Motif ID: NFIX.p2

Z-value: 1.819


Transcription factors associated with NFIX.p2:

Gene SymbolEntrez IDGene Name
NFIX 4784 nuclear factor I/X (CCAAT-binding transcription factor)



Activity profile for motif NFIX.p2.

activity profile for motif NFIX.p2


Sorted Z-values histogram for motif NFIX.p2

Sorted Z-values for motif NFIX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFIX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_88718167 3.722 NM_006829
C10orf116
chromosome 10 open reading frame 116
chr17_-_25112393 3.554 SSH2
slingshot homolog 2 (Drosophila)
chr5_+_178919298 3.375 NM_001040451
NM_001040452
RUFY1

RUN and FYVE domain containing 1

chr8_-_101227203 3.018 NM_001029860
FBXO43
F-box protein 43
chr1_+_78858675 2.972 NM_006820
IFI44L
interferon-induced protein 44-like
chr1_+_156417302 2.878 CD1D
CD1d molecule
chr21_+_32706615 2.780 NM_058187
C21orf63
chromosome 21 open reading frame 63
chr14_+_51025604 2.754 NM_001042481
FRMD6
FERM domain containing 6
chr12_+_26239755 2.665 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr5_+_148941228 2.636 NM_001001669
ARHGEF37
Rho guanine nucleotide exchange factor (GEF) 37
chr9_-_25668230 2.568 TUSC1
tumor suppressor candidate 1
chr4_-_85638410 2.461 NM_006168
NKX6-1
NK6 homeobox 1
chr17_-_5428491 2.450 NM_001033053
NM_014922
NM_033004
NM_033006
NM_033007
NLRP1




NLR family, pyrin domain containing 1




chr2_+_37425240 2.437 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr2_-_56266408 2.399 LOC100129434
hypothetical LOC100129434
chr7_-_123460722 2.381 NM_001136002
TMEM229A
transmembrane protein 229A
chr4_+_158216631 2.347 NM_000824
NM_001166061
NM_001166060
GLRB


glycine receptor, beta


chr16_+_65765256 2.298 NM_003946
NM_001185057
NOL3

nucleolar protein 3 (apoptosis repressor with CARD domain)

chr6_-_26125939 2.160 NM_005325
HIST1H1A
histone cluster 1, H1a
chr6_+_53767251 2.120 LRRC1
leucine rich repeat containing 1
chr10_-_128884411 2.073 NM_001039762
FAM196A
family with sequence similarity 196, member A
chr22_+_44828338 2.018


chr17_+_35587767 1.983 NM_016339
RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr12_+_26239535 1.975 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr9_+_70926205 1.961 TJP2
tight junction protein 2 (zona occludens 2)
chr15_+_38849450 1.955 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr15_+_61123327 1.949 TPM1
tropomyosin 1 (alpha)
chr3_-_197103848 1.943 TNK2
tyrosine kinase, non-receptor, 2
chr10_+_122206455 1.941 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr4_+_89597257 1.921 NM_016323
HERC5
hect domain and RLD 5
chr1_+_43386180 1.895 NM_001101376
FAM183A
family with sequence similarity 183, member A
chr9_-_21549696 1.852 LOC554202
hypothetical LOC554202
chr19_-_19599973 1.808 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr1_+_208568811 1.805 NM_001170587
NM_001170588
NM_018194
HHAT


hedgehog acyltransferase


chr1_+_77105746 1.799 NM_030965
ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr3_+_129117007 1.794 KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr4_-_143987053 1.772 NM_001101669
NM_003866
INPP4B

inositol polyphosphate-4-phosphatase, type II, 105kDa

chr9_+_111582317 1.767 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr4_-_75938710 1.765 NM_001729
BTC
betacellulin
chr1_+_219026661 1.759 NM_022746
MOSC1
MOCO sulphurase C-terminal domain containing 1
chr1_+_208569262 1.731 NM_001170580
HHAT
hedgehog acyltransferase
chr4_+_148621518 1.718 NM_001166055
NM_001957
EDNRA

endothelin receptor type A

chr14_+_104785898 1.710 NM_033271
BTBD6
BTB (POZ) domain containing 6
chr1_+_77105709 1.706 ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr3_+_44571600 1.671 NM_018651
NM_025169
ZNF167

