Motif ID: NRF1.p2

Z-value: 3.220


Transcription factors associated with NRF1.p2:

Gene SymbolEntrez IDGene Name
NRF1 4899 nuclear respiratory factor 1



Activity profile for motif NRF1.p2.

activity profile for motif NRF1.p2


Sorted Z-values histogram for motif NRF1.p2

Sorted Z-values for motif NRF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NRF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_24302597 5.189 NM_001033561
NM_020889
PHF12

PHD finger protein 12

chr1_-_3763480 5.169 KIAA0562
KIAA0562
chr9_+_109085643 4.643 RAD23B
RAD23 homolog B (S. cerevisiae)
chr1_+_3763704 4.581 NM_004402
DFFB
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
chr7_-_116854765 4.564 NM_130768
ASZ1
ankyrin repeat, SAM and basic leucine zipper domain containing 1
chr9_+_109085386 4.161 RAD23B
RAD23 homolog B (S. cerevisiae)
chr5_+_271355 4.117 NM_004168
SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr6_-_43651745 4.035 NM_020750
XPO5
exportin 5
chr6_-_43651727 3.993 XPO5
exportin 5
chr10_+_86078136 3.933 NM_018999
FAM190B
family with sequence similarity 190, member B
chr6_+_43651855 3.814 NM_006502
POLH
polymerase (DNA directed), eta
chr12_+_52960798 3.786 HNRNPA1L2
HNRNPA1
HNRNPA1P10
heterogeneous nuclear ribonucleoprotein A1-like 2
heterogeneous nuclear ribonucleoprotein A1
heterogeneous nuclear ribonucleoprotein A1 pseudogene 10
chr6_+_43651899 3.749 POLH
polymerase (DNA directed), eta
chr9_+_109085372 3.698 RAD23B
RAD23 homolog B (S. cerevisiae)
chr12_+_52960745 3.672 NM_002136
NM_031157
HNRNPA1

heterogeneous nuclear ribonucleoprotein A1

chr8_+_1699276 3.546 NM_018941
CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr5_+_271447 3.427 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr1_+_35507197 3.412 ZMYM4
zinc finger, MYM-type 4
chr9_+_109085337 3.402 NM_002874
RAD23B
RAD23 homolog B (S. cerevisiae)
chr17_-_24302450 3.402 PHF12
PHD finger protein 12
chr1_+_229540396 3.391 C1orf124
chromosome 1 open reading frame 124
chr5_+_10303410 3.373 CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr1_-_3763620 3.367 NM_014704
KIAA0562
KIAA0562
chr5_+_271428 3.366 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr19_-_4351470 3.314 NM_003025
SH3GL1
SH3-domain GRB2-like 1
chr6_-_43651578 3.305 XPO5
exportin 5
chr1_-_241484963 3.229 CEP170
centrosomal protein 170kDa
chr7_+_116289833 3.227 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr1_+_109558107 3.226 SARS
seryl-tRNA synthetase
chr5_+_10303281 3.197 NM_012073
CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr22_-_21193037 3.192 ZNF280B
zinc finger protein 280B
chr7_-_142695392 3.182


chr1_+_32251988 3.173 NM_006559
KHDRBS1
KH domain containing, RNA binding, signal transduction associated 1
chr19_+_54280521 3.160 SNRNP70
small nuclear ribonucleoprotein 70kDa (U1)
chr5_+_10303370 3.148 CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr1_+_229540304 3.148 NM_001010984
NM_032018
C1orf124

chromosome 1 open reading frame 124

chr5_+_10303440 3.138 CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr22_-_19543069 3.124 NM_058004
PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr2_-_152393209 3.098 NM_001037174
NM_012097
NM_177985
ARL5A


