Motif ID: IRF1,2,7.p3

Z-value: 3.616


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7



Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_78858675 15.736 NM_006820
IFI44L
interferon-induced protein 44-like
chr21_+_41655786 9.980 NM_002463
LOC100131190
MX2
hypothetical protein LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr16_-_88358946 8.675 FANCA
Fanconi anemia, complementation group A
chr12_+_111900650 8.390 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr10_+_91082218 7.145 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr9_+_5500544 6.441 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr1_+_157246305 6.329 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr7_-_76667045 6.011 NM_006682
FGL2
fibrinogen-like 2
chr9_-_21375258 5.415 NM_000605
IFNA2
interferon, alpha 2
chr22_-_34886727 5.216 NM_145640
APOL3
apolipoprotein L, 3
chr10_+_91142301 5.209 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr11_-_104274606 5.179 NM_001191016
CASP12
caspase 12 (gene/pseudogene)
chr17_-_37518213 5.151 NM_024119
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr22_-_16080265 5.059 CECR1
cat eye syndrome chromosome region, candidate 1
chr1_+_78888064 4.949 NM_006417
IFI44
interferon-induced protein 44
chr4_-_169476391 4.896 NM_017631
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr3_+_188568861 4.848 NM_022147
RTP4
receptor (chemosensory) transporter protein 4
chr20_-_55628852 4.746 NM_001160417
NM_001160418
NM_001160419
NM_030776
ZBP1



Z-DNA binding protein 1



chrX_+_110252960 4.697 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr6_+_116889248 4.628 NM_001010919
FAM26F
family with sequence similarity 26, member F
chr17_-_40695216 4.477 NM_152343
C17orf46
chromosome 17 open reading frame 46
chr6_-_133126278 4.474 NM_078488
VNN2
vanin 2
chr7_+_73826244 4.424 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr6_-_27948065 4.353 NM_003533
HIST1H3I
histone cluster 1, H3i
chr1_-_25164061 4.347 NM_001031680
RUNX3
runt-related transcription factor 3
chr1_-_9052207 4.333 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr11_-_104421240 4.215 NM_001017534
NM_052889
CARD16

CASP1
caspase recruitment domain family, member 16

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr16_-_49272617 4.188 SNX20
sorting nexin 20
chr1_-_9052170 4.183 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr19_-_7672978 4.168 NM_002002
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr3_+_120904555 4.101 NM_033364
C3orf15
chromosome 3 open reading frame 15
chr17_+_38719371 4.045 NM_145041
TMEM106A
FLJ77644
transmembrane protein 106A
hypothetical LOC728772
chr2_+_85665041 4.025 NM_006634
VAMP5
vesicle-associated membrane protein 5 (myobrevin)
chr10_+_22765996 3.956 LOC100289455
hypothetical LOC100289455
chr5_+_156628929 3.886 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr16_-_49272741 3.793 NM_001144972
NM_153337
NM_182854
SNX20


sorting nexin 20


chr16_+_10878539 3.767 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr21_-_42219849 3.710 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr11_+_1830763 3.626 NM_002339
LSP1
lymphocyte-specific protein 1
chr4_-_138673078 3.618 NM_019035
PCDH18
protocadherin 18
chr13_-_42464301 3.599 NM_001002264
NM_033255
EPSTI1

epithelial stromal interaction 1 (breast)

chr8_-_27997306 3.584 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr6_+_6533932 3.568 NM_004271
LY86
lymphocyte antigen 86
chr1_+_159334774 3.561 NM_001007255
NM_152366
KLHDC9

