Motif ID: TEAD1.p2

Z-value: 5.145


Transcription factors associated with TEAD1.p2:

Gene SymbolEntrez IDGene Name
TEAD1 7003 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TEAD2 8463 TEA domain family member 2
TEAD3 7005 TEAD3 TEA domain family member 3
TEAD4 7004 TEAD4 TEA domain family member 4



Activity profile for motif TEAD1.p2.

activity profile for motif TEAD1.p2


Sorted Z-values histogram for motif TEAD1.p2

Sorted Z-values for motif TEAD1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TEAD1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_39664706 16.623 NM_001080436
WTIP
Wilms tumor 1 interacting protein
chr6_-_132314004 13.814 NM_001901
CTGF
connective tissue growth factor
chr10_-_90702490 12.432 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr1_-_212791597 9.842 NM_005401
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr1_-_212791467 8.877 PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr5_-_148422799 8.714 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr11_-_8788765 7.570 NM_213618
ST5
suppression of tumorigenicity 5
chr5_-_39460687 7.370 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr3_+_50281582 7.202 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr6_-_42218692 6.825 NM_001164446
C6orf132
chromosome 6 open reading frame 132
chr3_-_115825742 6.703 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr22_+_40286957 6.374 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr12_-_45506001 6.263 NM_001143824
NM_018018
SLC38A4

solute carrier family 38, member 4

chr11_-_8789457 6.162 NM_139157
ST5
suppression of tumorigenicity 5
chr3_+_9919511 6.122 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr8_+_70541412 6.029 NM_001128204
NM_015170
SULF1

sulfatase 1

chr19_-_13909877 5.940 PODNL1
podocan-like 1
chr3_+_50281309 5.871 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr4_-_152368492 5.653 SH3D19
SH3 domain containing 19
chr18_+_30427279 5.538 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr5_-_39460787 5.353 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr10_+_24538094 5.348 KIAA1217
KIAA1217
chr2_-_189752575 5.235 NM_000393
COL5A2
collagen, type V, alpha 2
chr14_-_22516271 5.118 NM_198086
JUB
jub, ajuba homolog (Xenopus laevis)
chr8_-_38505331 5.101 NM_207412
C8orf86
chromosome 8 open reading frame 86
chr3_-_135575925 5.096 NM_016201
AMOTL2
angiomotin like 2
chr10_+_123862430 5.079 TACC2
transforming, acidic coiled-coil containing protein 2
chr15_+_61121806 5.058 NM_000366
NM_001018004
NM_001018005
NM_001018006
NM_001018007
NM_001018020
TPM1





tropomyosin 1 (alpha)





chr9_+_112470871 4.943 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr10_-_116382089 4.908 ABLIM1
actin binding LIM protein 1
chr10_-_123346148 4.873 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr9_-_72673753 4.821 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr7_+_134114701 4.785 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr2_+_102125616 4.718 IL1R1
interleukin 1 receptor, type I
chr1_+_114323552 4.661 NM_020190
OLFML3
olfactomedin-like 3
chr3_+_148609841 4.620 NM_003412
ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr12_-_94708641 4.592 NM_021229
NTN4
netrin 4
chr12_+_51728999 4.558 NM_015319
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr7_+_134114912 4.473 CALD1
caldesmon 1
chrX_-_114703273 4.406


chr8_-_42184194 4.392 PLAT
plasminogen activator, tissue
chr17_-_15495534 4.376 TRIM16
tripartite motif containing 16
chr6_+_152168500 4.342 NM_001122741
ESR1
estrogen receptor 1
chr15_+_61122139 4.326 TPM1
tropomyosin 1 (alpha)
chr5_-_39461054 4.321 NM_001343
DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr5_-_20024050 4.285 NM_001167667
NM_004934
CDH18

cadherin 18, type 2

chr15_+_73728402 4.197 NM_153271
SNX33
sorting nexin 33
chr11_-_85107569 4.128 NM_206929
SYTL2
synaptotagmin-like 2
chr7_-_155297576 4.114 NM_000193
SHH
sonic hedgehog
chr14_-_22515725 4.086 JUB
jub, ajuba homolog (Xenopus laevis)
chr19_-_54063522 4.066 NM_001161354
NM_020904
PLEKHA4

