Motif ID: NKX3-1.p2

Z-value: 2.162


Transcription factors associated with NKX3-1.p2:

Gene SymbolEntrez IDGene Name
NKX3-1 4824 NK3 homeobox 1



Activity profile for motif NKX3-1.p2.

activity profile for motif NKX3-1.p2


Sorted Z-values histogram for motif NKX3-1.p2

Sorted Z-values for motif NKX3-1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_132000134 6.166 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr17_-_53847937 4.841 RNF43
ring finger protein 43
chr5_+_156628929 3.838 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr17_-_18890963 3.286 NM_006613
GRAP
GRB2-related adaptor protein
chr20_+_30160952 2.880 NM_014742
TM9SF4
transmembrane 9 superfamily protein member 4
chr15_+_57691382 2.495 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr22_+_38652555 2.460 GRAP2
GRB2-related adaptor protein 2
chr2_-_32344192 2.331 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr6_+_30238961 2.261 NM_033229
TRIM15
tripartite motif containing 15
chr19_-_56612653 2.256 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
SIGLEC10






sialic acid binding Ig-like lectin 10






chr17_-_61655915 2.195 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chrX_+_99726445 2.146 NM_022144
TNMD
tenomodulin
chr10_-_11614279 2.109 NM_001080491
USP6NL
USP6 N-terminal like
chr3_-_198784590 2.065 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr14_+_87541220 2.052 NM_003608
GPR65
G protein-coupled receptor 65
chr20_-_52120710 2.031 NM_003657
BCAS1
breast carcinoma amplified sequence 1
chr4_+_89115862 1.998 SPP1
secreted phosphoprotein 1
chr12_+_91620749 1.965 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr10_-_74384485 1.949 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr15_+_57691272 1.891 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr4_+_89115892 1.797 SPP1
secreted phosphoprotein 1
chr4_+_166350620 1.771 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr14_+_66901237 1.755 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr1_+_165565006 1.744 POU2F1
POU class 2 homeobox 1
chr2_-_165259334 1.663 COBLL1
COBL-like 1
chr4_+_89115923 1.657 SPP1
secreted phosphoprotein 1
chr4_+_89115825 1.656 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr14_+_38772870 1.612 NM_054024
MIA2
melanoma inhibitory activity 2
chr3_-_57209319 1.600 NM_003865
HESX1
HESX homeobox 1
chr7_+_99654806 1.584 NM_024070
PVRIG
poliovirus receptor related immunoglobulin domain containing
chr1_-_246869181 1.577 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr6_+_53043729 1.558 NM_012347
FBXO9
F-box protein 9
chr4_+_74488947 1.553 ALB
albumin
chr1_+_246682699 1.542 NM_001004136
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chrX_+_105823723 1.502 NM_024539
RNF128
ring finger protein 128
chr6_-_138862271 1.484 NM_001144060
NHSL1
NHS-like 1
chr4_+_74491272 1.467 ALB
albumin
chr1_+_57093030 1.464 NM_000562
C8A
complement component 8, alpha polypeptide
chr4_-_186969041 1.417 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr6_-_138862273 1.415


chr1_+_205329206 1.411 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr12_+_130004404 1.410 NM_198827
GPR133
G protein-coupled receptor 133
chr6_+_64344307 1.396 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr16_+_82540172 1.377 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr12_-_101835510 1.344 NM_000277
PAH
phenylalanine hydroxylase
chr7_+_141457977 1.332 LOC93432
maltase-glucoamylase-like pseudogene
chr9_+_4829763 1.325 RCL1
RNA terminal phosphate cyclase-like 1
chr12_+_25096472 1.323 NM_006152
LRMP
lymphoid-restricted membrane protein
chr7_+_45899621 1.319


