Motif ID: POU1F1.p2

Z-value: 1.979


Transcription factors associated with POU1F1.p2:

Gene SymbolEntrez IDGene Name
POU1F1 5449 POU class 1 homeobox 1



Activity profile for motif POU1F1.p2.

activity profile for motif POU1F1.p2


Sorted Z-values histogram for motif POU1F1.p2

Sorted Z-values for motif POU1F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU1F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_149877955 2.395 SNX27
sorting nexin family member 27
chr6_+_105511615 2.261 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr5_+_140200995 2.207 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr2_-_88208650 2.044 NM_001443
FABP1
fatty acid binding protein 1, liver
chr4_-_110942783 2.015 NM_000204
CFI
complement factor I
chr6_+_132000134 1.799 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr6_+_167456230 1.694 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr4_-_100461530 1.550 NM_000668
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
chr3_-_69381995 1.533 FRMD4B
FERM domain containing 4B
chr6_+_64344307 1.512 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr16_-_28528780 1.409 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr2_-_77602843 1.353 NM_001134745
NM_024993
LRRTM4

leucine rich repeat transmembrane neuronal 4

chr2_+_143351536 1.311 NM_001032998
NM_003937
KYNU

kynureninase

chr12_-_14740694 1.293 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr7_+_143043871 1.288 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr16_-_28528149 1.255 NM_177530
NM_177534
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr11_+_59564323 1.213 NM_173801
PLAC1L
placenta-specific 1-like
chr3_+_152970904 1.161 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr18_-_62422195 1.152 NM_021153
CDH19
cadherin 19, type 2
chr5_-_41249270 1.151 NM_000065
C6
complement component 6
chr17_+_18588050 1.135 NM_031456
FBXW10
CDRT1
F-box and WD repeat domain containing 10
CMT1A duplicated region transcript 1
chr21_+_41663853 1.111 MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr19_-_53081326 1.097 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr18_+_52575442 1.087 WDR7
WD repeat domain 7
chr3_-_172227152 1.085 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr17_-_36418869 1.077 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr3_-_172227223 1.072 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr9_-_122852356 1.071 NM_001735
C5
complement component 5
chr1_-_1701313 1.063 NM_001198994
NADK
NAD kinase
chr17_-_64649608 1.035 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr17_-_59437782 1.028 NM_000873
ICAM2
intercellular adhesion molecule 2
chr1_-_159546348 1.016 NM_000530
MPZ
myelin protein zero
chrX_-_2892288 0.998 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr21_-_42659671 0.992 NM_003225
TFF1
trefoil factor 1
chr7_+_137411717 0.990 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr1_+_178232379 0.947 CEP350
centrosomal protein 350kDa
chr2_+_102136833 0.935 NM_000877
IL1R1
interleukin 1 receptor, type I
chr12_-_101835183 0.934 PAH
phenylalanine hydroxylase
chr4_-_100492854 0.896 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr20_-_36191623 0.888 TGM2
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr16_+_65938753 0.886 NM_001161575
LRRC36
leucine rich repeat containing 36
chr20_+_31334601 0.861 NM_033197
C20orf114
chromosome 20 open reading frame 114
chr5_-_78318112 0.842 NM_000046
ARSB
arylsulfatase B
chr5_+_141326620 0.839 NM_183399
RNF14
ring finger protein 14
chr1_+_205344200 0.825 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr2_-_224974954 0.823 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr6_-_26038817 0.820 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr8_+_39890484 0.817 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr2_-_39310176 0.802 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr4_+_100714995 0.788 MTTP
microsomal triglyceride transfer protein
chr15_-_32398220 0.785 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr9_+_130056513 0.781