kelch domain containing 9

chr4_-_153523113 3.537 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr1_-_89261021 3.474 NM_018284
GBP3
guanylate binding protein 3
chr16_-_11783908 3.465 NM_014153
ZC3H7A
zinc finger CCCH-type containing 7A
chr6_+_31648071 3.438 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr15_-_23659329 3.434 NM_024490
ATP10A
ATPase, class V, type 10A
chr2_+_6935246 3.422 NM_080657
RSAD2
radical S-adenosyl methionine domain containing 2
chr7_+_128367961 3.390 NM_001098627
IRF5
interferon regulatory factor 5
chr11_-_63087430 3.353 NM_017878
HRASLS2
HRAS-like suppressor 2
chr7_+_134483305 3.345 NM_018295
TMEM140
transmembrane protein 140
chr11_+_124438217 3.314 NM_001145290
NM_198277
SLC37A2

solute carrier family 37 (glycerol-3-phosphate transporter), member 2

chr13_+_30207668 3.296 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr17_-_44642934 3.284 NM_001198754
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr18_-_6404900 3.263 NM_173464
L3MBTL4
l(3)mbt-like 4 (Drosophila)
chr15_-_40537002 3.262 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr16_+_55580910 3.224 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr17_+_18320822 3.215 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr17_+_44643067 3.209 ABI3
ABI family, member 3
chr12_+_8499788 3.207 NM_001007033
CLEC6A
C-type lectin domain family 6, member A
chr2_-_55090759 3.183 NM_007008
RTN4
reticulon 4
chr4_+_37569093 3.145 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr11_-_60475558 3.121 NM_016582
SLC15A3
solute carrier family 15, member 3
chr17_-_30783631 3.105 NM_018042
SLFN12
schlafen family member 12
chr4_+_142777172 3.065 NM_000585
NM_172174
IL15

interleukin 15

chr1_+_157067729 3.056 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr1_-_89303478 3.056 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible, 67kDa
chr17_+_75851984 3.050


chr10_+_91077581 3.047 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr3_-_115960807 2.950 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr6_+_37081387 2.882 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr10_+_63478974 2.851 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr12_-_57600336 2.817 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr17_-_5344898 2.812 NM_001162371
LOC728392
hypothetical protein LOC728392
chr2_-_142605739 2.797 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr11_-_104344473 2.783 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr12_-_57600564 2.766 LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr9_-_94338072 2.760 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr1_-_9052253 2.742 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr19_-_55091942 2.739 NM_152899
IL4I1
interleukin 4 induced 1
chr19_-_18058632 2.712 NM_005535
NM_153701
IL12RB1

interleukin 12 receptor, beta 1

chr2_-_88946767 2.699


chr7_+_150013716 2.694 NM_015660
GIMAP2
GTPase, IMAP family member 2
chr17_+_6600080 2.687 XAF1
XIAP associated factor 1
chr9_+_5440455 2.662 NM_014143
CD274
CD274 molecule
chr19_+_59866217 2.647 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr11_-_60880799 2.642 NM_001161452
CYBASC3
cytochrome b, ascorbate dependent 3
chr12_+_93066370 2.639 NM_005761
PLXNC1
plexin C1
chr3_-_49826221 2.623 UBA7
ubiquitin-like modifier activating enzyme 7
chr12_+_8167494 2.606 NM_016184
NM_194447
NM_194448
NM_194450
CLEC4A



C-type lectin domain family 4, member A



chr13_+_30207690 2.597 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr2_-_227737009 2.574 COL4A4
collagen, type IV, alpha 4
chr3_-_49826360 2.572 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr1_-_159306369 2.571 NM_001025598
NM_181720
ARHGAP30

Rho GTPase activating protein 30

chr14_-_22358752 2.570 NM_001126106
SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr12_+_12115668 2.551 NM_030766
NM_138722
BCL2L14

