Motif ID: EVI1.p2

Z-value: 2.089


Transcription factors associated with EVI1.p2:

Gene SymbolEntrez IDGene Name
EVI1 2122 ecotropic viral integration site 1



Activity profile for motif EVI1.p2.

activity profile for motif EVI1.p2


Sorted Z-values histogram for motif EVI1.p2

Sorted Z-values for motif EVI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EVI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_50025115 4.359 NM_001166478
DEFB133
defensin, beta 133
chr1_-_28376041 3.852 NM_000952
PTAFR
platelet-activating factor receptor
chrX_-_119095544 3.797 NM_001099685
NM_032498
RHOXF2B
RHOXF2
Rhox homeobox family, member 2B
Rhox homeobox family, member 2
chr8_-_38127489 3.170 NM_000349
STAR
steroidogenic acute regulatory protein
chr6_-_41276901 3.163 NM_024807
TREML2
triggering receptor expressed on myeloid cells-like 2
chr15_+_64661560 2.790


chr12_-_9804682 2.608 NM_001781
CD69
CD69 molecule
chr6_+_105511615 2.551 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr1_+_58899 2.478 NM_001005484
OR4F4
OR4F5
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 5
chr22_+_43451351 2.406 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr4_-_40212670 2.396 NM_019027
RBM47
RNA binding motif protein 47
chr6_-_25044156 2.240 FAM65B
family with sequence similarity 65, member B
chr15_-_100280784 2.220 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr7_+_106292975 2.175 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr11_+_93940121 2.159 NM_152431
PIWIL4
piwi-like 4 (Drosophila)
chr7_+_106292932 2.062 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr18_-_65775139 1.966 NM_006566
CD226
CD226 molecule
chrX_-_11194015 1.954 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr14_+_54291255 1.925 NM_001161577
SAMD4A
sterile alpha motif domain containing 4A
chrX_+_30169977 1.910 NM_002367
MAGEB4
melanoma antigen family B, 4
chr17_+_53769562 1.897 LOC100506779
hypothetical LOC100506779
chr11_-_5247948 1.892 NM_005330
HBE1
hemoglobin, epsilon 1
chrX_+_135558001 1.861 NM_000074
CD40LG
CD40 ligand
chr2_-_175207521 1.841 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr6_-_11887265 1.827 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr1_-_180822686 1.791 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr7_+_106293112 1.780 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chrX_+_154880439 1.733 NM_002186
IL9R
interleukin 9 receptor
chr2_-_88946767 1.696


chr3_-_180467483 1.693 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr2_-_135498716 1.684 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr11_+_59580630 1.675 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr11_+_46339691 1.671 NM_001105540
DGKZ
diacylglycerol kinase, zeta
chr17_-_39822366 1.668 NM_000419
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr17_-_64462976 1.660 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr1_+_181028016 1.646 NM_030769
NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr1_+_15675182 1.628 NM_015849
CELA2B
chymotrypsin-like elastase family, member 2B
chr11_+_59902530 1.604 NM_021201
NM_206938
NM_206939
NM_206940
MS4A7



membrane-spanning 4-domains, subfamily A, member 7



chr11_+_59902598 1.603 MS4A7
membrane-spanning 4-domains, subfamily A, member 7
chr1_+_111217244 1.581 NM_000560
CD53
CD53 molecule
chr12_-_8110268 1.580 C3AR1
complement component 3a receptor 1
chr1_-_28375722 1.564 NM_001164723
PTAFR
platelet-activating factor receptor
chr11_+_59580705 1.563 MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr9_+_124355211 1.522 NM_001004457
OR1N2
olfactory receptor, family 1, subfamily N, member 2
chr19_-_56825400 1.511 NM_003830
SIGLEC5
sialic acid binding Ig-like lectin 5
chr11_+_64694200 1.493 NM_001008778
SPDYC
speedy homolog C (Xenopus laevis)
chr1_-_32054164 1.492 NM_144569
SPOCD1
SPOC domain containing 1
chr11_-_123816190 1.489 NM_012378
OR8B8
olfactory receptor, family 8, subfamily B, member 8
chr22_+_38652555 1.429 GRAP2
GRB2-related adaptor protein 2
chr11_+_123625632 1.390 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr9_-_99746923 1.354 NM_018437
HEMGN
hemogen
chr12_-_8110196 1.338 NM_004054
C3AR1
complement component 3a receptor 1
chr7_+_63410620 1.328 NM_001170905
ZNF736
zinc finger protein 736
chr8_-_110724594 1.327 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr10_-_48036698 1.327 NM_016204
GDF2
growth differentiation factor 2
chr17_+_53769659 1.317 LOC100506779
hypothetical LOC100506779
chr9_+_95886558 1.312 NM_152422
PTPDC1
protein tyrosine phosphatase domain containing 1
chr7_-_75794919 1.310 YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr6_+_38798529 1.304 NM_001371
DNAH8
dynein, axonemal, heavy chain 8
chr5_+_118993152 1.275 NM_001163991
NM_182761
FAM170A

