Motif ID: ZEB1.p2

Z-value: 3.128


Transcription factors associated with ZEB1.p2:

Gene SymbolEntrez IDGene Name
ZEB1 6935 zinc finger E-box binding homeobox 1



Activity profile for motif ZEB1.p2.

activity profile for motif ZEB1.p2


Sorted Z-values histogram for motif ZEB1.p2

Sorted Z-values for motif ZEB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZEB1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_6415259 10.337 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr7_-_22363036 7.705 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr22_+_38720881 6.798 NM_138435
FAM83F
family with sequence similarity 83, member F
chr19_+_43447262 6.213 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr14_+_71468902 5.129 RGS6
regulator of G-protein signaling 6
chr4_-_35922288 5.055 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr19_+_43446937 4.855 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr19_+_43447078 4.533 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr1_-_27159462 4.520 NM_152365
C1orf172
chromosome 1 open reading frame 172
chr8_+_120289735 4.327 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr19_+_40431359 4.307 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr18_-_45975163 4.233 NM_001080467
MYO5B
myosin VB
chr1_+_60053050 4.013 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr19_+_40431618 3.940 LSR
lipolysis stimulated lipoprotein receptor
chr17_-_60208083 3.866 LOC146880
hypothetical LOC146880
chr1_+_1971762 3.821 NM_002744
PRKCZ
protein kinase C, zeta
chr19_+_40431122 3.805 LSR
lipolysis stimulated lipoprotein receptor
chr16_-_66827449 3.605 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr12_+_6926014 3.410 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr17_-_40866062 3.378 NM_174919
SH3D20
SH3 domain containing 20
chr7_+_147667461 3.365 CNTNAP2
contactin associated protein-like 2
chr2_+_222997529 3.290 NM_152386
SGPP2
sphingosine-1-phosphate phosphatase 2
chr11_-_64368616 3.250 NM_017525
CDC42BPG
CDC42 binding protein kinase gamma (DMPK-like)
chr19_+_40431678 3.183 LSR
lipolysis stimulated lipoprotein receptor
chr2_-_73350103 3.169 NM_001080410
FBXO41
F-box protein 41
chr2_+_222997456 3.130 SGPP2
sphingosine-1-phosphate phosphatase 2
chr3_+_10832867 3.067 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr17_-_7106497 3.020 CLDN7
claudin 7
chr5_+_68746694 2.998 NM_001038603
MARVELD2
MARVEL domain containing 2
chr6_-_10527772 2.917 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr17_+_71033339 2.852 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr6_+_36206239 2.773 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr8_-_144887876 2.743 NM_198488
FAM83H
family with sequence similarity 83, member H
chr10_-_62163083 2.670 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr11_+_32808045 2.640 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr1_+_24518398 2.541 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr7_+_26298018 2.494 NM_013322
SNX10
sorting nexin 10
chr17_-_40865987 2.466 SH3D20
SH3 domain containing 20
chr2_-_97016027 2.458 NM_001122646
FAM178B
family with sequence similarity 178, member B
chr12_+_6925997 2.447 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr21_+_42807052 2.422 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr7_+_26298136 2.376 SNX10
sorting nexin 10
chr17_+_26839143 2.352 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr1_+_24518501 2.335 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr21_-_42060266 2.322 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr3_-_123223658 2.321 NM_175924
ILDR1
immunoglobulin-like domain containing receptor 1
chr8_+_95722448 2.276 ESRP1
epithelial splicing regulatory protein 1
chr14_-_60817946 2.271


chr5_-_138753443 2.257 NM_016459
MZB1
marginal zone B and B1 cell-specific protein
chr11_-_431995 2.243 NM_001012302
ANO9
anoctamin 9
chr21_-_41140908 2.223 NM_001389
DSCAM
Down syndrome cell adhesion molecule
chr22_-_39964001 2.222 CHADL
chondroadherin-like
chr11_-_431956 2.205 ANO9
anoctamin 9
chr14_-_60817663 2.146 TMEM30B
transmembrane protein 30B
chr17_+_38064787 2.138 NM_016437
TUBG2
tubulin, gamma 2
chr11_+_1287553 2.133 LOC255512
hypothetical LOC255512
chr5_+_167651063 2.118 NM_001161661
NM_001161662
NM_015238
WWC1


