Motif ID: MTF1.p2

Z-value: 4.411


Transcription factors associated with MTF1.p2:

Gene SymbolEntrez IDGene Name
MTF1 4520 metal-regulatory transcription factor 1



Activity profile for motif MTF1.p2.

activity profile for motif MTF1.p2


Sorted Z-values histogram for motif MTF1.p2

Sorted Z-values for motif MTF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MTF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_238060602 7.821 NM_001042467
NM_024101
MLPH

melanophilin

chr10_+_124211353 7.244 HTRA1
HtrA serine peptidase 1
chr16_+_55217180 7.033 MT1E
metallothionein 1E
chr2_-_40532651 6.589 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr15_+_77511912 6.319 NM_015206
KIAA1024
KIAA1024
chr3_-_185025989 5.639 NM_024871
MAP6D1
MAP6 domain containing 1
chr16_+_55217085 5.630 NM_175617
MT1E
metallothionein 1E
chr10_+_80672842 5.479 ZMIZ1
zinc finger, MIZ-type containing 1
chr3_+_160964574 5.466 SCHIP1
schwannomin interacting protein 1
chr10_-_128884411 5.307 NM_001039762
FAM196A
family with sequence similarity 196, member A
chr9_+_90339835 5.285 NM_001161625
NM_145283
NXNL2

nucleoredoxin-like 2

chr15_-_68933481 5.187 NM_018357
NM_197958
LARP6

La ribonucleoprotein domain family, member 6

chr5_+_65927895 4.988 NM_001164664
NM_198828
MAST4

microtubule associated serine/threonine kinase family member 4

chr13_-_25523164 4.932 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr16_+_12902955 4.916 NM_001145204
NM_001145205
SHISA9

shisa homolog 9 (Xenopus laevis)

chr7_-_27136876 4.787 NM_002141
HOXA4
homeobox A4
chr6_+_160689355 4.722 NM_021977
SLC22A3
solute carrier family 22 (extraneuronal monoamine transporter), member 3
chr13_-_43259032 4.682 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr8_-_120033240 4.677 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr2_+_207016525 4.623 NM_003812
ADAM23
ADAM metallopeptidase domain 23
chr1_-_85131439 4.623 NM_012152
LPAR3
lysophosphatidic acid receptor 3
chr8_-_121893468 4.595 NM_021021
SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr11_+_125279481 4.594 NM_013264
DDX25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr18_-_72336133 4.590 NM_014643
ZNF516
zinc finger protein 516
chr14_+_99181232 4.547 NM_001127258
NM_032425
HHIPL1

HHIP-like 1

chr10_+_124210980 4.472 NM_002775
HTRA1
HtrA serine peptidase 1
chr11_+_110675175 4.365 NM_001136105
C11orf93
chromosome 11 open reading frame 93
chr4_+_187302988 4.340 NM_015398
FAM149A
family with sequence similarity 149, member A
chr9_-_111300350 4.286 NM_001145368
NM_002829
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr16_+_55180767 4.230 NM_005954
MT3
metallothionein 3
chr6_-_170442090 4.220


chr18_+_42168180 4.216 NM_152470
C18orf23
RNF165
chromosome 18 open reading frame 23
ring finger protein 165
chrX_-_132376660 4.206 NM_001448
GPC4
glypican 4
chr3_-_48607596 4.200 NM_000094
COL7A1
collagen, type VII, alpha 1
chr18_+_42167904 4.192 RNF165
ring finger protein 165
chr10_-_116517945 4.165 ABLIM1
actin binding LIM protein 1
chr2_+_54537842 4.157 SPTBN1
spectrin, beta, non-erythrocytic 1
chr5_-_146869811 4.156 NM_001197294
DPYSL3
dihydropyrimidinase-like 3
chr8_-_121893449 4.095 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr2_-_210798232 4.067 NM_001608
ACADL
acyl-CoA dehydrogenase, long chain
chr22_-_44751671 4.032 NM_058238
WNT7B
wingless-type MMTV integration site family, member 7B
chr13_-_109757442 4.031 NM_001845
COL4A1
collagen, type IV, alpha 1
chr19_+_38377329 4.014 NM_002333
LRP3
low density lipoprotein receptor-related protein 3
chr2_+_120820140 4.013 NM_002193
INHBB
inhibin, beta B
chr20_+_34206070 3.968 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr16_+_55249355 3.951 NM_005949
MT1F
metallothionein 1F
chr12_-_1573591 3.940 NM_152441
FBXL14
F-box and leucine-rich repeat protein 14
chr17_-_5344898 3.921 NM_001162371
LOC728392
hypothetical protein LOC728392
chr5_-_16670085 3.919 NM_001034850
FAM134B
family with sequence similarity 134, member B
chr14_+_85069217 3.917