chr12_+_49155798 1.273 LARP4
La ribonucleoprotein domain family, member 4
chr4_-_10295412 1.270 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr3_-_42892195 1.269 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr20_+_30161173 1.230 TM9SF4
transmembrane 9 superfamily protein member 4
chr4_+_74520796 1.226 NM_001134
AFP
alpha-fetoprotein
chr20_+_43764068 1.197 NM_172005
WFDC13
WAP four-disulfide core domain 13
chr4_+_74493918 1.179 ALB
albumin
chr4_+_17125885 1.176 NM_001079827
CLRN2
clarin 2
chr13_+_51496679 1.174 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr4_+_71418886 1.165 NM_212557
AMTN
amelotin
chr9_-_103237851 1.158 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr14_-_24148658 1.145 NM_033423
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chrX_+_57329834 1.139 NM_174912
FAAH2
fatty acid amide hydrolase 2
chr14_-_105681377 1.138 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr5_-_179040580 1.135 NM_001164444
CBY3
chibby homolog 3 (Drosophila)
chr3_-_152403636 1.102 NM_013308
GPR171
G protein-coupled receptor 171
chr3_-_184756101 1.090 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr5_+_140709907 1.072 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr3_+_113200696 1.071 NM_001008273
TAGLN3
transgelin 3
chr1_+_103898844 1.057 NM_020978
AMY2B
amylase, alpha 2B (pancreatic)
chr1_-_205012348 1.055 NM_000572
IL10
interleukin 10
chr4_+_74488835 1.044 NM_000477
ALB
albumin
chr6_+_126282078 1.024 NCOA7
nuclear receptor coactivator 7
chr21_-_42659671 1.021 NM_003225
TFF1
trefoil factor 1
chr6_+_32003180 1.016 NM_000063
NM_001145903
C2

complement component 2

chr1_-_229627412 1.007 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr2_-_21106291 1.001 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_-_158815850 0.997 CD84
CD84 molecule
chr10_-_73953699 0.989 NM_001195519
CBARA1
calcium binding atopy-related autoantigen 1
chr4_+_39084936 0.982 KLB
klotho beta
chr14_+_31868229 0.973 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr2_-_233349469 0.966 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr9_-_205892 0.962 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr18_+_27210737 0.957 NM_001134453
NM_177986
DSG4

desmoglein 4

chr4_+_88748704 0.956 NM_014208
DSPP
dentin sialophosphoprotein
chr6_+_167445284 0.949 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr18_-_22696532 0.946 NM_004028
AQP4
aquaporin 4
chr11_-_30558495 0.939 NM_001584
MPPED2
metallophosphoesterase domain containing 2
chrX_-_135783496 0.935


chr17_-_16816113 0.931 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr3_+_123279439 0.926 NM_006889
CD86
CD86 molecule
chr1_+_66230977 0.924 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr21_+_29322100 0.920 USP16
ubiquitin specific peptidase 16
chr17_-_64752550 0.917 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr20_-_51633042 0.909 NM_006526
ZNF217
zinc finger protein 217
chr6_+_31538934 0.903 NM_006674
HCP5
HLA complex P5
chr2_+_135312655 0.887 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr20_-_34707971 0.866 NM_032214
NM_175077
SLA2

Src-like-adaptor 2

chr14_+_94148466 0.861 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr6_-_52060327 0.861 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr2_-_207291364 0.852 NM_001093730
DYTN
dystrotelin
chr19_-_58486686 0.852 NM_033341
BIRC8
baculoviral IAP repeat containing 8
chr8_-_59575249 0.839 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr5_+_43645018 0.838 NNT
nicotinamide nucleotide transhydrogenase
chr4_+_74498042 0.829 ALB
albumin
chr5_+_67622242 0.822 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr6_+_88021644 0.821 ZNF292
zinc finger protein 292
chr5_+_126887056 0.806 PRRC1
proline-rich coiled-coil 1
chr3_-_120761092 0.804 NM_005191
CD80
CD80 molecule
chr15_+_81275026 0.802 NM_001080435
WHAMM
WAS protein homolog associated with actin, golgi membranes and microtubules
chr11_+_89624017 0.791


chr8_+_24207524 0.789 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr17_+_71975224 0.784 NM_001088
AANAT
aralkylamine N-acetyltransferase
chr20_-_43163021 0.777 NM_002251
KCNS1
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
chr13_-_98708549 0.752 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr1_+_50348052 0.749 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr12_+_8167494 0.743 NM_016184
NM_194447
NM_194448
NM_194450
CLEC4A



