Motif ID: HNF4A_NR2F1,2.p2

Z-value: 7.194


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2



Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_102722275 19.870 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr12_+_51783540 17.341 NM_003578
SOAT2
sterol O-acyltransferase 2
chr12_+_51783554 16.880 SOAT2
sterol O-acyltransferase 2
chr10_-_101831579 15.811 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr2_+_241193492 15.315 NM_001195381
NM_001195382
GPR35

G protein-coupled receptor 35

chr6_+_131190237 15.179 NM_001195597
LOC285733
hypothetical LOC285733
chr14_-_23847000 14.943 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_23846993 14.188 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_23847024 14.139 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_23846904 14.018 CIDEB
cell death-inducing DFFA-like effector b
chr17_+_69950782 13.964 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr17_+_24394281 13.733 PIPOX
pipecolic acid oxidase
chr17_-_31353196 13.698 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr6_+_31731647 13.469 NM_019101
APOM
apolipoprotein M
chr6_+_31731667 13.376 APOM
apolipoprotein M
chr3_-_52454082 13.354 NM_020163
SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr16_+_21152516 13.183 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr20_-_3097070 12.645 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr1_+_15941503 12.608 NM_001013641
TMEM82
transmembrane protein 82
chr9_-_126309510 12.607 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr2_-_74606819 12.343 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1
chr19_+_46640902 12.307 NM_001130514
C19orf69
chromosome 19 open reading frame 69
chr1_-_172153087 12.174 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr1_-_172153024 12.025 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr6_+_32090516 11.977 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr2_-_238164042 11.425 RAB17
RAB17, member RAS oncogene family
chr20_+_34937928 11.380 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr20_-_52120421 11.354 BCAS1
breast carcinoma amplified sequence 1
chr19_+_4104593 11.288 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr1_-_176205672 11.260 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr19_-_63715135 11.200 NM_012254
SLC27A5
solute carrier family 27 (fatty acid transporter), member 5
chr9_-_129752687 11.092 NM_203305
FAM102A
family with sequence similarity 102, member A
chr8_+_21972631 10.964 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr20_-_52120710 10.634 NM_003657
BCAS1
breast carcinoma amplified sequence 1
chr17_-_31352643 10.555 CCL14-CCL15
CCL15
CCL14-CCL15 read-through transcript
chemokine (C-C motif) ligand 15
chr17_-_31352720 10.528 CCL14-CCL15
CCL14-CCL15 read-through transcript
chr1_-_176205970 10.385 SEC16B
SEC16 homolog B (S. cerevisiae)
chr1_-_153537810 10.169 NM_000298
PKLR
pyruvate kinase, liver and RBC
chr8_+_21972804 10.078 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr19_-_55708936 9.881 NM_001114598
ASPDH
aspartate dehydrogenase domain containing
chr20_+_55569542 9.854 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr13_+_112825113 9.609 NM_000504
F10
coagulation factor X
chr10_+_114123828 9.554 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr6_-_29635456 9.398 UBD
ubiquitin D
chr15_+_83228895 9.350 NM_004213
NM_201651
SLC28A1

solute carrier family 28 (sodium-coupled nucleoside transporter), member 1

chr15_+_41672543 9.316 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr7_+_101704145 9.282 CUX1
cut-like homeobox 1
chr9_-_14858974 9.088 FREM1
FRAS1 related extracellular matrix 1
chr16_+_464844 8.977 NM_001142272
RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr16_-_86527608 8.771 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr2_-_238164452 8.721 NM_022449
RAB17
RAB17, member RAS oncogene family
chr6_+_30238961 8.683 NM_033229
TRIM15
tripartite motif containing 15
chr6_-_31953425 8.660 NM_001178045
SLC44A4
solute carrier family 44, member 4
chr2_+_218992053 8.654 NM_007127
VIL1
villin 1
chr1_-_167822248 8.503 F5
coagulation factor V (proaccelerin, labile factor)
chr1_-_110108048 8.498 NM_024526
NM_133181
NM_139053
EPS8L3


