Motif ID: NFE2.p2

Z-value: 1.298


Transcription factors associated with NFE2.p2:

Gene SymbolEntrez IDGene Name
NFE2 4778 nuclear factor (erythroid-derived 2), 45kDa



Activity profile for motif NFE2.p2.

activity profile for motif NFE2.p2


Sorted Z-values histogram for motif NFE2.p2

Sorted Z-values for motif NFE2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_221955876 5.390 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr12_-_15005761 2.708 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr6_+_106653429 2.555 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr15_+_38849450 2.508 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr5_-_141041982 2.231 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr6_-_84197370 2.056 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr21_+_29439768 2.050 C21orf7
chromosome 21 open reading frame 7
chr6_-_84197573 2.040 NM_002395
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr19_-_53935648 2.006 NM_017805
RASIP1
Ras interacting protein 1
chr6_-_84197463 1.989 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr11_+_20342262 1.967 NM_001098523
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr1_+_153232685 1.954 NM_018655
LENEP
lens epithelial protein
chr6_-_84197477 1.949 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr13_-_98757634 1.856 NM_004951
GPR183
G protein-coupled receptor 183
chr5_-_141041933 1.822 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr6_-_28429950 1.810 NM_145909
ZNF323
zinc finger protein 323
chr11_+_67107852 1.768 GSTP1
glutathione S-transferase pi 1
chr17_+_29606408 1.745 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr9_+_102231616 1.708 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr1_+_181421984 1.683 LAMC2
laminin, gamma 2
chr1_-_93030538 1.652 NM_005665
EVI5
ecotropic viral integration site 5
chr11_+_20341806 1.646 NM_006410
NM_001098521
HTATIP2

HIV-1 Tat interactive protein 2, 30kDa

chr11_+_20341835 1.635 NM_001098520
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr11_+_20341900 1.589 NM_001098522
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr11_-_6298284 1.529 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr15_-_58477407 1.516 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr17_+_18566060 1.515 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr3_+_49002285 1.494 NM_177938
NM_177939
P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr21_-_35343065 1.453 RUNX1
runt-related transcription factor 1
chrX_+_12903145 1.443 NM_021109
NM_183049
TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chr12_-_68369322 1.420 NM_152439
BEST3
bestrophin 3
chrX_-_154216929 1.401 NM_001289
CLIC2
chloride intracellular channel 2
chr11_+_67107641 1.399 NM_000852
GSTP1
glutathione S-transferase pi 1
chr1_-_242073094 1.385 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr16_+_56219802 1.383 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr11_+_10434056 1.381 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chrX_-_24575146 1.358 PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr19_-_4510713 1.357 SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chrX_-_24575375 1.335 NM_001163265
NM_004845
PCYT1B

phosphate cytidylyltransferase 1, choline, beta

chr1_+_148747110 1.332 NM_004425
NM_022664
ECM1

extracellular matrix protein 1

chr3_+_69998064 1.330 NM_198177
MITF
microphthalmia-associated transcription factor
chr4_-_38710376 1.316 NM_024943
TMEM156
transmembrane protein 156
chr1_+_148747208 1.290 ECM1
extracellular matrix protein 1
chr13_+_51334117 1.288 NM_031290
CCDC70
coiled-coil domain containing 70
chr18_+_54039779 1.284 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr7_+_22733290 1.283 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr2_+_169634330 1.269 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_+_12046020 1.266 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr22_+_21495273 1.265


