Motif ID: TP53.p2

Z-value: 1.336


Transcription factors associated with TP53.p2:

Gene SymbolEntrez IDGene Name
TP53 7157 tumor protein p53



Activity profile for motif TP53.p2.

activity profile for motif TP53.p2


Sorted Z-values histogram for motif TP53.p2

Sorted Z-values for motif TP53.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TP53.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_-_62151216 1.833 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr4_-_40211324 1.434 RBM47
RNA binding motif protein 47
chr19_+_17766907 1.394 NM_014256
B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr19_+_15644885 1.296 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr19_+_17766935 1.250 B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr19_-_12807221 1.150 NM_031429
RTBDN
retbindin
chr11_-_47356642 1.141 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr11_-_47356650 1.115 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr11_-_47356672 1.071 NM_001080547
NM_003120
SPI1

spleen focus forming virus (SFFV) proviral integration oncogene spi1

chr9_-_114814286 1.058 NM_001101338
ZNF883
zinc finger protein 883
chr19_+_17766609 1.035 B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr1_+_25471470 1.014 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr1_-_25619863 0.978 NM_020485
NM_138616
NM_138617
NM_138618
RHCE



RHD
Rh blood group, CcEe antigens



Rh blood group, D antigen
chr8_-_145671947 0.972 FOXH1
forkhead box H1
chr3_-_52454082 0.960 NM_020163
SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr11_-_47356562 0.952 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr7_+_72206961 0.881 GTF2IP1
general transcription factor IIi, pseudogene 1
chr11_-_47356479 0.874 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr7_-_74291367 0.857 GTF2IP1
general transcription factor IIi, pseudogene 1
chr2_+_47021816 0.826 NM_020458
TTC7A
tetratricopeptide repeat domain 7A
chr1_-_54256390 0.817 NM_001010978
LDLRAD1
low density lipoprotein receptor class A domain containing 1
chr2_-_26058941 0.817 NM_002254
KIF3C
kinesin family member 3C
chr2_+_47021866 0.806 TTC7A
tetratricopeptide repeat domain 7A
chr16_+_56211410 0.793 NM_001145770
NM_005682
GPR56

G protein-coupled receptor 56

chr2_-_26058831 0.786 KIF3C
kinesin family member 3C
chr13_-_99422163 0.729 NM_033132
ZIC5
Zic family member 5 (odd-paired homolog, Drosophila)
chr22_-_37569962 0.723 NM_014293
NPTXR
neuronal pentraxin receptor
chr19_+_1358664 0.717 DAZAP1
DAZ associated protein 1
chr16_+_387176 0.714 NM_005009
NME4
non-metastatic cells 4, protein expressed in
chr19_+_7859380 0.703 NM_025061
LRRC8E
leucine rich repeat containing 8 family, member E
chr2_+_74594093 0.700 TLX2
T-cell leukemia homeobox 2
chr12_-_14887648 0.693 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chrX_+_151837064 0.687 NM_001178113
ZNF185
zinc finger protein 185 (LIM domain)
chr2_+_241193492 0.685 NM_001195381
NM_001195382
GPR35

G protein-coupled receptor 35

chr19_-_2407954 0.667 NM_032737
LMNB2
lamin B2
chr1_-_27802947 0.645 AHDC1
AT hook, DNA binding motif, containing 1
chr20_+_34667566 0.641 NM_018840
NM_199483
C20orf24

chromosome 20 open reading frame 24

chr3_-_49435114 0.635 NM_000481
NM_001164710
NM_001164711
NM_001164712
AMT



aminomethyltransferase



chr11_+_279113 0.628 NM_025092
ATHL1
ATH1, acid trehalase-like 1 (yeast)
chr17_+_69939130 0.625 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr20_+_4077409 0.619 NM_175839
NM_175840
NM_175841
NM_175842
SMOX



spermine oxidase



chr6_+_117910472 0.609 NM_173674
DCBLD1
discoidin, CUB and LCCL domain containing 1
chr12_+_108038774 0.608 ACACB
acetyl-CoA carboxylase beta
chr20_+_34667590 0.607 C20orf24
chromosome 20 open reading frame 24
chr1_+_149851112 0.597


chr9_-_137992967 0.591 NM_016172
UBAC1
UBA domain containing 1
chr1_-_10455190 0.581 NM_004401
NM_213566
DFFA

