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• Activity deltas table
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Motif ID: EOMES.p2

Z-value: 1.236

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr2_-_74606819	2.903	NM_133637	DQX1	DEAQ box RNA-dependent ATPase 1
chr17_-_40858775	2.094	NM_199282	ARHGAP27	Rho GTPase activating protein 27
chr16_+_11966464	2.000	NM_001192	TNFRSF17	tumor necrosis factor receptor superfamily, member 17
chr10_-_123346148	1.871	NM_001144915	FGFR2	fibroblast growth factor receptor 2
chr2_+_218954995	1.816	NM_000578	SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr11_-_65070625	1.679		LTBP3	latent transforming growth factor beta binding protein 3
chr6_+_167456230	1.674	NM_031409	CCR6	chemokine (C-C motif) receptor 6
chr4_-_186969202	1.294	NM_001145671	SORBS2	sorbin and SH3 domain containing 2
chr3_-_49434874	1.268		AMT	aminomethyltransferase
chr4_-_186969041	1.250	NM_001145672	SORBS2	sorbin and SH3 domain containing 2
chr2_+_228386800	1.202	NM_001130046 NM_004591	CCL20	chemokine (C-C motif) ligand 20
chr3_+_10832867	1.157	NM_014229	SLC6A11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr14_+_94148466	1.133	NM_001085	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr10_+_114125955	1.119		ACSL5	acyl-CoA synthetase long-chain family member 5
chr3_-_95230143	1.079	NM_001001850	STX19	syntaxin 19
chr10_+_4995685	1.045		AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chrX_+_70360184	0.995		GJB1	gap junction protein, beta 1, 32kDa
chrX_+_57329834	0.986	NM_174912	FAAH2	fatty acid amide hydrolase 2
chr8_-_42353719	0.942	NM_014420	DKK4	dickkopf homolog 4 (Xenopus laevis)
chr1_+_148496792	0.932	NM_012113	CA14	carbonic anhydrase XIV
chr12_-_192752	0.930	NM_003044	SLC6A12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr17_+_22823151	0.913	NM_014238	KSR1	kinase suppressor of ras 1
chr6_+_105511615	0.913	NM_001004317	LIN28B	lin-28 homolog B (C. elegans)
chr20_+_35406497	0.907	NM_005417	SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr10_+_4995597	0.899		AKR1C1 AKR1C3	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr17_-_36346240	0.888		KRT23	keratin 23 (histone deacetylase inducible)
chrX_+_69559605	0.885	NM_001171191 NM_001171192 NM_001171193 NM_017711	GDPD2	glycerophosphodiester phosphodiesterase domain containing 2
chr17_-_71535076	0.878	NM_001988	EVPL	envoplakin
chr20_+_32926452	0.847		ACSS2	acyl-CoA synthetase short-chain family member 2
chr12_-_51173238	0.804	NM_005554	KRT6A	keratin 6A
chr14_-_23106372	0.796		AP1G2	adaptor-related protein complex 1, gamma 2 subunit
chr14_-_23107106	0.794	NM_003917	AP1G2	adaptor-related protein complex 1, gamma 2 subunit
chr15_+_73803351	0.775	NM_175881	ODF3L1	outer dense fiber of sperm tails 3-like 1
chr18_-_54447168	0.771	NM_052947	ALPK2	alpha-kinase 2
chr14_-_23106779	0.768		AP1G2	adaptor-related protein complex 1, gamma 2 subunit
chr18_-_22696532	0.764	NM_004028	AQP4	aquaporin 4
chrX_-_135783496	0.760
chr5_+_147754467	0.751		FBXO38	F-box protein 38
chr11_+_73037382	0.743	NM_001130036	PLEKHB1	pleckstrin homology domain containing, family B (evectins) member 1
chr10_+_114125927	0.742	NM_016234	ACSL5	acyl-CoA synthetase long-chain family member 5