chr5_-_146869613 3.916 DPYSL3
dihydropyrimidinase-like 3
chr7_+_288195 3.828 FAM20C
family with sequence similarity 20, member C
chr6_-_153494076 3.811 NM_012419
RGS17
regulator of G-protein signaling 17
chr3_+_61522219 3.809 NM_002841
PTPRG
protein tyrosine phosphatase, receptor type, G
chr10_+_133850325 3.797 NM_006426
DPYSL4
dihydropyrimidinase-like 4
chr8_-_121893196 3.789


chr1_-_108308997 3.758 NM_006113
VAV3
vav 3 guanine nucleotide exchange factor
chr10_+_128583984 3.756 NM_001380
DOCK1
dedicator of cytokinesis 1
chr14_+_105012106 3.742 NM_001312
CRIP2
cysteine-rich protein 2
chr16_+_55224034 3.742 NM_176870
MT1M
metallothionein 1M
chr1_+_208472817 3.719 NM_019605
SERTAD4
SERTA domain containing 4
chr1_-_115682374 3.687 NM_002506
NGF
nerve growth factor (beta polypeptide)
chr7_-_81910956 3.678 NM_000722
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr10_+_71232281 3.657 COL13A1
collagen, type XIII, alpha 1
chr15_-_23659329 3.652 NM_024490
ATP10A
ATPase, class V, type 10A
chr12_-_22378833 3.647 NM_003034
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr8_+_26427378 3.646 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr8_-_75396016 3.635 NM_020647
JPH1
junctophilin 1
chr13_-_19665100 3.632 NM_004004
GJB2
gap junction protein, beta 2, 26kDa
chr14_-_24588916 3.611 NM_014178
STXBP6
syntaxin binding protein 6 (amisyn)
chr15_-_91417362 3.602 NM_001166286
RGMA
RGM domain family, member A
chr20_-_4752067 3.592 NM_014737
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr8_-_121892877 3.586 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr10_+_105243724 3.584 NM_004210
NEURL
neuralized homolog (Drosophila)
chr14_+_95575319 3.571 C14orf132
chromosome 14 open reading frame 132
chr6_+_142664490 3.563 NM_001032394
NM_001032395
NM_020455
NM_198569
GPR126



G protein-coupled receptor 126



chr15_+_78483624 3.554 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr15_+_90738108 3.551 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr9_+_115958051 3.549 NM_032888
COL27A1
collagen, type XXVII, alpha 1
chr1_-_15784048 3.540 NM_024758
AGMAT
agmatine ureohydrolase (agmatinase)
chr2_-_98919109 3.527 NM_207362
C2orf55
chromosome 2 open reading frame 55
chr12_+_56406296 3.523 LOC100130776
hypothetical LOC100130776
chr22_-_45311730 3.508 NM_014246
CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr10_-_131652364 3.505 EBF3
early B-cell factor 3
chr12_-_105056577 3.501 NUAK1
NUAK family, SNF1-like kinase, 1
chr3_+_61522310 3.461 PTPRG
protein tyrosine phosphatase, receptor type, G
chr22_-_49317408 3.454 ODF3B
outer dense fiber of sperm tails 3B
chr4_+_30330963 3.448 NM_001173523
NM_002589
NM_032456
NM_032457
PCDH7



protocadherin 7



chr21_+_41719847 3.426 NM_002462
NM_001178046
MX1

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

chr9_-_83494198 3.417 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr19_-_36531958 3.373 NM_020856
TSHZ3
teashirt zinc finger homeobox 3
chr7_-_27206249 3.354 NM_000522
HOXA13
homeobox A13
chr19_+_61742111 3.335 NM_020828
ZFP28
zinc finger protein 28 homolog (mouse)
chr7_+_288051 3.329 NM_020223
FAM20C
family with sequence similarity 20, member C
chr13_-_31900218 3.327 NM_001079691
NM_052818
N4BP2L1