zinc finger protein 167

chr9_+_70926009 1.669 NM_001170414
TJP2
tight junction protein 2 (zona occludens 2)
chr17_-_25587079 1.663 NM_001045
SLC6A4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
chr10_+_102782151 1.646 SFXN3
sideroflexin 3
chr13_-_100866839 1.622 NALCN
sodium leak channel, non-selective
chr5_+_94981735 1.615 NM_199243
GPR150
G protein-coupled receptor 150
chrX_+_154264931 1.615 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr14_+_104785936 1.610 BTBD6
BTB (POZ) domain containing 6
chr14_+_58174489 1.600 NM_001079520
NM_016651
DACT1

dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)

chr8_-_68037378 1.589 NM_001193502
TCF24
transcription factor 24
chr21_-_27139563 1.565 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr5_-_59819642 1.563 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr19_-_1188840 1.530 NM_152769
C19orf26
chromosome 19 open reading frame 26
chr7_+_33911636 1.512 NM_133468
BMPER
BMP binding endothelial regulator
chr22_+_16973556 1.472 TUBA8
tubulin, alpha 8
chr19_+_45807909 1.469


chr15_-_30798417 1.459


chr6_-_150285838 1.437 NM_001001788
RAET1G
retinoic acid early transcript 1G
chr3_-_162305319 1.425 NM_033169
NM_001038628
NM_003781
NM_033167
NM_033168
B3GALNT1




beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)




chr1_+_63832067 1.424 NM_001172819
PGM1
phosphoglucomutase 1
chr4_-_83938920 1.420 NM_001037582
NM_024906
SCD5

stearoyl-CoA desaturase 5

chr4_-_76774594 1.413 NM_003948
CDKL2
cyclin-dependent kinase-like 2 (CDC2-related kinase)
chr5_+_132111034 1.410 NM_001039780
CCNI2
cyclin I family, member 2
chr9_+_111850770 1.383 AKAP2
A kinase (PRKA) anchor protein 2
chr10_-_15170779 1.382 NM_001039844
ACBD7
acyl-CoA binding domain containing 7
chr9_-_129656413 1.372 ENG
endoglin
chr3_+_185762233 1.367 NM_004443
EPHB3
EPH receptor B3
chr16_+_65790514 1.341 NM_024712
ELMO3
engulfment and cell motility 3
chr4_+_146622154 1.338 NM_005900
SMAD1
SMAD family member 1
chr22_+_29974368 1.335 LIMK2
LIM domain kinase 2
chr2_-_40532651 1.327 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr5_+_122452739 1.325 NM_001136239
PRDM6
PR domain containing 6
chr14_-_104507862 1.319 AHNAK2
AHNAK nucleoprotein 2
chr10_-_105982052 1.315 NM_025145
WDR96
WD repeat domain 96
chr14_+_23575460 1.315 NM_001082488
DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 1
chr3_+_49211936 1.314 NM_001135197
CCDC36
coiled-coil domain containing 36
chr3_+_35656012 1.303 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr17_+_72795567 1.298 NM_001113492
SEPT9
septin 9
chr9_-_25668855 1.283 NM_001004125
TUSC1
tumor suppressor candidate 1
chr4_+_148621694 1.279 EDNRA
endothelin receptor type A
chr9_+_77695334 1.278 NM_001190482
NM_006200
PCSK5

proprotein convertase subtilisin/kexin type 5

chr10_+_124210980 1.272 NM_002775
HTRA1
HtrA serine peptidase 1
chr12_+_106236281 1.261 NM_001018072
BTBD11
BTB (POZ) domain containing 11
chr22_+_16973399 1.251 NM_001193414
NM_018943
TUBA8

tubulin, alpha 8

chr9_+_115382990 1.247 RGS3
regulator of G-protein signaling 3
chr1_-_150233337 1.240 NM_002966
S100A10
S100 calcium binding protein A10
chr13_+_27392136 1.239 NM_000209
PDX1
pancreatic and duodenal homeobox 1
chr12_+_81604752 1.227 TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr9_+_111850698 1.216 NM_001004065
NM_001198656
AKAP2

A kinase (PRKA) anchor protein 2

chr8_-_70908130 1.213 NM_001146008
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr14_-_99842519 1.204 NM_001039355
SLC25A29
solute carrier family 25, member 29
chrX_-_107866262 1.202 NM_003604
IRS4
insulin receptor substrate 4
chr8_-_41286088 1.198 NM_003012
SFRP1
secreted frizzled-related protein 1
chr10_-_45488162 1.186 NM_001128324
NM_174890
ANUBL1