EPS8-like 3


chr19_-_15451203 8.417 NM_052890
PGLYRP2
peptidoglycan recognition protein 2
chr16_-_45339605 8.376 NM_182493
MYLK3
myosin light chain kinase 3
chr10_+_114123765 8.366 ACSL5
acyl-CoA synthetase long-chain family member 5
chr7_-_50600536 8.361 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr17_+_38259620 8.310 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr17_+_7474177 8.304 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr8_-_82769761 8.109 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr22_+_43451600 7.986 PRR5
proline rich 5 (renal)
chr14_-_93924873 7.863 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr10_-_76529253 7.745 NM_016364
DUSP13
dual specificity phosphatase 13
chr17_+_7474128 7.742 SHBG
sex hormone-binding globulin
chr2_+_11597530 7.730 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr10_-_74384485 7.703 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr2_+_242398954 7.651 NEU4
sialidase 4
chr20_+_35406497 7.632 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr19_-_15906669 7.510 NM_001128932
NM_021187
CYP4F11

cytochrome P450, family 4, subfamily F, polypeptide 11

chr3_-_42892195 7.466 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr6_+_32057779 7.382 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr12_-_55637648 7.309 NM_003708
RDH16
retinol dehydrogenase 16 (all-trans)
chr3_-_195553297 7.292 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr19_-_38052481 7.289 NM_001126335
NM_014270
SLC7A9

solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

chr11_-_116213511 7.189 NM_000039
APOA1
apolipoprotein A-I
chr1_-_153537362 7.145 NM_181871
PKLR
pyruvate kinase, liver and RBC
chr10_-_74384569 7.097 PLA2G12B
phospholipase A2, group XIIB
chr19_-_63556632 7.095 NM_130786
A1BG
alpha-1-B glycoprotein
chr1_+_1351370 7.095 NM_001146685
TMEM88B
transmembrane protein 88B
chr12_+_107797985 6.915 NM_001917
DAO
D-amino-acid oxidase
chr2_+_27573206 6.884 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr13_+_112808102 6.852 NM_000131
NM_019616
F7

coagulation factor VII (serum prothrombin conversion accelerator)

chr8_-_110773195 6.831 NM_001099743
NM_001099744
SYBU

syntabulin (syntaxin-interacting)

chr8_+_22909305 6.815 NM_001160037
RHOBTB2
Rho-related BTB domain containing 2
chr19_+_40321584 6.758 FXYD1
FXYD domain containing ion transport regulator 1
chr17_+_24394043 6.686 NM_016518
PIPOX
pipecolic acid oxidase
chr17_-_68769613 6.668 NM_001129885
CPSF4L
cleavage and polyadenylation specific factor 4-like
chr1_-_159459814 6.607 APOA2
apolipoprotein A-II
chr12_+_119900931 6.533 NM_000545
HNF1A
HNF1 homeobox A
chr19_-_19142053 6.527 MEF2B
myocyte enhancer factor 2B
chr20_+_31059038 6.504 NM_025227
BPIL1
bactericidal/permeability-increasing protein-like 1
chr16_+_56211410 6.481 NM_001145770
NM_005682
GPR56

G protein-coupled receptor 56

chr6_+_32003380 6.468 C2
complement component 2
chr1_-_167822334 6.436 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr11_+_60858611 6.343 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr2_+_113648036 6.336 PSD4
pleckstrin and Sec7 domain containing 4
chr19_-_4253389 6.329 NM_001169126
NM_144615
TMIGD2

transmembrane and immunoglobulin domain containing 2

chr19_+_40321567 6.280 NM_021902
FXYD1
FXYD domain containing ion transport regulator 1
chr3_-_58497913 6.261 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr12_+_56114724 6.257 NM_005538
INHBC
inhibin, beta C
chr17_+_4621924 6.227 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr16_+_82540172 6.214 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr16_-_51138306 6.190 NM_001080430
TOX3
TOX high mobility group box family member 3
chr7_-_100630912 6.178 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr1_-_11029882 6.154 MASP2
mannan-binding lectin serine peptidase 2
chr2_-_88208650 6.138 NM_001443
FABP1
fatty acid binding protein 1, liver
chr1_-_24307514 6.136 MYOM3
myomesin family, member 3
chr22_+_19651446 6.092 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr17_+_38306339 6.084 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr2_-_208702760 6.039 NM_020989
CRYGC
crystallin, gamma C
chr12_+_119900677 6.025 HNF1A
HNF1 homeobox A
chr6_+_32021793 6.021 CFB
complement factor B
chr2_-_233586145 5.959 NGEF
neuronal guanine nucleotide exchange factor
chr17_-_33179118 5.939 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr17_-_33178987 5.898 HNF1B
HNF1 homeobox B
chr5_+_133870175 5.857