WW and C2 domain containing 1


chr16_+_67328715 2.112 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr7_+_149651202 2.110 NM_001142928
NM_023942
LRRC61

leucine rich repeat containing 61

chr16_+_67328693 2.103 NM_004360
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr2_-_121759237 2.080 NM_014553
TFCP2L1
transcription factor CP2-like 1
chr19_-_18409788 2.068 NM_001170939
ISYNA1
inositol-3-phosphate synthase 1
chr2_-_96145614 2.044 NM_000682
ADRA2B
adrenergic, alpha-2B-, receptor
chr2_+_10779191 2.021 NM_001039362
NM_144583
ATP6V1C2

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2

chr2_-_166358951 2.019 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr6_-_3172775 2.006 NM_178012
TUBB2B
tubulin, beta 2B
chr11_+_75157414 2.005 NM_032564
DGAT2
diacylglycerol O-acyltransferase 2
chr20_+_13150417 2.003 NM_080826
ISM1
isthmin 1 homolog (zebrafish)
chr8_-_75396016 1.979 NM_020647
JPH1
junctophilin 1
chr10_+_115988999 1.969 NM_198496
VWA2
von Willebrand factor A domain containing 2
chr2_-_166359016 1.955 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr19_-_60587414 1.948 NM_001190764
LOC388564
hypothetical protein LOC388564
chr2_-_166358792 1.935 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr9_-_139183675 1.933


chr16_+_67328805 1.929 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr14_-_60817709 1.924 TMEM30B
transmembrane protein 30B
chr14_-_60817621 1.918


chr11_+_75157450 1.910 DGAT2
diacylglycerol O-acyltransferase 2
chr11_-_1287467 1.908 NM_019009
TOLLIP
toll interacting protein
chr21_-_42060334 1.889 RIPK4
receptor-interacting serine-threonine kinase 4
chr9_-_125070675 1.872 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chr3_-_184316553 1.870 MCCC1
methylcrotonoyl-CoA carboxylase 1 (alpha)
chr2_-_237080830 1.847 NM_024726
IQCA1
IQ motif containing with AAA domain 1
chr5_-_132976094 1.824 FSTL4
follistatin-like 4
chr22_+_40107878 1.812 NM_003216
TEF
thyrotrophic embryonic factor
chr11_+_72607254 1.809 P2RY2
purinergic receptor P2Y, G-protein coupled, 2
chr12_+_119562737 1.801 NM_001033677
CABP1
calcium binding protein 1
chr18_+_58143499 1.799 NM_003839
TNFRSF11A
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
chr10_+_70881322 1.780


chr16_+_70217564 1.776 NM_001017967
NM_052858
MARVELD3

MARVEL domain containing 3

chr5_-_132976121 1.750 NM_015082
FSTL4
follistatin-like 4
chr17_+_32368611 1.732 NM_005568
LHX1
LIM homeobox 1
chr14_-_66948523 1.710 NM_016445
PLEK2
pleckstrin 2
chr19_+_7566698 1.695 NM_001080429
NM_020902
KIAA1543

KIAA1543

chr17_+_71229151 1.684 ITGB4
integrin, beta 4
chr3_-_48446405 1.675 NM_001130082
PLXNB1
plexin B1
chr14_-_66948612 1.670 PLEK2
pleckstrin 2
chr11_+_119616112 1.670 NM_014352
POU2F3
POU class 2 homeobox 3
chr17_+_71229191 1.665 ITGB4
integrin, beta 4
chr19_-_19599973 1.648 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr1_+_232416618 1.645 SLC35F3
solute carrier family 35, member F3
chr11_-_1287459 1.642 TOLLIP
toll interacting protein
chr6_-_32659958 1.626 HLA-DRB1
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 5
chr21_-_41140457 1.621 DSCAM
Down syndrome cell adhesion molecule
chr19_-_6150536 1.604


chr11_+_72607040 1.599 NM_176071
P2RY2
purinergic receptor P2Y, G-protein coupled, 2
chr7_+_17304707 1.592 NM_001621
AHR
aryl hydrocarbon receptor
chr17_-_3814334 1.581 NM_005173
NM_174953
NM_174954
NM_174955
NM_174956
NM_174957
NM_174958
ATP2A3






