Motif ID: FOXP3.p2

Z-value: 1.543


Transcription factors associated with FOXP3.p2:

Gene SymbolEntrez IDGene Name
FOXP3 50943 forkhead box P3



Activity profile for motif FOXP3.p2.

activity profile for motif FOXP3.p2


Sorted Z-values histogram for motif FOXP3.p2

Sorted Z-values for motif FOXP3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXP3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_100527799 6.348 NM_000061
BTK
Bruton agammaglobulinemia tyrosine kinase
chr9_-_70780574 4.856


chr4_+_39874921 3.879 NM_004310
RHOH
ras homolog gene family, member H
chr6_-_11887265 3.467 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr10_+_5976354 2.897 NM_032807
FBXO18
F-box protein, helicase, 18
chr9_-_99740243 2.883 NM_197978
HEMGN
hemogen
chr22_+_20316968 2.655 NM_152612
CCDC116
coiled-coil domain containing 116
chr7_-_142369519 2.124 KEL
Kell blood group, metallo-endopeptidase
chr14_+_19655405 2.051 NM_001004715
OR4K17
olfactory receptor, family 4, subfamily K, member 17
chr17_+_49255237 2.040 NM_032559
KIF2B
kinesin family member 2B
chr6_-_6632197 1.928


chr1_+_173111306 1.794 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr1_-_158815895 1.775 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr12_-_55929189 1.730


chr3_-_19950675 1.551 NM_144715
EFHB
EF-hand domain family, member B
chr1_-_205161821 1.525 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr7_-_142369534 1.521 NM_000420
KEL
Kell blood group, metallo-endopeptidase
chr15_-_91078307 1.521 FAM174B
family with sequence similarity 174, member B
chr6_+_64414389 1.510 NM_015153
PHF3
PHD finger protein 3
chr2_-_158008763 1.489 NM_004288
CYTIP
cytohesin 1 interacting protein
chr1_-_158815850 1.473 CD84
CD84 molecule
chr21_-_33107813 1.393 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr6_+_47774247 1.322 NM_153838
GPR115
G protein-coupled receptor 115
chr6_-_154719560 1.307 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chr14_-_20694023 1.245 NM_001004731
OR5AU1
olfactory receptor, family 5, subfamily AU, member 1
chrX_+_8392870 1.242 NM_001001888
VCX3B
VCX3A
variable charge, X-linked 3B
variable charge, X-linked 3A
chr21_-_32879617 1.240 NM_144659
TCP10L
t-complex 10 (mouse)-like
chr11_+_59580705 1.206 MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr11_-_56914668 1.193 NM_002728
PRG2
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
chr2_+_102401580 1.164 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr11_-_72057755 1.128 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr16_+_31446703 1.127 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr6_+_31016755 1.101 NM_080870
DPCR1
diffuse panbronchiolitis critical region 1
chr11_-_62231242 1.061 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr11_+_62231689 1.057 NM_012202
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr11_-_5487728 1.047 NM_017481
UBQLN3
ubiquilin 3
chr11_-_62231636 1.044 NM_001122955
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr21_-_30893063 1.035 NM_181604
KRTAP6-2
keratin associated protein 6-2
chr9_-_138762725 0.998 NM_198946
LCN6
lipocalin 6
chr1_+_159959072 0.996 NM_001002901
FCRLB
Fc receptor-like B
chr1_-_151333624 0.967 NM_001024209
SPRR2E
small proline-rich protein 2E
chr6_-_27988152 0.967 NM_033057
OR2B2
olfactory receptor, family 2, subfamily B, member 2
chrX_-_76824726 0.964 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr10_-_106083652 0.956 NM_033397
ITPRIP
inositol 1,4,5-triphosphate receptor interacting protein
chr19_+_17723285 0.952 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr3_-_71860958 0.933 NM_001134650
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr1_+_205694237 0.921 NM_001006658
NM_001877
CR2

complement component (3d/Epstein Barr virus) receptor 2

chr1_+_245779018 0.918 NM_145278
C1orf150
chromosome 1 open reading frame 150
chr8_-_110724594 0.917 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr5_-_37220702 0.910 C5orf42
chromosome 5 open reading frame 42
chr12_-_8110268 0.909 C3AR1
complement component 3a receptor 1
chr15_-_41300488 0.874 EPB42
erythrocyte membrane protein band 4.2
chr12_-_8110196 0.873 NM_004054
C3AR1
complement component 3a receptor 1
chr11_+_59580630 0.857 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr16_+_2807228 0.831 PRSS21
protease, serine, 21 (testisin)
chr5_+_34723420 0.828 NM_001145523
RAI14
retinoic acid induced 14
chr8_+_124263932 0.821 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr10_+_51246290 0.809 NM_001145262
NCOA4
nuclear receptor coactivator 4
chr16_+_56567839 0.807 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chrX_-_8099307 0.794 NM_016378
VCX2
variable charge, X-linked 2
chr10_+_49563520 0.791 NM_020945
WDFY4
WDFY family member 4
chr3_-_10309600 0.777 NM_001134944
NM_001134945
NM_001134946
GHRL


