Motif ID: IKZF1.p2

Z-value: 1.630


Transcription factors associated with IKZF1.p2:

Gene SymbolEntrez IDGene Name
IKZF1 10320 IKAROS family zinc finger 1 (Ikaros)



Activity profile for motif IKZF1.p2.

activity profile for motif IKZF1.p2


Sorted Z-values histogram for motif IKZF1.p2

Sorted Z-values for motif IKZF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_20000938 1.967 NAV2
neuron navigator 2
chr3_+_197427779 1.881 NM_152672
OSTalpha
organic solute transporter alpha
chr11_+_20001130 1.841 NM_001111019
NAV2
neuron navigator 2
chr20_+_55569542 1.721 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr2_-_108972048 1.643 EDAR
ectodysplasin A receptor
chr15_-_40236061 1.565 NM_213600
PLA2G4F
phospholipase A2, group IVF
chr8_-_95720870 1.494 LOC100288748
hypothetical LOC100288748
chr19_+_51493486 1.475 NM_022462
HIF3A
hypoxia inducible factor 3, alpha subunit
chr2_-_152538694 1.469 NM_001005747
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr2_-_108972100 1.443 NM_022336
EDAR
ectodysplasin A receptor
chr20_-_3097070 1.399 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr11_+_111294868 1.386 C11orf52
chromosome 11 open reading frame 52
chr14_+_38772870 1.341 NM_054024
MIA2
melanoma inhibitory activity 2
chr1_+_31814709 1.317 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr2_-_238164042 1.311 RAB17
RAB17, member RAS oncogene family
chr16_-_65510230 1.306 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr1_+_31814672 1.304 NM_022164
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr3_-_185578621 1.219 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr7_-_75876830 1.206 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr17_+_46067114 1.160 NM_001144070
NM_003786
ABCC3

ATP-binding cassette, sub-family C (CFTR/MRP), member 3

chr14_+_23527866 1.092 NM_198083
DHRS4
DHRS4L2
dehydrogenase/reductase (SDR family) member 4
dehydrogenase/reductase (SDR family) member 4 like 2
chr4_+_17125885 1.070 NM_001079827
CLRN2
clarin 2
chr15_+_61123327 1.055 TPM1
tropomyosin 1 (alpha)
chr1_+_31814712 1.043 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr4_-_155753207 1.035 FGG
fibrinogen gamma chain
chr17_+_71154240 1.003 NM_001162997
LOC100130933
hypothetical protein LOC100130933
chr1_-_28392966 1.002 NM_001164722
NM_001164721
PTAFR

platelet-activating factor receptor

chr12_-_57599571 0.995 NM_001136051
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr16_-_11587647 0.991 NM_004862
LITAF
lipopolysaccharide-induced TNF factor
chr1_-_228916470 0.990 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr2_+_27225362 0.989 NM_175769
TCF23
transcription factor 23
chr14_-_34168911 0.987 SNX6
sorting nexin 6
chr1_-_228916486 0.987 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr2_-_21120398 0.986 APOB
apolipoprotein B (including Ag(x) antigen)
chr17_+_70244945 0.986 NM_001006638
NM_001163990
RAB37

RAB37, member RAS oncogene family

chr2_-_238164452 0.981 NM_022449
RAB17
RAB17, member RAS oncogene family
chr4_-_155753249 0.979 FGG
fibrinogen gamma chain
chr10_-_74384569 0.975 PLA2G12B
phospholipase A2, group XIIB
chr13_+_112808102 0.960 NM_000131
NM_019616
F7

coagulation factor VII (serum prothrombin conversion accelerator)

chr9_+_129951552 0.960 NM_005564
LCN2
lipocalin 2
chr4_-_155753332 0.960 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr4_-_155753272 0.957 FGG
fibrinogen gamma chain
chr10_-_74384485 0.927 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr4_-_155753287 0.925 FGG
fibrinogen gamma chain
chr11_+_111294810 0.918 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr12_-_192990 0.904 NM_001122847
SLC6A12
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr17_-_76720342 0.904 AATK
apoptosis-associated tyrosine kinase
chr3_+_42176662 0.901 NM_014965
TRAK1
trafficking protein, kinesin binding 1
chr17_+_35728039 0.894 RARA
retinoic acid receptor, alpha
chr21_-_36774257 0.859 NM_001146079
NM_144492
CLDN14

