Motif ID: NKX6-1,2.p2

Z-value: 1.467


Transcription factors associated with NKX6-1,2.p2:

Gene SymbolEntrez IDGene Name
NKX6-1 4825 NK6 homeobox 1
NKX6-2 84504 NK6 homeobox 2



Activity profile for motif NKX6-1,2.p2.

activity profile for motif NKX6-1,2.p2


Sorted Z-values histogram for motif NKX6-1,2.p2

Sorted Z-values for motif NKX6-1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_185064654 3.808 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr4_-_90978469 3.515 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr4_+_75393053 2.988 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr20_+_19863716 2.871 RIN2
Ras and Rab interactor 2
chr4_-_152368492 2.806 SH3D19
SH3 domain containing 19
chr8_-_122722674 2.376 NM_005328
HAS2
hyaluronan synthase 2
chr1_+_78858675 2.326 NM_006820
IFI44L
interferon-induced protein 44-like
chr3_-_79899748 2.262 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr2_-_160764819 2.255 NM_000888
ITGB6
integrin, beta 6
chr3_-_143230124 2.106 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr7_-_41709191 2.086 NM_002192
INHBA
inhibin, beta A
chr1_+_207668787 1.948 NM_001104548
LOC642587
NPC-A-5
chr12_-_28016182 1.936 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr20_+_11846536 1.809 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr7_-_83662152 1.668 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr2_-_160765008 1.652 ITGB6
integrin, beta 6
chr3_-_64186151 1.618 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chrX_+_135058402 1.579 NM_001159700
FHL1
four and a half LIM domains 1
chr21_+_29439768 1.567 C21orf7
chromosome 21 open reading frame 7
chr11_+_7574992 1.548 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr18_+_54013575 1.520 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr11_-_128399218 1.495 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chrX_-_33139349 1.472 NM_004006
DMD
dystrophin
chr12_-_6103945 1.309 NM_000552
VWF
von Willebrand factor
chr14_+_62740878 1.309 NM_020663
RHOJ
ras homolog gene family, member J
chr1_+_208568218 1.306 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr8_+_79591074 1.302 PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr1_+_242691295 1.265 NM_001130957
NM_173807
C1orf101

chromosome 1 open reading frame 101

chr2_-_217267742 1.234 IGFBP5
insulin-like growth factor binding protein 5
chr13_-_32658215 1.227 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr4_-_138673078 1.212 NM_019035
PCDH18
protocadherin 18
chr1_+_78888064 1.181 NM_006417
IFI44
interferon-induced protein 44
chr5_+_145296313 1.175 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr6_-_26151863 1.145 NM_021062
HIST1H2BB
histone cluster 1, H2bb
chr4_-_70760381 1.142 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr18_+_59705918 1.126 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr2_-_202271598 1.117 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr7_+_28692122 1.097 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr13_-_47885653 1.094 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chr12_-_52939584 1.077 NM_001127322
CBX5
chromobox homolog 5
chr1_-_31251315 1.071 PUM1
pumilio homolog 1 (Drosophila)
chr6_+_116956868 1.049 NM_153036
FAM26D
family with sequence similarity 26, member D
chr15_-_91078307 1.037 FAM174B
family with sequence similarity 174, member B
chr8_-_28403652 1.032 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr18_+_30544193 1.006 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr9_-_21375258 1.005 NM_000605
IFNA2
interferon, alpha 2
chr3_-_95230143 0.990 NM_001001850
STX19
syntaxin 19
chr6_+_125346208 0.980 NM_152553
RNF217
ring finger protein 217
chr21_-_34820916 0.975 NM_203418
RCAN1
regulator of calcineurin 1
chr3_+_133518900 0.973 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr10_-_90601655 0.965 NM_144590
ANKRD22
ankyrin repeat domain 22
chr8_-_23768242 0.958 NM_003155
STC1
stanniocalcin 1
chr12_-_52939636 0.955 NM_001127321
CBX5
chromobox homolog 5
chr6_-_32892705 0.946 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr20_-_49747397 0.938 ATP9A
ATPase, class II, type 9A
chr13_-_47885248 0.935 LPAR6
lysophosphatidic acid receptor 6
chr18_+_59405513 0.915 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr12_+_74071116 0.912 GLIPR1L2
GLI pathogenesis-related 1 like 2
chrX_-_43717864 0.892 NM_000266
NDP
Norrie disease (pseudoglioma)
chr13_-_35327798 0.888 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr2_-_219614481 0.875 NM_152389
NM_194302
CCDC108