chr20_-_22513050	0.740	NM_021784	FOXA2	forkhead box A2
chr16_-_51139214	0.740	NM_001146188	TOX3	TOX high mobility group box family member 3
chr12_-_192990	0.728	NM_001122847	SLC6A12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr1_+_150958621	0.722	NM_001024679	C1orf68	chromosome 1 open reading frame 68
chr1_+_17719405	0.720		ARHGEF10L	Rho guanine nucleotide exchange factor (GEF) 10-like
chr10_+_114126004	0.670		ACSL5	acyl-CoA synthetase long-chain family member 5
chr17_+_53761293	0.667		LOC100506779	hypothetical LOC100506779
chr16_+_56259657	0.660	NM_170776	GPR97	G protein-coupled receptor 97
chr2_+_171280046	0.654	NM_001003845	SP5	Sp5 transcription factor
chr1_+_89602023	0.642	NM_198460	GBP6	guanylate binding protein family, member 6
chr11_+_66580884	0.641		RHOD	ras homolog gene family, member D
chr11_+_73036241	0.635	NM_001130034 NM_001130035	PLEKHB1	pleckstrin homology domain containing, family B (evectins) member 1
chr10_+_114125003	0.623	NM_203380	ACSL5	acyl-CoA synthetase long-chain family member 5
chr20_+_43531806	0.595	NM_006103	WFDC2	WAP four-disulfide core domain 2
chr11_+_20000938	0.594		NAV2	neuron navigator 2
chr10_+_44726635	0.591	NM_001123376	TMEM72	transmembrane protein 72
chr12_+_50342814	0.585	NM_001177984	SCN8A	sodium channel, voltage gated, type VIII, alpha subunit
chr5_-_138746917	0.584	NM_005847 NM_152685	SLC23A1	solute carrier family 23 (nucleobase transporters), member 1
chr17_+_7474177	0.584	NM_001040 NM_001146279 NM_001146280 NM_001146281	SHBG	sex hormone-binding globulin
chr8_-_8276598	0.580	NM_001080826	SGK223	homolog of rat pragma of Rnd2
chr6_+_64339869	0.577	NM_003463	PTP4A1	protein tyrosine phosphatase type IVA, member 1
chr1_+_151867483	0.577	NM_006271	S100A1	S100 calcium binding protein A1
chr3_-_110155237	0.568	NM_005459	GUCA1C	guanylate cyclase activator 1C
chr17_+_18320822	0.567	NM_001040078	LGALS9B LGALS9C	lectin, galactoside-binding, soluble, 9B lectin, galactoside-binding, soluble, 9C
chr12_+_130004404	0.565	NM_198827	GPR133	G protein-coupled receptor 133
chr3_-_49701085	0.562	NM_020998	MST1	macrophage stimulating 1 (hepatocyte growth factor-like)
chr1_+_32489426	0.560	NM_005356	LCK	lymphocyte-specific protein tyrosine kinase
chr2_+_171280944	0.560		SP5	Sp5 transcription factor
chr1_-_43523825	0.559	NM_182517 NM_001164829	C1orf210	chromosome 1 open reading frame 210
chr12_+_27740694	0.559	NM_001029874	REP15	RAB15 effector protein
chr5_-_138746840	0.553		SLC23A1	solute carrier family 23 (nucleobase transporters), member 1
chr11_+_60858611	0.552		DAK	dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr1_+_28458546	0.548	NM_031459	SESN2	sestrin 2
chr1_-_199259133	0.541		KIF21B	kinesin family member 21B
chrX_+_70359780	0.538	NM_000166	GJB1	gap junction protein, beta 1, 32kDa
chr3_-_42818221	0.535
chr10_+_24537725	0.534	NM_001098501 NM_019590	KIAA1217	KIAA1217
chr2_+_17861266	0.529	NM_001105569	MSGN1	mesogenin 1
chr1_-_151867338	0.527	NM_005979	S100A13	S100 calcium binding protein A13
chr7_-_36730525	0.526	NM_001177506 NM_001177507 NM_001637	AOAH	acyloxyacyl hydrolase (neutrophil)
chr17_-_76919068	0.522	NM_178520	TMEM105	transmembrane protein 105