NEDD4 binding protein 2-like 1

chr8_-_26427304 3.271 NM_007257
PNMA2
paraneoplastic antigen MA2
chr14_-_69725342 3.259 NM_033262
NM_058240
NM_182932
NM_183002
SLC8A3



solute carrier family 8 (sodium/calcium exchanger), member 3



chr19_+_58733144 3.257 NM_001079906
ZNF331
zinc finger protein 331
chr9_-_37566248 3.204 NM_012166
FBXO10
F-box protein 10
chr7_-_76883642 3.189 NM_017439
PION
pigeon homolog (Drosophila)
chr4_+_95898098 3.143 NM_001203
BMPR1B
bone morphogenetic protein receptor, type IB
chr7_+_150442652 3.138 AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr6_+_170441715 3.130 FAM120B
family with sequence similarity 120B
chr1_-_239587007 3.120 RGS7
regulator of G-protein signaling 7
chr2_-_39040981 3.093 LOC375196
hypothetical LOC375196
chr4_+_30331289 3.070 PCDH7
protocadherin 7
chr11_-_11986704 3.054 NM_001018057
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr1_-_3437834 3.043 MEGF6
multiple EGF-like-domains 6
chr20_+_6696744 3.023 NM_001200
BMP2
bone morphogenetic protein 2
chr6_-_170441493 2.995 NM_005618
DLL1
delta-like 1 (Drosophila)
chr14_+_73105618 2.990 ACOT2
acyl-CoA thioesterase 2
chr20_-_3714905 2.975 NM_001810
CENPB
centromere protein B, 80kDa
chr22_-_32646325 2.969 NM_004737
NM_133642
LARGE

like-glycosyltransferase

chr2_-_230287442 2.967 NM_139072
DNER
delta/notch-like EGF repeat containing
chr14_+_73073570 2.959 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr11_+_128266460 2.951 NM_000890
KCNJ5
potassium inwardly-rectifying channel, subfamily J, member 5
chr8_-_64161136 2.924 NM_000370
TTPA
tocopherol (alpha) transfer protein
chr3_+_191714533 2.924 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
IL1RAP





interleukin 1 receptor accessory protein





chr1_+_199108705 2.919 NM_005298
GPR25
G protein-coupled receptor 25
chr14_+_69415880 2.913 NM_001034852
NM_022137
SMOC1

SPARC related modular calcium binding 1

chr2_+_202607554 2.901 NM_003507
FZD7
frizzled homolog 7 (Drosophila)
chr15_-_99276933 2.900


chr17_+_77780177 2.884 NM_004207
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr1_+_218930542 2.881 C1orf115
chromosome 1 open reading frame 115
chr13_+_43845977 2.880 NM_001010897
SERP2
stress-associated endoplasmic reticulum protein family member 2
chr18_+_11679135 2.855 NM_182978
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr10_-_79067552 2.819 NM_001014797
NM_001161352
NM_001161353
NM_002247
KCNMA1



potassium large conductance calcium-activated channel, subfamily M, alpha member 1



chr16_+_85169615 2.818 NM_005250
FOXL1
forkhead box L1
chr2_-_96174502 2.812 DUSP2
dual specificity phosphatase 2
chr17_+_78630793 2.810 NM_001004431
METRNL
meteorin, glial cell differentiation regulator-like
chr5_+_68824143 2.807 OCLN
occludin
chr8_+_121892719 2.798


chr1_-_57661373 2.796 DAB1
disabled homolog 1 (Drosophila)
chr16_+_76379901 2.795 NM_020927
VAT1L
vesicle amine transport protein 1 homolog (T. californica)-like
chr11_+_111353218 2.788 NM_033425
DIXDC1
DIX domain containing 1
chr20_-_38751289 2.783 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr6_+_35290160 2.780 NM_152753
SCUBE3
signal peptide, CUB domain, EGF-like 3
chr15_+_99276982 2.765 NM_024652
LRRK1
leucine-rich repeat kinase 1
chr10_-_133971136 2.763 NM_173575
STK32C
serine/threonine kinase 32C
chr19_+_39664706 2.761 NM_001080436
WTIP
Wilms tumor 1 interacting protein
chr4_+_108965167 2.740 NM_001136258
SGMS2
sphingomyelin synthase 2
chr10_-_28074752 2.740 NM_173576
MKX
mohawk homeobox
chr11_+_124438217 2.737 NM_001145290
NM_198277
SLC37A2