coiled-coil domain containing 108

chr3_+_190990142 0.872 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr13_-_83354474 0.865 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chr13_-_37070862 0.861 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr5_+_147562531 0.852 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr6_-_56824371 0.849 DST
dystonin
chr22_-_25291268 0.839 NM_001008566
TPST2
tyrosylprotein sulfotransferase 2
chr1_-_89261021 0.833 NM_018284
GBP3
guanylate binding protein 3
chr4_-_16509126 0.833 LDB2
LIM domain binding 2
chr4_-_140420789 0.826 NM_032623
C4orf49
chromosome 4 open reading frame 49
chr3_+_133518966 0.824 ACPP
acid phosphatase, prostate
chr11_-_101906640 0.821 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr19_+_45973139 0.819 NM_006533
MIA
melanoma inhibitory activity
chr11_+_48466844 0.817 NM_001005512
OR4A47
olfactory receptor, family 4, subfamily A, member 47
chr2_-_225519974 0.816 DOCK10
dedicator of cytokinesis 10
chr2_+_17861266 0.801 NM_001105569
MSGN1
mesogenin 1
chr3_-_152585226 0.799 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr4_-_77147625 0.791 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr2_+_165858586 0.785 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr3_-_11585264 0.783 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr4_-_138673014 0.780 PCDH18
protocadherin 18
chr5_+_35892747 0.775 NM_002185
IL7R
interleukin 7 receptor
chr2_+_218698980 0.766 NM_001557
CXCR2
chemokine (C-X-C motif) receptor 2
chr1_-_149004916 0.765 NM_004079
CTSS
cathepsin S
chr2_+_219180821 0.747 PLCD4
phospholipase C, delta 4
chrX_+_10084984 0.745 NM_001830
CLCN4
chloride channel 4
chr2_-_65447267 0.741 SPRED2
sprouty-related, EVH1 domain containing 2
chr4_-_23500706 0.734 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr8_-_82557956 0.733 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr8_+_79590890 0.726 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr3_-_15814678 0.726 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr6_-_46811388 0.712 NM_001168357
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr2_-_227952249 0.710 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr13_-_83354425 0.708 SLITRK1
SLIT and NTRK-like family, member 1
chr21_-_30510113 0.705 NM_199328
CLDN8
claudin 8
chr1_+_85300580 0.704 NM_145172
WDR63
WD repeat domain 63
chr2_-_65447370 0.701 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr3_+_175641340 0.690 NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr4_-_163304567 0.690 NM_001128427
NM_001128428
NM_020116
FSTL5


follistatin-like 5


chr11_-_117552355 0.687 SCN2B
sodium channel, voltage-gated, type II, beta
chr4_-_185963859 0.685 ACSL1
acyl-CoA synthetase long-chain family member 1
chr4_-_16509446 0.676 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr3_-_58538110 0.674 FAM107A
family with sequence similarity 107, member A
chr6_-_56824672 0.671 DST
dystonin
chr3_-_113495763 0.663 NM_183061
SLC9A10
solute carrier family 9, member 10
chr8_-_38324809 0.654 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr10_+_86174665 0.640 FAM190B
family with sequence similarity 190, member B
chr3_-_45813030 0.634 NM_020208
NM_022405
SLC6A20

solute carrier family 6 (proline IMINO transporter), member 20

chr7_-_33047042 0.631 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chr6_-_32447626 0.624 NM_006781
C6orf10
chromosome 6 open reading frame 10
chr4_+_187227302 0.623 NM_003265
TLR3
toll-like receptor 3
chr1_-_149115667 0.623 ARNT
aryl hydrocarbon receptor nuclear translocator
chr9_+_115303527 0.623 NM_130795
RGS3
regulator of G-protein signaling 3
chr1_-_110735158 0.616 NM_004696
SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr2_+_201756048 0.616 CASP10
caspase 10, apoptosis-related cysteine peptidase
chr3_-_21767819 0.610 NM_024697
ZNF385D
zinc finger protein 385D
chr2_+_173394560 0.605 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr13_-_45323757 0.598 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr10_-_116276651 0.595 NM_006720
ABLIM1
actin binding LIM protein 1
chr10_+_50557689 0.585 NM_001042427
NM_182554
C10orf53

chromosome 10 open reading frame 53

chr19_+_24061717 0.581 NM_203282
ZNF254
zinc finger protein 254
chr1_-_116184846 0.580 NM_001111061
NHLH2
nescient helix loop helix 2
chr3_-_45812916 0.578 SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chr9_+_81376666 0.572 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr3_-_170348215 0.571 NM_001164000
MECOM
MDS1 and EVI1 complex locus
chr17_-_39191658 0.564 NM_025237
SOST
sclerostin
chr5_-_13997588 0.562 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr6_+_49626071 0.560 NM_001145652
C6orf141
chromosome 6 open reading frame 141
chr4_+_74825138 0.559 NM_000584
IL8
interleukin 8
chr9_-_92444886 0.558 NM_017594
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr6_-_138935359 0.555 NM_020464
NHSL1
NHS-like 1
chr2_+_218698242 0.553 NM_001168298
CXCR2
chemokine (C-X-C motif) receptor 2
chr21_+_30937053 0.550 NM_001128077
KRTAP20-3
keratin associated protein 20-3
chr6_+_36206239 0.550 NM_002754
MAPK13
mitogen-activated protein kinase 13
chrX_-_10504852 0.549 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr15_+_46271158 0.545 NM_001145668
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporters), member 1
chr2_+_190248955 0.540 NM_144708
ANKAR
ankyrin and armadillo repeat containing
chrX_+_15435351 0.537 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr3_-_52269467 0.534 WDR82
WD repeat domain 82
chr9_-_72673753 0.534 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr11_+_122258600 0.533 NM_024806
NM_199124
C11orf63