ghrelin/obestatin prepropeptide


chr11_-_62231565 0.755 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr1_+_67404756 0.754 NM_144701
IL23R
interleukin 23 receptor
chr7_-_107667728 0.748 NM_001037132
NRCAM
neuronal cell adhesion molecule
chrX_-_84250629 0.727 NM_001012980
SATL1
spermidine/spermine N1-acetyl transferase-like 1
chr15_+_41672543 0.710 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr17_-_59825221 0.697


chr1_+_86942810 0.696 NM_016009
SH3GLB1
SH3-domain GRB2-like endophilin B1
chr6_-_32665409 0.695 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr11_-_62231386 0.683 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr17_-_31281398 0.681 NM_001163122
NM_001163124
NM_001163125
NM_001163130
RDM1



RAD52 motif 1



chrX_+_134803450 0.678 NM_018666
SAGE1
sarcoma antigen 1
chr6_+_88111289 0.675 NM_001010868
C6orf163
chromosome 6 open reading frame 163
chr9_+_124072947 0.675 NM_199177
MRRF
mitochondrial ribosome recycling factor
chr19_-_44060729 0.675 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chr8_+_105421226 0.662 NM_030788
TM7SF4
transmembrane 7 superfamily member 4
chr2_-_157892391 0.662 NM_001009959
ERMN
ermin, ERM-like protein
chr11_-_62231358 0.649 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr11_-_117718532 0.644 NM_000732
NM_001040651
CD3D

CD3d molecule, delta (CD3-TCR complex)

chr10_-_50012058 0.644 NM_001164484
FAM170B
family with sequence similarity 170, member B
chr1_-_144793989 0.640 NM_183372
NBPF11
NBPF24
neuroblastoma breakpoint family, member 11
neuroblastoma breakpoint family, member 24
chr6_-_32605898 0.639 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr6_+_132901119 0.638 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr1_+_2927905 0.638 NM_080431
ACTRT2
actin-related protein T2
chr19_-_50271527 0.635 NM_145288
ZNF296
zinc finger protein 296
chr16_+_2807164 0.630 NM_006799
NM_144956
NM_144957
PRSS21


protease, serine, 21 (testisin)


chr12_+_46802695 0.628 NM_001166687
NM_001166688
PFKM

phosphofructokinase, muscle

chr7_+_143331954 0.628 NM_001005281
OR6B1
olfactory receptor, family 6, subfamily B, member 1
chr7_+_28441758 0.622 NM_004904
CREB5
cAMP responsive element binding protein 5
chr4_-_145281237 0.605 NM_002099
GYPA
glycophorin A (MNS blood group)
chr7_+_21434818 0.595


chr6_+_144227265 0.593 NM_001013623
C6orf94
chromosome 6 open reading frame 94
chr11_+_62231741 0.593 GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr11_+_59027624 0.590 NM_001004706
OR4D11
olfactory receptor, family 4, subfamily D, member 11
chr19_-_49076080 0.587 NM_001033719
ZNF404
zinc finger protein 404
chr12_-_10479810 0.580 NM_002260
KLRC2
KLRC3
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 3
chr3_-_168674502 0.578 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr1_+_23994914 0.575


chr11_-_5247948 0.572 NM_005330
HBE1
hemoglobin, epsilon 1
chr11_-_57275828 0.569 NM_001145101
BTBD18
BTB (POZ) domain containing 18
chr1_+_15862887 0.568


chr6_+_43060304 0.563 PPP2R5D
protein phosphatase 2, regulatory subunit B', delta
chr19_+_56958452 0.560 NM_001462
FPR2
formyl peptide receptor 2
chr6_-_11490487 0.559 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr17_-_64752550 0.556 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr1_-_151310707 0.552 NM_001017418
SPRR2B
small proline-rich protein 2B
chrX_+_153423652 0.545 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr11_-_123758448 0.545 NM_001005468
OR8B2
olfactory receptor, family 8, subfamily B, member 2
chr11_-_62231445 0.538 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr6_-_25982418 0.538 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr1_-_51560469 0.536 NM_001080494
TTC39A
tetratricopeptide repeat domain 39A
chr2_-_240618518 0.517 NM_001005853
OR6B2
olfactory receptor, family 6, subfamily B, member 2
chr1_+_40631603 0.505 NM_001198979
SMAP2
small ArfGAP2
chr20_-_3592045 0.505 NM_022139
NM_145762
GFRA4