ADP-ribosylation factor-like 5A


chr2_+_130655970 3.094 NM_025029
MZT2B
mitotic spindle organizing protein 2B
chr7_+_142695584 3.077 CASP2
caspase 2, apoptosis-related cysteine peptidase
chr10_-_69505048 3.050 NM_015601
NM_022079
HERC4

hect domain and RLD 4

chr7_+_142695511 3.038 NM_032982
NM_032983
CASP2

caspase 2, apoptosis-related cysteine peptidase

chr5_+_10303403 3.035 CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr19_+_43830154 3.027 NM_004924
ACTN4
actinin, alpha 4
chr19_+_54280528 3.009 SNRNP70
small nuclear ribonucleoprotein 70kDa (U1)
chr21_+_33066281 2.998 C21orf49
chromosome 21 open reading frame 49
chr19_+_54280497 2.991 SNRNP70
small nuclear ribonucleoprotein 70kDa (U1)
chr22_-_19543099 2.982 PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr3_+_10132314 2.969 NM_018462
C3orf10
chromosome 3 open reading frame 10
chr21_-_33065849 2.968 NM_013329
NM_016631
GCFC1

GC-rich sequence DNA-binding factor 1

chrX_-_73429101 2.956 MIR374AHG
mir-374a-545 cluster host gene (non-protein coding)
chr5_+_170747543 2.948 NPM1
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
chr19_+_43830146 2.943 ACTN4
actinin, alpha 4
chr1_+_109558085 2.917 SARS
seryl-tRNA synthetase
chr19_+_54280472 2.916 SNRNP70
small nuclear ribonucleoprotein 70kDa (U1)
chr9_+_132990760 2.913 NM_005085
NUP214
nucleoporin 214kDa
chr1_-_241485105 2.909 CEP170
centrosomal protein 170kDa
chr1_+_109558063 2.898 SARS
seryl-tRNA synthetase
chr9_+_132990834 2.897 NUP214
nucleoporin 214kDa
chr8_-_117956062 2.892 RAD21
RAD21 homolog (S. pombe)
chr7_+_99865340 2.877 MEPCE
methylphosphate capping enzyme
chr2_+_79593679 2.874 CTNNA2
catenin (cadherin-associated protein), alpha 2
chr10_-_69504956 2.865 HERC4
hect domain and RLD 4
chr19_-_55124543 2.853 NUP62
nucleoporin 62kDa
chr7_+_142695570 2.850 CASP2
caspase 2, apoptosis-related cysteine peptidase
chr22_-_19543012 2.843 PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr19_+_43830189 2.842 ACTN4
actinin, alpha 4
chr19_-_55124546 2.800 NM_012346
NM_153718
NM_153719
NM_001193357
NM_172374
NUP62



IL4I1
nucleoporin 62kDa



interleukin 4 induced 1
chr5_+_134209628 2.788 C5orf24
chromosome 5 open reading frame 24
chr10_-_74526596 2.777 P4HA1
prolyl 4-hydroxylase, alpha polypeptide I
chr7_+_116289827 2.774 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr19_+_54280211 2.748 NM_003089
SNRNP70
small nuclear ribonucleoprotein 70kDa (U1)
chr5_+_10303377 2.731 CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr13_-_78075683 2.723 NM_006237
POU4F1
POU class 4 homeobox 1
chr22_+_19543248 2.722 NM_004782
SNAP29
synaptosomal-associated protein, 29kDa
chr19_-_2734332 2.692 NM_003021
SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr18_+_72663446 2.678 ZNF236
zinc finger protein 236
chr12_-_123023052 2.669 NM_025140
CCDC92
coiled-coil domain containing 92
chr11_-_64301807 2.667 NM_001178031
SF1
splicing factor 1
chr3_-_14963980 2.659


chr21_+_33619147 2.654 IFNAR1
interferon (alpha, beta and omega) receptor 1
chr17_+_55325268 2.600 RPS6KB1
ribosomal protein S6 kinase, 70kDa, polypeptide 1
chr1_-_229181219 2.598 TTC13
tetratricopeptide repeat domain 13
chr7_+_116289765 2.595 NM_006136
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr12_-_123023312 2.594 CCDC92
coiled-coil domain containing 92
chr3_-_14963943 2.578