C-type lectin domain family 4, member A



chrX_+_115215985 0.738 NM_000686
AGTR2
angiotensin II receptor, type 2
chr20_+_56919233 0.736 GNAS
GNAS complex locus
chr5_+_140583098 0.728 NM_018934
PCDHB14
protocadherin beta 14
chrX_-_13744933 0.726 GPM6B
glycoprotein M6B
chr6_+_32003380 0.725 C2
complement component 2
chr12_-_120725210 0.722 LOC338799
hypothetical LOC338799
chr4_+_74497998 0.721 ALB
albumin
chr9_+_130056513 0.719


chr14_+_22859236 0.718 NM_004643
PABPN1
poly(A) binding protein, nuclear 1
chr2_-_208736533 0.711 NM_014617
CRYGA
crystallin, gamma A
chr9_+_109131814 0.709 RAD23B
RAD23 homolog B (S. cerevisiae)
chr3_+_171183203 0.707 SEC62
SEC62 homolog (S. cerevisiae)
chr4_+_187385618 0.698 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chrX_-_32340291 0.690 NM_004011
NM_004012
DMD

dystrophin

chr3_-_195553297 0.689 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr18_-_50776276 0.689 NM_001143829
CCDC68
coiled-coil domain containing 68
chr1_-_158815895 0.688 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chrX_-_130792297 0.673 LOC286467
hypothetical LOC286467
chr2_-_127817143 0.652 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr4_+_1872150 0.650 NM_133334
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr2_-_39310176 0.650 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr16_+_2195424 0.648 NM_022372
MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr9_-_124981125 0.644 STRBP
spermatid perinuclear RNA binding protein
chr17_-_5078773 0.643 NM_207103
C17orf87
chromosome 17 open reading frame 87
chr1_-_149681265 0.642 NM_207171
POGZ
pogo transposable element with ZNF domain
chr1_+_246195157 0.636 NM_001004491
OR2AK2
olfactory receptor, family 2, subfamily AK, member 2
chr3_-_180452096 0.636 NM_014407
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr15_+_97990705 0.634 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr7_+_45899080 0.631 IGFBP1
insulin-like growth factor binding protein 1
chr17_+_50698169 0.629 HLF
hepatic leukemia factor
chr4_+_74488910 0.628 ALB
albumin
chr7_-_36730525 0.627 NM_001177506
NM_001177507
NM_001637
AOAH


acyloxyacyl hydrolase (neutrophil)


chr2_+_228064531 0.608 AGFG1
ArfGAP with FG repeats 1
chr14_+_93562500 0.607 OTUB2
OTU domain, ubiquitin aldehyde binding 2
chr10_-_98021144 0.605 NM_001114094
NM_013314
BLNK

B-cell linker

chr14_-_22516271 0.605 NM_198086
JUB
jub, ajuba homolog (Xenopus laevis)
chr2_+_169465995 0.602 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr12_+_119617060 0.600


chr19_-_56549853 0.597 NM_001014763
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr5_+_147754467 0.596 FBXO38
F-box protein 38
chr3_+_120799411 0.594 NM_015900
PLA1A
phospholipase A1 member A
chr14_-_106282128 0.594 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_+_88130482 0.591 NM_207662
ZC3H14
zinc finger CCCH-type containing 14
chr2_-_191580567 0.590 STAT1
signal transducer and activator of transcription 1, 91kDa
chr2_+_42649105 0.588 NM_020744
MTA3
metastasis associated 1 family, member 3
chr3_-_121883647 0.584 HGD
homogentisate 1,2-dioxygenase
chr2_-_104834344 0.580 LOC100506421
hypothetical LOC100506421
chr14_+_93562436 0.580 NM_023112
OTUB2
OTU domain, ubiquitin aldehyde binding 2
chr8_-_17797127 0.574 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr2_+_218833982 0.573 NM_001077191
NM_001077194
NM_170699
GPBAR1


