1



BSD domain containing 1



chr2_+_177965734 0.295 AGPS
alkylglycerone phosphate synthase
chr4_+_4594619 0.293 LOC100507266
hypothetical LOC100507266
chr1_-_120285753 0.290 NOTCH2
notch 2
chr14_-_74713088 0.289 NM_006827
TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chrX_+_100241453 0.288 NM_006733
CENPI
centromere protein I
chr9_+_103335941 0.284 NM_019592
RNF20
ring finger protein 20
chr3_-_152173475 0.282 NM_001195794
NM_174878
CLRN1

clarin 1

chr3_-_49178738 0.279 CCDC71
coiled-coil domain containing 71
chr11_+_117948301 0.273 NM_001142281
NM_001655
ARCN1

archain 1

chr5_+_14717803 0.267 FAM105B
family with sequence similarity 105, member B
chr11_+_117948350 0.267 ARCN1
archain 1
chr5_-_14717703 0.267 LOC728178
hypothetical protein LOC728178
chr14_-_74713039 0.265 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr2_+_201691664 0.264 CFLAR
CASP8 and FADD-like apoptosis regulator
chr4_-_68249442 0.264 NM_018227
UBA6
ubiquitin-like modifier activating enzyme 6
chr19_+_50086350 0.264 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr1_-_6684465 0.258 DNAJC11
DnaJ (Hsp40) homolog, subfamily C, member 11
chr1_-_224441024 0.257 NM_022735
ACBD3
acyl-CoA binding domain containing 3
chr11_+_86426518 0.255 NM_001168724
NM_022918
TMEM135

transmembrane protein 135

chr10_+_119796324 0.254 CASC2
cancer susceptibility candidate 2
chr3_-_195874202 0.254 LSG1
large subunit GTPase 1 homolog (S. cerevisiae)
chr1_-_224441023 0.252 ACBD3
acyl-CoA binding domain containing 3
chr16_+_3102556 0.249 NM_001042428
NM_003456
ZNF205

zinc finger protein 205

chr9_+_139633264 0.248 NM_001145527
NM_024757
EHMT1

euchromatic histone-lysine N-methyltransferase 1

chr19_+_6323443 0.246 NM_032306
ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr2_+_198073257 0.244 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr3_-_49424397 0.243 RHOA
ras homolog gene family, member A
chr9_-_26995649 0.240 NM_022901
LRRC19
leucine rich repeat containing 19
chr1_+_158579685 0.236 NM_015331
NCSTN
nicastrin
chr3_-_195874227 0.236 LSG1
large subunit GTPase 1 homolog (S. cerevisiae)
chr12_+_67291016 0.236 RAP1B
RAP1B, member of RAS oncogene family
chr3_-_49178762 0.236 CCDC71
coiled-coil domain containing 71
chr4_-_84150885 0.235 LIN54
lin-54 homolog (C. elegans)
chr4_-_4594648 0.229 NM_016930
STX18
syntaxin 18
chr11_+_117735558 0.226 UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr1_-_149404954 0.226 NM_212551
NM_001136543
LYSMD1

LysM, putative peptidoglycan-binding, domain containing 1

chr2_+_26422495 0.224 EPT1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr5_+_172416959 0.224 C5orf41
chromosome 5 open reading frame 41
chr2_+_27966985 0.223 NM_199193
NM_199194
NM_004899
NM_199191
NM_199192
BRE




brain and reproductive organ-expressed (TNFRSF1A modulator)




chr5_-_32480174 0.221


chr20_+_30409649 0.219 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr14_+_23937766 0.218 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr2_+_219354692 0.212 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr1_-_201411533 0.210 NM_004997
MYBPH
myosin binding protein H
chr3_-_49424427 0.210 RHOA
ras homolog gene family, member A
chr3_-_49178773 0.209 NM_022903
CCDC71
coiled-coil domain containing 71
chr3_-_151746954 0.208 SERP1
stress-associated endoplasmic reticulum protein 1
chr18_+_52469559 0.203 NM_015285
NM_052834
WDR7

WD repeat domain 7

chr19_+_60691733 0.203 SSC5D
scavenger receptor cysteine rich domain containing (5 domains)
chr4_-_68249386 0.203 UBA6
ubiquitin-like modifier activating enzyme 6
chr5_-_42847716 0.201 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr13_+_99539269 0.200 NM_000282
NM_001127692
NM_001178004
PCCA


propionyl CoA carboxylase, alpha polypeptide


chr12_+_67290951 0.197 RAP1B
RAP1BL
RAP1B, member of RAS oncogene family
RAP1B, member of RAS oncogene family pseudogene
chr10_-_62431203 0.185 RHOBTB1
Rho-related BTB domain containing 1
chr12_+_67290881 0.184 NM_001010942
NM_015646
RAP1B

RAP1B, member of RAS oncogene family

chr4_-_84150997 0.183 NM_001115008
NM_194282
LIN54

lin-54 homolog (C. elegans)

chr16_+_30617962 0.177 NM_006662
SRCAP
Snf2-related CREBBP activator protein
chr14_+_94693744 0.177 FLJ45244
hypothetical locus FLJ45244
chr14_-_74713012 0.176 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr2_-_218843109 0.174 NM_001087
AAMP
angio-associated, migratory cell protein
chr9_-_139632870 0.169 C9orf37
chromosome 9 open reading frame 37
chr18_-_45594206 0.167 NM_006111
ACAA2
acetyl-CoA acyltransferase 2
chr14_-_94693418 0.166 NM_177438
DICER1
dicer 1, ribonuclease type III
chr19_+_60487345 0.165 NM_032430
BRSK1
BR serine/threonine kinase 1
chr3_-_49424404 0.162 RHOA
ras homolog gene family, member A
chr6_-_2785682 0.161 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr1_+_45046740 0.159 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr12_+_67290975 0.158 RAP1B
RAP1B, member of RAS oncogene family
chr11_+_117735530 0.157 UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr19_-_40317829 0.156 NM_139284
LGI4
leucine-rich repeat LGI family, member 4
chr2_+_108432097 0.156 GCC2
GRIP and coiled-coil domain containing 2
chr2_+_27967102 0.155 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr2_-_177965626 0.153 LOC100130691
hypothetical LOC100130691
chr19_-_41514437 0.153 LOC100506930
hypothetical LOC100506930
chr1_-_153213454 0.153 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr11_-_65962836 0.152 NM_016050
NM_170738
NM_170739
MRPL11


mitochondrial ribosomal protein L11



Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.30 1.66e-03 GO:0043231 intracellular membrane-bounded organelle
1.30 1.79e-03 GO:0043227 membrane-bounded organelle
1.24 9.28e-03 GO:0043229 intracellular organelle
1.24 1.04e-02 GO:0043226 organelle
1.38 1.50e-02 GO:0044444 cytoplasmic part
2.50 2.24e-02 GO:0044429 mitochondrial part
3.67 2.26e-02 GO:0005759 mitochondrial matrix
1.18 2.94e-02 GO:0044424 intracellular part

Gene overrepresentation in function category:

enrichment   p-value GO term description
7.94 2.21e-02 GO:0033293 monocarboxylic acid binding