solute carrier family 37 (glycerol-3-phosphate transporter), member 2

chr22_-_30072329 2.732 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr2_-_96174865 2.715 NM_004418
DUSP2
dual specificity phosphatase 2
chr3_+_61522922 2.711 PTPRG
protein tyrosine phosphatase, receptor type, G
chr13_+_109757593 2.705 NM_001846
COL4A2
collagen, type IV, alpha 2
chr1_-_9111674 2.701 NM_024980
GPR157
G protein-coupled receptor 157
chr20_+_60810610 2.700 NM_002531
NTSR1
neurotensin receptor 1 (high affinity)
chr11_+_124438407 2.700 SLC37A2
solute carrier family 37 (glycerol-3-phosphate transporter), member 2
chr20_-_30534848 2.691 NM_080616
C20orf112
chromosome 20 open reading frame 112
chr19_-_41787999 2.683 NM_001145649
NM_001145650
ZNF529

zinc finger protein 529

chr19_-_14951349 2.672 SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr18_-_72973698 2.665 MBP
myelin basic protein
chr11_+_128751044 2.662 NM_003658
BARX2
BARX homeobox 2
chr4_-_78038025 2.622 NM_001029870
ANKRD56
ankyrin repeat domain 56
chr12_-_70952410 2.619 LOC283392
hypothetical LOC283392
chr7_-_81910740 2.619 CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr15_+_87147667 2.610 NM_001135
NM_013227
ACAN

aggrecan

chr8_+_1699418 2.588 CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr9_-_83493415 2.586 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr12_+_5411534 2.571 NM_001102654
NTF3
neurotrophin 3
chr3_+_3816079 2.567 NM_020873
LRRN1
leucine rich repeat neuronal 1
chr5_+_72452131 2.564 NM_001161342
NM_173490
TMEM171

transmembrane protein 171

chr2_+_25118417 2.543 NM_014971
EFR3B
EFR3 homolog B (S. cerevisiae)
chr17_+_46067114 2.536 NM_001144070
NM_003786
ABCC3

ATP-binding cassette, sub-family C (CFTR/MRP), member 3

chr16_-_63713485 2.530 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr4_+_30331543 2.529 PCDH7
protocadherin 7
chr5_+_148631636 2.528 AFAP1L1
actin filament associated protein 1-like 1
chr7_+_27102508 2.521


chr12_-_29827952 2.521 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chrX_-_8660132 2.520 KAL1
Kallmann syndrome 1 sequence
chr5_+_148631588 2.514 NM_001146337
NM_152406
AFAP1L1

actin filament associated protein 1-like 1

chr14_-_99695684 2.492 NM_206918
DEGS2
degenerative spermatocyte homolog 2, lipid desaturase (Drosophila)
chr1_+_92268072 2.492 NM_173567
EPHX4
epoxide hydrolase 4
chr8_-_6680429 2.483 NM_207411
XKR5
XK, Kell blood group complex subunit-related family, member 5
chr1_-_239587090 2.482 NM_002924
RGS7
regulator of G-protein signaling 7
chr19_+_41788065 2.482 ZNF382
zinc finger protein 382
chr6_+_1257674 2.473 NM_033260
FOXQ1
forkhead box Q1
chr11_+_35596310 2.464 NM_014344
FJX1
four jointed box 1 (Drosophila)
chr2_-_238861830 2.463 NM_022817
PER2
period homolog 2 (Drosophila)
chr16_-_63713466 2.448 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr6_+_53767697 2.445 NM_018214
LRRC1
leucine rich repeat containing 1
chr16_-_63713382 2.444 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr19_+_41788042 2.432 NM_032825
ZNF382
zinc finger protein 382
chr16_+_49139694 2.428 NM_033119
NKD1
naked cuticle homolog 1 (Drosophila)
chr4_-_122213018 2.428 NM_024574
C4orf31
chromosome 4 open reading frame 31
chr15_+_66658626 2.427 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr8_-_125809559 2.426 MTSS1
metastasis suppressor 1
chr20_+_13150417 2.413 NM_080826
ISM1
isthmin 1 homolog (zebrafish)
chr9_+_70161634 2.411 NM_021965
PGM5
phosphoglucomutase 5
chr4_-_24641404 2.396 NM_018176
LGI2
leucine-rich repeat LGI family, member 2
chr12_-_56418295 2.389 NM_001122772
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr12_+_6179736 2.383 NM_001769
CD9
CD9 molecule
chr20_+_24398269 2.378 TMEM90B
transmembrane protein 90B
chr3_-_135575925 2.372 NM_016201
AMOTL2
angiomotin like 2
chr13_+_97593411 2.366 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr3_-_64648370 2.363 NM_182920
ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr9_+_102830851 2.356 NM_207299
LPPR1
lipid phosphate phosphatase-related protein type 1
chr2_-_180434311 2.348 ZNF385B
zinc finger protein 385B

