Motif ID: MSX1,2.p2

Z-value: 2.613


Transcription factors associated with MSX1,2.p2:

Gene SymbolEntrez IDGene Name
MSX1 4487 msh homeobox 1
MSX2 4488 msh homeobox 2



Activity profile for motif MSX1,2.p2.

activity profile for motif MSX1,2.p2


Sorted Z-values histogram for motif MSX1,2.p2

Sorted Z-values for motif MSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_74384485 5.906 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr10_-_74384569 5.748 PLA2G12B
phospholipase A2, group XIIB
chr11_-_85074848 5.554 NM_152723
CCDC89
coiled-coil domain containing 89
chr1_-_108032645 5.476 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr21_-_36774257 5.177 NM_001146079
NM_144492
CLDN14

claudin 14

chr19_-_40696393 4.568 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr2_-_180135559 4.399 NM_001113398
ZNF385B
zinc finger protein 385B
chr9_-_115880372 4.386 AMBP
alpha-1-microglobulin/bikunin precursor
chr14_-_64479198 4.232 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr10_+_7785360 4.030 ITIH2
inter-alpha (globulin) inhibitor H2
chr14_-_93324518 3.814 NM_178013
PRIMA1
proline rich membrane anchor 1
chr9_-_126309510 3.729 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr3_-_150422474 3.643 NM_000096
CP
ceruloplasmin (ferroxidase)
chr9_-_115880281 3.499 AMBP
alpha-1-microglobulin/bikunin precursor
chr10_+_7785331 3.316 ITIH2
inter-alpha (globulin) inhibitor H2
chr12_+_52105131 3.202 AMHR2
anti-Mullerian hormone receptor, type II
chr4_+_89115862 2.962 SPP1
secreted phosphoprotein 1
chr9_-_115880425 2.953 AMBP
alpha-1-microglobulin/bikunin precursor
chrX_+_115481774 2.949 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr5_+_59819761 2.916 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr3_+_52803823 2.898 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr6_-_52060327 2.875 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr12_+_70119785 2.870 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr2_-_192420168 2.802 NM_004657
SDPR
serum deprivation response
chr7_-_96471544 2.709 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr4_+_89115825 2.664 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr16_-_29817841 2.614 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr4_+_155703581 2.445 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr5_-_148738980 2.443 NM_014443
IL17B
interleukin 17B
chr4_+_89115892 2.427 SPP1
secreted phosphoprotein 1
chr2_-_192419896 2.135 SDPR
serum deprivation response
chr12_+_108038774 2.114 ACACB
acetyl-CoA carboxylase beta
chr20_-_48686832 2.108 NM_080829
FAM65C
family with sequence similarity 65, member C
chr3_-_150578148 2.067 TM4SF1
transmembrane 4 L six family member 1
chr16_-_11918019 2.053 NM_001130007
GSPT1
G1 to S phase transition 1
chrX_+_115481848 2.040 SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr12_-_6354818 2.036 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr22_+_33792125 2.022 NM_001008494
ISX
intestine-specific homeobox
chr3_-_150578207 1.928 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr5_+_140509803 1.906 NM_018939
PCDHB6
protocadherin beta 6
chr10_+_7785347 1.890 ITIH2
inter-alpha (globulin) inhibitor H2
chr6_-_48186868 1.885 C6orf138
chromosome 6 open reading frame 138
chr1_+_200246370 1.869 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chrX_+_128966844 1.853 NM_021946
BCORL1
BCL6 corepressor-like 1
chr8_-_145613058 1.773 NM_130849
SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr9_-_115880366 1.689 AMBP
alpha-1-microglobulin/bikunin precursor
chr17_-_19592178 1.666 NM_000691
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr2_+_84597087 1.662 NM_001370
DNAH6
dynein, axonemal, heavy chain 6
chr10_+_7785290 1.643 ITIH2
inter-alpha (globulin) inhibitor H2
chr8_-_145613034 1.639 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr12_+_56114724 1.592 NM_005538
INHBC
inhibin, beta C
chr4_+_89115923 1.586 SPP1
secreted phosphoprotein 1
chr4_-_159311959 1.496 FAM198B
family with sequence similarity 198, member B
chr10_-_51678318 1.472 NM_001143974
NM_019893
ASAH2