chr18_+_54039730 1.246 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr18_+_54039818 1.245 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr3_+_11153778 1.232 NM_001098213
HRH1
histamine receptor H1
chr17_+_72827185 1.219 NM_006640
SEPT9
septin 9
chr1_+_181422016 1.186 LAMC2
laminin, gamma 2
chr6_+_44302973 1.178 SLC29A1
solute carrier family 29 (nucleoside transporters), member 1
chr17_+_72827227 1.166 SEPT9
septin 9
chr1_+_181421796 1.163 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr2_-_219881937 1.159 PTPRN
protein tyrosine phosphatase, receptor type, N
chr6_+_41712907 1.158 MDFI
MyoD family inhibitor
chr5_-_75954807 1.152 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chrX_-_53327473 1.144 NM_015075
IQSEC2
IQ motif and Sec7 domain 2
chrX_-_100527799 1.115 NM_000061
BTK
Bruton agammaglobulinemia tyrosine kinase
chr17_-_77474597 1.114 NM_032711
MAFG
v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr17_+_44643067 1.101 ABI3
ABI family, member 3
chr11_+_118463906 1.084 NM_001024382
HMBS
hydroxymethylbilane synthase
chr6_+_31190505 1.074 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr6_-_29563657 1.067 NM_052967
MAS1L
MAS1 oncogene-like
chr8_-_145097031 1.066 NM_201380
PLEC
plectin
chrX_+_65299352 1.064 HEPH
hephaestin
chr1_+_81544432 1.063 LPHN2
latrophilin 2
chr3_+_156280129 1.056 NM_000902
MME
membrane metallo-endopeptidase
chr1_+_17507276 1.051 NM_012387
PADI4
peptidyl arginine deiminase, type IV
chr3_-_197549640 1.034 NM_138461
TM4SF19
transmembrane 4 L six family member 19
chr11_-_102174032 1.032 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr14_-_104507862 1.010 AHNAK2
AHNAK nucleoprotein 2
chr11_-_102174102 1.002 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr4_+_74825138 0.996 NM_000584
IL8
interleukin 8
chr3_+_48482213 0.995 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr8_-_82557956 0.995 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr3_+_185377341 0.995 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr3_+_48482625 0.984 TREX1
three prime repair exonuclease 1
chr4_-_101658094 0.980 NM_001159694
NM_016242
EMCN

endomucin

chr3_-_197549588 0.980 TM4SF19
transmembrane 4 L six family member 19
chr2_-_85494664 0.974 CAPG
capping protein (actin filament), gelsolin-like
chr12_+_76749199 0.970 NM_014903
NAV3
neuron navigator 3
chr16_+_15503623 0.961 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr2_-_85494639 0.961 CAPG
capping protein (actin filament), gelsolin-like
chr9_-_35744271 0.955 NM_001044264
MSMP
microseminoprotein, prostate associated
chr22_+_21393107 0.954 IGLJ3
immunoglobulin lambda joining 3
chr4_-_174687104 0.954 HAND2
heart and neural crest derivatives expressed 2
chrX_+_99786044 0.943 SRPX2
sushi-repeat containing protein, X-linked 2
chrX_-_2896285 0.930 ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr5_+_35892747 0.929 NM_002185
IL7R
interleukin 7 receptor
chr10_+_17310263 0.926 NM_003380
VIM
vimentin
chr7_+_142205266 0.923


chr10_+_70745615 0.918 NM_033496
HK1
hexokinase 1
chr19_+_54723044 0.908 RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr3_+_185377430 0.903 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr6_+_47732181 0.899 NM_153839
GPR111
G protein-coupled receptor 111
chrX_+_69314060 0.898 NM_198512
DGAT2L6
diacylglycerol O-acyltransferase 2-like 6
chr20_+_33223434 0.888 NM_006404
PROCR
protein C receptor, endothelial
chr1_-_115682374 0.885 NM_002506
NGF
nerve growth factor (beta polypeptide)
chr19_+_45564549 0.875 PLD3
phospholipase D family, member 3
chr17_-_26665194 0.872 EVI2B
ecotropic viral integration site 2B
chr3_+_154035425 0.853 NM_002563
P2RY1
purinergic receptor P2Y, G-protein coupled, 1
chr5_+_150000394 0.850 NM_001109974
NM_007286
SYNPO

synaptopodin

chr1_-_156923111 0.841 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr15_+_99276982 0.835 NM_024652
LRRK1
leucine-rich repeat kinase 1
chr7_-_86526880 0.832 NM_001142749
KIAA1324L
KIAA1324-like
chr10_+_17310475 0.827 VIM
vimentin
chr17_-_26665213 0.805 EVI2B
ecotropic viral integration site 2B
chrX_+_65299157 0.800 NM_138737
HEPH
hephaestin
chrX_-_15421279 0.799 NM_001018109
NM_003662
PIR

pirin (iron-binding nuclear protein)