chr1_+_109558062 2.578 SARS
seryl-tRNA synthetase
chr22_-_21193504 2.578 NM_080764
ZNF280B
zinc finger protein 280B
chr3_-_47798341 2.575 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr8_+_145486245 2.574 HSF1
heat shock transcription factor 1
chr19_+_43830128 2.569 ACTN4
actinin, alpha 4
chr5_+_271441 2.568 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr2_-_150152531 2.563 NM_015702
MMADHC
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr2_-_152393179 2.562 ARL5A
ADP-ribosylation factor-like 5A
chr1_+_109557984 2.551 NM_006513
SARS
seryl-tRNA synthetase
chr10_+_27833167 2.549 NM_021252
RAB18
RAB18, member RAS oncogene family
chr20_-_55533544 2.545 NM_080618
CTCFL
CCCTC-binding factor (zinc finger protein)-like
chr8_-_145485897 2.540 BOP1
block of proliferation 1
chr10_-_73281056 2.523 NM_001042465
NM_001042466
NM_002778
PSAP


prosaposin


chr5_-_88214720 2.522 MEF2C
myocyte enhancer factor 2C
chr19_-_47413733 2.520 DEDD2
death effector domain containing 2
chr12_-_52960168 2.514 NM_012117
CBX5
chromobox homolog 5
chr1_-_229181203 2.508 TTC13
tetratricopeptide repeat domain 13
chr21_+_46703192 2.507 NM_001146114
NM_001146115
NM_001146116
NM_015151
NM_206889
NM_206890
NM_206891
DIP2A






DIP2 disco-interacting protein 2 homolog A (Drosophila)






chr15_+_94674849 2.494 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr1_-_201124848 2.486 NM_002871
RABIF
RAB interacting factor
chr1_-_154574716 2.482 CCT3
chaperonin containing TCP1, subunit 3 (gamma)
chr4_+_6768682 2.480 NM_018366
CNO
cappuccino homolog (mouse)
chr1_-_154574688 2.480 CCT3
chaperonin containing TCP1, subunit 3 (gamma)
chr2_-_152393128 2.479 ARL5A
ADP-ribosylation factor-like 5A
chr6_+_41148869 2.459 NFYA
nuclear transcription factor Y, alpha
chr2_-_150152482 2.446 MMADHC
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr22_+_19543350 2.441 SNAP29
synaptosomal-associated protein, 29kDa
chr1_-_174442987 2.440 NM_001001740
NM_022457
RFWD2

ring finger and WD repeat domain 2

chr18_+_10516022 2.437 NAPG
N-ethylmaleimide-sensitive factor attachment protein, gamma
chr5_-_271235 2.434 NM_145265
CCDC127
coiled-coil domain containing 127
chr10_-_74526662 2.430 NM_000917
NM_001017962
NM_001142595
NM_001142596
P4HA1



prolyl 4-hydroxylase, alpha polypeptide I



chr2_-_17798489 2.426 SMC6
structural maintenance of chromosomes 6
chr12_+_123023521 2.425 NM_152437
ZNF664
zinc finger protein 664
chr16_+_28742066 2.413 ATXN2L
ataxin 2-like
chr1_-_154574671 2.412 CCT3
chaperonin containing TCP1, subunit 3 (gamma)
chr1_+_24842298 2.412 SRRM1
serine/arginine repetitive matrix 1
chr6_-_135417647 2.408 NM_001145158
NM_001145207
NM_006620
HBS1L


HBS1-like (S. cerevisiae)


chr3_+_151803755 2.402 NM_016275
SELT
selenoprotein T
chr1_-_229181229 2.387 TTC13
tetratricopeptide repeat domain 13
chr12_-_52960206 2.385 CBX5
chromobox homolog 5
chr1_-_229540101 2.383 NM_175876
EXOC8
exocyst complex component 8
chr2_-_17798560 2.380 NM_001142286
NM_024624
SMC6