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2

chr12_+_7039453 1.426


chrX_-_15530112 1.396 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr14_-_106282128 1.391 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr2_-_165133239 1.370 GRB14
growth factor receptor-bound protein 14
chr2_-_237987554 1.364 COL6A3
collagen, type VI, alpha 3
chr2_-_237987553 1.358 COL6A3
collagen, type VI, alpha 3
chr2_-_237987545 1.344 COL6A3
collagen, type VI, alpha 3
chr3_+_25445071 1.339 RARB
retinoic acid receptor, beta
chr2_-_237987579 1.331 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chrX_-_19598912 1.326 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr3_+_129690735 1.285


chr7_+_116238309 1.272 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr16_-_67943157 1.268 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr7_+_94377145 1.257 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr12_-_69837831 1.221 TSPAN8
tetraspanin 8
chr6_-_39801088 1.214 NM_145027
KIF6
kinesin family member 6
chr6_+_16237264 1.206 NM_013262
MYLIP
myosin regulatory light chain interacting protein
chr17_-_61655915 1.190 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr20_+_31613800 1.165 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr21_+_44729875 1.150


chr3_+_25444753 1.101 NM_016152
RARB
retinoic acid receptor, beta
chr2_-_237987509 1.097 COL6A3
collagen, type VI, alpha 3
chr3_-_121884091 1.097 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr16_-_21197072 1.096 CRYM
crystallin, mu
chr8_-_15140162 1.095 NM_139167
SGCZ
sarcoglycan, zeta
chr13_-_45577144 1.087 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr10_+_685887 1.085 C10orf108
chromosome 10 open reading frame 108
chr14_+_22375632 1.076 NM_004995
MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr16_+_55042936 1.053 OGFOD1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr5_-_22248630 1.036 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr3_+_9919295 1.028 NM_153483
IL17RE
interleukin 17 receptor E
chrX_-_24600661 1.007 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr17_-_36113502 0.999 NM_019016
KRT24
keratin 24
chr4_-_155753332 0.987 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr16_-_74056083 0.987 NM_145254
TMEM170A
transmembrane protein 170A
chr3_-_121883647 0.980 HGD
homogentisate 1,2-dioxygenase
chr19_-_14030970 0.979 NM_001145028
PALM3
paralemmin 3
chr16_+_55042924 0.974 NM_018233
OGFOD1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr3_-_150578023 0.972 TM4SF1
transmembrane 4 L six family member 1
chr1_+_54132447 0.965 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr2_-_77602843 0.963 NM_001134745
NM_024993
LRRTM4

leucine rich repeat transmembrane neuronal 4

chr4_+_71096830 0.944 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr12_-_6354650 0.943 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr9_+_134843918 0.914 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr3_+_25444837 0.910 NM_000965
RARB
retinoic acid receptor, beta
chr13_+_51496679 0.903 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr3_-_139315011 0.881 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr12_-_15757114 0.880 EPS8
epidermal growth factor receptor pathway substrate 8
chr7_-_13992351 0.877 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr5_+_176726918 0.872 RGS14
regulator of G-protein signaling 14
chr3_-_150578103 0.871 TM4SF1
transmembrane 4 L six family member 1
chr6_+_64289585 0.864 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr12_+_32546243 0.855 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr3_+_9919511 0.848 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr9_-_96395828 0.841 NM_003837
FBP2
fructose-1,6-bisphosphatase 2
chr5_+_73145098 0.822 RGNEF
190 kDa guanine nucleotide exchange factor
chr5_+_139856688 0.804 ANKHD1
ankyrin repeat and KH domain containing 1
chr17_+_38306339 0.773 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr1_+_31655607 0.772 NM_001199037
SERINC2
serine incorporator 2
chr16_-_55042614 0.769 NM_007006
NUDT21
nudix (nucleoside diphosphate linked moiety X)-type motif 21
chr3_+_187866464 0.767 NM_000412
HRG
histidine-rich glycoprotein
chr7_+_80145461 0.766 CD36
CD36 molecule (thrombospondin receptor)
chr10_-_44794146 0.765 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr19_-_17236522 0.765 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chrX_+_99726445 0.765 NM_022144
TNMD
tenomodulin
chr12_-_110410730 0.762 ATXN2
ataxin 2
chr10_+_7785235 0.760 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr16_+_80626459 0.755 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr11_-_40272239 0.738 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr11_-_8789457 0.729 NM_139157
ST5
suppression of tumorigenicity 5
chr15_-_64644758 0.729 NM_207338
LCTL
lactase-like
chr1_+_200246312 0.729 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr16_+_80626402 0.726 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr7_+_111850367 0.724 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr3_-_101316038 0.712 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr10_+_114123828 0.711 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr5_-_59819642 0.706 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_-_25685175 0.705 NM_206832
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr16_+_80626456 0.686 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr11_+_101488380 0.680 NM_001195045
YAP1
Yes-associated protein 1
chr6_-_31789824 0.678


chr9_-_115880494 0.664 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr2_+_138438277 0.661 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr1_+_31654998 0.647 NM_001199038
SERINC2
serine incorporator 2
chr6_-_123999640 0.646 NM_006073
TRDN
triadin
chr11_+_101693403 0.646 NM_001165
NM_182962
BIRC3