chr22_-_25343959 0.798 NM_001887
CRYBB1
crystallin, beta B1
chr9_+_35528890 0.795 RUSC2
RUN and SH3 domain containing 2
chr8_-_42742729 0.787 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr1_+_226399026 0.786 NM_001159391
GUK1
guanylate kinase 1
chr21_-_35343331 0.774 RUNX1
runt-related transcription factor 1
chr22_-_25344037 0.770 CRYBB1
crystallin, beta B1
chr4_+_111053488 0.767 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr11_-_128399218 0.763 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr3_+_50259329 0.757 NM_001166425
GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr19_+_59107802 0.757 NM_031896
CACNG7
calcium channel, voltage-dependent, gamma subunit 7
chr8_-_122722674 0.755 NM_005328
HAS2
hyaluronan synthase 2
chr22_-_43986896 0.755 KIAA0930
KIAA0930
chr17_+_27795598 0.754 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr1_+_24522116 0.753 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr4_-_5879488 0.748 CRMP1
collapsin response mediator protein 1
chr9_+_35528628 0.743 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr4_+_154397975 0.743 TRIM2
tripartite motif containing 2
chr17_+_27795645 0.738 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr19_-_55914837 0.734


chr17_-_26665144 0.733 EVI2B
ecotropic viral integration site 2B
chr17_+_27795633 0.730 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_22823151 0.729 NM_014238
KSR1
kinase suppressor of ras 1
chr16_-_70763524 0.727 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr6_+_34314545 0.723 NM_145905
HMGA1
high mobility group AT-hook 1
chr17_+_27795635 0.722 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr3_+_66094324 0.713 NM_173471
SLC25A26
solute carrier family 25, member 26
chrX_+_100361588 0.713 NM_001171184
NM_001939
DRP2

dystrophin related protein 2

chr11_-_66092534 0.707 NM_003793
CTSF
cathepsin F
chr3_-_193609531 0.701 NM_021032
FGF12
fibroblast growth factor 12
chr1_+_12698704 0.700 NM_001103169
NM_001103170
AADACL3

arylacetamide deacetylase-like 3

chr7_-_128330615 0.699 KCP
kielin/chordin-like protein
chr22_+_20715340 0.699


chr19_+_43572679 0.695 NM_001039616
NM_001042522
SPRED3

sprouty-related, EVH1 domain containing 3

chr12_-_90097384 0.694 NM_133503
DCN
decorin
chr3_+_185520744 0.694 NM_004953
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr12_-_8110268 0.693 C3AR1
complement component 3a receptor 1
chrX_+_99785818 0.691 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr21_-_35343428 0.683 RUNX1
runt-related transcription factor 1
chr3_+_185499679 0.682 NM_002808
PSMD2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr14_-_90780604 0.676 NM_001177676
GPR68
G protein-coupled receptor 68
chr7_+_150065594 0.673 GIMAP5
GTPase, IMAP family member 5
chr12_-_101115677 0.671 NM_002674
PMCH
pro-melanin-concentrating hormone
chr15_+_76345577 0.669 NM_001130183
DNAJA4
DnaJ (Hsp40) homolog, subfamily A, member 4
chr3_+_101720753 0.669 TMEM45A
transmembrane protein 45A
chr11_-_47502115 0.661 NM_001172639
CELF1
CUGBP, Elav-like family member 1
chr4_-_68678181 0.655 NM_207407
TMPRSS11F
transmembrane protease, serine 11F
chr12_-_53099269 0.653 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr7_-_38355949 0.651


chr17_-_37022465 0.651 NM_005557
KRT16
keratin 16
chr9_-_116920232 0.650 NM_002160
TNC
tenascin C
chr11_-_71458739 0.649 NUMA1
nuclear mitotic apparatus protein 1
chr17_-_26665220 0.644 NM_006495
EVI2B
ecotropic viral integration site 2B
chr22_+_21464980 0.644


