Motif ID: EBF1.p2

Z-value: 2.193


Transcription factors associated with EBF1.p2:

Gene SymbolEntrez IDGene Name
EBF1 1879 early B-cell factor 1



Activity profile for motif EBF1.p2.

activity profile for motif EBF1.p2


Sorted Z-values histogram for motif EBF1.p2

Sorted Z-values for motif EBF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EBF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_-_35875890 3.969 NM_000878
IL2RB
interleukin 2 receptor, beta
chr10_-_135021502 3.909 NM_001098483
NM_198472
C10orf125

chromosome 10 open reading frame 125

chr9_-_135334003 3.702 NM_001145099
NM_017585
SLC2A6

solute carrier family 2 (facilitated glucose transporter), member 6

chr19_+_55627971 3.547 NM_004533
MYBPC2
myosin binding protein C, fast type
chr2_+_43919606 3.408 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr2_-_43919392 3.360 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr16_+_66236559 3.261 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr4_+_42094612 3.110 NM_001080505
SHISA3
shisa homolog 3 (Xenopus laevis)
chr16_-_4528380 3.071 NM_001199054
C16orf5
chromosome 16 open reading frame 5
chr16_+_28850760 3.036 NM_001178098
NM_001770
CD19

CD19 molecule

chr1_+_232416618 3.011 SLC35F3
solute carrier family 35, member F3
chr2_+_109729176 3.000 NM_023016
ANKRD57
ankyrin repeat domain 57
chr17_-_10042579 2.988 NM_201433
GAS7
growth arrest-specific 7
chr6_-_167195647 2.938 NM_001006932
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr17_+_71095733 2.721 MYO15B
myosin XVB pseudogene
chr11_+_122806196 2.639 LOC100128242
hypothetical LOC100128242
chr21_-_36836767 2.636 NM_001146078
CLDN14
claudin 14
chr19_-_1993022 2.594 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr14_+_60858151 2.555 NM_006255
PRKCH
protein kinase C, eta
chr16_+_28413421 2.555 NM_018690
APOBR
apolipoprotein B receptor
chr17_-_35975227 2.552 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr16_-_4528739 2.531 NM_001199055
NM_001199056
NM_013399
C16orf5


chromosome 16 open reading frame 5


chr7_+_128365226 2.403 NM_001098629
NM_001098630
IRF5

interferon regulatory factor 5

chr7_-_960534 2.358 ADAP1
ArfGAP with dual PH domains 1
chr6_-_43586401 2.274 NM_001012974
C6orf154
chromosome 6 open reading frame 154
chr17_+_73638430 2.222 NM_152468
TMC8
transmembrane channel-like 8
chr22_+_35586950 2.169 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr19_+_47073029 2.158 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr6_-_167195987 2.128 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr15_-_77024375 2.119 CTSH
cathepsin H
chr1_+_32489426 2.060 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr18_-_6404900 2.036 NM_173464
L3MBTL4
l(3)mbt-like 4 (Drosophila)
chr4_+_2789686 2.007 NM_001145856
SH3BP2
SH3-domain binding protein 2
chr4_-_40327396 2.001 RBM47
RNA binding motif protein 47
chr2_-_219826854 2.000 NM_006000
TUBA4A
tubulin, alpha 4a
chr9_-_116190038 2.000 AKNA
AT-hook transcription factor
chr8_-_38445272 1.996 FGFR1
fibroblast growth factor receptor 1
chr19_+_17723285 1.964 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr5_+_75414994 1.958 NM_014979
SV2C
synaptic vesicle glycoprotein 2C
chr7_+_49783774 1.953 NM_198570
VWC2
von Willebrand factor C domain containing 2
chr13_+_112671497 1.941 MCF2L
MCF.2 cell line derived transforming sequence-like
chr10_-_73518269 1.934 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr8_+_104582151 1.933 NM_001100117
RIMS2
regulating synaptic membrane exocytosis 2
chr14_-_104602784 1.931 NM_013345
GPR132
G protein-coupled receptor 132
chr17_-_40843530 1.884 ARHGAP27
Rho GTPase activating protein 27
chr14_-_106330781 1.866 IGHV5-78
immunoglobulin heavy variable 5-78 pseudogene
chr22_+_23153529 1.838 NM_000675
ADORA2A
adenosine A2a receptor
chr1_-_200397300 1.837 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr19_-_1992862 1.827 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr5_-_57791544 1.822 NM_006622
PLK2
polo-like kinase 2
chr8_-_11361594 1.818 NM_053279
FAM167A
family with sequence similarity 167, member A
chr6_-_32742265 1.818 NM_002123
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr10_-_73518284 1.809 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr17_-_59363352 1.799 NM_000626
NM_001039933
NM_021602
CD79B


