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• Activity deltas table
• Regulatory interactions
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Motif ID: PAX2.p2

Z-value: 0.941

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr11_-_85457469	1.825		PICALM	phosphatidylinositol binding clathrin assembly protein
chr15_-_68781662	1.389	NM_001008224	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats
chr11_-_85457736	1.004		PICALM	phosphatidylinositol binding clathrin assembly protein
chr11_-_85457753	0.948	NM_001008660 NM_007166	PICALM	phosphatidylinositol binding clathrin assembly protein
chr7_-_105712565	0.846		NAMPT	nicotinamide phosphoribosyltransferase
chr4_-_113777569	0.825	NM_018392	C4orf21	chromosome 4 open reading frame 21
chr8_+_126173264	0.794	NM_173685	NSMCE2	non-SMC element 2, MMS21 homolog (S. cerevisiae)
chr15_+_41597097	0.786	NM_002373	MAP1A	microtubule-associated protein 1A
chr17_+_55051818	0.780	NM_004859	CLTC	clathrin, heavy chain (Hc)
chr3_+_19963534	0.766	NM_004162	RAB5A	RAB5A, member RAS oncogene family
chr12_-_56432377	0.757		CDK4	cyclin-dependent kinase 4
chr1_+_221168388	0.742	NM_032890	DISP1	dispatched homolog 1 (Drosophila)
chr11_+_58103212	0.740		ZFP91-CNTF ZFP91	ZFP91-CNTF readthrough transcript zinc finger protein 91 homolog (mouse)
chr8_-_126173108	0.736		KIAA0196	KIAA0196
chr12_-_56432375	0.729		CDK4	cyclin-dependent kinase 4
chr12_-_56432385	0.728	NM_000075	CDK4	cyclin-dependent kinase 4
chr13_+_47776026	0.724		RB1	retinoblastoma 1
chr1_-_77920914	0.719	NM_015534	ZZZ3	zinc finger, ZZ-type containing 3
chr1_-_154205675	0.713		ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr8_-_126173186	0.699		KIAA0196	KIAA0196
chr6_-_37061920	0.683		MTCH1	mitochondrial carrier homolog 1 (C. elegans)
chr19_+_10626106	0.679		ILF3	interleukin enhancer binding factor 3, 90kDa
chr13_+_47775951	0.678		RB1	retinoblastoma 1
chr14_+_54807855	0.674		FBXO34	F-box protein 34
chr6_-_109810396	0.663	NM_001142401 NM_001142402 NM_001142403 NM_001142404 NM_006016	CD164	CD164 molecule, sialomucin
chr12_+_104025667	0.662		KIAA1033	KIAA1033
chr17_+_70984173	0.661		KIAA0195	KIAA0195
chr8_-_126173203	0.657		KIAA0196	KIAA0196
chr8_-_13416554	0.656	NM_024767 NM_182643	DLC1	deleted in liver cancer 1
chr8_-_126173189	0.655		KIAA0196	KIAA0196
chr12_+_104025675	0.650		KIAA1033	KIAA1033
chrX_+_100549885	0.648		HNRNPH2	heterogeneous nuclear ribonucleoprotein H2 (H')
chr5_-_167938875	0.646		PANK3	pantothenate kinase 3
chr10_+_5478521	0.641	NM_005863	NET1	neuroepithelial cell transforming 1
chr1_+_36462625	0.638		THRAP3	thyroid hormone receptor associated protein 3
chr15_-_63871492	0.638		DENND4A	DENN/MADD domain containing 4A
chr3_-_198509276	0.627		DLG1	discs, large homolog 1 (Drosophila)
chr5_-_75954807	0.619	NM_004101	F2RL2	coagulation factor II (thrombin) receptor-like 2
chr12_-_56432292	0.615		CDK4	cyclin-dependent kinase 4
chr4_+_144325502	0.615	NM_032557	USP38	ubiquitin specific peptidase 38
chr4_-_113777470	0.600		C4orf21	chromosome 4 open reading frame 21
