Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 3.079


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)



Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_11597530 11.678 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr6_+_167624792 5.318 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr7_+_72883128 4.982 NM_001305
CLDN4
claudin 4
chr2_+_233443237 4.955 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr12_-_120781002 4.796 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr5_-_16791346 4.437 MYO10
myosin X
chr3_-_150422474 4.172 NM_000096
CP
ceruloplasmin (ferroxidase)
chr17_-_76985538 4.095


chr2_+_228386800 4.058 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr20_+_34937928 3.973 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr10_+_7785347 3.556 ITIH2
inter-alpha (globulin) inhibitor H2
chr17_-_36347197 3.549 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr20_-_42457717 3.509


chr17_-_43390108 3.452 NM_024320
PRR15L
proline rich 15-like
chr10_+_7785360 3.411 ITIH2
inter-alpha (globulin) inhibitor H2
chr14_-_64479198 3.358 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr13_+_75232797 3.325 NM_015842
LMO7
LIM domain 7
chr16_+_56259657 3.273 NM_170776
GPR97
G protein-coupled receptor 97
chr2_+_11600238 3.261 GREB1
growth regulation by estrogen in breast cancer 1
chr15_+_38082041 3.214 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr6_-_138935359 3.154 NM_020464
NHSL1
NHS-like 1
chr1_+_16203317 3.140 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr20_-_32363268 3.056 NM_001161766
AHCY
adenosylhomocysteinase
chr9_+_115265827 3.040 NM_017790
RGS3
regulator of G-protein signaling 3
chr2_+_11600287 3.020 NM_033090
GREB1
growth regulation by estrogen in breast cancer 1
chr10_+_7785331 2.989 ITIH2
inter-alpha (globulin) inhibitor H2
chr6_+_131190237 2.962 NM_001195597
LOC285733
hypothetical LOC285733
chr8_-_145613034 2.957 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr2_-_241484245 2.847 NM_001085437
C2orf54
chromosome 2 open reading frame 54
chr20_+_31334601 2.832 NM_033197
C20orf114
chromosome 20 open reading frame 114
chr20_+_42399039 2.729 NM_178491
R3HDML
R3H domain containing-like
chr11_+_22646229 2.679 NM_177553
GAS2
growth arrest-specific 2
chr10_+_53744043 2.660 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr2_-_74606819 2.641 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1
chr10_+_7785235 2.618 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr11_+_62813947 2.611 NM_001039752
SLC22A10
solute carrier family 22, member 10
chr12_+_1608672 2.606 NM_032642
WNT5B
wingless-type MMTV integration site family, member 5B
chr10_+_7785290 2.501 ITIH2
inter-alpha (globulin) inhibitor H2
chr13_+_23042722 2.497 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr10_+_135010833 2.463 NM_001145201
NM_145202
PRAP1

proline-rich acidic protein 1

chr10_+_114144512 2.443 ACSL5
acyl-CoA synthetase long-chain family member 5
chrX_-_105169370 2.393 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr16_+_70646008 2.392 NM_001126102
NM_005143
HP

haptoglobin

chr1_+_48460943 2.386 NM_001011547
NM_001135181
SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr17_-_40348378 2.357 NM_001131019
NM_002055
GFAP

glial fibrillary acidic protein

chr10_+_102722275 2.336 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr3_+_152970904 2.296 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr6_-_2785682 2.261 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr1_+_15957832 2.241 NM_017556
FBLIM1
filamin binding LIM protein 1
chr8_-_42353719 2.238 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chr11_+_101488380 2.200 NM_001195045
YAP1
Yes-associated protein 1
chr17_-_36346240 2.200 KRT23
keratin 23 (histone deacetylase inducible)
chr2_+_219354948 2.190 CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chrX_+_49718954 2.166 NM_000084
CLCN5
chloride channel 5
chr17_+_7900926 2.159


chr10_-_123346148 2.143 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr17_+_69939806 2.130 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr2_-_75641535 2.106 FAM176A
family with sequence similarity 176, member A
chr17_-_44226595 2.105 NM_173623
TTLL6
tubulin tyrosine ligase-like family, member 6
chr2_-_75641587 2.085 NM_001135032
FAM176A
family with sequence similarity 176, member A
chr9_-_126309510 2.064 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr9_-_35640852 2.064 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr1_+_57093030 2.063 NM_000562
C8A
complement component 8, alpha polypeptide
chr22_+_18330049 2.058 NM_007310
COMT
catechol-O-methyltransferase
chr9_-_14858974 2.031 FREM1
FRAS1 related extracellular matrix 1
chr17_-_1359745 2.015 INPP5K
inositol polyphosphate-5-phosphatase K
chr15_-_63457378 1.932 NM_004884
IGDCC3
immunoglobulin superfamily, DCC subclass, member 3
chr6_-_29635456 1.871 UBD
ubiquitin D
chr19_-_17236522 1.836 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr6_-_29635680 1.835 NM_006398
UBD
ubiquitin D
chr8_+_18072250 1.831 NM_001160179
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr8_+_121892719 1.829