structural maintenance of chromosomes 6

chr10_+_99175994 2.378 PGAM1
phosphoglycerate mutase 1 (brain)
chr17_+_55325224 2.369 NM_003161
RPS6KB1
ribosomal protein S6 kinase, 70kDa, polypeptide 1
chr1_-_174442906 2.366 RFWD2
ring finger and WD repeat domain 2
chr19_-_55124484 2.359 IL4I1
interleukin 4 induced 1
chr2_-_37164962 2.346 NM_019024
HEATR5B
HEAT repeat containing 5B
chr16_+_83291107 2.346 USP10
ubiquitin specific peptidase 10
chr12_+_52132176 2.313 PCBP2
poly(rC) binding protein 2
chr7_-_42938304 2.312 NM_002787
PSMA2
proteasome (prosome, macropain) subunit, alpha type, 2
chr2_+_26110487 2.311 RAB10
RAB10, member RAS oncogene family
chr13_-_19255081 2.306 NM_001042414
PSPC1
paraspeckle component 1
chr16_+_83291097 2.306 USP10
ubiquitin specific peptidase 10
chr1_+_24842353 2.294 SRRM1
serine/arginine repetitive matrix 1
chr3_-_47798372 2.289 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr6_-_135417522 2.285 HBS1L
HBS1-like (S. cerevisiae)
chr16_+_83291112 2.277 USP10
ubiquitin specific peptidase 10
chr1_-_154574595 2.277 CCT3
chaperonin containing TCP1, subunit 3 (gamma)
chr8_+_145486093 2.275 HSF1
heat shock transcription factor 1
chr4_+_6768800 2.268 CNO
cappuccino homolog (mouse)
chr19_-_55124491 2.263 NUP62
IL4I1
nucleoporin 62kDa
interleukin 4 induced 1
chr1_-_154574723 2.260 NM_001008800
NM_005998
CCT3

chaperonin containing TCP1, subunit 3 (gamma)

chrX_-_153016173 2.254 MECP2
LOC728653
methyl CpG binding protein 2 (Rett syndrome)
hypothetical protein LOC728653
chr1_+_227473458 2.251 NM_004578
RAB4A
RAB4A, member RAS oncogene family
chr5_+_134209444 2.250 NM_001135586
C5orf24
chromosome 5 open reading frame 24
chr2_+_26110232 2.248 NM_016131
RAB10
RAB10, member RAS oncogene family
chr3_-_40473723 2.245


chr19_-_55124490 2.237 NUP62
nucleoporin 62kDa
chr12_-_52960146 2.234 CBX5
chromobox homolog 5
chr7_+_158341961 2.229 NM_018051
WDR60
WD repeat domain 60
chr2_-_150152361 2.227 MMADHC
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr8_+_145486096 2.225 HSF1
heat shock transcription factor 1
chr1_-_154987708 2.221 HDGF
hepatoma-derived growth factor
chr16_+_83291055 2.220 NM_005153
USP10
ubiquitin specific peptidase 10
chr1_-_16551514 2.203 NM_018994
FBXO42
F-box protein 42
chr2_-_17798537 2.201 SMC6
structural maintenance of chromosomes 6
chr1_+_165456572 2.194 NM_001198786
NM_002697
POU2F1