AN1, ubiquitin-like, homolog (Xenopus laevis)

chr5_-_80725704 1.171 NM_130767
ACOT12
acyl-CoA thioesterase 12
chr9_-_122731263 1.158 NM_001190945
TRAF1
TNF receptor-associated factor 1
chr14_-_99695684 1.148 NM_206918
DEGS2
degenerative spermatocyte homolog 2, lipid desaturase (Drosophila)
chr1_-_19487790 1.139 NM_012067
AKR7A3
aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
chr9_-_129656581 1.134 ENG
endoglin
chr15_-_83002421 1.132 NMB
neuromedin B
chr1_+_148521852 1.128 NM_144697
C1orf51
chromosome 1 open reading frame 51
chrX_+_10084984 1.128 NM_001830
CLCN4
chloride channel 4
chr4_+_148621567 1.124 EDNRA
endothelin receptor type A
chr9_+_115382760 1.123 NM_021106
RGS3
regulator of G-protein signaling 3
chr1_+_199975674 1.115 NAV1
neuron navigator 1
chr5_+_96024434 1.106 CAST
calpastatin
chr10_+_71232281 1.081 COL13A1
collagen, type XIII, alpha 1
chr11_-_30564338 1.055 NM_001145399
MPPED2
metallophosphoesterase domain containing 2
chr4_+_166097548 1.052 NM_153027
C4orf39
chromosome 4 open reading frame 39
chr1_+_6008956 1.037 NM_003636
NM_172130
KCNAB2

potassium voltage-gated channel, shaker-related subfamily, beta member 2

chr15_+_61122957 1.035 TPM1
tropomyosin 1 (alpha)
chr3_-_50371896 1.035 TMEM115
transmembrane protein 115
chr1_+_226261374 1.022 NM_033131
WNT3A
wingless-type MMTV integration site family, member 3A
chr6_-_55551812 1.016 NM_001042406
NM_019036
HMGCLL1

3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1

chr5_+_76418545 1.013 LOC728723
hypothetical LOC728723
chr21_-_27139143 1.011 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr11_-_75057299 1.007 MAP6
microtubule-associated protein 6
chr4_+_156899575 0.983 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr10_+_89409332 0.977 NM_001015880
NM_004670
PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr1_+_199975563 0.976 NM_001167738
NAV1
neuron navigator 1
chr11_-_63014986 0.973 NM_001146728
NM_001146729
NM_054108
HRASLS5


HRAS-like suppressor family, member 5


chr5_+_76418214 0.956 LOC728723
hypothetical LOC728723
chr3_-_46710137 0.953 NM_001190707
NM_147129
ALS2CL

ALS2 C-terminal like

chr9_-_112840801 0.950 LPAR1
lysophosphatidic acid receptor 1
chr2_-_127694123 0.949 CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr3_-_50371934 0.948 NM_007024
TMEM115
transmembrane protein 115
chr1_-_234295293 0.945 NID1
nidogen 1
chr9_-_111300350 0.943 NM_001145368
NM_002829
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr1_-_68470585 0.942 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr6_+_86216020 0.936 NM_002526
NT5E
5'-nucleotidase, ecto (CD73)
chr20_-_3696344 0.936 NM_001039140
C20orf27
chromosome 20 open reading frame 27
chrX_-_20044670 0.934 NM_001168467
MAP7D2
MAP7 domain containing 2
chr1_+_26744929 0.930 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr10_-_123346148 0.924 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr6_-_119512035 0.922 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr11_+_122258600 0.919 NM_024806
NM_199124
C11orf63

chromosome 11 open reading frame 63

chr13_-_100866706 0.914 NM_052867
NALCN
sodium leak channel, non-selective
chr11_+_10428799 0.913 NM_000480
AMPD3
adenosine monophosphate deaminase 3
chr2_-_96174502 0.912 DUSP2
dual specificity phosphatase 2
chr5_-_169340321 0.909 NM_001129891
FAM196B
family with sequence similarity 196, member B
chr9_-_129656778 0.909 ENG
endoglin
chr21_+_25856311 0.908 MIR155HG
MIR155 host gene (non-protein coding)
chr1_-_159306327 0.902 ARHGAP30
Rho GTPase activating protein 30
chr1_-_72520735 0.902 NM_173808
NEGR1
neuronal growth regulator 1
chr22_+_29974314 0.899 NM_001031801
NM_016733
LIMK2