DNA fragmentation factor, 45kDa, alpha polypeptide

chr2_-_120697382 0.580 TMEM185B
transmembrane protein 185B (pseudogene)
chr3_-_42892195 0.557 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr1_-_10455100 0.547 DFFA
DNA fragmentation factor, 45kDa, alpha polypeptide
chr22_-_21231421 0.544 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
PRAME




preferentially expressed antigen in melanoma




chrX_+_38548316 0.542 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr22_-_16637221 0.535 BID
BH3 interacting domain death agonist
chr15_+_76952210 0.535 NM_006791
NM_206839
MORF4L1

mortality factor 4 like 1

chr16_+_56211150 0.529 GPR56
G protein-coupled receptor 56
chr20_+_34667624 0.524 C20orf24
chromosome 20 open reading frame 24
chr2_+_233443237 0.520 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr22_+_21852551 0.518 NM_004327
NM_021574
BCR

breakpoint cluster region

chr1_+_32417909 0.518 NM_175852
TXLNA
taxilin alpha
chr7_-_100077072 0.515 NM_003227
TFR2
transferrin receptor 2
chr15_+_76952250 0.512 MORF4L1
mortality factor 4 like 1
chr22_+_27498628 0.508 NM_173510
CCDC117
coiled-coil domain containing 117
chrX_+_38548373 0.504 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr4_-_9727384 0.502


chr22_-_16637194 0.500 BID
BH3 interacting domain death agonist
chr5_-_95323353 0.495 NM_012081
ELL2
elongation factor, RNA polymerase II, 2
chr11_+_817584 0.492 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr19_+_13090101 0.489 NM_052876
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr7_-_74705276 0.485 NM_001145064
GATSL2
GATS protein-like 2
chr20_+_42417752 0.484 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr1_+_149851138 0.481 NM_030918
SNX27
sorting nexin family member 27
chr22_+_27498721 0.477 CCDC117
coiled-coil domain containing 117
chr11_+_66927955 0.475 TBC1D10C
TBC1 domain family, member 10C
chr18_-_26876622 0.475 NM_001941
NM_024423
DSC3

desmocollin 3

chr20_-_47238082 0.474 STAU1
staufen, RNA binding protein, homolog 1 (Drosophila)
chr2_-_74610325 0.473 AUP1
ancient ubiquitous protein 1
chr19_-_6432765 0.464 NM_024898
DENND1C
DENN/MADD domain containing 1C
chr15_-_62242352 0.458 NM_000942
PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr17_+_73721924 0.452 BIRC5
baculoviral IAP repeat containing 5
chr3_-_49434874 0.452 AMT
aminomethyltransferase
chr1_-_38185291 0.450 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr5_-_95323180 0.447 ELL2
elongation factor, RNA polymerase II, 2
chr1_-_38185307 0.443 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr12_-_52980914 0.442 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr1_+_149851287 0.441 SNX27
sorting nexin family member 27
chr2_-_74610331 0.439 AUP1
ancient ubiquitous protein 1
chr7_+_100792841 0.437 NM_133457
EMID2
EMI domain containing 2
chr2_+_169021001 0.437 LASS6
LAG1 homolog, ceramide synthase 6
chr8_-_145672525 0.429 NM_003923
FOXH1
forkhead box H1
chr21_+_45649429 0.424 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chrX_-_152938441 0.423 IRAK1
interleukin-1 receptor-associated kinase 1
chr1_-_38185312 0.423 NM_005540
INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr4_+_6835354 0.418 NM_001100590
NM_014743
KIAA0232

KIAA0232

chr20_-_60435983 0.406 NM_080833
C20orf151
chromosome 20 open reading frame 151
chr4_+_6835363 0.403 KIAA0232
KIAA0232
chr1_-_52936602 0.402 C1orf163
chromosome 1 open reading frame 163
chr16_-_10943716 0.402 NM_014015
DEXI
Dexi homolog (mouse)
chr1_-_52936611 0.399 NM_023077
C1orf163
chromosome 1 open reading frame 163
chr1_-_38185254 0.396 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr22_-_16637238 0.394 NM_001196
NM_197967
BID