CD79b molecule, immunoglobulin-associated beta


chr20_-_61755145 1.786 NM_015894
STMN3
stathmin-like 3
chr2_-_242449662 1.772 NM_005018
PDCD1
programmed cell death 1
chr8_+_95977135 1.742 C8orf38
chromosome 8 open reading frame 38
chr20_-_43974092 1.717 NM_006227
NM_182676
PLTP

phospholipid transfer protein

chr7_+_128365482 1.716 NM_032643
IRF5
interferon regulatory factor 5
chr10_-_73518315 1.708 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr7_+_139175420 1.684 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr11_-_66961709 1.669 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr8_-_38445508 1.667 NM_001174063
NM_001174064
NM_015850
NM_023105
NM_023106
NM_023110
FGFR1





fibroblast growth factor receptor 1





chr10_+_114125003 1.665 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr10_+_73393998 1.649 NM_004273
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chrX_-_119329334 1.641 NM_001104544
NM_001104545
NM_017938
FAM70A


family with sequence similarity 70, member A


chr19_-_43608641 1.630 NM_001146202
NM_001146203
NM_001146204
NM_001146205
NM_001146206
NM_001146207
NM_170604
RASGRP4






RAS guanyl releasing protein 4






chr22_-_16080265 1.626 CECR1
cat eye syndrome chromosome region, candidate 1
chr16_+_716936 1.615 NM_207112
NM_032304
HAGHL

hydroxyacylglutathione hydrolase-like

chr16_+_55963883 1.614 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr15_-_77024408 1.602 NM_004390
CTSH
cathepsin H
chr17_-_16816113 1.593 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chrX_-_119329307 1.526 FAM70A
family with sequence similarity 70, member A
chr9_-_132804243 1.507 NM_001145106
FIBCD1
fibrinogen C domain containing 1
chr19_+_4180494 1.500 NM_005755
EBI3
Epstein-Barr virus induced 3
chr19_-_54250808 1.469 NM_033142
CGB7
chorionic gonadotropin, beta polypeptide 7
chr1_+_891739 1.460 NM_001160184
NM_032129
PLEKHN1

pleckstrin homology domain containing, family N member 1

chr16_+_70217564 1.459 NM_001017967
NM_052858
MARVELD3

MARVEL domain containing 3

chr1_+_27541049 1.446 NM_001193308
NM_032872
SYTL1

synaptotagmin-like 1

chr20_+_30814048 1.440 DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
chr3_-_27385856 1.432 NM_199347
NEK10
NIMA (never in mitosis gene a)- related kinase 10
chr9_+_139292094 1.426 NM_017723
C9orf167
chromosome 9 open reading frame 167
chr16_+_1979959 1.425 NM_004209
SYNGR3
synaptogyrin 3
chr22_-_28992787 1.424 NM_020530
OSM
oncostatin M
chr17_-_43862480 1.415 NM_001075099
NM_003726
SKAP1