chr16_+_70646008	0.516	NM_001126102 NM_005143	HP	haptoglobin
chr14_-_22516271	0.514	NM_198086	JUB	jub, ajuba homolog (Xenopus laevis)
chr2_+_171280182	0.514
chr10_+_24538094	0.510		KIAA1217	KIAA1217
chr4_+_100957003	0.509	NM_014395	DAPP1	dual adaptor of phosphotyrosine and 3-phosphoinositides
chr3_-_48446405	0.506	NM_001130082	PLXNB1	plexin B1
chrX_-_18600108	0.501	NM_000330	RS1	retinoschisin 1
chr8_-_11742668	0.496
chr7_-_96471544	0.488		DLX6-AS1	DLX6 antisense RNA 1 (non-protein coding)
chr11_+_20001130	0.487	NM_001111019	NAV2	neuron navigator 2
chr17_-_20311411	0.486	NM_001042685	LGALS9B	lectin, galactoside-binding, soluble, 9B
chr8_-_143830930	0.477	NM_205545	LYPD2	LY6/PLAUR domain containing 2
chr3_-_101316038	0.474	NM_001042459 NM_182909	FILIP1L	filamin A interacting protein 1-like
chr17_-_53761119	0.460	NM_004758 NM_024418	BZRAP1	benzodiazapine receptor (peripheral) associated protein 1
chr9_-_112010233	0.458	NM_001012993	C9orf152	chromosome 9 open reading frame 152
chr3_+_137224266	0.441	NM_181897	PPP2R3A	protein phosphatase 2, regulatory subunit B'', alpha
chr5_+_154072654	0.422	NM_015315	LARP1	La ribonucleoprotein domain family, member 1
chr2_+_152900076	0.421		FMNL2	formin-like 2
chr15_+_38849450	0.412	NM_001130448	C15orf62	chromosome 15 open reading frame 62
chr15_+_70477707	0.407	NM_001080462	TMEM202	transmembrane protein 202
chr1_-_155053124	0.405	NM_001161441 NM_001161442 NM_001161444 NM_003975	SH2D2A	SH2 domain containing 2A
chrX_-_106033202	0.404	NM_001171706 NM_138382	RIPPLY1	ripply1 homolog (zebrafish)
chr6_+_88024152	0.400		ZNF292	zinc finger protein 292
chr1_+_224477941	0.394	NM_031944	MIXL1	Mix1 homeobox-like 1 (Xenopus laevis)
chr2_+_218992053	0.394	NM_007127	VIL1	villin 1
chr6_+_31651319	0.391	NM_000594	TNF	tumor necrosis factor
chr1_+_35019376	0.390	NM_024009	GJB3	gap junction protein, beta 3, 31kDa
chr12_-_55730125	0.389	NM_005379	MYO1A	myosin IA
chr11_+_66580861	0.387	NM_014578	RHOD	ras homolog gene family, member D
chr7_-_20793028	0.385	NM_182700 NM_198956	SP8	Sp8 transcription factor
chr12_-_1791146	0.379		CACNA2D4	calcium channel, voltage-dependent, alpha 2/delta subunit 4
chr2_-_31491057	0.371		XDH	xanthine dehydrogenase
chr16_+_70654625	0.366	NM_020995	HPR	haptoglobin-related protein
chr5_-_49772973	0.359	NM_198449	EMB	embigin
chr11_-_118405288	0.358	NM_001164280	SLC37A4	solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr17_-_71534906	0.354		EVPL	envoplakin
chr2_+_219432789	0.350	NM_006522	WNT6	wingless-type MMTV integration site family, member 6
chr2_+_10103735	0.350
chr3_-_186752952	0.349	NM_139248	LIPH	lipase, member H
chr9_-_33455191	0.349		NOL6	nucleolar protein family 6 (RNA-associated)
chr1_+_26609893	0.345		LIN28A	lin-28 homolog A (C. elegans)
chr20_+_42463350	0.340		HNF4A	hepatocyte nuclear factor 4, alpha
chr20_-_43177137	0.336	NM_145652	WFDC5	WAP four-disulfide core domain 5
chr3_+_52786642	0.331	NM_002215	ITIH1	inter-alpha (globulin) inhibitor H1
chr4_-_54152480	0.331	NM_001126328	LNX1	ligand of numb-protein X 1
chr19_+_52504914	0.329	NM_001736	C5AR1	complement component 5a receptor 1
chr6_-_135312899	0.327	NM_001193480 NM_022568 NM_170771	ALDH8A1	aldehyde dehydrogenase 8 family, member A1