BH3 interacting domain death agonist

chr2_-_74610332 0.392 AUP1
ancient ubiquitous protein 1
chr2_-_74610346 0.390 AUP1
ancient ubiquitous protein 1
chr1_-_45578193 0.389 NM_001048174
NM_001048172
NM_001048173
NM_001048171
NM_001128425
NM_012222
MUTYH





mutY homolog (E. coli)





chr22_+_27498679 0.388 CCDC117
coiled-coil domain containing 117
chr1_-_52936573 0.386 C1orf163
chromosome 1 open reading frame 163
chrX_+_152565849 0.385 DUSP9
dual specificity phosphatase 9
chr2_-_74610323 0.384 AUP1
ancient ubiquitous protein 1
chr1_+_149851289 0.383 SNX27
sorting nexin family member 27
chr7_+_43589163 0.382 NM_004760
STK17A
serine/threonine kinase 17a
chr1_+_221966835 0.379 CAPN2
calpain 2, (m/II) large subunit
chr2_+_11213053 0.377 PQLC3
PQ loop repeat containing 3
chr16_-_10943656 0.375 DEXI
Dexi homolog (mouse)
chr15_+_76952398 0.373 MORF4L1
mortality factor 4 like 1
chr4_+_103641585 0.371 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chrX_+_38548447 0.370 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr1_-_207892420 0.369 NM_000228
LAMB3
laminin, beta 3
chr22_-_16637160 0.366 BID
BH3 interacting domain death agonist
chr20_-_33007243 0.364 NM_000178
GSS
glutathione synthetase
chr20_+_61760084 0.363 NM_016434
NM_032957
RTEL1

regulator of telomere elongation helicase 1

chr2_-_171998681 0.362 METTL8
methyltransferase like 8
chr14_-_30959487 0.360 HEATR5A
HEAT repeat containing 5A
chr2_+_74610494 0.358 HTRA2
HtrA serine peptidase 2
chr16_-_14695930 0.358 NM_003561
PLA2G10
phospholipase A2, group X
chr19_-_2407921 0.355 LMNB2
lamin B2
chrX_-_152938456 0.355 IRAK1
interleukin-1 receptor-associated kinase 1
chr2_+_74610333 0.351 HTRA2
HtrA serine peptidase 2
chr7_-_100091912 0.349 ACTL6B
actin-like 6B
chr16_-_87244896 0.348 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr20_-_33007242 0.346 GSS
glutathione synthetase
chr3_-_44494160 0.344 NM_181489
ZNF445
zinc finger protein 445
chr15_+_76952356 0.344 MORF4L1
mortality factor 4 like 1
chr2_-_74610263 0.343 AUP1
ancient ubiquitous protein 1
chr12_-_121277972 0.341 NM_019887
NM_138929
DIABLO

diablo homolog (Drosophila)

chr2_+_113119985 0.341 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr16_-_31013594 0.341 VKORC1
vitamin K epoxide reductase complex, subunit 1
chrX_-_153716130 0.338 NM_001162936
LOC100132963
hypothetical protein LOC100132963
chr12_-_14612057 0.337 NM_024829
PLBD1
phospholipase B domain containing 1
chr11_-_64267037 0.337 RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr19_-_15869870 0.330 NM_001082
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chr4_+_6835388 0.330 KIAA0232
KIAA0232
chr16_-_10943803 0.326 DEXI
Dexi homolog (mouse)
chr1_+_32417846 0.325 TXLNA
taxilin alpha
chr20_+_56900116 0.325 NM_001077488
GNAS
GNAS complex locus
chr8_-_22982435 0.324 NM_003842
NM_147187
TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

chr14_+_23771464 0.324 NM_001002000
NM_001002001
GMPR2

guanosine monophosphate reductase 2

chr8_+_145692916 0.323 NM_032902
PPP1R16A
protein phosphatase 1, regulatory (inhibitor) subunit 16A
chr16_-_31013626 0.320 NM_024006
NM_206824
VKORC1

vitamin K epoxide reductase complex, subunit 1

chr1_+_3679168 0.319 NM_001163724
LOC388588
hypothetical protein LOC388588
chr13_+_47775776 0.317 NM_000321
RB1
retinoblastoma 1
chr20_+_47862656 0.313 NM_015266
SLC9A8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
chr20_-_33007209 0.313 GSS
glutathione synthetase
chr20_+_30409649 0.312 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chrX_+_38548394 0.308 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr2_+_171998988 0.308 NM_001164821
NM_025000
DCAF17