claudin 14

chr14_-_23847024 0.851 CIDEB
cell death-inducing DFFA-like effector b
chr11_+_22652957 0.850 GAS2
growth arrest-specific 2
chr17_+_4621924 0.846 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr15_-_88256922 0.841 NM_001199058
NM_182616
C15orf38-AP3S2
C15orf38
C15orf38-AP3S2 readthrough
chromosome 15 open reading frame 38
chr17_+_45527507 0.818 NM_002611
PDK2
pyruvate dehydrogenase kinase, isozyme 2
chr12_+_64504408 0.816 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr20_+_41621119 0.810 SGK2
serum/glucocorticoid regulated kinase 2
chr17_+_35728070 0.809 RARA
retinoic acid receptor, alpha
chr16_+_66129481 0.794 FAM65A
family with sequence similarity 65, member A
chr14_-_23106779 0.789 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr1_+_17738863 0.787 NM_018125
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr17_+_35718948 0.784 NM_000964
RARA
retinoic acid receptor, alpha
chr20_+_41621079 0.778 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr2_-_21120314 0.777 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_-_228916559 0.771 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr11_+_22646229 0.770 NM_177553
GAS2
growth arrest-specific 2
chrX_-_55037235 0.769 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr12_-_49708279 0.768 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr3_-_189354510 0.761 LOC339929
hypothetical LOC339929
chr7_+_147667461 0.757 CNTNAP2
contactin associated protein-like 2
chr11_-_18214891 0.751 NM_006512
SAA4
serum amyloid A4, constitutive
chr10_-_92670764 0.744 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr19_+_50004134 0.740 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr20_+_43895802 0.739 NM_001042632
NM_001042633
NM_033421
NM_152897
SNX21



sorting nexin family member 21



chr2_-_165133239 0.726 GRB14
growth factor receptor-bound protein 14
chr14_+_23575460 0.724 NM_001082488
DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 1
chr4_+_108965167 0.723 NM_001136258
SGMS2
sphingomyelin synthase 2
chr12_-_192752 0.722 NM_003044
SLC6A12
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr2_+_201158824 0.721 AOX1
aldehyde oxidase 1
chr2_+_96566190 0.719 NM_212481
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr1_+_1207351 0.719 NM_001130413
NM_002978
SCNN1D

sodium channel, nonvoltage-gated 1, delta

chr18_+_53865455 0.717 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr14_+_23492780 0.712 NM_021004
DHRS4
dehydrogenase/reductase (SDR family) member 4
chr19_-_19245022 0.709 NM_001001524
TM6SF2
transmembrane 6 superfamily member 2
chr10_+_102881050 0.709 NM_001195517
NM_005521
TLX1

T-cell leukemia homeobox 1

chr14_-_26136799 0.705 NM_002515
NM_006489
NM_006491
NOVA1


neuro-oncological ventral antigen 1


chr20_+_43896178 0.705 SNX21
sorting nexin family member 21
chr2_+_17585287 0.704 NM_003385
VSNL1
visinin-like 1
chr5_+_175231144 0.704 CPLX2
complexin 2
chr11_+_118544625 0.703 NM_024618
NM_170722
NLRX1

NLR family member X1

chr20_+_34206070 0.698 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr17_+_35727998 0.696 NM_001145301
NM_001145302
RARA

retinoic acid receptor, alpha

chr2_-_180135559 0.694 NM_001113398
ZNF385B
zinc finger protein 385B
chr12_-_56445653 0.692 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr5_+_178255521 0.686 NM_030613
ZFP2
zinc finger protein 2 homolog (mouse)
chr14_+_64240902 0.686 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr1_-_199635057 0.685 LAD1
ladinin 1
chr20_-_23808313 0.682 NM_001900
CST5
cystatin D
chr1_+_15955719 0.682 FBLIM1
filamin binding LIM protein 1
chr2_-_142605739 0.678 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr16_-_69277194 0.676 MTSS1L
metastasis suppressor 1-like
chr11_+_22652894 0.676 NM_005256
GAS2
growth arrest-specific 2
chr11_+_47236072 0.671 NM_001130101
NM_005693
NR1H3