family with sequence similarity 170, member A

chr22_+_21340757 1.265


chr11_-_33848013 1.260 LMO2
LIM domain only 2 (rhombotin-like 1)
chr19_-_11425568 1.249 ELAVL3
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
chr21_+_29322100 1.245 USP16
ubiquitin specific peptidase 16
chrX_+_101388810 1.228 NM_022053
NXF2
nuclear RNA export factor 2
chr8_-_17812151 1.226


chr1_+_160868822 1.226 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr19_-_45022993 1.225 FBL
fibrillarin
chr19_+_59820413 1.222 NM_006669
LILRB1
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr10_-_29794484 1.204 SVIL
supervillin
chr14_+_75058518 1.195 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr8_-_91164100 1.184 NM_004929
CALB1
calbindin 1, 28kDa
chrX_-_55225668 1.184 NM_001190708
MTRNR2L10
MT-RNR2-like 10
chr12_-_53044495 1.184 NM_020370
GPR84
G protein-coupled receptor 84
chr3_+_123256902 1.183 NM_175862
CD86
CD86 molecule
chr4_+_111053488 1.183 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr21_+_37714470 1.180 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chrX_-_101581504 1.176 NM_022053
NXF2
nuclear RNA export factor 2
chr11_+_60746396 1.171 NM_001079808
PGA5
PGA3
PGA4
pepsinogen 5, group I (pepsinogen A)
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr1_+_111217314 1.171 CD53
CD53 molecule
chr11_-_33848061 1.169 NM_001142315
LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_+_60727559 1.163 NM_001079807
PGA3
PGA4
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr12_-_242255 1.162 NM_001190997
NM_016615
SLC6A13

solute carrier family 6 (neurotransmitter transporter, GABA), member 13

chr11_-_118405288 1.160 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr19_+_61624 1.159 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr14_-_62638336 1.156 NM_172376
KCNH5
potassium voltage-gated channel, subfamily H (eag-related), member 5
chr1_+_160868932 1.155 DDR2
discoidin domain receptor tyrosine kinase 2
chr12_-_101396459 1.153 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr16_+_33168191 1.144 NM_001099687
TP53TG3B
TP53 target 3B
chr6_+_167445284 1.143 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr20_+_36365965 1.140 NM_001725
BPI
bactericidal/permeability-increasing protein
chr14_+_75058591 1.134 BATF
basic leucine zipper transcription factor, ATF-like
chr1_+_50342168 1.122 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr1_+_203503214 1.108 TMCC2
transmembrane and coiled-coil domain family 2
chr11_-_33847937 1.086 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr6_-_130585650 1.084 NM_001017373
SAMD3
sterile alpha motif domain containing 3
chr6_+_135558744 1.076 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr5_+_125723686 1.073 NM_001146319
GRAMD3
GRAM domain containing 3
chr8_+_11388918 1.071 NM_001715
BLK
B lymphoid tyrosine kinase
chr17_-_31441390 1.062 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr12_+_56802 1.058 NM_015232
IQSEC3
IQ motif and Sec7 domain 3
chr9_+_33230165 1.054 NM_014471
SPINK4
serine peptidase inhibitor, Kazal type 4
chr16_+_2807228 1.050 PRSS21
protease, serine, 21 (testisin)
chr9_-_85773899 1.041 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr3_+_66527586 1.031


chr1_-_153537810 1.023 NM_000298
PKLR
pyruvate kinase, liver and RBC
chr19_+_48776598 1.019 LOC390940
hypothetical protein LOC390940
chr16_+_28850760 1.017 NM_001178098
NM_001770
CD19