chromosome 11 open reading frame 63

chr19_-_23390707 0.527


chr1_-_171286634 0.524 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr9_+_76302071 0.523 NM_006914
RORB
RAR-related orphan receptor B
chr11_-_117552545 0.513 NM_004588
SCN2B
sodium channel, voltage-gated, type II, beta
chr2_-_113310796 0.512 NM_000576
IL1B
interleukin 1, beta
chr15_-_40089736 0.512 NM_001080490
PLA2G4E
phospholipase A2, group IVE
chr4_+_54790190 0.509 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr11_-_40271086 0.506 LRRC4C
leucine rich repeat containing 4C
chrX_-_102973762 0.505 NM_016370
RAB9B
RAB9B, member RAS oncogene family
chr3_+_150065732 0.503 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr6_-_133126278 0.499 NM_078488
VNN2
vanin 2
chr5_+_76418214 0.497 LOC728723
hypothetical LOC728723
chr12_+_49522967 0.497 NM_182559
TMPRSS12
transmembrane (C-terminal) protease, serine 12
chr7_-_136679045 0.494 NM_002825
PTN
pleiotrophin
chr14_-_94669547 0.493 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr19_-_23390679 0.493


chrX_-_78509662 0.492 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr3_-_152449591 0.490 NM_001081455
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chrX_+_85404626 0.487 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr8_+_26206648 0.485 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr1_-_149004852 0.480 CTSS
cathepsin S
chr5_+_49997489 0.478 NM_001178055
PARP8
poly (ADP-ribose) polymerase family, member 8
chr3_-_12561962 0.476 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr4_+_54790020 0.474 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr15_-_74091817 0.472 NM_138573
NRG4
neuregulin 4
chr1_-_221920023 0.470 NM_001143962
CAPN8
calpain 8
chr17_-_36074812 0.468 NM_152349
KRT222
keratin 222
chr5_-_22889192 0.467 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr1_+_194887630 0.467 NM_000186
NM_001014975
CFH

complement factor H

chr6_-_79732391 0.465 PHIP
pleckstrin homology domain interacting protein
chr12_+_46799279 0.463 NM_000289
PFKM
phosphofructokinase, muscle
chr8_+_67507271 0.457 NM_144650
ADHFE1
alcohol dehydrogenase, iron containing, 1
chr8_+_76614757 0.452 NM_004133
HNF4G
hepatocyte nuclear factor 4, gamma
chr15_+_97990705 0.451 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr3_-_58538530 0.450 NM_001076778
NM_007177
FAM107A

family with sequence similarity 107, member A

chr1_-_149115686 0.449 ARNT
aryl hydrocarbon receptor nuclear translocator
chr12_+_56406296 0.448 LOC100130776
hypothetical LOC100130776
chr16_-_3783475 0.447 CREBBP
CREB binding protein
chr14_-_79748273 0.445 NM_000793
NM_013989
DIO2

deiodinase, iodothyronine, type II

chr2_-_121964373 0.437 CLASP1
cytoplasmic linker associated protein 1
chr3_+_138159396 0.428 NM_144717
IL20RB
interleukin 20 receptor beta
chr1_-_149004879 0.427 CTSS
cathepsin S
chr8_-_109868945 0.427 NM_153015
TMEM74
transmembrane protein 74
chr21_+_42492867 0.422 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr1_+_15145001 0.422 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr17_-_7434113 0.420 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chrX_+_55951280 0.415


chr7_+_18502342 0.414 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr19_+_50086299 0.406 NM_001128916
NM_001128917
NM_006114
TOMM40


translocase of outer mitochondrial membrane 40 homolog (yeast)


chr3_+_188397967 0.404 NM_153708
RTP1
receptor (chemosensory) transporter protein 1
chrX_-_119550402 0.402 CUL4B
cullin 4B
chr21_-_41140908 0.399 NM_001389
DSCAM
Down syndrome cell adhesion molecule
chr6_+_26548678 0.396 NM_006994
NM_197974
BTN3A3

butyrophilin, subfamily 3, member A3

chr21_-_42219849 0.396 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr21_-_35343065 0.396 RUNX1
runt-related transcription factor 1
chr7_-_93027057 0.396 NM_001164738
CALCR
calcitonin receptor
chr12_-_80676562 0.395 PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr19_+_50086405 0.394 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chrX_+_35847771 0.392 NM_152632
CXorf22
chromosome X open reading frame 22

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.23 1.56e-03 GO:0050896 response to stimulus
1.33 1.64e-03 GO:0023052 signaling
1.35 1.70e-03 GO:0007165 signal transduction
1.49 5.43e-03 GO:0007166 cell surface receptor linked signaling pathway
6.80 2.56e-02 GO:0002053 positive regulation of mesenchymal cell proliferation
5.80 3.16e-02 GO:0048806 genitalia development
1.27 3.69e-02 GO:0051716 cellular response to stimulus

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.62 5.07e-03 GO:0005102 receptor binding