POU class 2 homeobox 1

chr22_+_19601940 2.193 CRKL
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
chr17_+_46692908 2.187 UTP18
UTP18, small subunit (SSU) processome component, homolog (yeast)
chr8_+_145486052 2.185 NM_005526
HSF1
heat shock transcription factor 1
chr16_+_23754997 2.185 PRKCB
protein kinase C, beta
chrX_-_153360789 2.177 NM_006014
LAGE3
L antigen family, member 3
chr10_+_6170972 2.174 RBM17
RNA binding motif protein 17
chr3_+_15222747 2.169 CAPN7
calpain 7
chr19_+_60803412 2.166 NM_153219
ZNF524
zinc finger protein 524
chr2_+_37165097 2.162 NM_174931
CCDC75
coiled-coil domain containing 75
chr7_-_42938255 2.160 PSMA2
proteasome (prosome, macropain) subunit, alpha type, 2
chr1_+_35507145 2.159 NM_005095
ZMYM4
zinc finger, MYM-type 4
chr9_-_37894098 2.148 MCART1
mitochondrial carrier triple repeat 1
chr19_-_55124764 2.147 NM_016553
NUP62
nucleoporin 62kDa
chr8_-_145485879 2.145 BOP1
block of proliferation 1
chr10_-_73281047 2.141 PSAP
prosaposin
chr18_+_10516044 2.140 NAPG
N-ethylmaleimide-sensitive factor attachment protein, gamma
chr18_+_10515861 2.140 NM_003826
NAPG
N-ethylmaleimide-sensitive factor attachment protein, gamma
chr10_+_105716925 2.122 SLK
STE20-like kinase
chr8_+_145486087 2.121 HSF1
heat shock transcription factor 1
chr8_-_145485822 2.121 BOP1
block of proliferation 1
chr2_-_37164919 2.118 HEATR5B
HEAT repeat containing 5B
chr10_-_69505018 2.114 HERC4
hect domain and RLD 4
chr17_+_46692891 2.108 NM_016001
UTP18
UTP18, small subunit (SSU) processome component, homolog (yeast)
chr12_+_129922570 2.100 RAN
RAN, member RAS oncogene family
chr11_-_75769514 2.074 NM_004705
PRKRIR
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
chr2_+_28828112 2.063 NM_206876
NM_002709
PPP1CB