ATPase, Ca++ transporting, ubiquitous






chr16_+_67328737 1.579 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr11_-_1287416 1.573 TOLLIP
toll interacting protein
chr21_-_38954433 1.569 ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr10_+_70881221 1.564 NM_012339
TSPAN15
tetraspanin 15
chr14_+_73073570 1.563 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr19_-_18409971 1.558 NM_001170938
NM_016368
ISYNA1

inositol-3-phosphate synthase 1

chr6_-_63053811 1.557 NM_152688
KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr11_-_65895640 1.556 NM_001532
SLC29A2
solute carrier family 29 (nucleoside transporters), member 2
chr19_-_6718417 1.555 NM_005490
SH2D3A
SH2 domain containing 3A
chr17_+_71229110 1.552 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr5_+_132111034 1.549 NM_001039780
CCNI2
cyclin I family, member 2
chr1_+_12046020 1.539 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr15_-_50375143 1.536 NM_018728
MYO5C
myosin VC
chr5_-_94646033 1.533 NM_024717
MCTP1
multiple C2 domains, transmembrane 1
chr8_+_144888275 1.532 LOC100128338
hypothetical LOC100128338
chr14_-_60818263 1.529 NM_001017970
TMEM30B
transmembrane protein 30B
chr3_+_98016114 1.524 NM_001080448
EPHA6
EPH receptor A6
chr19_+_45811856 1.522 LTBP4
latent transforming growth factor beta binding protein 4
chr1_-_55039458 1.521 NM_001114108
NM_017904
TTC22

tetratricopeptide repeat domain 22

chr2_+_74595073 1.516 NM_016170
TLX2
T-cell leukemia homeobox 2
chr19_+_45811647 1.504 LTBP4
latent transforming growth factor beta binding protein 4
chr17_+_35147738 1.498 GRB7
growth factor receptor-bound protein 7
chr7_-_76883642 1.492 NM_017439
PION
pigeon homolog (Drosophila)
chr16_-_73365975 1.483 FA2H
fatty acid 2-hydroxylase
chr19_+_7608015 1.465 STXBP2
syntaxin binding protein 2
chr11_-_1287384 1.460 TOLLIP
toll interacting protein
chr19_+_7608020 1.450 STXBP2
syntaxin binding protein 2
chr16_-_73366200 1.447 NM_024306
FA2H
fatty acid 2-hydroxylase
chr11_+_72606950 1.446 NM_002564
NM_176072
P2RY2

purinergic receptor P2Y, G-protein coupled, 2

chr11_+_110675175 1.445 NM_001136105
C11orf93
chromosome 11 open reading frame 93
chr8_+_102574012 1.437 GRHL2
grainyhead-like 2 (Drosophila)
chr18_+_27332024 1.431 NM_001943
DSG2
desmoglein 2
chr19_+_7607976 1.418 NM_001127396
NM_006949
STXBP2

syntaxin binding protein 2

chr19_-_7607852 1.416


chr1_-_58815415 1.412 TACSTD2
tumor-associated calcium signal transducer 2
chr9_-_139184247 1.406 NM_001013653
LRRC26
leucine rich repeat containing 26
chr11_+_45900731 1.385 GYLTL1B
glycosyltransferase-like 1B
chr14_-_77034853 1.383 NM_182509
NM_199296
ISM2

isthmin 2 homolog (zebrafish)

chr16_-_14695930 1.379 NM_003561
PLA2G10
phospholipase A2, group X
chr14_+_30413393 1.373 NM_001135058
NM_004086
COCH

coagulation factor C homolog, cochlin (Limulus polyphemus)

chr9_-_38610579 1.365 ANKRD18A
ankyrin repeat domain 18A
chr1_+_26744893 1.363 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr2_+_47449951 1.360 EPCAM
epithelial cell adhesion molecule
chr1_+_3360880 1.357 NM_014448
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr11_-_407324 1.356 NM_001135053
NM_021805
SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

chr9_-_125070613 1.356 NM_018387
STRBP
spermatid perinuclear RNA binding protein
chr17_+_1905104 1.354 NM_006497
HIC1
hypermethylated in cancer 1
chr5_-_157011665 1.343