chr21_-_32879617 0.768 NM_144659
TCP10L
t-complex 10 (mouse)-like
chr19_+_47073029 0.767 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chrX_+_105823723 0.762 NM_024539
RNF128
ring finger protein 128
chr14_+_20595820 0.742 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr12_+_9925354 0.742 NM_001190765
KLRF2
killer cell lectin-like receptor subfamily F, member 2
chr3_-_195553297 0.739 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr18_-_50776276 0.734 NM_001143829
CCDC68
coiled-coil domain containing 68
chr4_+_74500748 0.726 ALB
albumin
chr6_+_44076281 0.724 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr17_-_15463742 0.714 NM_006382
CDRT1
CMT1A duplicated region transcript 1
chr3_-_147805715 0.712 PLSCR5
phospholipid scramblase family, member 5
chr13_-_45577144 0.707 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr3_+_181803649 0.704 TTC14
tetratricopeptide repeat domain 14
chr2_-_88066423 0.703 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr6_+_31647854 0.699 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr10_-_73953699 0.699 NM_001195519
CBARA1
calcium binding atopy-related autoantigen 1
chr12_+_77963563 0.693 NM_001135806
SYT1
synaptotagmin I
chr4_-_83566045 0.682


chr17_+_3324096 0.677 NM_001128085
ASPA
aspartoacylase
chr11_+_18150959 0.672 NM_054032
MRGPRX4
MAS-related GPR, member X4
chr5_+_137701122 0.666 NM_001135647
FAM53C
family with sequence similarity 53, member C
chr21_-_14840506 0.656 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr12_+_130004404 0.656 NM_198827
GPR133
G protein-coupled receptor 133
chr4_-_16509126 0.655 LDB2
LIM domain binding 2
chr2_+_135312655 0.646 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr2_+_11600238 0.638 GREB1
growth regulation by estrogen in breast cancer 1
chr2_-_27215781 0.636 NM_178553
C2orf53
chromosome 2 open reading frame 53
chr6_-_131333173 0.632 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr15_+_32425357 0.630 NM_175741
C15orf55
chromosome 15 open reading frame 55
chr17_-_59817456 0.627 PECAM1
platelet/endothelial cell adhesion molecule
chr3_-_198784590 0.627 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr5_-_75954807 0.627 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr6_+_26359805 0.626 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr16_+_80626331 0.624 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr2_+_201464884 0.624 NM_001142356
NIF3L1
NIF3 NGG1 interacting factor 3-like 1 (S. pombe)
chr9_+_99807257 0.622


chr4_+_74488947 0.621 ALB
albumin
chr1_+_165565006 0.616 POU2F1
POU class 2 homeobox 1
chr4_+_187385618 0.613 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chr21_-_31995972 0.613 SCAF4
SR-related CTD-associated factor 4
chr2_+_183290912 0.610 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr6_-_149847809 0.609 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr19_-_11355882 0.609 NM_000121
EPOR
erythropoietin receptor
chr17_-_36232366 0.605 NM_000421
KRT10
keratin 10
chr13_+_45174446 0.603 NM_152719
SPERT
spermatid associated
chr6_-_109795925 0.601 CD164
CD164 molecule, sialomucin
chr17_+_54587882 0.600 PRR11
proline rich 11
chr14_+_38772870 0.597 NM_054024
MIA2
melanoma inhibitory activity 2
chr3_+_82117978 0.596


chr6_+_46869052 0.593 NM_005588
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr16_+_80626456 0.585 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr16_+_82540172 0.584 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr6_-_52736231 0.577 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr4_+_88076418 0.575


chr2_-_230798687 0.569 NM_001185015
SP110
SP110 nuclear body protein
chr16_+_80626402 0.566 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr11_-_64459910 0.565 NM_130769
GPHA2
glycoprotein hormone alpha 2
chr4_-_83566246 0.563 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr3_+_51870684 0.562 NM_203424
IQCF2
IQ motif containing F2
chrX_+_153908257 0.557 NM_023934
FUNDC2
FUN14 domain containing 2
chr4_+_74488910 0.556 ALB
albumin
chr10_+_89107404 0.552 NM_001009610
FAM22A
FAM22D
family with sequence similarity 22, member A
family with sequence similarity 22, member D
chr6_-_149847718 0.550 ZC3H12D
zinc finger CCCH-type containing 12D
chr10_+_5976354 0.545 NM_032807
FBXO18
F-box protein, helicase, 18
chr20_+_56397568 0.541 NM_001195677
NM_004738
VAPB