nuclear receptor subfamily 1, group H, member 3

chr14_+_102636233 0.669 NM_001077594
EXOC3L4
exocyst complex component 3-like 4
chr5_+_175231210 0.666 CPLX2
complexin 2
chr14_-_23107106 0.663 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr19_+_51492136 0.662 NM_152795
HIF3A
hypoxia inducible factor 3, alpha subunit
chr12_-_55730125 0.660 NM_005379
MYO1A
myosin IA
chr2_+_17585462 0.660 VSNL1
visinin-like 1
chr20_+_43896195 0.656 SNX21
sorting nexin family member 21
chr1_-_158306570 0.656 NM_002241
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr20_-_24986501 0.655 ACSS1
acyl-CoA synthetase short-chain family member 1
chr1_+_92268072 0.653 NM_173567
EPHX4
epoxide hydrolase 4
chr1_+_3378030 0.650 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr5_+_175231170 0.647


chr14_-_106282128 0.644 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr7_+_33911636 0.634 NM_133468
BMPER
BMP binding endothelial regulator
chr17_-_74433048 0.626 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr1_-_26553168 0.626 NM_001039775
AIM1L
absent in melanoma 1-like
chr17_-_64108331 0.626 FAM20A
family with sequence similarity 20, member A
chr19_+_59062982 0.624 MYADM
myeloid-associated differentiation marker
chr15_+_56511466 0.619 NM_000236
LIPC
lipase, hepatic
chr4_-_159311959 0.619 FAM198B
family with sequence similarity 198, member B
chr19_+_59062937 0.619 NM_001020819
NM_138373
MYADM

myeloid-associated differentiation marker

chr20_-_49612745 0.618 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr1_-_200879203 0.611 NM_001136504
SYT2
synaptotagmin II
chr22_+_36531059 0.611 NM_005318
H1F0
H1 histone family, member 0
chr14_+_23508922 0.611 NM_001193636
NM_001193637
NM_001193635
DHRS4L2


DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 2


dehydrogenase/reductase (SDR family) member 4 like 1
chr19_+_59062962 0.602 MYADM
myeloid-associated differentiation marker
chr1_-_109651140 0.600 NM_001010985
MYBPHL
myosin binding protein H-like
chr1_-_159474503 0.596 NM_001077469
NM_001077470
NM_001077471
NM_001077472
NM_001077473
NM_001077474
NM_001077475
NM_001077476
NM_001077477
NM_001077478
NM_001077479
NM_001077480
NM_001077481
NM_001077482
NM_005122
NR1I3