GDNF family receptor alpha 4

chr6_+_28601767 0.505 NM_001509
NM_003996
GPX5

glutathione peroxidase 5 (epididymal androgen-related protein)

chr1_-_109201228 0.498 NM_152763
AKNAD1
AKNA domain containing 1
chr7_+_141124710 0.492 NM_016944
TAS2R4
taste receptor, type 2, member 4
chr19_+_47073029 0.489 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr15_-_77994652 0.485 NM_001100879
ST20
suppressor of tumorigenicity 20
chr2_+_65517316 0.479 FLJ16124
FLJ16124 protein
chr10_-_91092410 0.478 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr15_+_19869841 0.472 NM_001004719
OR4M2
olfactory receptor, family 4, subfamily M, member 2
chr6_+_106653429 0.471 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chrX_-_135691168 0.470 NM_004840
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr1_+_116727514 0.469 NM_001160234
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr8_+_107807415 0.469 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr8_+_9990471 0.466 NM_001135671
MSRA
methionine sulfoxide reductase A
chr4_+_22608252 0.460


chr6_-_29431950 0.459 NM_030876
OR5V1
olfactory receptor, family 5, subfamily V, member 1
chr2_+_170149092 0.446 NM_004792
PPIG
peptidylprolyl isomerase G (cyclophilin G)
chrX_-_135166306 0.445 NM_001173516
MAP7D3
MAP7 domain containing 3
chr5_+_67622242 0.441 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_+_196874759 0.434 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr1_-_159099090 0.430 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr1_+_171871283 0.426 NM_001195190
LOC730159
hypothetical protein LOC730159
chr19_+_56990222 0.425 NM_002030
FPR3
formyl peptide receptor 3
chr3_-_180467483 0.421 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr3_+_42679602 0.419 ZBTB47
zinc finger and BTB domain containing 47
chr5_+_161210280 0.416 NM_001127648
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr18_+_3584056 0.413 FLJ35776
hypothetical LOC649446
chrX_-_135690770 0.410 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr6_+_88026338 0.407 ZNF292
zinc finger protein 292
chr1_+_190811479 0.400 NM_002922
RGS1
regulator of G-protein signaling 1
chr12_-_10453409 0.394 NM_013431
KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 read-through transcript
killer cell lectin-like receptor subfamily C, member 4
chr11_+_63730720 0.394 NM_031471
NM_178443
FERMT3

fermitin family member 3

chr1_-_151296611 0.394 NM_005988
SPRR2A
small proline-rich protein 2A
chr20_+_29492071 0.393 NM_153324
DEFB123
defensin, beta 123
chr15_-_48198697 0.387 NM_024837
ATP8B4
ATPase, class I, type 8B, member 4
chr6_-_88095714 0.387 NM_198568
GJB7
gap junction protein, beta 7, 25kDa
chr13_+_45174446 0.381 NM_152719
SPERT
spermatid associated
chr6_+_29187565 0.372 NM_001005216
OR2J3
olfactory receptor, family 2, subfamily J, member 3
chr14_-_106352471 0.370


chr6_-_167717907 0.367 NM_004610
TCP10
t-complex 10 homolog (mouse)
chr14_+_21203136 0.367 NM_001001912
OR4E2
olfactory receptor, family 4, subfamily E, member 2
chr14_+_20568184 0.362 NM_173846
TPPP2
tubulin polymerization-promoting protein family member 2
chr7_-_128330615 0.362 KCP
kielin/chordin-like protein
chr10_-_6144119 0.359 NM_000417
IL2RA
interleukin 2 receptor, alpha
chr1_-_150070849 0.351 NM_005060
RORC
RAR-related orphan receptor C
chr17_+_72692889 0.348 NM_001144001
SEC14L1
SEC14-like 1 (S. cerevisiae)
chr1_-_209732881 0.342 NM_001164688
NM_183059
RD3

retinal degeneration 3

chr6_+_31838751 0.341 NM_001039651
C6orf26
chromosome 6 open reading frame 26
chr17_+_72827968 0.336 SEPT9
septin 9
chr17_-_64462976 0.335 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr16_+_14976333 0.331 NM_015027
PDXDC1
pyridoxal-dependent decarboxylase domain containing 1
chr3_-_46761248 0.331 NM_199183
PRSS45
protease, serine, 45
chr12_+_54838408 0.330 MYL6
myosin, light chain 6, alkali, smooth muscle and non-muscle
chr12_+_6424293 0.330 NM_001242
CD27
CD27 molecule
chr5_+_140723939 0.326 NM_018918
NM_032054
PCDHGA5