DDB1 and CUL4 associated factor 17

chr20_-_44713466 0.307 NM_001193339
NM_001193342
NM_022829
SLC13A3


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3


chr2_-_74610481 0.306 NM_181575
AUP1
ancient ubiquitous protein 1
chr13_-_47775797 0.305


chr20_+_56899904 0.304 GNAS
GNAS complex locus
chr3_+_9919511 0.302 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr16_+_2593351 0.302 LOC652276
hypothetical LOC652276
chr16_-_56389176 0.301 NM_001130099
KIFC3
kinesin family member C3
chr2_+_74610624 0.300 HTRA2
HtrA serine peptidase 2
chr1_-_153799186 0.296 ASH1L
ash1 (absent, small, or homeotic)-like (Drosophila)
chr2_-_241484245 0.296 NM_001085437
C2orf54
chromosome 2 open reading frame 54
chr19_+_44379440 0.295 NM_001001414
NCCRP1
non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
chr20_-_43022286 0.293 NM_006809
TOMM34
translocase of outer mitochondrial membrane 34
chr16_-_10943778 0.292 DEXI
Dexi homolog (mouse)
chr16_-_15057328 0.290 NM_173474
NTAN1
N-terminal asparagine amidase
chr18_+_9904017 0.289 VAPA
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
chr1_+_1199203 0.288


chrX_+_12719443 0.286 PRPS2
phosphoribosyl pyrophosphate synthetase 2
chr2_+_74610666 0.286 HTRA2
HtrA serine peptidase 2
chr17_-_58877276 0.285 NM_001017916
NM_001915
CYB561

cytochrome b-561

chr17_+_73721871 0.282 NM_001012270
NM_001012271
NM_001168
BIRC5


baculoviral IAP repeat containing 5


chr4_-_9727394 0.282 WDR1
WD repeat domain 1
chr6_+_24511123 0.282 NM_020662
MRS2
MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
chr4_+_103641511 0.279 NM_001165412
NM_003998
NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

chr20_+_4077466 0.278 SMOX
spermine oxidase
chr1_-_93418491 0.278 TMED5
transmembrane emp24 protein transport domain containing 5
chr18_+_9904032 0.275 VAPA
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
chr20_+_47862782 0.274 SLC9A8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
chr2_+_169021039 0.274 NM_203463
LASS6
LAG1 homolog, ceramide synthase 6
chr7_-_99707708 0.274 NM_178831
GATS
GATS, stromal antigen 3 opposite strand
chr10_-_118755077 0.274 NM_001127211
NM_018330
KIAA1598

KIAA1598

chr4_-_9727598 0.270 NM_005112
NM_017491
WDR1

WD repeat domain 1

chr6_+_15353681 0.269 JARID2
jumonji, AT rich interactive domain 2
chr1_-_40903897 0.268 NM_014747
RIMS3
regulating synaptic membrane exocytosis 3
chr3_+_32123004 0.266 NM_015141
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr19_-_2407870 0.265 LMNB2
lamin B2
chr18_+_9904000 0.264 VAPA
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
chr4_-_103641468 0.264


chr6_+_36206239 0.264 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr17_+_7495436 0.262 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr1_-_110108048 0.262 NM_024526
NM_133181
NM_139053
EPS8L3


EPS8-like 3


chr17_-_59304729 0.260 NM_020991
NM_022644
NM_022645
CSH2


chorionic somatomammotropin hormone 2


chr6_-_30820264 0.259 NM_003897
IER3
immediate early response 3
chr1_+_45578256 0.257 TOE1
target of EGR1, member 1 (nuclear)
chr10_-_82039158 0.257 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr17_+_20423628 0.257 NM_001190790
CDRT15L2
CMT1A duplicated region transcript 15-like 2
chr19_+_60580015 0.254 NM_139172
TMEM190
transmembrane protein 190

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.29 3.57e-05 GO:0044444 cytoplasmic part
1.62 4.57e-04 GO:0012505 endomembrane system
1.86 1.73e-03 GO:0031982 vesicle
1.85 2.80e-03 GO:0031410 cytoplasmic vesicle
1.47 3.72e-03 GO:0031090 organelle membrane
1.75 3.41e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.15 4.18e-02 GO:0005737 cytoplasm

Nothing significant found in function category.