protein phosphatase 1, catalytic subunit, beta isozyme

chr10_-_135229035 2.058 NM_001143763
NM_001143764
SYCE1

synaptonemal complex central element protein 1

chr22_-_19686351 2.055 NM_001008695
NM_030573
THAP7

THAP domain containing 7

chr19_-_55124459 2.054 IL4I1
interleukin 4 induced 1
chr10_+_70150936 2.040 NM_018237
CCAR1
cell division cycle and apoptosis regulator 1
chr3_+_14964080 2.038 NM_003298
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr18_+_10516095 2.036 NAPG
N-ethylmaleimide-sensitive factor attachment protein, gamma
chrX_+_135406903 2.025 NM_001163280
HTATSF1
HIV-1 Tat specific factor 1
chr22_+_19601723 2.023 CRKL
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
chr21_+_33619067 2.020 NM_000629
IFNAR1
interferon (alpha, beta and omega) receptor 1
chr5_-_88215034 2.009 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.58 3.54e-48 GO:0044260 cellular macromolecule metabolic process
1.40 1.34e-38 GO:0044237 cellular metabolic process
1.47 2.44e-37 GO:0043170 macromolecule metabolic process
1.36 3.19e-32 GO:0044238 primary metabolic process
1.72 8.44e-30 GO:0090304 nucleic acid metabolic process
1.62 3.36e-29 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.31 3.53e-29 GO:0008152 metabolic process
1.73 7.91e-25 GO:0010467 gene expression
1.60 5.38e-24 GO:0044267 cellular protein metabolic process
1.74 1.87e-23 GO:0016070 RNA metabolic process
1.50 7.57e-23 GO:0034641 cellular nitrogen compound metabolic process
1.49 3.43e-22 GO:0006807 nitrogen compound metabolic process
2.24 3.93e-21 GO:0006396 RNA processing
2.27 6.56e-18 GO:0016071 mRNA metabolic process
1.44 2.72e-16 GO:0019538 protein metabolic process
2.42 9.16e-16 GO:0006397 mRNA processing
2.49 2.46e-13 GO:0008380 RNA splicing
1.56 1.97e-12 GO:0034645 cellular macromolecule biosynthetic process
1.54 5.56e-12 GO:0009059 macromolecule biosynthetic process
1.56 5.65e-12 GO:0006996 organelle organization
2.75 8.00e-12 GO:0000375 RNA splicing, via transesterification reactions
1.12 8.49e-12 GO:0009987 cellular process
1.95 9.88e-12 GO:0051276 chromosome organization
2.36 3.11e-11 GO:0006412 translation
4.13 5.23e-11 GO:0006405 RNA export from nucleus
2.70 9.96e-11 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.70 9.96e-11 GO:0000398 nuclear mRNA splicing, via spliceosome
3.71 1.26e-10 GO:0051168 nuclear export
1.83 4.74e-10 GO:0022403 cell cycle phase
1.38 5.37e-10 GO:0071841 cellular component organization or biogenesis at cellular level
3.09 6.80e-10 GO:0006403 RNA localization
3.12 7.36e-10 GO:0050657 nucleic acid transport
3.12 7.36e-10 GO:0050658 RNA transport
3.12 7.36e-10 GO:0051236 establishment of RNA localization
3.19 1.87e-09 GO:0051028 mRNA transport
2.04 2.07e-09 GO:0000279 M phase
1.93 2.64e-09 GO:0044265 cellular macromolecule catabolic process
4.07 2.82e-09 GO:0006406 mRNA export from nucleus
1.44 6.25e-09 GO:0043412 macromolecule modification
1.93 6.47e-09 GO:0006974 response to DNA damage stimulus
2.81 2.22e-08 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
1.36 2.40e-08 GO:0071842 cellular component organization at cellular level
1.37 3.54e-08 GO:0044249 cellular biosynthetic process
1.82 5.02e-08 GO:0006259 DNA metabolic process
1.68 6.64e-08 GO:0033554 cellular response to stress
1.43 6.82e-08 GO:0006464 protein modification process
1.60 7.52e-08 GO:0007049 cell cycle
1.80 7.62e-08 GO:0009057 macromolecule catabolic process
2.52 1.47e-07 GO:0051169 nuclear transport
1.67 1.69e-07 GO:0022402 cell cycle process
1.80 1.98e-07 GO:0000278 mitotic cell cycle
1.34 2.78e-07 GO:0009058 biosynthetic process
2.50 2.96e-07 GO:0006913 nucleocytoplasmic transport
1.66 4.85e-07 GO:0046907 intracellular transport
1.53 7.60e-07 GO:0044248 cellular catabolic process
2.10 7.80e-07 GO:0000087 M phase of mitotic cell cycle
2.02 9.52e-07 GO:0006281 DNA repair
2.06 2.36e-06 GO:0048285 organelle fission
2.07 3.26e-06 GO:0000280 nuclear division
2.07 3.26e-06 GO:0007067 mitosis
1.25 1.22e-05 GO:0071840 cellular component organization or biogenesis
2.06 1.23e-05 GO:0032446 protein modification by small protein conjugation
1.78 2.77e-05 GO:0006325 chromatin organization
1.93 2.88e-05 GO:0070647 protein modification by small protein conjugation or removal
3.02 4.64e-05 GO:0000956 nuclear-transcribed mRNA catabolic process
2.04 5.88e-05 GO:0016567 protein ubiquitination
1.81 6.04e-05 GO:0016032 viral reproduction
2.90 7.96e-05 GO:0006402 mRNA catabolic process
2.99 1.02e-04 GO:0031123 RNA 3'-end processing
3.18 1.33e-04 GO:0031124 mRNA 3'-end processing
1.24 1.89e-04 GO:0016043 cellular component organization
1.96 3.37e-04 GO:0034660 ncRNA metabolic process
2.55 3.81e-04 GO:0006401 RNA catabolic process