chr7_-_105712646	0.600	NM_005746	NAMPT	nicotinamide phosphoribosyltransferase
chr17_-_32730804	0.596	NM_198837 NM_198838	ACACA	acetyl-CoA carboxylase alpha
chr6_+_87921980	0.593	NM_015021	ZNF292	zinc finger protein 292
chr14_-_19993032	0.585	NM_017807	OSGEP	O-sialoglycoprotein endopeptidase
chr7_-_121731721	0.582	NM_001024613 NM_001160264	FEZF1	FEZ family zinc finger 1
chr1_-_113300138	0.582	NM_001166496	SLC16A1	solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
chr17_+_55052046	0.581		CLTC	clathrin, heavy chain (Hc)
chrX_-_100549561	0.574	NM_000169	GLA	galactosidase, alpha
chr1_+_36462583	0.572	NM_005119	THRAP3	thyroid hormone receptor associated protein 3
chr6_+_127629677	0.572	NM_030963	RNF146	ring finger protein 146
chr4_+_113777568	0.567	NM_016648	LARP7	La ribonucleoprotein domain family, member 7
chr1_-_51198328	0.563		FAF1	Fas (TNFRSF6) associated factor 1
chr4_+_144325533	0.563		USP38	ubiquitin specific peptidase 38
chr8_-_126173055	0.562		KIAA0196	KIAA0196
chr5_+_14493905	0.558		TRIO	triple functional domain (PTPRF interacting)
chr17_+_55052060	0.556		CLTC	clathrin, heavy chain (Hc)
chr1_-_51198383	0.553		FAF1	Fas (TNFRSF6) associated factor 1
chr12_+_54700955	0.552	NM_022465	IKZF4	IKAROS family zinc finger 4 (Eos)
chrX_-_100549444	0.551		GLA	galactosidase, alpha
chr6_-_37061908	0.550		MTCH1	mitochondrial carrier homolog 1 (C. elegans)
chr1_-_171286634	0.549	NM_005092	TNFSF18	tumor necrosis factor (ligand) superfamily, member 18
chr13_+_47775901	0.546		RB1	retinoblastoma 1
chr6_-_37061897	0.545		MTCH1	mitochondrial carrier homolog 1 (C. elegans)
chr1_-_109957195	0.544	NM_005272	GNAT2	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr8_-_126173227	0.541	NM_014846	KIAA0196	KIAA0196
chr1_-_51198417	0.538		FAF1	Fas (TNFRSF6) associated factor 1
chr17_+_25467948	0.524	NM_032141	CCDC55	coiled-coil domain containing 55
chr6_+_34964999	0.521	NM_015245	ANKS1A	ankyrin repeat and sterile alpha motif domain containing 1A
chr1_-_51198506	0.520	NM_007051	FAF1	Fas (TNFRSF6) associated factor 1
chr6_-_37061902	0.518		MTCH1	mitochondrial carrier homolog 1 (C. elegans)
chr15_-_63871598	0.515	NM_001144823 NM_005848	DENND4A	DENN/MADD domain containing 4A
chr12_+_104025578	0.513	NM_015275	KIAA1033	KIAA1033
chrX_+_47305459	0.511	NM_001654	ARAF	v-raf murine sarcoma 3611 viral oncogene homolog
chr11_-_107598538	0.511	NM_002519	NPAT	nuclear protein, ataxia-telangiectasia locus
chr10_+_69314714	0.511		SIRT1	sirtuin 1
chr12_+_70434927	0.510		RAB21	RAB21, member RAS oncogene family
chr1_-_202595666	0.508	NM_014935	PLEKHA6	pleckstrin homology domain containing, family A member 6
chr16_-_65984836	0.507	NM_015964 NM_016140	TPPP3	tubulin polymerization-promoting protein family member 3
chr11_+_125586828	0.492	NM_024556	FAM118B	family with sequence similarity 118, member B
chr9_-_37894098	0.491		MCART1	mitochondrial carrier triple repeat 1
chrX_+_100549869	0.491		HNRNPH2	heterogeneous nuclear ribonucleoprotein H2 (H')
chr11_-_116474196	0.490	NM_025164	SIK3	SIK family kinase 3
chr6_-_109810296	0.489		CD164	CD164 molecule, sialomucin