chr1_-_36721501 1.826 NM_000760
NM_156039
NM_172313
CSF3R


colony stimulating factor 3 receptor (granulocyte)


chr6_-_128883125 1.813 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr8_-_16903911 1.811 NM_019851
FGF20
fibroblast growth factor 20
chr10_-_101831579 1.805 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr1_-_172153087 1.793 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr14_-_34413831 1.789 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr12_+_107797985 1.777 NM_001917
DAO
D-amino-acid oxidase
chr1_+_221168388 1.764 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr6_+_30212488 1.747 NM_138700
TRIM40
tripartite motif containing 40
chr6_+_64339869 1.745 NM_003463
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr1_-_11029737 1.734 NM_006610
NM_139208
MASP2

mannan-binding lectin serine peptidase 2

chr17_-_39437362 1.672 NM_004160
PYY
peptide YY
chr11_+_46697312 1.659 NM_000506
F2
coagulation factor II (thrombin)
chr13_+_109936080 1.659 COL4A2
collagen, type IV, alpha 2
chr17_+_72795567 1.654 NM_001113492
SEPT9
septin 9
chr17_-_23721468 1.642 VTN
vitronectin
chr14_-_34414277 1.628 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr16_-_71639670 1.626 NM_006885
ZFHX3
zinc finger homeobox 3
chr2_+_97696462 1.623 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr14_-_30746577 1.623


chr6_+_35812836 1.616 NM_145028
C6orf81
chromosome 6 open reading frame 81
chr20_-_17459973 1.602 NM_001195
BFSP1
beaded filament structural protein 1, filensin
chr15_-_87565813 1.580 NM_000326
RLBP1
retinaldehyde binding protein 1
chr19_-_50506883 1.568 CKM
creatine kinase, muscle
chr21_-_42608531 1.565 TFF3
trefoil factor 3 (intestinal)
chr7_+_29200636 1.563 NM_004067
CHN2
chimerin (chimaerin) 2
chr10_-_73518284 1.560 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr7_+_142692165 1.553 NM_153345
TMEM139
transmembrane protein 139
chr11_+_46697345 1.527 F2
coagulation factor II (thrombin)
chr1_+_2026014 1.525 NM_001033582
PRKCZ
protein kinase C, zeta
chr7_+_94953148 1.516 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr1_-_172153024 1.508 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr7_+_100169184 1.506 NM_003386
NM_173059
ZAN

zonadhesin

chr14_-_30746431 1.501 NM_015382
HECTD1
HECT domain containing 1
chr14_-_34414201 1.488 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr11_+_46697335 1.484 F2
coagulation factor II (thrombin)
chr6_+_167456230 1.474 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr2_+_69093641 1.473 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr18_-_24010944 1.467 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr17_+_7474177 1.459 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr1_-_108032645 1.456 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr14_-_34414241 1.455 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr17_+_35425139 1.440 NM_000759
NM_001178147
NM_172219
NM_172220
CSF3



colony stimulating factor 3 (granulocyte)



chr20_+_39199263 1.437 PLCG1
phospholipase C, gamma 1
chr4_+_17125885 1.419 NM_001079827
CLRN2
clarin 2
chr14_-_22521544 1.410 NM_032876
JUB
jub, ajuba homolog (Xenopus laevis)
chr11_-_124311106 1.401 HEPACAM
hepatic and glial cell adhesion molecule
chr1_-_110108048 1.395 NM_024526
NM_133181
NM_139053
EPS8L3


EPS8-like 3


chr7_+_139175420 1.392 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr11_+_74548472 1.381 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr13_+_75108450 1.377 LMO7
LIM domain 7
chr1_-_1346465 1.366 NM_001145210
LOC441869
hypothetical protein LOC441869
chr10_-_52315390 1.364 A1CF
APOBEC1 complementation factor
chr8_-_121893196 1.354


chr2_+_135312655 1.352 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr8_-_121892877 1.333 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr11_+_62893836 1.333 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr9_+_111927601 1.329 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr2_-_169927258 1.326 NM_004525
LRP2
low density lipoprotein receptor-related protein 2
chr11_-_75599433 1.326 WNT11
wingless-type MMTV integration site family, member 11
chr4_-_158111504 1.314 PDGFC
platelet derived growth factor C
chrX_+_152413646 1.311 BGN
biglycan
chr5_-_58370693 1.310 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr15_+_60146467 1.310 NM_207322
C2CD4A
C2 calcium-dependent domain containing 4A
chr14_-_20642629 1.305 NM_001102454
ZNF219
zinc finger protein 219
chr2_+_158666627 1.292 NM_173355
UPP2
uridine phosphorylase 2
chr9_-_116190038 1.273 AKNA
AT-hook transcription factor
chr20_-_1396336 1.261 NM_016143
NM_018839
NM_182483
NSFL1C