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.58 5.27e-26 GO:0007399 nervous system development
1.66 2.14e-19 GO:0022008 neurogenesis
1.67 4.96e-19 GO:0048699 generation of neurons
1.33 3.03e-18 GO:0048731 system development
1.30 4.16e-18 GO:0007275 multicellular organismal development
1.28 7.19e-18 GO:0032502 developmental process
1.27 3.78e-17 GO:0023052 signaling
1.29 1.32e-15 GO:0048856 anatomical structure development
1.68 1.83e-15 GO:0030182 neuron differentiation
1.40 2.04e-13 GO:0023051 regulation of signaling
1.14 4.22e-13 GO:0065007 biological regulation
1.15 8.11e-13 GO:0050794 regulation of cellular process
1.34 2.23e-12 GO:0030154 cell differentiation
1.33 1.08e-11 GO:0048869 cellular developmental process
1.39 1.63e-11 GO:0009653 anatomical structure morphogenesis
1.14 2.32e-11 GO:0050789 regulation of biological process
1.24 3.02e-11 GO:0007165 signal transduction
1.71 3.42e-11 GO:0000904 cell morphogenesis involved in differentiation
1.74 6.19e-11 GO:0048812 neuron projection morphogenesis
1.59 1.02e-10 GO:0045595 regulation of cell differentiation
1.68 2.43e-10 GO:0031175 neuron projection development
1.55 2.51e-10 GO:2000026 regulation of multicellular organismal development
1.73 2.87e-10 GO:0048667 cell morphogenesis involved in neuron differentiation
1.38 4.23e-10 GO:0009966 regulation of signal transduction
1.73 5.24e-10 GO:0007409 axonogenesis
1.48 6.28e-10 GO:0050793 regulation of developmental process
1.40 7.80e-10 GO:0051239 regulation of multicellular organismal process
1.33 1.90e-09 GO:0007166 cell surface receptor linked signaling pathway
1.61 2.18e-09 GO:0048666 neuron development
1.58 9.13e-09 GO:0000902 cell morphogenesis
1.56 1.37e-08 GO:0032989 cellular component morphogenesis
1.54 3.13e-08 GO:0030030 cell projection organization
1.61 3.39e-08 GO:0048858 cell projection morphogenesis
1.44 3.63e-08 GO:0048468 cell development
1.61 4.68e-08 GO:0007417 central nervous system development
1.41 4.77e-08 GO:0010646 regulation of cell communication
1.60 7.66e-08 GO:0032990 cell part morphogenesis
1.76 8.48e-08 GO:0060284 regulation of cell development
1.81 9.42e-08 GO:0035295 tube development
1.41 9.61e-08 GO:0007154 cell communication
1.62 1.17e-07 GO:0048646 anatomical structure formation involved in morphogenesis
1.85 2.04e-07 GO:0050767 regulation of neurogenesis
1.71 3.47e-07 GO:0007389 pattern specification process
1.18 3.76e-07 GO:0051716 cellular response to stimulus
1.72 4.31e-07 GO:0007411 axon guidance
1.92 6.20e-07 GO:0045664 regulation of neuron differentiation
1.52 6.28e-07 GO:0009887 organ morphogenesis
1.28 6.57e-07 GO:0048583 regulation of response to stimulus
1.26 9.47e-07 GO:0048523 negative regulation of cellular process
1.57 1.11e-06 GO:0019226 transmission of nerve impulse
1.57 1.11e-06 GO:0035637 multicellular organismal signaling
1.74 1.11e-06 GO:0048729 tissue morphogenesis
1.24 2.10e-06 GO:0048519 negative regulation of biological process
1.71 2.77e-06 GO:0022603 regulation of anatomical structure morphogenesis
1.48 2.99e-06 GO:0007167 enzyme linked receptor protein signaling pathway
1.46 3.16e-06 GO:0009790 embryo development
1.59 3.82e-06 GO:0007268 synaptic transmission
1.67 5.63e-06 GO:0045597 positive regulation of cell differentiation
1.73 6.72e-06 GO:0051960 regulation of nervous system development
1.80 7.37e-06 GO:0002009 morphogenesis of an epithelium
1.14 7.83e-06 GO:0032501 multicellular organismal process
1.89 9.83e-06 GO:0035239 tube morphogenesis
1.42 1.36e-05 GO:0007267 cell-cell signaling