BCL2-like 14 (apoptosis facilitator)

chr19_+_59866237 2.538 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr11_+_71388310 2.537 NM_001145057
IL18BP
interleukin 18 binding protein
chr1_-_159306327 2.536 ARHGAP30
Rho GTPase activating protein 30
chr19_-_52427698 2.513 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr10_+_91051685 2.505 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr5_-_77880731 2.475 LHFPL2
lipoma HMGIC fusion partner-like 2
chr2_+_218641982 2.420 NM_198483
RUFY4
RUN and FYVE domain containing 4
chr9_-_35802142 2.375 NM_001039592
NM_172312
SPAG8

sperm associated antigen 8

chr2_-_231697999 2.362 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr22_-_48604455 2.360 NM_014577
BRD1
bromodomain containing 1
chr17_-_15526917 2.344 NM_006470
TRIM16
tripartite motif containing 16
chr11_+_63060848 2.331 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr4_+_160408447 2.327 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr17_+_6599879 2.297 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr15_+_73278285 2.286 C15orf39
chromosome 15 open reading frame 39
chr9_+_139758336 2.263 EHMT1
euchromatic histone-lysine N-methyltransferase 1
chr3_+_48482625 2.246 TREX1
three prime repair exonuclease 1
chr14_-_94677807 2.245 NM_030621
DICER1
dicer 1, ribonuclease type III
chr21_+_41714311 2.228 NM_001144925
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr12_+_111829121 2.210 NM_001032409
NM_002534
NM_016816
OAS1


2',5'-oligoadenylate synthetase 1, 40/46kDa


chr12_+_25096472 2.196 NM_006152
LRMP
lymphoid-restricted membrane protein
chr7_-_76883642 2.193 NM_017439
PION
pigeon homolog (Drosophila)
chr9_-_21229975 2.181 NM_002172
IFNA14
interferon, alpha 14
chr12_+_6431437 2.164 NM_018009
TAPBPL
TAP binding protein-like
chr11_+_5667392 2.137 TRIM22
tripartite motif containing 22
chr5_+_36642424 2.130 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_-_242449662 2.093 NM_005018
PDCD1
programmed cell death 1
chr16_+_29739256 2.082 MVP
major vault protein
chr12_+_38905053 2.063 NM_198578
LRRK2
leucine-rich repeat kinase 2
chr17_+_44642587 2.063 NM_001135186
NM_016428
ABI3

ABI family, member 3

chr15_+_68971835 2.011 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr21_+_41719847 2.003 NM_002462
NM_001178046
MX1

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

chr11_-_605998 1.996 NM_001572
NM_004029
IRF7

interferon regulatory factor 7

chr1_+_156416360 1.979 NM_001766
CD1D
CD1d molecule
chr6_+_170441715 1.972 FAM120B
family with sequence similarity 120B
chr7_+_113513726 1.964 FOXP2
forkhead box P2
chr12_+_12115139 1.958 NM_138723
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr6_-_137407504 1.953 IL20RA
interleukin 20 receptor, alpha
chr6_-_30289092 1.951 NM_003449
TRIM26
tripartite motif containing 26
chr1_+_208568811 1.945 NM_001170587
NM_001170588
NM_018194
HHAT


hedgehog acyltransferase


chr2_+_230900121 1.944 NM_138402
SP140L
SP140 nuclear body protein-like
chr6_-_170441493 1.941 NM_005618
DLL1
delta-like 1 (Drosophila)
chr19_-_2233174 1.926 NM_198532
C19orf35
chromosome 19 open reading frame 35
chr4_+_89597257 1.916 NM_016323
HERC5
hect domain and RLD 5
chr22_+_34374358 1.908 NM_030641
APOL6
apolipoprotein L, 6
chr12_-_9913199 1.904 CLEC2B
C-type lectin domain family 2, member B
chr7_-_92615593 1.863 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr17_+_69974361 1.856 CD300A
CD300a molecule
chr1_+_157167965 1.853 NM_152501
NM_198928
NM_198929
NM_198930
PYHIN1



pyrin and HIN domain family, member 1



chr2_-_225519974 1.840 DOCK10
dedicator of cytokinesis 10
chr12_+_9713472 1.835 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr2_-_175337386 1.833 NM_000079
NM_001039523
CHRNA1

cholinergic receptor, nicotinic, alpha 1 (muscle)