nuclear receptor subfamily 1, group I, member 3














chr3_+_52504410 0.596 STAB1
stabilin 1
chr14_-_23493169 0.590 C14orf167
chromosome 14 open reading frame 167
chr22_+_36531246 0.589 H1F0
H1 histone family, member 0
chr22_+_36531178 0.586 H1F0
H1 histone family, member 0
chr13_-_98202884 0.585 NM_005073
SLC15A1
solute carrier family 15 (oligopeptide transporter), member 1
chr15_+_70477707 0.584 NM_001080462
TMEM202
transmembrane protein 202
chr7_-_96471544 0.577 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr4_-_69852090 0.576 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr1_+_204710409 0.575 IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr8_-_79880095 0.571 NM_000880
IL7
interleukin 7
chr5_+_175231098 0.569 NM_001008220
CPLX2
complexin 2
chr5_+_140509803 0.568 NM_018939
PCDHB6
protocadherin beta 6
chr14_+_22845851 0.563 NM_004050
BCL2L2-PABPN1
BCL2L2
BCL2L2-PABPN1 read-through transcript
BCL2-like 2
chr2_-_220144254 0.560 OBSL1
obscurin-like 1
chr2_-_218516950 0.557 NM_022648
TNS1
tensin 1
chr11_+_46697335 0.557 F2
coagulation factor II (thrombin)
chr8_-_125809831 0.547 NM_014751
MTSS1
metastasis suppressor 1
chr19_-_41191423 0.543 NM_001039876
C19orf46
chromosome 19 open reading frame 46
chr16_+_4654710 0.542 MGRN1
mahogunin, ring finger 1
chr11_-_64582568 0.541 NM_005468
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr19_-_56537189 0.541 NM_001163922
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr2_+_203587807 0.540 NM_001114132
NBEAL1
neurobeachin-like 1
chr19_+_4104593 0.535 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr14_-_47213906 0.534 NM_001113498
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr10_-_102880892 0.531 NM_001085398
TLX1NB
TLX1 neighbor
chr3_+_32255215 0.529 CMTM8
CKLF-like MARVEL transmembrane domain containing 8
chrX_+_115481848 0.529 SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr2_-_21081694 0.528 APOB
apolipoprotein B (including Ag(x) antigen)
chr14_+_22633728 0.527 C14orf119
chromosome 14 open reading frame 119
chr8_-_53640520 0.526 NM_207413
FAM150A
family with sequence similarity 150, member A
chr14_+_23590939 0.526 NM_138360
LRRC16B
leucine rich repeat containing 16B
chr20_-_49612574 0.525 NM_001136021
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr19_+_10597167 0.523 NM_020428
SLC44A2
solute carrier family 44, member 2
chr14_+_23675206 0.521 NM_006263
NM_176783
PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chr2_+_218790364 0.517 NM_005731
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr20_-_62181588 0.514 NM_001039467
RGS19
regulator of G-protein signaling 19
chr17_+_75319476 0.514 NM_178543
ENPP7
ectonucleotide pyrophosphatase/phosphodiesterase 7
chr19_-_10558906 0.508 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr8_-_23317577 0.508 LOXL2
lysyl oxidase-like 2
chr14_+_64240996 0.501 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr15_-_64644758 0.500 NM_207338
LCTL
lactase-like
chr1_-_110108048 0.496 NM_024526
NM_133181
NM_139053
EPS8L3


EPS8-like 3


chr7_-_22363036 0.496 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr8_-_23317571 0.495 LOXL2
lysyl oxidase-like 2
chr16_-_3008162 0.492 NM_021195
CLDN6
claudin 6
chr7_-_50600536 0.487 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr7_+_288051 0.486 NM_020223
FAM20C
family with sequence similarity 20, member C
chr7_+_1543644 0.485 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr17_-_74432800 0.484 TIMP2
TIMP metallopeptidase inhibitor 2
chr1_+_218988199 0.484 NM_017898
MOSC2
MOCO sulphurase C-terminal domain containing 2
chr4_-_100359353 0.483 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr1_+_218930542 0.483 C1orf115
chromosome 1 open reading frame 115
chr6_+_30335314 0.482 HLA-L
major histocompatibility complex, class I, L, pseudogene
chr19_-_49552638 0.482 NM_001083335
NM_013380
ZFP112

zinc finger protein 112 homolog (mouse)

chr3_-_12561962 0.481 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr7_+_288195 0.480 FAM20C
family with sequence similarity 20, member C
chr16_+_55217180 0.480 MT1E
metallothionein 1E
chr2_-_227372574 0.479 IRS1
insulin receptor substrate 1
chr20_-_44370537 0.479 CDH22
cadherin 22, type 2
chr10_+_53744043 0.479 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr10_+_123862430 0.478 TACC2
transforming, acidic coiled-coil containing protein 2
chr1_+_204710453 0.478 IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr15_-_38908197 0.477 NM_001130143
NM_017726
PPP1R14D

protein phosphatase 1, regulatory (inhibitor) subunit 14D

chr9_+_102830851 0.475 NM_207299
LPPR1
lipid phosphate phosphatase-related protein type 1
chr17_+_54763689 0.472 NM_001005404
YPEL2
yippee-like 2 (Drosophila)
chr18_-_6404900 0.472 NM_173464
L3MBTL4
l(3)mbt-like 4 (Drosophila)
chr1_+_196153122 0.468 NM_020204
LHX9
LIM homeobox 9
chr15_+_38484977 0.464 NM_001159508
NM_002225
IVD

isovaleryl-CoA dehydrogenase

chr4_-_83771386 0.461 SCD5
stearoyl-CoA desaturase 5

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 1.35e-02 GO:0009987 cellular process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 2.44e-02 GO:0005515 protein binding