chr19_+_3317575 0.637 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chrX_-_33139349 0.636 NM_004006
DMD
dystrophin
chr15_+_38318528 0.636 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr17_+_27795632 0.625 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr21_-_35343500 0.622 RUNX1
runt-related transcription factor 1
chr15_-_74091817 0.620 NM_138573
NRG4
neuregulin 4
chr12_-_119172339 0.609 NM_025157
PXN
paxillin
chr5_-_169657312 0.609 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr17_+_27795607 0.605 NM_002815
PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr21_-_35343456 0.604 NM_001754
RUNX1
runt-related transcription factor 1
chr18_-_51219880 0.602 TCF4
transcription factor 4
chr17_-_44642934 0.601 NM_001198754
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr3_-_15814678 0.597 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr1_-_109770474 0.596 NM_002790
PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr22_+_21340757 0.594


chrX_+_133952633 0.593 NM_001163438
LOC644538
hypothetical protein LOC644538
chr1_-_119333701 0.590 NM_152380
TBX15
T-box 15
chr5_-_169657192 0.589 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr17_-_74244539 0.588


chr1_-_109770581 0.588 PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr5_-_169657395 0.587 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr17_-_35975227 0.586 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr2_-_65447370 0.584 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr1_-_109770567 0.584 PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr19_+_3317536 0.584 NM_005597
NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chrX_-_72351348 0.583 NAP1L2
nucleosome assembly protein 1-like 2
chr3_+_70131572 0.583


chr10_+_85889164 0.583 NM_014394
GHITM
growth hormone inducible transmembrane protein
chr17_-_39700960 0.582 NM_000342
SLC4A1
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
chr12_-_53099277 0.579 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr3_+_194441586 0.578 NM_020386
HRASLS
HRAS-like suppressor
chr9_+_130231027 0.578 CERCAM
cerebral endothelial cell adhesion molecule
chr22_-_43987010 0.573 NM_015264
KIAA0930
KIAA0930
chr15_+_38319326 0.571 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.33 1.15e-03 GO:0071158 positive regulation of cell cycle arrest
1.22 1.71e-03 GO:0050896 response to stimulus
4.26 3.27e-03 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
4.26 3.27e-03 GO:0072395 signal transduction involved in cell cycle checkpoint
4.26 3.27e-03 GO:0072401 signal transduction involved in DNA integrity checkpoint
4.26 3.27e-03 GO:0072404 signal transduction involved in G1/S transition checkpoint
4.26 3.27e-03 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
4.26 3.27e-03 GO:0072422 signal transduction involved in DNA damage checkpoint
4.26 3.27e-03 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
4.26 3.27e-03 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
1.63 5.50e-03 GO:0051246 regulation of protein metabolic process
3.27 5.77e-03 GO:0000077 DNA damage checkpoint
1.32 6.50e-03 GO:0007165 signal transduction
1.19 8.15e-03 GO:0050794 regulation of cellular process
3.82 1.41e-02 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
3.07 1.60e-02 GO:0031570 DNA integrity checkpoint
4.25 1.69e-02 GO:0006521 regulation of cellular amino acid metabolic process
3.55 1.88e-02 GO:0031575 mitotic cell cycle G1/S transition checkpoint
3.55 1.88e-02 GO:0071779 G1/S transition checkpoint
1.28 2.11e-02 GO:0023052 signaling
3.66 2.46e-02 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.26 2.90e-02 GO:0051716 cellular response to stimulus
1.69 3.10e-02 GO:0031399 regulation of protein modification process
1.64 3.50e-02 GO:0009611 response to wounding
3.38 3.67e-02 GO:0051351 positive regulation of ligase activity
3.38 3.67e-02 GO:2000045 regulation of G1/S transition of mitotic cell cycle
1.58 3.89e-02 GO:0043067 regulation of programmed cell death
1.17 4.48e-02 GO:0050789 regulation of biological process
1.58 4.68e-02 GO:0032268 regulation of cellular protein metabolic process
1.58 4.89e-02 GO:0042981 regulation of apoptosis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.40 1.45e-04 GO:0000502 proteasome complex
6.60 4.60e-03 GO:0001533 cornified envelope
1.53 1.06e-02 GO:0000267 cell fraction
1.60 1.99e-02 GO:0005626 insoluble fraction

Gene overrepresentation in function category:

enrichment   p-value GO term description
17.32 6.06e-03 GO:0015037 peptide disulfide oxidoreductase activity
5.03 2.44e-02 GO:0015036 disulfide oxidoreductase activity