LIM domain kinase 2

chr9_-_83493415 0.897 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr3_+_127170717 0.895 NM_001012337
ROPN1B
rhophilin associated tail protein 1B
chr3_-_50371960 0.893 TMEM115
transmembrane protein 115
chr1_-_159306273 0.890 ARHGAP30
Rho GTPase activating protein 30
chr8_-_70907957 0.888 NM_001146009
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr8_+_24827173 0.887 NM_005382
NEFM
neurofilament, medium polypeptide
chr1_-_115433570 0.886 NM_005725
TSPAN2
tetraspanin 2
chr17_+_18069593 0.886 NM_004140
LLGL1
lethal giant larvae homolog 1 (Drosophila)
chr17_-_68100537 0.883 LOC100499467
hypothetical LOC100499467
chr4_+_166097579 0.882 C4orf39
chromosome 4 open reading frame 39
chr1_+_20788027 0.880 NM_001785
CDA
cytidine deaminase
chr1_+_46632505 0.878 NM_001441
FAAH
fatty acid amide hydrolase
chr17_-_53335748 0.876 NM_017949
CUEDC1
CUE domain containing 1
chr9_-_129656830 0.873 NM_000118
NM_001114753
ENG

endoglin

chr12_+_81605032 0.872 NM_152588
TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr4_+_3264509 0.865 RGS12
regulator of G-protein signaling 12
chr3_+_191714533 0.863 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
IL1RAP





interleukin 1 receptor accessory protein





chr10_-_91001496 0.858 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr15_+_39739864 0.849 NM_001080541
NM_001164273
MGA

MAX gene associated

chr18_-_24010944 0.845 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr5_-_157011949 0.845 NM_007017
NM_178424
SOX30

SRY (sex determining region Y)-box 30

chr11_-_11986704 0.840 NM_001018057
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr11_+_34599227 0.840 EHF
ets homologous factor
chr4_+_107036042 0.837 NM_001033047
NM_001184690
NM_001184691
NM_001184692
NM_001184693
NPNT




nephronectin




chr1_-_234295117 0.835 NID1
nidogen 1
chr10_-_123343320 0.834 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chr1_+_891739 0.832 NM_001160184
NM_032129
PLEKHN1

pleckstrin homology domain containing, family N member 1

chr15_-_83002797 0.830 NM_021077
NM_205858
NMB

neuromedin B

chr21_+_33364316 0.825 NM_138983
OLIG1
oligodendrocyte transcription factor 1
chr12_+_50271283 0.820 NM_014191
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr6_+_150326802 0.816 NM_025218
ULBP1
UL16 binding protein 1
chr2_-_96174865 0.813 NM_004418
DUSP2
dual specificity phosphatase 2
chr11_+_125262164 0.810 NM_001134793
HYLS1
hydrolethalus syndrome 1
chrX_-_100070553 0.797 NM_212559
XKRX
XK, Kell blood group complex subunit-related, X-linked
chr11_+_63815348 0.797 NM_033310
KCNK4
potassium channel, subfamily K, member 4
chr17_+_6495694 0.796 NM_001105520
C17orf100
chromosome 17 open reading frame 100
chr16_-_674357 0.793 NM_001005920
JMJD8
jumonji domain containing 8
chr14_-_103248193 0.784 XRCC3
X-ray repair complementing defective repair in Chinese hamster cells 3
chr7_-_76883642 0.783 NM_017439
PION
pigeon homolog (Drosophila)
chr2_-_225615556 0.780 NM_014689
DOCK10
dedicator of cytokinesis 10
chr4_-_99798563 0.777 NM_005723
TSPAN5
tetraspanin 5
chr12_+_122812994 0.774 NM_207437
DNAH10
dynein, axonemal, heavy chain 10
chr17_-_78249750 0.769 NM_006822
RAB40B
RAB40B, member RAS oncogene family
chr12_+_74160779 0.766 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr3_-_126414252 0.761 NM_024628
SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr17_+_74531873 0.760 C1QTNF1
C1q and tumor necrosis factor related protein 1
chr22_+_38720881 0.759 NM_138435
FAM83F
family with sequence similarity 83, member F
chr4_-_154900466 0.753


chr11_+_124438407 0.752 SLC37A2
solute carrier family 37 (glycerol-3-phosphate transporter), member 2
chr3_+_32408346 0.751 CMTM7
CKLF-like MARVEL transmembrane domain containing 7
chr9_+_5440455 0.746 NM_014143
CD274
CD274 molecule

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.26 7.74e-03 GO:0023052 signaling
2.87 9.81e-03 GO:0035023 regulation of Rho protein signal transduction
1.40 2.82e-02 GO:0023051 regulation of signaling
1.09 4.84e-02 GO:0009987 cellular process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.15 1.47e-03 GO:0016020 membrane
1.12 1.36e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.16 1.07e-02 GO:0005089 Rho guanyl-nucleotide exchange factor activity