chr16_-_28425632 1.828 NM_145659
IL27
interleukin 27
chr4_-_77163609 1.828 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr7_-_149960218 1.826 GIMAP6
GTPase, IMAP family member 6
chr4_+_86918870 1.815 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr3_+_161189322 1.811 NM_000882
IL12A
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr17_+_22982372 1.803 LGALS9
lectin, galactoside-binding, soluble, 9
chr6_+_32713160 1.797 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr9_-_21132143 1.797 NM_002177
IFNW1
interferon, omega 1
chr9_-_21218132 1.787 NM_021268
IFNA17
interferon, alpha 17
chr15_-_48192804 1.781 ATP8B4
ATPase, class I, type 8B, member 4
chr22_+_34979118 1.780 APOL1
apolipoprotein L, 1
chr17_+_22982383 1.779 LGALS9
lectin, galactoside-binding, soluble, 9
chr17_+_22982319 1.779 LGALS9
lectin, galactoside-binding, soluble, 9
chr13_+_42046182 1.765 NM_003701
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chrX_-_138742050 1.762 NM_001010986
NM_173694
ATP11C

ATPase, class VI, type 11C

chr1_+_245646080 1.753 NM_001079821
NM_001127461
NLRP3

NLR family, pyrin domain containing 3

chr12_-_9913724 1.741 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr17_+_22982344 1.738 LGALS9
lectin, galactoside-binding, soluble, 9
chr18_+_59726183 1.733 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr11_+_58146721 1.728 NM_000614
CNTF
ciliary neurotrophic factor
chr16_+_29739215 1.728 NM_005115
NM_017458
MVP

major vault protein

chr2_-_242205556 1.725 NM_001164356
THAP4
THAP domain containing 4
chr10_+_97505398 1.718 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr1_-_2486313 1.710 NM_003820
TNFRSF14
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
chr2_+_73911477 1.706 STAMBP
STAM binding protein
chr15_-_23659962 1.688 ATP10A
ATPase, class V, type 10A
chr6_-_32919751 1.681 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr17_+_22982278 1.667 NM_002308
NM_009587
LGALS9

lectin, galactoside-binding, soluble, 9

chr1_+_63831479 1.662 NM_002633
PGM1
phosphoglucomutase 1
chr4_+_187227302 1.633 NM_003265
TLR3
toll-like receptor 3
chr15_+_86983038 1.620 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr11_+_71388619 1.609 NM_001145055
IL18BP
interleukin 18 binding protein
chr11_-_605649 1.588 NM_004031
IRF7
interferon regulatory factor 7
chr5_+_36642213 1.587 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr15_-_97607108 1.584 NM_001040655
NM_001040656
NM_001040657
NM_001040658
NM_001040659
NM_001040660
NM_022905
TTC23






tetratricopeptide repeat domain 23






chr17_-_44022595 1.582 HOXB3
homeobox B3
chr1_+_117345894 1.575 NM_004258
CD101
CD101 molecule
chr17_+_72982919 1.562 NM_001113495
SEPT9
septin 9
chr9_+_21430439 1.551 NM_024013
IFNA1
interferon, alpha 1
chr5_-_149772528 1.544


chr1_+_154390939 1.542 SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr3_-_162305319 1.541 NM_033169
NM_001038628
NM_003781
NM_033167
NM_033168
B3GALNT1




beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)




chr11_+_71387572 1.538 NM_001039659
NM_001039660
NM_173042
IL18BP


interleukin 18 binding protein


chr8_+_39890484 1.520 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr4_+_86918882 1.510 ARHGAP24
Rho GTPase activating protein 24
chr17_-_67628523 1.506 FLJ37644
hypothetical LOC400618
chr2_+_68445821 1.502 NM_002664
PLEK
pleckstrin
chr19_-_47724365 1.501 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001712
CEACAM1




carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)