src kinase associated phosphoprotein 1

chr17_-_3407780 1.406 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr11_+_817584 1.406 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr6_-_10946698 1.401 MAK
male germ cell-associated kinase
chrX_-_154146930 1.398 NM_171998
RAB39B
RAB39B, member RAS oncogene family
chr4_+_2764510 1.396 NM_001122681
SH3BP2
SH3-domain binding protein 2
chr12_-_123617962 1.390 NM_001077261
NM_006312
NCOR2

nuclear receptor corepressor 2

chr15_+_38923470 1.387 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr10_+_71908535 1.379 NM_014431
KIAA1274
KIAA1274
chr1_-_24386324 1.373 NM_170743
NM_173064
NM_173065
IL28RA


interleukin 28 receptor, alpha (interferon, lambda receptor)


chr4_-_57382584 1.369 NM_021114
SPINK2
serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
chr16_+_23101538 1.360 NM_001039
SCNN1G
sodium channel, nonvoltage-gated 1, gamma
chr18_+_50049846 1.360 NM_007195
POLI
polymerase (DNA directed) iota
chr1_-_55039458 1.347 NM_001114108
NM_017904
TTC22

tetratricopeptide repeat domain 22

chr16_+_65840275 1.341 NM_004594
SLC9A5
solute carrier family 9 (sodium/hydrogen exchanger), member 5
chr1_-_110950497 1.340 KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr5_-_149772563 1.337 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr14_-_106352471 1.335


chr22_-_49315265 1.333 TYMP
thymidine phosphorylase
chr1_+_205694237 1.330 NM_001006658
NM_001877
CR2

complement component (3d/Epstein Barr virus) receptor 2

chr1_+_1971762 1.327 NM_002744
PRKCZ
protein kinase C, zeta
chr1_-_2451543 1.323 NM_001010926
HES5
hairy and enhancer of split 5 (Drosophila)
chr5_-_132194488 1.322 NM_001172700
SHROOM1
shroom family member 1
chr10_-_88720908 1.321 LOC100133190
hypothetical LOC100133190
chr1_-_20931719 1.318 NM_001103160
NM_001103161
SH2D5

SH2 domain containing 5

chr17_+_53769659 1.313 LOC100506779
hypothetical LOC100506779
chr11_+_65164167 1.304 NM_153253
SIPA1
signal-induced proliferation-associated 1
chr12_+_5023345 1.302 NM_002234
KCNA5
potassium voltage-gated channel, shaker-related subfamily, member 5
chr11_+_73037382 1.301 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr2_+_96355661 1.298 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chr7_-_960785 1.293 NM_006869
ADAP1
ArfGAP with dual PH domains 1
chr10_+_82158186 1.292 NM_032333
C10orf58
chromosome 10 open reading frame 58
chrX_+_128741562 1.291 NM_018990
SASH3
SAM and SH3 domain containing 3
chr4_+_2764609 1.290 SH3BP2
SH3-domain binding protein 2
chr6_-_30188845 1.281 NM_007028
TRIM31
tripartite motif containing 31
chr16_+_3036682 1.279 NM_022468
MMP25
matrix metallopeptidase 25
chr17_-_71386229 1.276 NM_033452
TRIM47
tripartite motif containing 47
chr3_-_58175437 1.273 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr11_+_712282 1.273 EPS8L2
EPS8-like 2
chr9_+_126579203 1.267 NM_182487
OLFML2A
olfactomedin-like 2A
chr4_+_4912272 1.267 NM_002448
MSX1
msh homeobox 1
chr12_+_6925997 1.265 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr7_+_101860958 1.261 NM_001126340
NM_032831
ORAI2