NSFL1 (p97) cofactor (p47)


chr3_+_187813405 1.249 AHSG
alpha-2-HS-glycoprotein
chrX_+_152413540 1.244 NM_001711
BGN
biglycan
chr7_-_27186400 1.233 NM_153715
HOXA10
homeobox A10
chr19_-_18578467 1.230 CRLF1
cytokine receptor-like factor 1
chr19_+_59061422 1.230 NM_001020820
MYADM
myeloid-associated differentiation marker
chr3_-_140677990 1.224 NM_004164
RBP2
retinol binding protein 2, cellular
chr3_-_115960807 1.224 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr2_+_171280046 1.215 NM_001003845
SP5
Sp5 transcription factor
chr19_+_8180179 1.202 NM_024552
LASS4
LAG1 homolog, ceramide synthase 4
chr14_-_34414603 1.197 NM_013448
NM_182648
BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chr19_-_6671585 1.189 NM_000064
C3
complement component 3
chrX_+_46822751 1.189 RGN
regucalcin (senescence marker protein-30)
chr13_-_22905822 1.184 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr10_-_98935369 1.183 SLIT1
slit homolog 1 (Drosophila)
chr6_-_31789824 1.178


chr14_+_38720085 1.155 PNN
pinin, desmosome associated protein
chr17_-_53849888 1.138 RNF43
ring finger protein 43
chr4_-_40911212 1.130 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr18_-_24011349 1.129 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr1_-_75854281 1.127 SLC44A5
solute carrier family 44, member 5
chr4_-_7991992 1.124 NM_001134647
NM_198595
AFAP1

actin filament associated protein 1

chr8_+_17478214 1.119 NM_006207
PDGFRL
platelet-derived growth factor receptor-like
chrX_-_55037235 1.118 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr2_+_70981223 1.101 NM_012476
VAX2
ventral anterior homeobox 2
chr6_+_44076281 1.097 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr2_+_218992053 1.083 NM_007127
VIL1
villin 1
chr14_-_91111135 1.082 NM_001080113
C14orf184
chromosome 14 open reading frame 184
chr2_+_54537842 1.075 SPTBN1
spectrin, beta, non-erythrocytic 1
chr4_-_158111916 1.061 PDGFC
platelet derived growth factor C
chr17_-_60988226 1.054 AXIN2
axin 2
chr11_-_62753574 1.051 NM_199352
SLC22A25
solute carrier family 22, member 25
chr14_-_93924663 1.051 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr3_-_121883647 1.050 HGD
homogentisate 1,2-dioxygenase
chr1_+_42701460 1.035 CCDC30
coiled-coil domain containing 30
chr10_-_116434364 1.032 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr11_+_117982422 1.031 NM_015157
PHLDB1
pleckstrin homology-like domain, family B, member 1
chr1_-_153537362 1.015 NM_181871
PKLR
pyruvate kinase, liver and RBC
chr6_-_26038817 1.015 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr11_-_34491878 1.006 NM_001422
ELF5
E74-like factor 5 (ets domain transcription factor)
chr5_+_140509803 1.003 NM_018939
PCDHB6
protocadherin beta 6
chr3_-_150858274 1.002 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr7_-_133794404 1.001 NM_001628
AKR1B1
aldo-keto reductase family 1, member B1 (aldose reductase)
chr19_-_18578631 0.990 NM_004750
CRLF1
cytokine receptor-like factor 1
chr3_-_114643008 0.990 NM_001164496
NM_018338
WDR52

WD repeat domain 52

chr1_-_16217871 0.989 NM_014424
HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr2_-_135498716 0.986 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr17_-_36376663 0.967 NM_213656
KRT39
keratin 39
chr10_+_104619199 0.964 NM_020682
AS3MT
arsenic (+3 oxidation state) methyltransferase
chr19_-_18578577 0.961 CRLF1
cytokine receptor-like factor 1
chr2_+_233961538 0.958 NM_003648
DGKD
diacylglycerol kinase, delta 130kDa
chr8_+_103889733 0.958 FLJ45248
FLJ45248 protein
chr2_+_219432789 0.952 NM_006522
WNT6
wingless-type MMTV integration site family, member 6
chr7_+_128615948 0.952 NM_005631
SMO
smoothened homolog (Drosophila)
chr17_+_19377732 0.946 NM_018242
SLC47A1
solute carrier family 47, member 1
chr17_+_4621924 0.942 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr19_-_5789740 0.940 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr4_-_158111995 0.939 NM_016205
PDGFC
platelet derived growth factor C
chr11_+_75106512 0.930 NM_025098
MOGAT2
monoacylglycerol O-acyltransferase 2
chrX_+_46822688 0.929 NM_004683
NM_152869
RGN

regucalcin (senescence marker protein-30)

chr12_+_48784057 0.925 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.28 3.60e-03 GO:0007275 multicellular organismal development
1.21 3.88e-03 GO:0032501 multicellular organismal process
1.28 1.15e-02 GO:0048856 anatomical structure development
1.24 2.13e-02 GO:0032502 developmental process

Nothing significant found in compartment category.

Nothing significant found in function category.