chr5_-_167938991	0.489	NM_024594	PANK3	pantothenate kinase 3
chr10_-_45410197	0.487	NM_001002265 NM_145021	MARCH8	membrane-associated ring finger (C3HC4) 8
chr6_-_112515329	0.487	NM_016262	TUBE1	tubulin, epsilon 1
chr6_+_112515366	0.487	NM_001033564	C6orf225	chromosome 6 open reading frame 225
chr6_-_37061924	0.486	NM_014341	MTCH1	mitochondrial carrier homolog 1 (C. elegans)
chrX_+_100549839	0.484	NM_001032393 NM_019597	HNRNPH2	heterogeneous nuclear ribonucleoprotein H2 (H')
chr5_+_65476418	0.483	NM_139168	SREK1	splicing regulatory glutamine/lysine-rich protein 1
chr12_+_104025686	0.482
chr6_+_116939500	0.481	NM_153711	FAM26E	family with sequence similarity 26, member E
chr7_-_140270749	0.478	NM_004333	BRAF	v-raf murine sarcoma viral oncogene homolog B1
chr10_+_70553936	0.478		VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr2_+_177785667	0.476	NM_194247	HNRNPA3P1 HNRNPA3	heterogeneous nuclear ribonucleoprotein A3 pseudogene 1 heterogeneous nuclear ribonucleoprotein A3
chr1_+_152460381	0.474		UBAP2L	ubiquitin associated protein 2-like
chr11_-_18300246	0.473	NM_007216 NM_181507 NM_181508	HPS5	Hermansky-Pudlak syndrome 5
chr10_-_50066386	0.471	NM_001010863	C10orf128	chromosome 10 open reading frame 128
chr21_-_39642712	0.469		HMGN1	high-mobility group nucleosome binding domain 1
chr12_-_44670475	0.469		SCAF11	SR-related CTD-associated factor 11
chr8_-_82557956	0.467	NM_001442	FABP4	fatty acid binding protein 4, adipocyte
chr6_-_109810310	0.461		CD164	CD164 molecule, sialomucin
chr10_+_22645370	0.460		COMMD3	COMM domain containing 3
chr14_+_19993181	0.458		APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1
chr1_-_152459506	0.457		C1orf43	chromosome 1 open reading frame 43
chr11_-_107598472	0.456		NPAT	nuclear protein, ataxia-telangiectasia locus
chr11_-_125586733	0.453	NM_001144827 NM_032795	RPUSD4	RNA pseudouridylate synthase domain containing 4
chr10_+_70553949	0.448		VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chrX_+_100549861	0.447		HNRNPH2	heterogeneous nuclear ribonucleoprotein H2 (H')
chr1_-_148868535	0.446		ENSA	endosulfine alpha
chr10_+_70553945	0.445		VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr3_-_197293331	0.445		TFRC	transferrin receptor (p90, CD71)
chr14_+_54807773	0.444	NM_017943	FBXO34	F-box protein 34
chr2_-_171725604	0.440	NM_012290	TLK1	tousled-like kinase 1
chr5_+_15553768	0.440		FBXL7	F-box and leucine-rich repeat protein 7
chr10_+_70553993	0.440		VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr10_+_76640607	0.436		VDAC2	voltage-dependent anion channel 2
chr3_-_197293377	0.431		TFRC	transferrin receptor (p90, CD71)
chr12_-_113330574	0.429	NM_000192 NM_080717	TBX5	T-box 5
chr12_-_8993460	0.428		M6PR	mannose-6-phosphate receptor (cation dependent)
chr1_-_115060904	0.427		NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog
chr3_-_99724373	0.427		CLDND1	claudin domain containing 1
chr15_-_32289561	0.426	NM_024713	C15orf29	chromosome 15 open reading frame 29
chr6_-_109810354	0.424		CD164	CD164 molecule, sialomucin