chr2_+_230798687 1.498 NM_001005176
NM_007237
SP140

SP140 nuclear body protein

chr22_+_34979062 1.471 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1




Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
9.50 4.42e-21 GO:0060337 type I interferon-mediated signaling pathway
9.50 4.42e-21 GO:0071357 cellular response to type I interferon
9.35 8.52e-21 GO:0034340 response to type I interferon
2.70 6.00e-17 GO:0006955 immune response
2.18 1.03e-14 GO:0002376 immune system process
4.90 1.56e-14 GO:0009615 response to virus
3.35 3.09e-14 GO:0045087 innate immune response
3.88 2.42e-11 GO:0071345 cellular response to cytokine stimulus
10.43 3.98e-11 GO:0060338 regulation of type I interferon-mediated signaling pathway
4.00 7.05e-11 GO:0019221 cytokine-mediated signaling pathway
2.28 1.57e-10 GO:0006952 defense response
3.19 9.97e-10 GO:0034097 response to cytokine stimulus
2.71 1.95e-08 GO:0051707 response to other organism
2.24 4.83e-08 GO:0002682 regulation of immune system process
2.87 1.45e-07 GO:0031347 regulation of defense response
2.00 6.92e-07 GO:0051704 multi-organism process
2.34 2.19e-06 GO:0009607 response to biotic stimulus
2.41 4.24e-06 GO:0050776 regulation of immune response
3.38 4.96e-06 GO:0045088 regulation of innate immune response
5.34 6.61e-06 GO:0001959 regulation of cytokine-mediated signaling pathway
5.26 8.79e-06 GO:0060759 regulation of response to cytokine stimulus
1.49 5.13e-05 GO:0006950 response to stress
1.22 5.44e-05 GO:0050789 regulation of biological process
1.25 6.42e-05 GO:0050896 response to stimulus
2.18 7.12e-05 GO:0080134 regulation of response to stress
1.56 7.51e-05 GO:0048583 regulation of response to stimulus
1.22 1.50e-04 GO:0050794 regulation of cellular process
1.20 2.62e-04 GO:0065007 biological regulation
1.57 4.01e-04 GO:0023051 regulation of signaling
3.80 9.71e-04 GO:0051222 positive regulation of protein transport
3.26 1.16e-03 GO:0001819 positive regulation of cytokine production
1.59 1.40e-03 GO:0009966 regulation of signal transduction
1.93 1.47e-03 GO:0071310 cellular response to organic substance
3.96 2.14e-03 GO:0043900 regulation of multi-organism process
4.99 2.59e-03 GO:0032479 regulation of type I interferon production
2.44 3.37e-03 GO:0001817 regulation of cytokine production
6.35 3.99e-03 GO:0050715 positive regulation of cytokine secretion
1.29 4.31e-03 GO:0051716 cellular response to stimulus
2.08 5.17e-03 GO:0002684 positive regulation of immune system process
15.34 6.48e-03 GO:0060907 positive regulation of macrophage cytokine production
1.70 6.57e-03 GO:0070887 cellular response to chemical stimulus
2.88 1.04e-02 GO:0002697 regulation of immune effector process
3.31 1.55e-02 GO:0050670 regulation of lymphocyte proliferation
3.28 1.80e-02 GO:0032944 regulation of mononuclear cell proliferation
1.35 1.96e-02 GO:0048518 positive regulation of biological process
13.15 2.16e-02 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response
5.92 2.58e-02 GO:2000242 negative regulation of reproductive process
2.66 2.62e-02 GO:0050863 regulation of T cell activation
2.89 2.63e-02 GO:0050870 positive regulation of T cell activation
3.19 2.74e-02 GO:0070663 regulation of leukocyte proliferation
2.57 3.20e-02 GO:0050867 positive regulation of cell activation
7.58 3.96e-02 GO:0050691 regulation of defense response to virus by host
1.36 4.72e-02 GO:0048522 positive regulation of cellular process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.80 5.55e-03 GO:0009897 external side of plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.38 1.66e-07 GO:0005126 cytokine receptor binding
16.11 5.32e-06 GO:0005132 interferon-alpha/beta receptor binding
2.87 5.56e-05 GO:0005125 cytokine activity
1.53 4.09e-02 GO:0005102 receptor binding