chr22_-_44751671 1.341 NM_058238
WNT7B
wingless-type MMTV integration site family, member 7B
chr22_-_49317408 1.339 ODF3B
outer dense fiber of sperm tails 3B
chr16_+_67236730 1.335 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr1_+_36544549 1.324 NM_001162530
SH3D21
SH3 domain containing 21
chr20_-_17986520 1.320 NM_021220
OVOL2
ovo-like 2 (Drosophila)
chr12_+_7174230 1.311 NM_014718
CLSTN3
calsyntenin 3
chr8_-_95720870 1.305 LOC100288748
hypothetical LOC100288748
chr22_-_30016707 1.293 PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr19_+_7608010 1.291 STXBP2
syntaxin binding protein 2
chr1_+_9979841 1.291 NM_052960
RBP7
retinol binding protein 7, cellular
chr9_-_66233945 1.288


chr19_-_56214765 1.277 NM_145888
KLK10
kallikrein-related peptidase 10
chr1_+_26744929 1.267 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr14_-_105392671 1.262


chr19_-_51690989 1.262 NM_020709
PNMAL2
PNMA-like 2
chr16_+_23101538 1.251 NM_001039
SCNN1G
sodium channel, nonvoltage-gated 1, gamma
chr11_-_1287256 1.250 TOLLIP
toll interacting protein
chr17_-_58877276 1.247 NM_001017916
NM_001915
CYB561

cytochrome b-561

chr10_-_133971136 1.245 NM_173575
STK32C
serine/threonine kinase 32C
chr8_-_145609737 1.244 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr18_-_70110089 1.229 NM_001190807
NM_001914
NM_148923
CYB5A


cytochrome b5 type A (microsomal)


chr1_-_44269719 1.228 NM_001024845
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr17_-_19589363 1.228 NM_001135168
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr1_-_58815753 1.226 NM_002353
TACSTD2
tumor-associated calcium signal transducer 2
chr1_+_61980679 1.226 NM_176877
INADL
InaD-like (Drosophila)
chr2_+_231968578 1.221 NM_145236
B3GNT7
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
chr17_-_47590669 1.209 CA10
carbonic anhydrase X
chr17_+_35147697 1.208 NM_005310
GRB7
growth factor receptor-bound protein 7
chr2_+_111594921 1.205 NM_006538
NM_138621
NM_207002
BCL2L11


BCL2-like 11 (apoptosis facilitator)


chr1_-_208046011 1.204 NM_006147
IRF6
interferon regulatory factor 6
chr16_-_66007650 1.202 NM_013304
ZDHHC1
zinc finger, DHHC-type containing 1
chr17_-_47591123 1.195 NM_020178
CA10
carbonic anhydrase X
chr1_+_63561632 1.194 FOXD3
forkhead box D3
chr10_-_1769669 1.194 NM_018702
ADARB2
adenosine deaminase, RNA-specific, B2
chr13_-_19704533 1.193 NM_001110219
NM_001110220
NM_001110221
GJB6


gap junction protein, beta 6, 30kDa


chr17_+_45008175 1.193 NM_007225
NXPH3
neurexophilin 3
chrX_+_69591639 1.177 NM_001166278
DLG3
discs, large homolog 3 (Drosophila)
chr2_-_238164042 1.177 RAB17
RAB17, member RAS oncogene family
chr12_-_44949474 1.163 NM_001077484
NM_030674
SLC38A1

solute carrier family 38, member 1

chr17_+_40681060 1.160 LOC100133991
similar to hCG1995169
chr1_-_150079656 1.159 NM_001136003
C2CD4D
C2 calcium-dependent domain containing 4D
chr9_+_134927185 1.153 NM_001807
CEL
carboxyl ester lipase (bile salt-stimulated lipase)
chr20_+_60744231 1.151 NM_016354
SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr2_-_224410444 1.149 AP1S3
adaptor-related protein complex 1, sigma 3 subunit

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.26 2.18e-02 GO:0009966 regulation of signal transduction
1.22 2.98e-02 GO:0048583 regulation of response to stimulus
1.32 4.21e-02 GO:0050793 regulation of developmental process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 3.76e-03 GO:0005737 cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.19 1.58e-02 GO:0042169 SH2 domain binding
1.75 2.26e-02 GO:0005085 guanyl-nucleotide exchange factor activity