1.07 1.37e-05 GO:0009987 cellular process
1.56 1.61e-05 GO:0051094 positive regulation of developmental process
1.26 1.72e-05 GO:0048513 organ development
1.62 1.93e-05 GO:0007420 brain development
2.03 3.49e-05 GO:0022604 regulation of cell morphogenesis
1.74 6.11e-05 GO:0003002 regionalization
1.56 6.92e-05 GO:0009968 negative regulation of signal transduction
2.01 7.19e-05 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.53 9.86e-05 GO:0010648 negative regulation of cell communication
2.01 1.03e-04 GO:0010975 regulation of neuron projection development
1.57 1.16e-04 GO:0051056 regulation of small GTPase mediated signal transduction
1.56 1.20e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.52 1.53e-04 GO:0023057 negative regulation of signaling
2.25 1.83e-04 GO:0050769 positive regulation of neurogenesis
1.89 2.48e-04 GO:0031344 regulation of cell projection organization
1.48 2.58e-04 GO:0048585 negative regulation of response to stimulus
2.53 2.88e-04 GO:0045667 regulation of osteoblast differentiation
1.64 3.67e-04 GO:0007423 sensory organ development
2.22 4.17e-04 GO:0021953 central nervous system neuron differentiation
1.87 4.75e-04 GO:0060562 epithelial tube morphogenesis
2.29 4.90e-04 GO:0050770 regulation of axonogenesis
1.35 5.79e-04 GO:0009888 tissue development
2.04 5.99e-04 GO:0010720 positive regulation of cell development
1.46 6.96e-04 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.44 8.69e-04 GO:0045892 negative regulation of transcription, DNA-dependent
1.43 1.29e-03 GO:0051253 negative regulation of RNA metabolic process
1.65 1.39e-03 GO:0046578 regulation of Ras protein signal transduction
1.32 1.53e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
2.93 1.74e-03 GO:0045778 positive regulation of ossification
1.40 1.92e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.52 1.96e-03 GO:0048598 embryonic morphogenesis
1.88 2.09e-03 GO:0030111 regulation of Wnt receptor signaling pathway
2.76 2.11e-03 GO:0050772 positive regulation of axonogenesis
1.82 2.26e-03 GO:0045165 cell fate commitment
2.03 2.52e-03 GO:0030278 regulation of ossification
1.25 3.75e-03 GO:0035556 intracellular signal transduction
1.18 4.27e-03 GO:0048522 positive regulation of cellular process
1.38 4.76e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
2.88 5.14e-03 GO:0045669 positive regulation of osteoblast differentiation
1.44 6.25e-03 GO:0072358 cardiovascular system development
1.44 6.25e-03 GO:0072359 circulatory system development
1.51 7.60e-03 GO:0044057 regulation of system process
1.79 7.65e-03 GO:0001655 urogenital system development
1.70 8.36e-03 GO:0014070 response to organic cyclic compound
1.17 8.40e-03 GO:0048518 positive regulation of biological process
2.19 8.43e-03 GO:0032526 response to retinoic acid
1.89 9.21e-03 GO:0035023 regulation of Rho protein signal transduction
1.35 1.03e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.17 1.20e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.52 1.20e-02 GO:0001501 skeletal system development
1.35 1.24e-02 GO:0009890 negative regulation of biosynthetic process
1.14 1.26e-02 GO:0016043 cellular component organization
1.37 1.36e-02 GO:0010629 negative regulation of gene expression
2.13 1.37e-02 GO:0001657 ureteric bud development
1.86 1.70e-02 GO:0060541 respiratory system development
1.47 1.90e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.56 1.93e-02 GO:0045596 negative regulation of cell differentiation
2.07 2.10e-02 GO:0022612 gland morphogenesis