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4

chr3_-_113842350 4.042 CCDC80
coiled-coil domain containing 80
chr10_+_24537725 4.032 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr8_+_1759502 4.026 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr11_-_47427263 4.009 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr5_-_83052606 3.949 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr11_-_85108030 3.898 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr3_+_9919295 3.887 NM_153483
IL17RE
interleukin 17 receptor E
chr8_-_42184350 3.886 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr2_-_192419896 3.770 SDPR
serum deprivation response
chr6_-_75972286 3.730 NM_004370
NM_080645
COL12A1

collagen, type XII, alpha 1

chr3_-_113841941 3.706 CCDC80
coiled-coil domain containing 80
chr18_+_50646616 3.684 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr7_+_134114957 3.673 CALD1
caldesmon 1
chr11_+_93394025 3.641 NM_001098672
HEPHL1
hephaestin-like 1
chr2_+_102169864 3.631 NM_003854
IL1RL2
interleukin 1 receptor-like 2
chr2_-_192420168 3.619 NM_004657
SDPR
serum deprivation response
chr9_+_136673534 3.618 COL5A1
collagen, type V, alpha 1
chr12_-_78608873 3.603 NM_002583
PAWR
PRKC, apoptosis, WT1, regulator
chr14_-_22974707 3.597 NM_000257
MYH7
myosin, heavy chain 7, cardiac muscle, beta
chr11_+_1812115 3.589 NM_138567
SYT8
synaptotagmin VIII
chr7_+_94377145 3.587 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr4_+_158361185 3.526 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr10_-_125843092 3.515 CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr5_+_152850276 3.491 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr1_-_16355013 3.484 NM_004431
EPHA2
EPH receptor A2
chr1_+_238321794 3.484 NM_020066
FMN2
formin 2
chr2_-_238164452 3.419 NM_022449
RAB17
RAB17, member RAS oncogene family
chr3_-_113841967 3.391 CCDC80
coiled-coil domain containing 80
chr3_-_113842255 3.380 CCDC80
coiled-coil domain containing 80
chr16_-_30983909 3.332 NM_001172669
NM_001172670
ZNF668

zinc finger protein 668

chr3_-_113842133 3.330 CCDC80
coiled-coil domain containing 80
chr15_-_93671314 3.302 LOC400456
hypothetical LOC400456
chr2_+_95303947 3.289 PROM2
prominin 2
chr15_+_37660568 3.280 NM_003246
THBS1
thrombospondin 1
chr3_-_113842237 3.269 CCDC80
coiled-coil domain containing 80
chr15_+_46271158 3.268 NM_001145668
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporters), member 1
chr3_-_113842553 3.165 CCDC80
coiled-coil domain containing 80
chr1_-_151848039 3.083 S100A16
S100 calcium binding protein A16
chr11_+_113671744 3.013 NM_006169
NNMT
nicotinamide N-methyltransferase
chr12_-_15706340 3.004 EPS8
epidermal growth factor receptor pathway substrate 8
chr19_-_13910167 3.002 NM_024825
PODNL1
podocan-like 1
chr7_+_72883128 2.976 NM_001305
CLDN4
claudin 4
chr1_-_54392030 2.876 NM_201546
CDCP2
CUB domain containing protein 2
chr5_+_118719591 2.830 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr18_-_51219880 2.816 TCF4
transcription factor 4
chr4_+_8322358 2.768 NM_053044
HTRA3
HtrA serine peptidase 3
chr2_+_95303922 2.764 NM_001165977
NM_001165978
NM_144707
PROM2


prominin 2


chr5_+_38882017 2.714 OSMR
oncostatin M receptor
chr5_-_58607673 2.711 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr3_-_12561962 2.694 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr9_-_16717887 2.676 BNC2
basonuclin 2
chr3_+_148610516 2.667 ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr10_+_99334069 2.656 NM_001134670
NM_138413
HOGA1