baculoviral IAP repeat containing 3

chr4_-_39199527 0.632 UGDH
UDP-glucose 6-dehydrogenase
chr6_-_24491498 0.617 NM_001195610
DCDC2
doublecortin domain containing 2
chr5_-_35083996 0.586 NM_031900
AGXT2
alanine--glyoxylate aminotransferase 2
chr14_+_20595820 0.577 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr5_-_42847716 0.571 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr6_-_56615544 0.546 NM_001723
NM_015548
DST

dystonin

chr4_+_90252990 0.542 NM_145715
TIGD2
tigger transposable element derived 2
chr3_+_46591048 0.531 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr20_+_71230 0.520 NM_030931
DEFB126
defensin, beta 126
chr4_+_71330797 0.502 NM_001145006
MUC7
mucin 7, secreted
chr10_+_115501202 0.494 NM_001193434
NM_001193435
NM_024889
C10orf81


chromosome 10 open reading frame 81


chr6_-_26038817 0.481 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr6_+_71192862 0.480 NM_001162529
FAM135A
family with sequence similarity 135, member A
chr2_-_21081694 0.478 APOB
apolipoprotein B (including Ag(x) antigen)
chr8_+_67096344 0.472 NM_033105
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr1_-_229071957 0.464 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr2_-_21087435 0.447 APOB
apolipoprotein B (including Ag(x) antigen)
chr2_+_233633348 0.443 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr14_+_22375656 0.442 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr12_+_99712504 0.435 NM_178826
ANO4
anoctamin 4
chr11_+_61473931 0.434 NM_001139443
NM_004183
BEST1

bestrophin 1

chr15_-_41381744 0.427 NM_052955
TGM7
transglutaminase 7
chr17_-_15109315 0.422 NM_000304
PMP22
peripheral myelin protein 22
chr12_-_89922888 0.413 NM_004950
EPYC
epiphycan
chr4_+_47403107 0.413


chr6_+_16237300 0.408 MYLIP
myosin regulatory light chain interacting protein
chrX_+_123062143 0.405 STAG2
stromal antigen 2
chr21_-_31995972 0.394 SCAF4
SR-related CTD-associated factor 4
chr3_-_115380539 0.390 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr7_-_99555399 0.387 NM_001190415
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr2_-_162638174 0.380 DPP4
dipeptidyl-peptidase 4
chr14_-_23653965 0.378 NRL
neural retina leucine zipper
chrX_-_129347101 0.370 NM_178471
GPR119
G protein-coupled receptor 119
chr6_-_31215089 0.369 NM_014069
PSORS1C2
psoriasis susceptibility 1 candidate 2
chrX_+_38096679 0.367 NM_000531
OTC
ornithine carbamoyltransferase
chr19_+_50863341 0.358 NM_000164
GIPR
gastric inhibitory polypeptide receptor
chr4_+_74566325 0.353 NM_001133
AFM
afamin
chr11_-_114593838 0.352 CADM1
cell adhesion molecule 1
chr17_+_39213328 0.346 NM_001136483
C17orf105
chromosome 17 open reading frame 105
chr16_-_74055998 0.342 TMEM170A
transmembrane protein 170A
chr19_+_53016910 0.340 NM_000554
CRX
cone-rod homeobox
chr12_-_89922875 0.333 EPYC
epiphycan
chr1_+_162795328 0.322 NM_002585
PBX1
pre-B-cell leukemia homeobox 1
chr2_+_162908828 0.315 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr8_-_27171814 0.311 NM_030795
STMN4
stathmin-like 4
chr2_-_208736533 0.302 NM_014617
CRYGA
crystallin, gamma A
chr4_-_68793928 0.297 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr7_+_38984133 0.284 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr8_+_76614757 0.283 NM_004133
HNF4G
hepatocyte nuclear factor 4, gamma
chr1_+_205344200 0.281 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr1_-_19089971 0.274 NM_001161504
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr1_-_200182090 0.265 LMOD1
leiomodin 1 (smooth muscle)
chr2_-_134042500 0.265 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chrX_+_16874651 0.262 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr11_-_55460451 0.256 NM_006637
OR5I1
olfactory receptor, family 5, subfamily I, member 1
chr12_-_9252227 0.253 NM_002864
PZP
pregnancy-zone protein
chr4_-_70760381 0.253 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr7_+_17349425 0.251 AHR
aryl hydrocarbon receptor
chr6_-_55848346 0.245 BMP5
bone morphogenetic protein 5
chr14_-_23752875 0.243 NM_014169
CHMP4A
chromatin modifying protein 4A

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.07 3.88e-02 GO:0005626 insoluble fraction

Nothing significant found in function category.