chr20_+_42463279	0.326	NM_000457 NM_178849 NM_178850	HNF4A	hepatocyte nuclear factor 4, alpha
chr11_-_110755112	0.325		POU2AF1	POU class 2 associating factor 1
chr8_+_103633023	0.323	NM_024410	ODF1	outer dense fiber of sperm tails 1
chr2_-_151052391	0.322	NM_005168	RND3	Rho family GTPase 3
chr15_-_31147376	0.321	NM_001103184	FMN1	formin 1
chr6_+_64344307	0.318		PTP4A1	protein tyrosine phosphatase type IVA, member 1
chr15_+_64481270	0.317		MAP2K1	mitogen-activated protein kinase kinase 1
chr12_+_53229625	0.315		PDE1B	phosphodiesterase 1B, calmodulin-dependent
chr5_+_67622242	0.313	NM_181504	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr11_+_93394025	0.309	NM_001098672	HEPHL1	hephaestin-like 1
chr16_+_67778441	0.309	NM_006750	SNTB2	syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr13_+_51496679	0.306	NM_021645	ALG11 UTP14C	asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast) UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr2_-_31491102	0.305	NM_000379	XDH	xanthine dehydrogenase
chr1_-_1131795	0.305	NM_004195 NM_148901 NM_148902	TNFRSF18	tumor necrosis factor receptor superfamily, member 18
chr4_+_75393053	0.304	NM_001013442	EPGN	epithelial mitogen homolog (mouse)
chr6_-_149847718	0.300		ZC3H12D	zinc finger CCCH-type containing 12D
chr1_+_158317967	0.300	NM_004983	KCNJ9	potassium inwardly-rectifying channel, subfamily J, member 9
chr12_+_53229443	0.297	NM_000924	PDE1B	phosphodiesterase 1B, calmodulin-dependent
chr14_+_20537253	0.293	NM_014579	SLC39A2	solute carrier family 39 (zinc transporter), member 2
chr1_+_149877955	0.292		SNX27	sorting nexin family member 27
chr8_+_62363078	0.290	NM_173519	CLVS1	clavesin 1
chr7_+_113853790	0.287	NM_001172767 NM_148899	FOXP2	forkhead box P2
chr1_+_15935395	0.287	NM_207348	SLC25A34	solute carrier family 25, member 34
chr6_+_131936057	0.286	NM_000045	ARG1	arginase, liver
chr7_+_50318801	0.285		IKZF1	IKAROS family zinc finger 1 (Ikaros)
chr20_+_42463387	0.284		HNF4A	hepatocyte nuclear factor 4, alpha
chr10_-_98935369	0.280		SLIT1	slit homolog 1 (Drosophila)
chr11_-_34491878	0.278	NM_001422	ELF5	E74-like factor 5 (ets domain transcription factor)
chr1_-_167822248	0.278		F5	coagulation factor V (proaccelerin, labile factor)
chr17_-_73867748	0.277	NM_003955	SOCS3	suppressor of cytokine signaling 3
chr20_+_42463419	0.276		HNF4A	hepatocyte nuclear factor 4, alpha
chr12_+_6424293	0.272	NM_001242	CD27	CD27 molecule
chr7_+_69869099	0.271		AUTS2	autism susceptibility candidate 2
chr1_+_154389945	0.269	NM_001193300 NM_022367 NM_001193302	SEMA4A	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr17_+_18221803	0.269	NM_001145127	EVPLL	envoplakin-like
chr16_+_28850760	0.269	NM_001178098 NM_001770	CD19	CD19 molecule
chr1_+_180836050	0.268
chr11_-_62278109	0.267	NM_024784	ZBTB3	zinc finger and BTB domain containing 3
chr5_-_49772940	0.265		EMB	embigin
chrX_+_152608159	0.265	NM_001142806	SLC6A8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr17_-_44226595	0.265	NM_173623	TTLL6	tubulin tyrosine ligase-like family, member 6
chr17_-_59312892	0.263	NM_002059 NM_022556 NM_022557 NM_022558	GH2	growth hormone 2
chr19_+_60283571	0.262	NM_017729	EPS8L1	EPS8-like 1