protocadherin gamma subfamily A, 5

chr1_+_190394214 0.326 NM_130782
RGS18
regulator of G-protein signaling 18
chr20_-_118263 0.324 NM_001037732
DEFB128
defensin, beta 128
chr17_+_38306339 0.323 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr1_-_172153087 0.322 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr15_+_83467295 0.317 PDE8A
phosphodiesterase 8A
chr19_-_60458915 0.315 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr6_+_167504070 0.308 NM_001145121
TCP10L2
TCP10
t-complex 10-like 2 (mouse)
t-complex 10 homolog (mouse)
chr6_-_32227645 0.304 PRRT1
proline-rich transmembrane protein 1
chr10_-_45350804 0.303 NM_001002266
MARCH8
membrane-associated ring finger (C3HC4) 8
chr22_+_19458378 0.296 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr22_-_48865980 0.293 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr18_+_70317802 0.293 NM_001168499
CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr6_-_32227695 0.290 NM_030651
PRRT1
proline-rich transmembrane protein 1
chr1_+_559618 0.288


chr5_+_137447479 0.287 NM_058244
WNT8A
wingless-type MMTV integration site family, member 8A
chr9_+_95886625 0.287 PTPDC1
protein tyrosine phosphatase domain containing 1
chr4_-_164754106 0.286 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr7_+_102176561 0.286 NM_001145268
NM_001145269
FAM185A

family with sequence similarity 185, member A

chr11_+_123945102 0.284 NM_001005194
OR8A1
olfactory receptor, family 8, subfamily A, member 1
chr12_-_54409107 0.283 NM_001040034
NM_001780
CD63

CD63 molecule

chr7_+_77307382 0.283 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr19_+_39402167 0.278 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr12_+_54838733 0.275 MYL6
myosin, light chain 6, alkali, smooth muscle and non-muscle
chr5_-_126394338 0.274 NM_178450
MARCH3
membrane-associated ring finger (C3HC4) 3
chr1_-_100416358 0.272 NM_144620
LRRC39
leucine rich repeat containing 39
chr11_-_4346191 0.271 NM_001005161
OR52B4
olfactory receptor, family 52, subfamily B, member 4
chr2_+_108360798 0.268 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr12_-_48902692 0.266 NM_001113547
LIMA1
LIM domain and actin binding 1
chr10_-_50402148 0.263 NM_170753
PGBD3
piggyBac transposable element derived 3
chr19_-_21985560 0.260 NM_007153
ZNF208
zinc finger protein 208
chr1_-_245988330 0.259 NM_012353
OR1C1
olfactory receptor, family 1, subfamily C, member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.53 8.09e-09 GO:0007608 sensory perception of smell
3.32 1.62e-08 GO:0007606 sensory perception of chemical stimulus
1.35 3.13e-05 GO:0050896 response to stimulus
3.13 9.53e-04 GO:0050778 positive regulation of immune response
4.90 1.14e-03 GO:0002429 immune response-activating cell surface receptor signaling pathway
4.71 1.84e-03 GO:0002768 immune response-regulating cell surface receptor signaling pathway
2.09 3.19e-03 GO:0006952 defense response
2.05 5.54e-03 GO:0007600 sensory perception
2.51 6.19e-03 GO:0002684 positive regulation of immune system process
1.82 6.49e-03 GO:0002376 immune system process
1.67 8.37e-03 GO:0003008 system process
3.15 1.24e-02 GO:0002253 activation of immune response
1.74 1.52e-02 GO:0050877 neurological system process
5.78 2.72e-02 GO:0016064 immunoglobulin mediated immune response
5.68 3.17e-02 GO:0019724 B cell mediated immunity

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.50 3.44e-07 GO:0071944 cell periphery
1.50 3.88e-07 GO:0005886 plasma membrane
1.31 8.13e-04 GO:0016021 integral to membrane
1.30 1.25e-03 GO:0031224 intrinsic to membrane
3.17 1.42e-02 GO:0005882 intermediate filament
2.93 2.14e-02 GO:0045111 intermediate filament cytoskeleton
1.21 3.72e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.40 1.70e-11 GO:0004888 transmembrane receptor activity
2.14 6.30e-11 GO:0004872 receptor activity
3.70 4.23e-10 GO:0004984 olfactory receptor activity
2.69 4.35e-10 GO:0004930 G-protein coupled receptor activity
1.88 2.03e-08 GO:0004871 signal transducer activity
1.88 2.03e-08 GO:0060089 molecular transducer activity
6.18 3.39e-02 GO:0003823 antigen binding