ORAI calcium release-activated calcium modulator 2

chr8_-_48813236 1.259 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr17_-_8034071 1.255 C17orf59
chromosome 17 open reading frame 59
chr17_-_1874927 1.251 NM_178568
RTN4RL1
reticulon 4 receptor-like 1
chr4_+_37569093 1.248 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr19_+_11936868 1.238 NM_001012753
ZNF763
zinc finger protein 763
chr6_+_118335381 1.237 NM_001029858
SLC35F1
solute carrier family 35, member F1
chr12_-_50004102 1.237 BIN2
bridging integrator 2
chr19_+_60688349 1.234 NM_020378
NAT14
N-acetyltransferase 14 (GCN5-related, putative)
chr6_-_3172775 1.230 NM_178012
TUBB2B
tubulin, beta 2B
chr7_-_149960218 1.226 GIMAP6
GTPase, IMAP family member 6
chr3_-_198180005 1.226 NM_025163
PIGZ
phosphatidylinositol glycan anchor biosynthesis, class Z
chr19_+_8180179 1.222 NM_024552
LASS4
LAG1 homolog, ceramide synthase 4
chr4_-_6253152 1.219 NM_001099433
NM_144720
JAKMIP1

janus kinase and microtubule interacting protein 1

chr12_+_6926014 1.216 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr3_-_13032130 1.210


chr16_+_66236512 1.207 NM_001013838
RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr15_+_88545510 1.207 NM_198925
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr19_+_58715988 1.204 NM_018555
ZNF331
zinc finger protein 331
chr20_-_3167835 1.203 NM_001174089
SLC4A11
solute carrier family 4, sodium borate transporter, member 11
chr14_+_72773957 1.202 NM_173462
NDRG2
PAPLN
NDRG family member 2
papilin, proteoglycan-like sulfated glycoprotein
chr9_-_122516399 1.200 NM_001080497
MEGF9
multiple EGF-like-domains 9
chr1_-_92722088 1.195 GFI1
growth factor independent 1 transcription repressor
chr11_-_57038891 1.193 NM_001198810
SLC43A1
solute carrier family 43, member 1
chr8_+_145674247 1.189 PPP1R16A
protein phosphatase 1, regulatory (inhibitor) subunit 16A
chr17_-_5428491 1.188 NM_001033053
NM_014922
NM_033004
NM_033006
NM_033007
NLRP1




NLR family, pyrin domain containing 1




chr22_+_48971067 1.182 TRABD
TraB domain containing
chr3_-_123223658 1.180 NM_175924
ILDR1
immunoglobulin-like domain containing receptor 1
chr3_+_185430910 1.180 NM_138345
VWA5B2
von Willebrand factor A domain containing 5B2
chr8_-_99375739 1.177 NM_024759
NIPAL2
NIPA-like domain containing 2
chr15_-_38188333 1.173 NM_001003940
BMF
Bcl2 modifying factor
chr15_-_36644122 1.171 NM_001128602
NM_005739
RASGRP1

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

chr3_-_49882308 1.165 NM_024046
CAMKV
CaM kinase-like vesicle-associated
chr1_+_27541086 1.164 SYTL1
synaptotagmin-like 1
chr9_+_4480193 1.153 NM_004170
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr16_+_57091546 1.152 NDRG4
NDRG family member 4
chr22_+_36008369 1.150 NM_013385
CYTH4
cytohesin 4
chr7_+_101861007 1.142 ORAI2
ORAI calcium release-activated calcium modulator 2
chr16_+_55963899 1.138 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr12_-_107238568 1.134 NM_001142345
CMKLR1
chemokine-like receptor 1
chr11_+_60448487 1.134 NM_017870
NM_178031
TMEM132A

transmembrane protein 132A

chr5_-_172130766 1.133 NM_004417
DUSP1
dual specificity phosphatase 1
chr22_-_49315003 1.132 NM_001113756
TYMP
thymidine phosphorylase
chr4_-_647424 1.126