CD19 molecule

chr21_+_42583259 1.007 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr7_+_123036312 1.001 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chr1_+_242582559 0.997 NM_001012970
C1orf100
chromosome 1 open reading frame 100
chr1_-_165754325 0.997 NM_000734
NM_198053
CD247

CD247 molecule

chr12_-_69434650 0.990 PTPRR
protein tyrosine phosphatase, receptor type, R
chr2_+_102401580 0.988 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr9_+_95886625 0.978 PTPDC1
protein tyrosine phosphatase domain containing 1
chr7_+_18296569 0.958 HDAC9
histone deacetylase 9
chr1_+_12325632 0.958 VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr12_+_25096755 0.950 LRMP
lymphoid-restricted membrane protein
chr16_+_33111656 0.945 NM_001099687
TP53TG3B
TP53 target 3B
chr11_-_10487212 0.944 NM_001190702
MTRNR2L8
MT-RNR2-like 8
chr16_-_4794749 0.937 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr6_-_49712483 0.933 NM_000324
RHAG
Rh-associated glycoprotein
chr17_-_53849888 0.921 RNF43
ring finger protein 43
chr12_-_69434598 0.920 NM_130846
PTPRR
protein tyrosine phosphatase, receptor type, R
chr9_+_124072947 0.919 NM_199177
MRRF
mitochondrial ribosome recycling factor
chr1_-_47468029 0.919 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr8_-_101384633 0.916 NM_015435
RNF19A
ring finger protein 19A
chr8_-_110411283 0.914 NM_001128211
NUDCD1
NudC domain containing 1
chr10_-_69125932 0.896 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr1_+_3658821 0.896 NM_152492
CCDC27
coiled-coil domain containing 27
chr16_-_4795160 0.889 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr6_-_88911708 0.885 NM_033181
CNR1
cannabinoid receptor 1 (brain)
chr22_+_21464980 0.883


chr2_+_157822355 0.881 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr2_+_169637255 0.877 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr17_-_53849929 0.874 NM_017763
RNF43
ring finger protein 43
chr22_-_25343959 0.860 NM_001887
CRYBB1
crystallin, beta B1
chr16_-_79811475 0.855 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr21_-_30836051 0.853 NM_181612
KRTAP19-6
keratin associated protein 19-6
chr2_+_233417348 0.841 GIGYF2
GRB10 interacting GYF protein 2
chr5_-_156468571 0.836 HAVCR2
hepatitis A virus cellular receptor 2
chr4_+_38740246 0.829 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr19_+_56452775 0.823 NM_173635
C19orf75
chromosome 19 open reading frame 75
chr11_-_64520964 0.820 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr5_+_171553780 0.816 NM_001171183
EFCAB9
EF-hand calcium binding domain 9
chr9_+_134843918 0.811 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr11_-_123772456 0.807 NM_001005467
OR8B3
olfactory receptor, family 8, subfamily B, member 3
chr2_-_144994349 0.802 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chrX_-_24600661 0.795 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr1_+_152560179 0.793 NM_080429
AQP10
aquaporin 10
chr7_+_100302885 0.792 NM_003302
TRIP6
thyroid hormone receptor interactor 6
chr11_-_117589283 0.789 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr17_-_59437782 0.787 NM_000873
ICAM2
intercellular adhesion molecule 2
chr6_+_29732736 0.787 NM_001008228
NM_001008229
NM_001170418
NM_002433
NM_206809
NM_206810
NM_206811
NM_206812
NM_206814
MOG








myelin oligodendrocyte glycoprotein








chr17_+_19917420 0.779 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr6_-_31789824 0.775


chr6_-_49862858 0.772 NM_138733
PGK2
phosphoglycerate kinase 2
chr20_+_35445350 0.767 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr1_+_200698493 0.766 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory (inhibitor) subunit 12B

chr18_-_27594696 0.760 NM_001034172
MCART2
mitochondrial carrier triple repeat 2
chr12_-_94469357 0.752 NM_032147
USP44
ubiquitin specific peptidase 44
chr15_-_91078307 0.751 FAM174B
family with sequence similarity 174, member B
chr5_+_140719773 0.749 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr17_+_53761293 0.743 LOC100506779
hypothetical LOC100506779
chr11_-_113935789 0.743 NM_152315
FAM55A
family with sequence similarity 55, member A
chr2_-_158008763 0.742 NM_004288
CYTIP
cytohesin 1 interacting protein
chr17_+_21946563 0.738 NM_001190452
MTRNR2L1
MT-RNR2-like 1
chr22_-_37214480 0.735 NM_001098505
NM_030881
DDX17