1.51 4.07e-04 GO:0015031 protein transport
1.38 6.48e-04 GO:0009056 catabolic process
1.50 7.38e-04 GO:0045184 establishment of protein localization
1.79 7.55e-04 GO:0030163 protein catabolic process
1.84 8.88e-04 GO:0043632 modification-dependent macromolecule catabolic process
1.83 9.06e-04 GO:0051603 proteolysis involved in cellular protein catabolic process
1.82 9.23e-04 GO:0044257 cellular protein catabolic process
1.39 9.37e-04 GO:0033036 macromolecule localization
3.61 1.08e-03 GO:0006413 translational initiation
1.78 1.38e-03 GO:0051301 cell division
1.83 1.44e-03 GO:0006511 ubiquitin-dependent protein catabolic process
2.86 1.46e-03 GO:0006302 double-strand break repair
1.82 1.47e-03 GO:0019941 modification-dependent protein catabolic process
1.41 2.27e-03 GO:0051649 establishment of localization in cell
1.45 2.27e-03 GO:0032774 RNA biosynthetic process
1.38 3.19e-03 GO:0051641 cellular localization
1.75 3.21e-03 GO:0044419 interspecies interaction between organisms
1.72 5.72e-03 GO:0016568 chromatin modification
1.81 6.26e-03 GO:0006366 transcription from RNA polymerase II promoter
1.95 6.52e-03 GO:0009203 ribonucleoside triphosphate catabolic process
1.95 6.52e-03 GO:0009207 purine ribonucleoside triphosphate catabolic process
1.94 7.56e-03 GO:0009146 purine nucleoside triphosphate catabolic process
1.91 1.17e-02 GO:0009143 nucleoside triphosphate catabolic process
1.91 1.17e-02 GO:0009154 purine ribonucleotide catabolic process
1.59 1.25e-02 GO:0034621 cellular macromolecular complex subunit organization
1.89 1.56e-02 GO:0009261 ribonucleotide catabolic process
1.79 1.86e-02 GO:0010608 posttranscriptional regulation of gene expression
1.38 1.88e-02 GO:0008104 protein localization
1.82 2.54e-02 GO:0072523 purine-containing compound catabolic process
1.41 3.96e-02 GO:0006351 transcription, DNA-dependent
2.59 4.36e-02 GO:0006200 ATP catabolic process
2.08 4.61e-02 GO:0006310 DNA recombination
1.65 4.62e-02 GO:0034622 cellular macromolecular complex assembly
1.69 4.68e-02 GO:0009150 purine ribonucleotide metabolic process
1.77 4.84e-02 GO:0009166 nucleotide catabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.24 1.34e-60 GO:0044424 intracellular part
1.23 7.51e-60 GO:0005622 intracellular
1.34 3.13e-59 GO:0043231 intracellular membrane-bounded organelle
1.34 3.37e-59 GO:0043227 membrane-bounded organelle
1.30 4.03e-56 GO:0043229 intracellular organelle
1.29 8.03e-56 GO:0043226 organelle
1.48 3.75e-50 GO:0005634 nucleus
1.77 1.25e-35 GO:0044428 nuclear part
1.41 3.18e-35 GO:0044446 intracellular organelle part
1.39 7.83e-34 GO:0044422 organelle part
1.70 1.80e-30 GO:0070013 intracellular organelle lumen
1.67 8.68e-30 GO:0031974 membrane-enclosed lumen
1.67 5.49e-29 GO:0043233 organelle lumen
1.74 5.22e-27 GO:0031981 nuclear lumen
1.47 2.42e-24 GO:0032991 macromolecular complex
1.77 3.34e-20 GO:0005654 nucleoplasm
1.21 1.20e-19 GO:0005737 cytoplasm
2.21 4.33e-17 GO:0030529 ribonucleoprotein complex
2.11 9.58e-16 GO:0005694 chromosome
1.24 3.26e-13 GO:0044444 cytoplasmic part
1.40 3.69e-13 GO:0043228 non-membrane-bounded organelle
1.40 3.69e-13 GO:0043232 intracellular non-membrane-bounded organelle
2.08 2.80e-12 GO:0044427 chromosomal part
1.36 1.28e-11 GO:0043234 protein complex
1.41 1.44e-09 GO:0005829 cytosol
1.05 2.11e-08 GO:0044464 cell part
1.05 2.23e-08 GO:0005623 cell
1.67 1.78e-07 GO:0044451 nucleoplasm part
1.76 2.05e-06 GO:0005730 nucleolus
1.44 2.67e-06 GO:0005739 mitochondrion
2.10 5.16e-06 GO:0000785 chromatin
1.61 8.28e-06 GO:0044429 mitochondrial part
2.17 4.69e-05 GO:0005819 spindle
2.35 1.00e-04 GO:0005681 spliceosomal complex
2.17 1.17e-04 GO:0044454 nuclear chromosome part
2.36 2.47e-04 GO:0044455 mitochondrial membrane part
1.54 2.69e-04 GO:0015630 microtubule cytoskeleton
2.25 3.53e-04 GO:0000151 ubiquitin ligase complex
1.98 4.11e-04 GO:0000228 nuclear chromosome
1.51 4.25e-04 GO:0031967 organelle envelope
1.50 6.57e-04 GO:0031975 envelope
1.73 1.10e-03 GO:0005815 microtubule organizing center
1.85 1.10e-03 GO:0005759 mitochondrial matrix
1.97 2.71e-03 GO:0005840 ribosome
2.54 3.49e-03 GO:0031461 cullin-RING ubiquitin ligase complex
2.63 6.37e-03 GO:0000922 spindle pole
3.85 8.19e-03 GO:0005680 anaphase-promoting complex
3.13 8.55e-03 GO:0008287 protein serine/threonine phosphatase complex
3.59 9.14e-03 GO:0000152 nuclear ubiquitin ligase complex
2.10 1.55e-02 GO:0016607 nuclear speck
1.62 2.32e-02 GO:0019866 organelle inner membrane
1.63 3.54e-02 GO:0005743 mitochondrial inner membrane
2.33 3.55e-02 GO:0071013 catalytic step 2 spliceosome
1.75 3.85e-02 GO:0016604 nuclear body
1.74 4.33e-02 GO:0005813 centrosome
1.95 4.83e-02 GO:0000793 condensed chromosome