chr12_-_192752 5.795 NM_003044
SLC6A12
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr15_+_38082041 5.653 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr17_-_33982580 5.649 SRCIN1
SRC kinase signaling inhibitor 1
chr2_-_233586164 5.611 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr20_-_32363268 5.599 NM_001161766
AHCY
adenosylhomocysteinase
chr17_+_73638430 5.546 NM_152468
TMC8
transmembrane channel-like 8
chr4_+_100714995 5.535 MTTP
microsomal triglyceride transfer protein
chr12_-_1791146 5.525 CACNA2D4
calcium channel, voltage-dependent, alpha 2/delta subunit 4
chr4_-_1156959 5.493 NM_001128325
SPON2
spondin 2, extracellular matrix protein
chr17_+_35147697 5.476 NM_005310
GRB7
growth factor receptor-bound protein 7
chr3_-_198784590 5.438 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr4_-_9632192 5.436 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr17_-_71352090 5.405 UNC13D
unc-13 homolog D (C. elegans)
chr16_+_68542126 5.399 NM_001136214
CLEC18A
C-type lectin domain family 18, member A
chr2_+_218929822 5.354 NM_198559
C2orf62
chromosome 2 open reading frame 62
chr1_-_1346465 5.318 NM_001145210
LOC441869
hypothetical protein LOC441869
chr11_-_116168316 5.315 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr17_-_71352017 5.305 UNC13D
unc-13 homolog D (C. elegans)
chr7_+_142692165 5.281 NM_153345
TMEM139
transmembrane protein 139
chr17_-_7023378 5.234 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr12_-_7935010 5.211 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr11_+_66070949 5.192 NM_001104
ACTN3
actinin, alpha 3
chr21_+_41616590 5.192 FAM3B
family with sequence similarity 3, member B
chr3_-_121883647 5.169 HGD
homogentisate 1,2-dioxygenase
chr8_-_142307854 5.119 NM_001080431
SLC45A4
solute carrier family 45, member 4
chr12_+_50342814 5.049 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr8_+_144192011 5.031 NM_173687
C8orf31
chromosome 8 open reading frame 31
chr3_-_140677990 5.025 NM_004164
RBP2
retinol binding protein 2, cellular
chr6_+_32003180 5.025 NM_000063
NM_001145903
C2

complement component 2

chr7_+_100037817 5.015 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr17_-_71352182 5.006 NM_199242
UNC13D
unc-13 homolog D (C. elegans)
chr6_+_46869052 5.001 NM_005588
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr5_-_42847716 4.995 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr1_-_159459999 4.989 NM_001643
APOA2
apolipoprotein A-II
chr3_-_197422653 4.987 NM_001039617
ZDHHC19
zinc finger, DHHC-type containing 19
chr16_+_8722068 4.974 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr12_+_56802 4.824 NM_015232
IQSEC3
IQ motif and Sec7 domain 3
chr19_-_19142090 4.822 NM_001145785
MEF2B
myocyte enhancer factor 2B
chr16_-_46826588 4.817 NM_032583
NM_145186
ABCC11

ATP-binding cassette, sub-family C (CFTR/MRP), member 11

chr6_-_31853027 4.807 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr11_-_6418705 4.798 NM_000613
HPX
hemopexin
chr1_+_226404037 4.767 NM_020435
GJC2
gap junction protein, gamma 2, 47kDa
chr17_-_23721351 4.744 VTN
vitronectin
chr22_-_40856821 4.744 NM_000106
NM_001025161
CYP2D6