chr3_-_99724047	0.423		CLDND1	claudin domain containing 1
chr6_-_79844658	0.423	NM_017934	PHIP	pleckstrin homology domain interacting protein
chr10_+_70553962	0.420		VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr6_-_49712483	0.416	NM_000324	RHAG	Rh-associated glycoprotein
chr11_+_18300370	0.413	NM_001142307 NM_005316	GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa
chr10_-_74055824	0.410		CBARA1	calcium binding atopy-related autoantigen 1
chr3_+_19963865	0.409		RAB5A	RAB5A, member RAS oncogene family
chr1_-_51198052	0.408		FAF1	Fas (TNFRSF6) associated factor 1
chr4_-_977163	0.408	NM_022042 NM_134425 NM_213613	SLC26A1	solute carrier family 26 (sulfate transporter), member 1
chr5_-_16795336	0.407		MYO10	myosin X
chr3_-_197293355	0.407	NM_003234	TFRC	transferrin receptor (p90, CD71)
chr12_+_50592379	0.405	NM_001077401	ACVRL1	activin A receptor type II-like 1
chr3_-_197293394	0.404	NM_001128148	TFRC	transferrin receptor (p90, CD71)
chr3_+_134239860	0.402	NM_001136469 NM_023943	TMEM108	transmembrane protein 108
chr2_+_105320440	0.401	NM_024093	C2orf49	chromosome 2 open reading frame 49
chr12_-_90097384	0.396	NM_133503	DCN	decorin
chr11_+_107598768	0.396	NM_000051	ATM	ataxia telangiectasia mutated
chr3_+_159845067	0.395		GFM1	G elongation factor, mitochondrial 1
chr1_-_148868644	0.392		ENSA	endosulfine alpha
chr5_-_90645974	0.392		LOC100505994	hypothetical LOC100505994
chr3_+_134239906	0.391		TMEM108	transmembrane protein 108
chr12_-_90096275	0.390	NM_133504 NM_133505 NM_133506 NM_133507	DCN	decorin
chrX_+_101862297	0.389	NM_001142524 NM_001142525 NM_001142526 NM_001142527 NM_001142528 NM_030639	BHLHB9	basic helix-loop-helix domain containing, class B, 9
chr2_-_177836773	0.389	NM_001145412 NM_001145413	NFE2L2	nuclear factor (erythroid-derived 2)-like 2
chr1_+_52294554	0.388		BTF3L4	basic transcription factor 3-like 4
chr9_+_102380156	0.388	NM_001018116	MURC	muscle-related coiled-coil protein
chr3_+_185515108	0.386		EIF4G1	eukaryotic translation initiation factor 4 gamma, 1
chr17_-_54538816	0.386		TRIM37	tripartite motif containing 37
chr1_-_70443748	0.384		LRRC40	leucine rich repeat containing 40
chr6_+_143423656	0.384	NM_016108	AIG1	androgen-induced 1
chr1_-_203985701	0.383		NUCKS1	nuclear casein kinase and cyclin-dependent kinase substrate 1
chr3_-_12680329	0.383		RAF1	v-raf-1 murine leukemia viral oncogene homolog 1
chr22_+_39583001	0.383	NM_022098	XPNPEP3	X-prolyl aminopeptidase (aminopeptidase P) 3, putative
chr17_-_54538896	0.382		TRIM37	tripartite motif containing 37
chr9_-_124707314	0.381	NM_001100588 NM_018835	RC3H2	ring finger and CCCH-type domains 2
chr1_-_203985752	0.380		NUCKS1	nuclear casein kinase and cyclin-dependent kinase substrate 1
chr1_-_227828416	0.380	NM_001025247 NM_014409	TAF5L	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
chr1_-_152797760	0.380		UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1
chr6_-_109810246	0.379		CD164	CD164 molecule, sialomucin
chr1_-_152797707	0.379	NM_017582	UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1