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.50 5.91e-26 GO:0003676 nucleic acid binding
1.27 1.45e-23 GO:0005515 protein binding
2.06 4.29e-22 GO:0003723 RNA binding
1.12 2.00e-15 GO:0005488 binding
1.41 1.03e-10 GO:0000166 nucleotide binding
1.91 1.99e-08 GO:0016874 ligase activity
1.34 5.38e-07 GO:0003677 DNA binding
1.19 6.13e-07 GO:0003824 catalytic activity
2.05 3.93e-06 GO:0016881 acid-amino acid ligase activity
1.98 4.87e-06 GO:0016879 ligase activity, forming carbon-nitrogen bonds
2.06 2.83e-05 GO:0019787 small conjugating protein ligase activity
1.37 8.45e-05 GO:0005524 ATP binding
1.32 9.62e-05 GO:0035639 purine ribonucleoside triphosphate binding
1.36 1.45e-04 GO:0030554 adenyl nucleotide binding
1.35 2.05e-04 GO:0032559 adenyl ribonucleotide binding
1.31 2.46e-04 GO:0017076 purine nucleotide binding
1.31 3.05e-04 GO:0032553 ribonucleotide binding
1.31 3.05e-04 GO:0032555 purine ribonucleotide binding
1.96 7.24e-04 GO:0004842 ubiquitin-protein ligase activity
2.26 6.16e-03 GO:0016779 nucleotidyltransferase activity
3.00 6.99e-03 GO:0003743 translation initiation factor activity
2.47 8.12e-03 GO:0008135 translation factor activity, nucleic acid binding
2.52 1.24e-02 GO:0047485 protein N-terminus binding
1.42 1.25e-02 GO:0016462 pyrophosphatase activity
1.41 1.53e-02 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
2.16 1.63e-02 GO:0051082 unfolded protein binding
2.00 1.75e-02 GO:0003735 structural constituent of ribosome
1.41 1.86e-02 GO:0016817 hydrolase activity, acting on acid anhydrides
1.42 1.96e-02 GO:0017111 nucleoside-triphosphatase activity
8.01 2.33e-02 GO:0017070 U6 snRNA binding
1.86 2.70e-02 GO:0043566 structure-specific DNA binding
2.67 2.77e-02 GO:0003697 single-stranded DNA binding
1.84 3.55e-02 GO:0003682 chromatin binding
1.25 4.91e-02 GO:0016740 transferase activity