cytochrome P450, family 2, subfamily D, polypeptide 6

chr6_+_32021742 4.741 CFB
complement factor B
chr11_+_46697312 4.734 NM_000506
F2
coagulation factor II (thrombin)
chr17_+_70244553 4.728 NM_001163989
RAB37
RAB37, member RAS oncogene family
chr17_-_71535076 4.723 NM_001988
EVPL
envoplakin
chr14_+_20226762 4.716 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chrX_+_128700605 4.710 NM_003399
XPNPEP2
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
chr17_-_31332568 4.666 NM_004590
CCL16
chemokine (C-C motif) ligand 16
chr16_+_24765052 4.658 NM_052944
SLC5A11
solute carrier family 5 (sodium/glucose cotransporter), member 11
chr6_-_168222645 4.653 NM_024919
FRMD1
FERM domain containing 1
chr11_+_45899747 4.633 NM_152312
GYLTL1B
glycosyltransferase-like 1B
chr1_-_11029737 4.630 NM_006610
NM_139208
MASP2

mannan-binding lectin serine peptidase 2

chr22_-_35835548 4.625 TMPRSS6
transmembrane protease, serine 6
chr11_+_46697335 4.619 F2
coagulation factor II (thrombin)
chr11_+_73036241 4.614 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr13_-_112392051 4.604 LOC440149
hypothetical LOC440149
chr14_-_22658078 4.603 NM_001805
CEBPE
CCAAT/enhancer binding protein (C/EBP), epsilon
chr4_+_3413489 4.575 NM_001528
HGFAC
HGF activator
chr13_+_49658016 4.554


chr16_-_54424517 4.535 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr2_+_242398832 4.526 NM_001167600
NM_001167601
NEU4

sialidase 4

chr22_-_40856736 4.496 CYP2D6
cytochrome P450, family 2, subfamily D, polypeptide 6
chr11_+_74548472 4.490 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr1_-_120112989 4.480 NM_001166107
NM_005518
HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

chr19_-_4491078 4.475 LRG1
leucine-rich alpha-2-glycoprotein 1
chr3_-_42892636 4.466 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr7_-_142816019 4.455 NM_005232
EPHA1
EPH receptor A1
chr17_-_6958773 4.449 NM_001181
NM_080912
NM_080913
ASGR2


asialoglycoprotein receptor 2


chr1_+_144439069 4.449 NM_002614
PDZK1
PDZ domain containing 1
chr19_+_6415259 4.445 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr11_+_46697345 4.427 F2
coagulation factor II (thrombin)
chr6_+_43373986 4.427 SLC22A7
solute carrier family 22 (organic anion transporter), member 7
chr4_+_3413457 4.414 HGFAC
HGF activator
chr12_-_49708279 4.408 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr3_-_10522340 4.387 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr9_-_35640852 4.368 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr16_-_30032330 4.348 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr16_+_55963883 4.332 CX3CL1
chemokine (C-X3-C motif) ligand 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.35 3.82e-08 GO:0042221 response to chemical stimulus
1.34 2.62e-05 GO:0044281 small molecule metabolic process
1.53 1.49e-04 GO:0006082 organic acid metabolic process
1.52 5.26e-04 GO:0019752 carboxylic acid metabolic process
1.52 5.26e-04 GO:0043436 oxoacid metabolic process
1.27 5.28e-04 GO:0065008 regulation of biological quality
1.50 6.98e-04 GO:0042180 cellular ketone metabolic process
1.36 1.01e-03 GO:0010033 response to organic substance
1.13 2.15e-03 GO:0050896 response to stimulus
1.84 7.82e-03 GO:0006631 fatty acid metabolic process
1.38 1.63e-02 GO:0070887 cellular response to chemical stimulus
1.67 1.71e-02 GO:0032787 monocarboxylic acid metabolic process
1.80 2.35e-02 GO:0016053 organic acid biosynthetic process
1.80 2.35e-02 GO:0046394 carboxylic acid biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.48 1.77e-05 GO:0005626 insoluble fraction
1.40 3.59e-05 GO:0000267 cell fraction
1.47 6.56e-05 GO:0005624 membrane fraction
1.10 1.48e-03 GO:0016020 membrane
3.75 1.58e-02 GO:0034361 very-low-density lipoprotein particle
3.75 1.58e-02 GO:0034385 triglyceride-rich lipoprotein particle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.38 3.53e-02 GO:0016491 oxidoreductase activity
3.41 4.50e-02 GO:0070330 aromatase activity