G protein-coupled bile acid receptor 1


chr6_-_28294642 0.566 LOC222699
transducer of ERBB2, 2 pseudogene
chr6_+_10629550 0.560 NM_145649
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chrX_+_90977115 0.558 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr11_-_83661878 0.553 NM_001142700
DLG2
discs, large homolog 2 (Drosophila)
chr1_-_205272619 0.552 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr3_-_42892636 0.551 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr2_+_201806410 0.550 NM_001080124
NM_001228
NM_033355
NM_033358
CASP8



caspase 8, apoptosis-related cysteine peptidase



chr3_-_152541129 0.549 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr3_-_168853982 0.547 NM_178824
WDR49
WD repeat domain 49
chr21_-_26175068 0.546 APP
amyloid beta (A4) precursor protein
chr11_+_67133502 0.545 NDUFV1
NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
chr4_-_84254932 0.543 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chrX_-_30505804 0.541 NM_025159
CXorf21
chromosome X open reading frame 21
chr3_+_129124591 0.539 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr16_+_11966464 0.536 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr2_+_183290912 0.535 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr12_+_55018925 0.529 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr5_-_88155360 0.523 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr6_-_33016561 0.522 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr14_-_88948486 0.521 FOXN3
forkhead box N3
chr6_+_36752244 0.521 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chrX_-_76824726 0.517 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr17_+_3324096 0.514 NM_001128085
ASPA
aspartoacylase
chr12_-_86947276 0.512 NM_152589
C12orf50
chromosome 12 open reading frame 50
chr9_+_89302239 0.510 DAPK1
death-associated protein kinase 1
chr1_+_158975662 0.509 NM_021181
SLAMF7
SLAM family member 7
chr6_+_46869052 0.507 NM_005588
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr19_+_17906904 0.507 NM_138442
CCDC124
coiled-coil domain containing 124
chr17_-_39500512 0.506 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr20_-_44612619 0.504 NM_080721
C20orf123
chromosome 20 open reading frame 123
chr20_-_31055892 0.503 NM_080675
SUN5
Sad1 and UNC84 domain containing 5
chrX_+_38096679 0.499 NM_000531
OTC
ornithine carbamoyltransferase
chr16_+_80626459 0.497 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr16_-_88604029 0.496 NM_024043
DBNDD1
dysbindin (dystrobrevin binding protein 1) domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.05 4.33e-26 GO:0007608 sensory perception of smell
3.84 6.41e-26 GO:0007606 sensory perception of chemical stimulus
2.63 2.91e-17 GO:0007600 sensory perception
1.95 1.09e-10 GO:0050877 neurological system process
1.79 1.28e-09 GO:0003008 system process
1.35 7.81e-08 GO:0032501 multicellular organismal process
1.29 1.31e-06 GO:0050896 response to stimulus
1.81 1.61e-03 GO:0006952 defense response
2.12 1.95e-03 GO:0050776 regulation of immune response
5.45 2.11e-03 GO:0031214 biomineral tissue development
2.27 2.00e-02 GO:0050778 positive regulation of immune response
7.67 3.24e-02 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation
7.67 3.24e-02 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.38 1.10e-07 GO:0005886 plasma membrane
1.38 1.30e-07 GO:0071944 cell periphery
1.49 5.68e-05 GO:0005576 extracellular region
1.21 4.19e-03 GO:0031224 intrinsic to membrane
1.21 6.64e-03 GO:0016021 integral to membrane
1.17 2.01e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.15 8.28e-27 GO:0004984 olfactory receptor activity
2.58 1.12e-17 GO:0004930 G-protein coupled receptor activity
1.82 2.52e-11 GO:0004872 receptor activity
1.97 3.57e-11 GO:0004888 transmembrane receptor activity
1.64 7.64e-09 GO:0004871 signal transducer activity
1.64 7.64e-09 GO:0060089 molecular transducer activity
11.64 1.05e-02 GO:0005132 interferon-alpha/beta receptor binding
3.73 3.33e-02 GO:0035591 signaling adaptor activity