chr3_-_140879463	0.262	NM_178177	NMNAT3	nicotinamide nucleotide adenylyltransferase 3
chr6_-_130578110	0.261	NM_152552	SAMD3	sterile alpha motif domain containing 3
chr11_-_124311512	0.261	NM_152722	HEPACAM	hepatic and glial cell adhesion molecule
chr2_-_215711313	0.261	NM_173076	ABCA12	ATP-binding cassette, sub-family A (ABC1), member 12
chr12_-_51200347	0.261	NM_000424	KRT5	keratin 5
chr11_-_16387001	0.259	NM_001145811	SOX6	SRY (sex determining region Y)-box 6
chr1_-_246804680	0.254	NM_001001821	OR2T34	olfactory receptor, family 2, subfamily T, member 34
chr19_+_10242763	0.253		ICAM1	intercellular adhesion molecule 1
chr4_-_186970366	0.253	NM_003603 NM_001145670	SORBS2	sorbin and SH3 domain containing 2
chr5_+_137447479	0.252	NM_058244	WNT8A	wingless-type MMTV integration site family, member 8A
chrX_+_122145776	0.252	NM_000828 NM_007325	GRIA3	glutamate receptor, ionotrophic, AMPA 3
chr7_+_147667461	0.250		CNTNAP2	contactin associated protein-like 2
chr6_+_47774247	0.250	NM_153838	GPR115	G protein-coupled receptor 115
chr17_+_43082273	0.250	NM_002265	KPNB1	karyopherin (importin) beta 1
chr2_-_37397669	0.249	NM_005813	PRKD3	protein kinase D3
chr20_-_2589476	0.249		IDH3B	isocitrate dehydrogenase 3 (NAD+) beta
chr11_-_30558495	0.246	NM_001584	MPPED2	metallophosphoesterase domain containing 2
chr6_+_30402986	0.246	NM_172016	TRIM39	tripartite motif containing 39
chr1_+_2026014	0.243	NM_001033582	PRKCZ	protein kinase C, zeta
chr9_-_116307531	0.242	NM_001173425 NM_015404	DFNB31	deafness, autosomal recessive 31
chr10_-_101680645	0.242		DNMBP	dynamin binding protein
chr1_-_159459814	0.242		APOA2	apolipoprotein A-II
chr20_-_61669550	0.241	NM_033405	PRIC285	peroxisomal proliferator-activated receptor A interacting complex 285
chr6_+_131190237	0.240	NM_001195597	LOC285733	hypothetical LOC285733
chr2_+_62787534	0.238	NM_001142614	EHBP1	EH domain binding protein 1
chr2_+_65070030	0.238		SLC1A4	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr11_+_20005704	0.238		NAV2	neuron navigator 2
chr1_+_31814709	0.238		TINAGL1	tubulointerstitial nephritis antigen-like 1
chrX_-_84521398	0.237	NM_024921	POF1B	premature ovarian failure, 1B

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.36	2.93e-06	GO:0023052	signaling
1.32	7.69e-04	GO:0007165	signal transduction
1.21	1.06e-03	GO:0050896	response to stimulus
2.00	2.95e-03	GO:0007243	intracellular protein kinase cascade
2.00	2.95e-03	GO:0023014	signal transduction via phosphorylation event
1.22	3.29e-03	GO:0032501	multicellular organismal process
1.25	1.09e-02	GO:0051716	cellular response to stimulus
1.38	4.69e-02	GO:0048583	regulation of response to stimulus
1.63	4.87e-02	GO:0006468	protein phosphorylation

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.78	6.98e-04	GO:0030054	cell junction
1.36	1.54e-03	GO:0044459	plasma membrane part
1.37	1.62e-03	GO:0005576	extracellular region
1.22	1.09e-02	GO:0071944	cell periphery
1.21	2.49e-02	GO:0005886	plasma membrane

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
6.44	7.35e-03	GO:0005328	neurotransmitter:sodium symporter activity
1.50	2.27e-02	GO:0005102	receptor binding
5.27	4.18e-02	GO:0005326	neurotransmitter transporter activity