4-hydroxy-2-oxoglutarate aldolase 1

chrX_-_83644054 2.647 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr1_+_183970093 2.644 NM_031935
HMCN1
hemicentin 1
chr3_-_113842652 2.632 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr5_-_138822475 2.618 NM_001077693
ECSCR
endothelial cell-specific chemotaxis regulator
chr2_-_238164042 2.613 RAB17
RAB17, member RAS oncogene family
chr11_-_2127368 2.610 NM_001007139
IGF2
insulin-like growth factor 2 (somatomedin A)
chr6_+_116956868 2.583 NM_153036
FAM26D
family with sequence similarity 26, member D
chr4_+_19864332 2.571 NM_004787
SLIT2
slit homolog 2 (Drosophila)
chr4_-_40326603 2.527 NM_001098634
RBM47
RNA binding motif protein 47
chr17_+_46267603 2.522 NM_175575
WFIKKN2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chrX_-_31436335 2.506 NM_004014
DMD
dystrophin
chr4_+_15089931 2.503 CC2D2A
coiled-coil and C2 domain containing 2A
chr2_+_151922350 2.502 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr19_-_56204615 2.499 NM_012315
KLK9
kallikrein-related peptidase 9
chr12_-_8706637 2.486 NM_003480
MFAP5
microfibrillar associated protein 5
chr1_-_24311212 2.480 NM_152372
MYOM3
myomesin family, member 3
chr19_-_56147971 2.465 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr11_+_7463175 2.459 NM_198474
OLFML1
olfactomedin-like 1
chr6_+_41712907 2.441 MDFI
MyoD family inhibitor
chrX_-_6156655 2.437 NM_181332
NLGN4X
neuroligin 4, X-linked
chr3_-_52844274 2.427 NM_205853
MUSTN1
musculoskeletal, embryonic nuclear protein 1
chr11_+_57123927 2.401 SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr3_+_25444753 2.395 NM_016152
RARB
retinoic acid receptor, beta
chr11_-_126375895 2.359 NM_001161707
NM_032531
KIRREL3

kin of IRRE like 3 (Drosophila)

chr9_+_117955890 2.358 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr2_-_158439868 2.349 NM_001105
ACVR1
activin A receptor, type I
chr19_-_13478037 2.341 NM_000068
NM_001127221
NM_001127222
NM_001174080
NM_023035
CACNA1A




calcium channel, voltage-dependent, P/Q type, alpha 1A subunit




chrX_-_53327473 2.340 NM_015075
IQSEC2
IQ motif and Sec7 domain 2
chr1_-_27604656 2.321 WASF2
WAS protein family, member 2
chr7_-_100667750 2.298 NM_014343
CLDN15
claudin 15
chr18_+_19947314 2.293 TTC39C
tetratricopeptide repeat domain 39C
chr1_-_199613406 2.289 TNNT2
troponin T type 2 (cardiac)
chr8_-_13018123 2.281 NM_001164271
DLC1
deleted in liver cancer 1
chr2_-_220116062 2.277 NM_001195731
CHPF
chondroitin polymerizing factor
chr12_-_8706746 2.274 MFAP5
microfibrillar associated protein 5
chr9_+_122923864 2.258 CEP110
centrosomal protein 110kDa
chr1_-_16217025 2.243 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr7_-_83116414 2.211 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr17_-_36347197 2.203 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr17_-_15463742 2.202 NM_006382
CDRT1
CMT1A duplicated region transcript 1
chr3_+_191588354 2.182 NM_006580
CLDN16
claudin 16
chr1_-_199613427 2.181 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr16_-_31054321 2.175 PRSS8
protease, serine, 8
chr4_-_186815116 2.152 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr3_+_25444837 2.149 NM_000965
RARB
retinoic acid receptor, beta
chr3_-_162572441 2.132 NM_001040100
C3orf57
chromosome 3 open reading frame 57
chr8_-_37847095 2.126 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr15_-_97366313 2.126 NM_001102612
PGPEP1L
pyroglutamyl-peptidase I-like
chr19_-_56163815 2.122 NM_001012964
NM_001012965
KLK6

kallikrein-related peptidase 6

chr3_+_125586241 2.104 KALRN
kalirin, RhoGEF kinase
chr19_+_55918405 2.072 NM_002975
CLEC11A
C-type lectin domain family 11, member A
chr12_-_13044314 2.061 HEBP1
heme binding protein 1
chr5_+_140848905 2.049 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr6_+_31190505 2.037 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr5_-_37871685 1.977 NM_001190468
NM_001190469
GDNF

glial cell derived neurotrophic factor

chr19_-_4468715 1.970 NM_001080400
PLIN4
perilipin 4
chr1_-_148175345 1.952 MTMR11
myotubularin related protein 11
chr8_-_108579270 1.931 NM_001146
ANGPT1
angiopoietin 1
chr11_-_126375864 1.929 KIRREL3
kin of IRRE like 3 (Drosophila)
chr12_-_54522881 1.896 NM_002429
MMP19
matrix metallopeptidase 19
chr19_+_55918450 1.876 CLEC11A
C-type lectin domain family 11, member A
chr1_+_176577228 1.858 NM_004841
RASAL2
RAS protein activator like 2
chr16_+_55963899 1.855 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr5_-_38881636 1.850