VAMP (vesicle-associated membrane protein)-associated protein B and C

chr7_-_44985175 0.535 MYO1G
myosin IG
chr6_+_3022030 0.522 NM_003804
RIPK1
receptor (TNFRSF)-interacting serine-threonine kinase 1
chr3_-_122862447 0.516 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr4_+_73123712 0.514 NM_001144756
NM_053036
NPFFR2

neuropeptide FF receptor 2

chr20_+_5935897 0.514 NM_001127458
CRLS1
cardiolipin synthase 1
chr1_-_167822248 0.508 F5
coagulation factor V (proaccelerin, labile factor)
chr7_+_29486010 0.504 NM_001039936
CHN2
chimerin (chimaerin) 2
chr5_+_86712376 0.503


chr6_-_76022565 0.499 TMEM30A
transmembrane protein 30A
chr11_+_30209138 0.497 NM_000510
NM_001018080
FSHB

follicle stimulating hormone, beta polypeptide

chr17_-_38385511 0.496 NM_025267
AARSD1
alanyl-tRNA synthetase domain containing 1
chr4_+_155703581 0.494 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr4_-_100431093 0.493 NM_000667
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr19_-_53444733 0.485 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr12_-_101835026 0.482 PAH
phenylalanine hydroxylase
chr13_-_48008118 0.482 RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr11_-_102250876 0.481 NM_002426
MMP12
matrix metallopeptidase 12 (macrophage elastase)
chr5_+_140709907 0.481 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr7_-_87180499 0.478 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr6_-_33149244 0.478 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr13_+_23742846 0.476 SPATA13
spermatogenesis associated 13
chr7_-_44985084 0.475 MYO1G
myosin IG
chr4_+_166350620 0.471 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr10_+_118370441 0.471 NM_005396
PNLIPRP2
pancreatic lipase-related protein 2
chr18_-_3001944 0.470 NM_014646
LPIN2
lipin 2
chr6_+_16251260 0.468 MYLIP
myosin regulatory light chain interacting protein
chr4_+_74488835 0.467 NM_000477
ALB
albumin
chr19_-_45141473 0.465 LOC440525
PRR13
proline rich 13 pseudogene
proline rich 13
chr12_+_94200306 0.464 VEZT
vezatin, adherens junctions transmembrane protein
chr5_+_40945374 0.461 C7
complement component 7
chr20_+_56397695 0.461 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr8_-_38127489 0.458 NM_000349
STAR
steroidogenic acute regulatory protein
chr6_+_90660906 0.457 NM_032602
GJA10
gap junction protein, alpha 10, 62kDa
chr7_-_122422989 0.453 NM_016945
TAS2R16
taste receptor, type 2, member 16
chr17_-_59817575 0.453 PECAM1
platelet/endothelial cell adhesion molecule
chr8_-_82557956 0.445 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr1_+_158603480 0.439 NM_005598
NHLH1
nescient helix loop helix 1
chr3_-_17716515 0.431 NM_001134381
TBC1D5
TBC1 domain family, member 5
chr1_+_169421011 0.431 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr10_-_127559841 0.430 NM_018180
DHX32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr12_-_23628774 0.428 NM_178010
SOX5
SRY (sex determining region Y)-box 5
chr3_+_192413015 0.428 NM_198184
OSTN
osteocrin
chr1_+_166516901 0.428 NM_005149
TBX19
T-box 19
chr2_-_174475528 0.428


chr3_-_122862391 0.427 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr3_-_19950675 0.425 NM_144715
EFHB
EF-hand domain family, member B
chr11_-_101292462 0.418 NM_178127
ANGPTL5
angiopoietin-like 5
chr5_+_40945315 0.416 NM_000587
C7
complement component 7
chr5_+_140207540 0.414 NM_014005
NM_031857
PCDHA9

protocadherin alpha 9

chr5_-_78317444 0.413 NM_198709
ARSB
arylsulfatase B
chr9_-_36365965 0.413 RNF38
ring finger protein 38
chr12_-_120276394 0.410 NM_001137559
ANAPC5
anaphase promoting complex subunit 5
chr9_+_101717278 0.406 STX17
syntaxin 17
chr15_-_75259714 0.406 PEAK1
NKF3 kinase family member
chr14_+_38653177 0.401 NM_001009182
NM_001009183
NM_003616
SIP1