chr3_+_52694975	0.379	NM_014366 NM_206825 NM_206826	GNL3	guanine nucleotide binding protein-like 3 (nucleolar)
chr12_+_34066679	0.378		ALG10	asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog (S. pombe)
chr1_-_203985780	0.378		NUCKS1	nuclear casein kinase and cyclin-dependent kinase substrate 1
chr1_+_220952518	0.377	NM_144695	BROX	BRO1 domain and CAAX motif containing
chr12_+_99185289	0.375		SCYL2	SCY1-like 2 (S. cerevisiae)
chr12_+_99185334	0.375	NM_017988	SCYL2	SCY1-like 2 (S. cerevisiae)
chr1_-_148868664	0.374		ENSA	endosulfine alpha
chr12_-_69317441	0.372	NM_001109754	PTPRB	protein tyrosine phosphatase, receptor type, B
chr6_+_144040751	0.370	NM_001100164 NM_001100165	PHACTR2	phosphatase and actin regulator 2
chr9_-_90983195	0.369		SHC3	SHC (Src homology 2 domain containing) transforming protein 3
chr1_+_181871830	0.369	NM_015149	RGL1	ral guanine nucleotide dissociation stimulator-like 1
chr17_+_55052065	0.369		CLTC	clathrin, heavy chain (Hc)
chr12_-_8993515	0.369	NM_002355	M6PR	mannose-6-phosphate receptor (cation dependent)
chr1_-_148868713	0.369	NM_004436 NM_207042 NM_207043 NM_207044 NM_207168	ENSA	endosulfine alpha
chr1_-_33055431	0.368		YARS	tyrosyl-tRNA synthetase
chr10_+_70553983	0.368		VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr10_+_22645304	0.367	NM_012071	COMMD3-BMI1 COMMD3	COMMD3-BMI1 read-through transcript COMM domain containing 3
chr4_+_175441402	0.367	NM_001040157	KIAA1712	KIAA1712
chr12_+_70434920	0.367	NM_014999	RAB21	RAB21, member RAS oncogene family
chr14_-_21014871	0.366	NM_032846	RAB2B	RAB2B, member RAS oncogene family
chr10_-_74055859	0.366		CBARA1	calcium binding atopy-related autoantigen 1
chr1_-_148868671	0.366		ENSA	endosulfine alpha
chr5_-_94916416	0.365	NM_014639	TTC37	tetratricopeptide repeat domain 37
chr1_+_52294563	0.364		BTF3L4	basic transcription factor 3-like 4
chr14_+_19993129	0.363	NM_001641 NM_080648 NM_080649	APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1
chr12_-_122415327	0.363		SBNO1	strawberry notch homolog 1 (Drosophila)
chr1_+_220952681	0.362		BROX	BRO1 domain and CAAX motif containing
chr10_+_76640522	0.361		VDAC2	voltage-dependent anion channel 2
chrX_-_48699702	0.361		OTUD5	OTU domain containing 5
chr16_+_23754822	0.360		PRKCB	protein kinase C, beta
chr6_-_32121784	0.360	NM_032470	TNXB	tenascin XB
chr1_+_1994943	0.359	NM_001033581	PRKCZ	protein kinase C, zeta
chr19_-_9908014	0.358	NM_058164	OLFM2	olfactomedin 2
chr1_+_10015736	0.357		UBE4B	ubiquitination factor E4B (UFD2 homolog, yeast)
chr6_+_109437599	0.356

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.43	9.04e-13	GO:0090304	nucleic acid metabolic process
1.37	1.91e-12	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.47	3.34e-11	GO:0016070	RNA metabolic process
1.26	1.24e-10	GO:0044260	cellular macromolecule metabolic process
1.44	1.40e-10	GO:0010467	gene expression
1.23	1.23e-09	GO:0043170	macromolecule metabolic process
1.30	1.27e-09	GO:0006807	nitrogen compound metabolic process
1.30	1.41e-09	GO:0034641	cellular nitrogen compound metabolic process