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

chr16_+_24475129 0.732 RBBP6
retinoblastoma binding protein 6
chr19_-_8548232 0.723 MYO1F
myosin IF
chr17_-_53515563 0.715


chr10_+_35934343 0.713 NM_153368
GJD4
gap junction protein, delta 4, 40.1kDa
chr1_+_149395728 0.712 NM_024575
TNFAIP8L2
tumor necrosis factor, alpha-induced protein 8-like 2
chr7_-_18033970 0.712 NM_175886
PRPS1L1
phosphoribosyl pyrophosphate synthetase 1-like 1
chr1_+_208067986 0.710 DIEXF
digestive organ expansion factor homolog (zebrafish)
chr3_-_38967055 0.705 NM_014139
SCN11A
sodium channel, voltage-gated, type XI, alpha subunit
chr1_-_202726068 0.705 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr6_-_87861492 0.704 NM_000735
CGA
glycoprotein hormones, alpha polypeptide
chr1_-_178100204 0.703


chr4_+_123311207 0.701 NM_015312
KIAA1109
KIAA1109
chr5_-_134290789 0.700


chr14_-_22354389 0.697 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr10_-_64698831 0.696 NM_004241
JMJD1C
jumonji domain containing 1C
chr19_-_8548337 0.695 MYO1F
myosin IF
chr2_+_101874809 0.693 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr9_+_110664366 0.692 NM_006687
ACTL7A
actin-like 7A
chr4_-_77163609 0.688 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr6_-_150109324 0.686 NM_198887
NUP43
nucleoporin 43kDa
chr11_-_59707074 0.679 NM_022349
NM_152851
NM_152852
MS4A6A


membrane-spanning 4-domains, subfamily A, member 6A


chr7_+_142053693 0.671 NM_001190487
MTRNR2L6
MT-RNR2-like 6
chr19_-_46080496 0.670 NM_000764
NM_030589
CYP2A7

cytochrome P450, family 2, subfamily A, polypeptide 7

chr7_+_129634935 0.670 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr17_+_53515725 0.669 NM_080677
DYNLL2
dynein, light chain, LC8-type 2
chr1_+_117345894 0.669 NM_004258
CD101
CD101 molecule
chr16_+_2807164 0.667 NM_006799
NM_144956
NM_144957
PRSS21


protease, serine, 21 (testisin)


chr13_+_49487390 0.666 NM_173605
NM_199464
TRIM13
KCNRG

tripartite motif containing 13
potassium channel regulator

chr16_+_31446703 0.663 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr6_+_154373323 0.655 NM_001145279
NM_001145280
NM_001145281
OPRM1


opioid receptor, mu 1


chr8_+_77928372 0.654 ZFHX4
zinc finger homeobox 4
chr14_+_59782222 0.654 NM_177952
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.57 1.39e-10 GO:0007608 sensory perception of smell
2.33 1.35e-08 GO:0007606 sensory perception of chemical stimulus
1.77 4.95e-05 GO:0007600 sensory perception
1.44 1.51e-03 GO:0003008 system process
10.48 7.20e-03 GO:0002827 positive regulation of T-helper 1 type immune response
9.31 2.03e-02 GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production
1.83 2.44e-02 GO:0050776 regulation of immune response
6.98 4.54e-02 GO:0046640 regulation of alpha-beta T cell proliferation
8.38 4.77e-02 GO:0046641 positive regulation of alpha-beta T cell proliferation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.40 4.31e-12 GO:0005886 plasma membrane
1.39 5.52e-12 GO:0071944 cell periphery
1.24 2.24e-06 GO:0031224 intrinsic to membrane
1.21 6.35e-06 GO:0044425 membrane part
1.23 1.66e-05 GO:0016021 integral to membrane
1.16 9.03e-05 GO:0016020 membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.70 2.98e-12 GO:0004984 olfactory receptor activity
2.02 9.47e-11 GO:0004930 G-protein coupled receptor activity
1.77 6.63e-10 GO:0004888 transmembrane receptor activity
1.56 1.59e-09 GO:0004871 signal transducer activity
1.56 1.59e-09 GO:0060089 molecular transducer activity
1.63 2.65e-09 GO:0004872 receptor activity