survival of motor neuron protein interacting protein 1


chrX_-_49347279 0.401 NM_003785
PAGE1
P antigen family, member 1 (prostate associated)
chr6_+_131936057 0.400 NM_000045
ARG1
arginase, liver
chr14_-_105862080 0.398 IGHV4-31
IGHA1
IGHD
IGHG1
IGHG2
IGHG3
IGHM
SCFV
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
single-chain Fv fragment
chr9_-_5958367 0.395


chr7_-_75794919 0.393 YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr4_+_74520796 0.392 NM_001134
AFP
alpha-fetoprotein
chr7_+_106897737 0.391 NM_005295
GPR22
G protein-coupled receptor 22
chr3_+_150065732 0.390 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr9_-_115877104 0.389 AMBP
alpha-1-microglobulin/bikunin precursor
chr1_+_179164195 0.389


chr4_+_74505710 0.384


chr5_-_37220702 0.383 C5orf42
chromosome 5 open reading frame 42
chr3_+_159844980 0.379 NM_024996
GFM1
G elongation factor, mitochondrial 1
chr3_-_124821868 0.376 MYLK
myosin light chain kinase
chr22_-_25205376 0.375 NM_152841
HPS4
Hermansky-Pudlak syndrome 4
chr1_+_146843980 0.375 NM_001102663
NBPF15
NBPF8
NBPF16
neuroblastoma breakpoint family, member 15
neuroblastoma breakpoint family, member 8
neuroblastoma breakpoint family, member 16
chr5_+_40945244 0.375 C7
complement component 7
chr16_-_20246309 0.374 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr16_+_80626459 0.371 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr3_+_149930656 0.368 NM_032049
AGTR1
angiotensin II receptor, type 1
chr8_-_17811750 0.367 FGL1
fibrinogen-like 1
chr6_+_53043729 0.367 NM_012347
FBXO9
F-box protein 9
chr2_-_121875610 0.365 CLASP1
cytoplasmic linker associated protein 1
chr1_+_190811479 0.364 NM_002922
RGS1
regulator of G-protein signaling 1
chr14_-_19867372 0.363 NM_182852
NM_182851
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr17_-_29714293 0.362 NM_002981
CCL1
chemokine (C-C motif) ligand 1
chr11_+_123600553 0.354 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chrX_-_130250880 0.353 IGSF1
immunoglobulin superfamily, member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.42 7.91e-17 GO:0007606 sensory perception of chemical stimulus
3.50 9.65e-16 GO:0007608 sensory perception of smell
1.33 4.03e-08 GO:0050896 response to stimulus
2.19 6.30e-08 GO:0007600 sensory perception
1.95 1.26e-04 GO:0006952 defense response
1.98 1.72e-04 GO:0006955 immune response
1.66 6.37e-04 GO:0050877 neurological system process
1.58 7.70e-04 GO:0003008 system process
1.64 4.23e-03 GO:0002376 immune system process
8.66 1.21e-02 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
2.94 2.52e-02 GO:0002252 immune effector process
1.24 2.53e-02 GO:0032501 multicellular organismal process
2.04 2.85e-02 GO:0050776 regulation of immune response
3.00 3.02e-02 GO:0006805 xenobiotic metabolic process
3.00 3.02e-02 GO:0071466 cellular response to xenobiotic stimulus
2.98 3.36e-02 GO:0009410 response to xenobiotic stimulus
3.90 3.90e-02 GO:0002449 lymphocyte mediated immunity
4.14 4.39e-02 GO:0072376 protein activation cascade

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.35 1.39e-05 GO:0071944 cell periphery
1.35 2.21e-05 GO:0005886 plasma membrane
10.51 3.87e-04 GO:0042613 MHC class II protein complex
1.45 1.56e-03 GO:0005576 extracellular region
1.22 7.46e-03 GO:0031224 intrinsic to membrane
1.22 1.06e-02 GO:0016021 integral to membrane
1.17 4.65e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.61 8.47e-17 GO:0004984 olfactory receptor activity
2.35 1.85e-11 GO:0004930 G-protein coupled receptor activity
2.05 2.49e-11 GO:0004888 transmembrane receptor activity
1.76 1.67e-08 GO:0004872 receptor activity
1.64 1.52e-07 GO:0004871 signal transducer activity
1.64 1.52e-07 GO:0060089 molecular transducer activity
4.73 3.75e-02 GO:0003823 antigen binding