chr7_-_102044374 1.126 RASA4
RAS p21 protein activator 4
chr19_+_54314292 1.115 NM_003660
PPFIA3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr15_+_73426383 1.113 NM_024608
NEIL1
nei endonuclease VIII-like 1 (E. coli)
chr2_+_109112428 1.111 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr19_-_2187648 1.109 PLEKHJ1
pleckstrin homology domain containing, family J member 1
chr6_+_144649142 1.108 UTRN
utrophin
chr6_-_43585958 1.106 C6orf154
chromosome 6 open reading frame 154
chr16_+_155972 1.104 NM_001003938
HBM
hemoglobin, mu
chr15_+_88696480 1.103 NM_001004309
ZNF774
zinc finger protein 774
chr22_+_34107087 1.101 HMOX1
heme oxygenase (decycling) 1
chr3_-_181237210 1.088 NM_016559
PEX5L
peroxisomal biogenesis factor 5-like
chr19_+_10242763 1.084 ICAM1
intercellular adhesion molecule 1
chrX_+_128741578 1.081 SASH3
SAM and SH3 domain containing 3
chr7_-_86942910 1.078 NM_000443
NM_018849
NM_018850
ABCB4


ATP-binding cassette, sub-family B (MDR/TAP), member 4


chr20_+_30813851 1.070 NM_006892
NM_175848
NM_175849
DNMT3B


DNA (cytosine-5-)-methyltransferase 3 beta


chr5_+_156819604 1.070 NM_001099287
NM_001172292
NIPAL4

NIPA-like domain containing 4

chr14_+_105024301 1.062 NM_001311
CRIP1
cysteine-rich protein 1 (intestinal)
chr17_+_27617307 1.058 NM_138328
RHBDL3
rhomboid, veinlet-like 3 (Drosophila)
chr1_+_179719338 1.057 NM_000721
CACNA1E
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr1_+_180836050 1.051


chr7_-_102044419 1.050 NM_001079877
NM_006989
RASA4

RAS p21 protein activator 4

chr17_+_9489578 1.049 NM_153210
USP43
ubiquitin specific peptidase 43
chr8_-_70907957 1.045 NM_001146009
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr17_-_8034217 1.044 NM_017622
C17orf59
chromosome 17 open reading frame 59
chr2_-_241146077 1.040 NM_016552
NM_017844
ANKMY1

ankyrin repeat and MYND domain containing 1

chr2_+_26924466 1.035 NM_020134
DPYSL5
dihydropyrimidinase-like 5
chr5_-_149772469 1.031 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr22_-_49315341 1.024 NM_001113755
NM_001953
TYMP

thymidine phosphorylase

chr12_-_50004208 1.018 BIN2
bridging integrator 2
chr17_-_45562112 1.016 NM_174920
SAMD14
sterile alpha motif domain containing 14

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.39 1.55e-04 GO:0009966 regulation of signal transduction
1.35 2.37e-04 GO:0023051 regulation of signaling
1.32 2.44e-04 GO:0048583 regulation of response to stimulus
2.36 2.01e-03 GO:0035023 regulation of Rho protein signal transduction
1.71 2.52e-03 GO:0051056 regulation of small GTPase mediated signal transduction
1.84 8.40e-03 GO:0046578 regulation of Ras protein signal transduction
1.11 9.82e-03 GO:0065007 biological regulation
1.11 2.31e-02 GO:0050789 regulation of biological process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.66 5.32e-03 GO:0005773 vacuole
1.71 8.01e-03 GO:0000323 lytic vacuole
1.71 8.01e-03 GO:0005764 lysosome
2.04 2.43e-02 GO:0005765 lysosomal membrane
1.42 4.35e-02 GO:0044431 Golgi apparatus part

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.08 8.32e-04 GO:0005085 guanyl-nucleotide exchange factor activity
3.31 1.29e-03 GO:0003823 antigen binding
2.34 5.66e-03 GO:0005088 Ras guanyl-nucleotide exchange factor activity
2.52 5.84e-03 GO:0005089 Rho guanyl-nucleotide exchange factor activity
1.56 6.62e-03 GO:0030695 GTPase regulator activity
1.70 7.74e-03 GO:0005083 small GTPase regulator activity
1.53 1.18e-02 GO:0060589 nucleoside-triphosphatase regulator activity