chr4_-_171247757 1.830 NM_016228
AADAT
aminoadipate aminotransferase
chr14_+_75114692 1.813 NM_017791
FLVCR2
feline leukemia virus subgroup C cellular receptor family, member 2
chr12_-_8706533 1.805 MFAP5
microfibrillar associated protein 5
chr15_+_40353657 1.800 NM_198141
GANC
glucosidase, alpha; neutral C
chr10_+_99334411 1.795 HOGA1
4-hydroxy-2-oxoglutarate aldolase 1
chr22_-_43986896 1.784 KIAA0930
KIAA0930
chr16_+_751050 1.772 NM_013404
MSLN
mesothelin
chr2_+_210344945 1.766 NM_032504
NM_182587
UNC80

unc-80 homolog (C. elegans)

chr10_+_91077581 1.748 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr16_-_62573 1.740 NM_022450
RHBDF1
rhomboid 5 homolog 1 (Drosophila)
chr5_+_118719448 1.740 NM_014350
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr21_-_26345294 1.733


chr5_-_59100091 1.721 PDE4D
phosphodiesterase 4D, cAMP-specific
chr6_-_75972473 1.711 COL12A1
collagen, type XII, alpha 1
chr1_-_148175383 1.704 NM_001145862
MTMR11
myotubularin related protein 11
chr2_+_45732416 1.704 NM_005400
PRKCE
protein kinase C, epsilon
chr17_+_7199178 1.695 NM_198154
TMEM95
transmembrane protein 95
chr9_+_88953378 1.689 NM_001001709
C9orf170
chromosome 9 open reading frame 170
chrX_-_2892288 1.663 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr16_-_31054563 1.649 NM_002773
PRSS8
protease, serine, 8
chr17_+_45404677 1.645 DLX4
distal-less homeobox 4
chr18_-_19496590 1.639 NM_173505
ANKRD29
ankyrin repeat domain 29
chrX_-_13307425 1.636


chr16_+_55963883 1.625 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr12_-_13044448 1.598 HEBP1
heme binding protein 1
chr17_-_31104009 1.592 NM_139285
GAS2L2
growth arrest-specific 2 like 2
chr5_-_127901376 1.590 FBN2
fibrillin 2
chr1_-_115682374 1.578 NM_002506
NGF
nerve growth factor (beta polypeptide)
chr10_-_71576415 1.563 TYSND1
trypsin domain containing 1
chr10_+_102782151 1.563 SFXN3
sideroflexin 3
chr12_+_26239755 1.562 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr14_+_94117483 1.522 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.61 1.39e-04 GO:0022603 regulation of anatomical structure morphogenesis
2.65 3.30e-04 GO:0061061 muscle structure development
1.40 2.03e-03 GO:0048731 system development
1.50 2.98e-03 GO:0048513 organ development
1.75 4.63e-03 GO:0048468 cell development
1.36 4.81e-03 GO:0048856 anatomical structure development
2.05 1.02e-02 GO:0072358 cardiovascular system development
2.05 1.02e-02 GO:0072359 circulatory system development
2.66 1.78e-02 GO:0007517 muscle organ development
3.77 1.85e-02 GO:0051146 striated muscle cell differentiation
1.52 2.46e-02 GO:0009653 anatomical structure morphogenesis
1.83 3.17e-02 GO:0030030 cell projection organization
3.58 3.50e-02 GO:0042306 regulation of protein import into nucleus
2.96 4.95e-02 GO:0042692 muscle cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.58 9.11e-07 GO:0005576 extracellular region
1.75 8.45e-05 GO:0044421 extracellular region part
3.12 5.73e-03 GO:0044420 extracellular matrix part
1.26 6.33e-03 GO:0071944 cell periphery
1.26 8.61e-03 GO:0005886 plasma membrane
1.38 1.09e-02 GO:0044459 plasma membrane part
2.01 1.61e-02 GO:0031012 extracellular matrix
3.64 1.64e-02 GO:0005604 basement membrane
3.54 2.24e-02 GO:0042383 sarcolemma
1.64 2.79e-02 GO:0005615 extracellular space
13.06 3.26e-02 GO:0001527 microfibril

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.23 3.00e-03 GO:0003779 actin binding
1.78 9.09e-03 GO:0005509 calcium ion binding
2.78 1.07e-02 GO:0005539 glycosaminoglycan binding
2.69 1.13e-02 GO:0001871 pattern binding
2.69 1.13e-02 GO:0030247 polysaccharide binding
2.97 2.70e-02 GO:0008201 heparin binding
7.84 3.01e-02 GO:0043236 laminin binding
1.16 3.51e-02 GO:0005515 protein binding
1.78 4.92e-02 GO:0008092 cytoskeletal protein binding