1.74	2.77e-09	GO:0006396	RNA processing
1.17	1.37e-07	GO:0044237	cellular metabolic process
1.16	1.14e-06	GO:0044238	primary metabolic process
1.68	7.59e-06	GO:0016071	mRNA metabolic process
1.54	1.09e-05	GO:0046907	intracellular transport
1.14	1.18e-05	GO:0008152	metabolic process
1.77	2.89e-05	GO:0006397	mRNA processing
1.37	2.25e-04	GO:0033036	macromolecule localization
1.38	1.48e-03	GO:0051649	establishment of localization in cell
1.51	2.38e-03	GO:0009057	macromolecule catabolic process
2.16	3.23e-03	GO:0006403	RNA localization
1.72	4.09e-03	GO:0008380	RNA splicing
1.89	4.79e-03	GO:0000375	RNA splicing, via transesterification reactions
1.33	7.27e-03	GO:0051641	cellular localization
1.07	7.93e-03	GO:0009987	cellular process
1.52	9.63e-03	GO:0044265	cellular macromolecule catabolic process
2.12	9.78e-03	GO:0050657	nucleic acid transport
2.12	9.78e-03	GO:0050658	RNA transport
2.12	9.78e-03	GO:0051236	establishment of RNA localization
1.87	1.05e-02	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
1.87	1.05e-02	GO:0000398	nuclear mRNA splicing, via spliceosome
2.37	2.63e-02	GO:0031123	RNA 3'-end processing
1.97	3.16e-02	GO:0015931	nucleobase, nucleoside, nucleotide and nucleic acid transport
1.26	3.19e-02	GO:0009059	macromolecule biosynthetic process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.12	8.44e-16	GO:0044424	intracellular part
1.12	2.07e-15	GO:0005622	intracellular
1.14	5.75e-14	GO:0043229	intracellular organelle
1.14	1.36e-13	GO:0043226	organelle
1.14	1.68e-11	GO:0043231	intracellular membrane-bounded organelle
1.14	2.62e-11	GO:0043227	membrane-bounded organelle
1.21	3.73e-11	GO:0044422	organelle part
1.15	2.03e-10	GO:0005737	cytoplasm
1.20	3.85e-10	GO:0044446	intracellular organelle part
1.20	4.69e-10	GO:0005634	nucleus
1.35	5.70e-09	GO:0044428	nuclear part
1.25	2.40e-08	GO:0032991	macromolecular complex
1.43	1.74e-07	GO:0005654	nucleoplasm
1.30	1.03e-06	GO:0070013	intracellular organelle lumen
1.29	1.08e-06	GO:0031974	membrane-enclosed lumen
1.30	1.10e-06	GO:0043233	organelle lumen
1.34	1.40e-06	GO:0031981	nuclear lumen
1.15	1.41e-05	GO:0044444	cytoplasmic part
1.22	1.08e-04	GO:0043234	protein complex
1.22	2.58e-04	GO:0043228	non-membrane-bounded organelle
1.22	2.58e-04	GO:0043232	intracellular non-membrane-bounded organelle
1.52	1.40e-03	GO:0030529	ribonucleoprotein complex
1.24	1.42e-03	GO:0005829	cytosol
1.55	2.04e-03	GO:0005768	endosome
1.98	6.11e-03	GO:0005681	spliceosomal complex

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.21	2.13e-18	GO:0005515	protein binding
1.08	2.88e-07	GO:0005488	binding
1.50	7.67e-06	GO:0003723	RNA binding
1.60	3.10e-03	GO:0000988	protein binding transcription factor activity
1.60	3.10e-03	GO:0000989	transcription factor binding transcription factor activity
1.22	4.86e-03	GO:0000166	nucleotide binding
1.59	5.07e-03	GO:0003712	transcription cofactor activity
1.18	6.31e-03	GO:0003676	nucleic acid binding
1.72	1.79e-02	GO:0003713	transcription coactivator activity
1.66	4.69e-02	GO:0019787	small conjugating protein ligase activity