1.65 2.43e-02 GO:0048732 gland development
1.86 2.49e-02 GO:0072001 renal system development
1.80 2.59e-02 GO:0001763 morphogenesis of a branching structure
2.93 2.65e-02 GO:0070169 positive regulation of biomineral tissue development
1.52 2.75e-02 GO:0001944 vasculature development
1.34 2.91e-02 GO:0009719 response to endogenous stimulus
2.07 3.03e-02 GO:0031346 positive regulation of cell projection organization
1.35 3.03e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.13 3.22e-02 GO:0031323 regulation of cellular metabolic process
1.27 3.27e-02 GO:0009605 response to external stimulus
4.39 3.36e-02 GO:0005513 detection of calcium ion
4.39 3.36e-02 GO:0071559 response to transforming growth factor beta stimulus
2.99 3.45e-02 GO:0030501 positive regulation of bone mineralization
1.15 3.65e-02 GO:0051171 regulation of nitrogen compound metabolic process
1.63 3.74e-02 GO:0032582 negative regulation of gene-specific transcription
1.70 4.23e-02 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.13 4.36e-02 GO:0080090 regulation of primary metabolic process
1.97 4.42e-02 GO:0060485 mesenchyme development
2.04 4.42e-02 GO:0010721 negative regulation of cell development
2.02 4.45e-02 GO:0016331 morphogenesis of embryonic epithelium
2.02 4.45e-02 GO:0033189 response to vitamin A
2.41 4.81e-02 GO:0001656 metanephros development
1.30 4.84e-02 GO:0051128 regulation of cellular component organization
1.85 4.93e-02 GO:0001822 kidney development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.30 1.64e-11 GO:0044459 plasma membrane part
1.66 1.23e-08 GO:0045202 synapse
1.62 1.19e-07 GO:0043005 neuron projection
1.50 2.20e-07 GO:0030054 cell junction
1.71 2.70e-07 GO:0044456 synapse part
1.53 6.22e-05 GO:0031012 extracellular matrix
1.72 2.01e-04 GO:0030425 dendrite
1.55 2.22e-04 GO:0005578 proteinaceous extracellular matrix
1.08 3.58e-04 GO:0016020 membrane
1.77 8.52e-04 GO:0005912 adherens junction
1.12 2.23e-03 GO:0005886 plasma membrane
1.29 2.47e-03 GO:0042995 cell projection
1.67 3.29e-03 GO:0043025 neuronal cell body
1.68 3.85e-03 GO:0070161 anchoring junction
2.00 4.15e-03 GO:0014069 postsynaptic density
1.12 4.28e-03 GO:0071944 cell periphery
1.65 4.74e-03 GO:0044297 cell body
1.03 6.85e-03 GO:0044464 cell part
1.23 6.86e-03 GO:0031226 intrinsic to plasma membrane
1.03 7.21e-03 GO:0005623 cell
1.22 1.45e-02 GO:0005887 integral to plasma membrane
1.66 1.66e-02 GO:0045211 postsynaptic membrane
1.49 4.08e-02 GO:0016323 basolateral plasma membrane
2.11 4.98e-02 GO:0044309 neuron spine

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.33 3.70e-06 GO:0019199 transmembrane receptor protein kinase activity
1.46 2.52e-04 GO:0030695 GTPase regulator activity
1.45 3.00e-04 GO:0060589 nucleoside-triphosphatase regulator activity
1.30 8.62e-04 GO:0001071 nucleic acid binding transcription factor activity
1.30 8.62e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.05 1.97e-03 GO:0005488 binding
1.31 9.12e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
2.09 1.56e-02 GO:0004714 transmembrane receptor protein tyrosine kinase activity
1.32 2.70e-02 GO:0004672 protein kinase activity
3.00 3.47e-02 GO:0004675 transmembrane receptor protein serine/threonine kinase activity
1.25 3.57e-02 GO:0030234 enzyme regulator activity
1.71 4.32e-02 GO:0005267 potassium channel activity
3.10 4.43e-02 GO:0005024 transforming growth factor beta receptor activity
1.07 4.81e-02 GO:0005515 protein binding
1.27 4.85e-02 GO:0016301 kinase activity