Motif ID: HAND1,2.p2

Z-value: 3.606


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2



Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_-_45339605 8.992 NM_182493
MYLK3
myosin light chain kinase 3
chr16_-_28515868 8.395 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr11_+_66927976 8.212 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr19_-_10074332 8.209 NM_031917
ANGPTL6
angiopoietin-like 6
chr22_+_23329113 5.833 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr22_+_43451600 5.405 PRR5
proline rich 5 (renal)
chr16_+_56286212 5.050 NM_032269
CCDC135
coiled-coil domain containing 135
chr20_-_1113116 4.899 NM_018354
C20orf46
chromosome 20 open reading frame 46
chr19_+_40465249 4.788 NM_021175
HAMP
hepcidin antimicrobial peptide
chr6_-_25940247 4.745 NM_005074
SLC17A1
solute carrier family 17 (sodium phosphate), member 1
chr20_+_34937928 4.738 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr4_+_76700281 4.703 NM_178497
C4orf26
chromosome 4 open reading frame 26
chr21_+_41616590 4.684 FAM3B
family with sequence similarity 3, member B
chrX_-_48213508 4.539 SLC38A5
solute carrier family 38, member 5
chr5_-_149772563 4.505 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr11_-_63087430 4.422 NM_017878
HRASLS2
HRAS-like suppressor 2
chr16_+_28413421 4.420 NM_018690
APOBR
apolipoprotein B receptor
chr6_+_167445284 4.284 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr12_+_56114724 4.208 NM_005538
INHBC
inhibin, beta C
chr6_+_6533932 4.182 NM_004271
LY86
lymphocyte antigen 86
chr8_-_82769761 4.122 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chrX_-_48213545 4.049 NM_033518
SLC38A5
solute carrier family 38, member 5
chr16_-_31054321 3.952 PRSS8
protease, serine, 8
chr14_-_64479198 3.946 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr2_+_218954995 3.800 NM_000578
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr16_-_31054563 3.736 NM_002773
PRSS8
protease, serine, 8
chr17_-_37590910 3.734 NM_001524
HCRT
hypocretin (orexin) neuropeptide precursor
chr13_+_112860968 3.698 NM_003891
PROZ
protein Z, vitamin K-dependent plasma glycoprotein
chr5_-_149772528 3.661


chr19_-_12807221 3.622 NM_031429
RTBDN
retbindin
chr9_-_99740243 3.542 NM_197978
HEMGN
hemogen
chrX_+_49718954 3.533 NM_000084
CLCN5
chloride channel 5
chr22_+_43451351 3.493 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr22_+_23333610 3.409 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr15_+_42815851 3.385 NM_080745
NM_182985
TRIM69

tripartite motif containing 69

chr2_-_73781974 3.351 NM_016347
NAT8B
N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)
chr11_+_22652894 3.314 NM_005256
GAS2
growth arrest-specific 2
chr19_+_55614006 3.252 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr1_-_166149867 3.203 NM_001167749
NM_018417
ADCY10

adenylate cyclase 10 (soluble)

chr1_+_205328834 3.122 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr16_+_29582065 3.052 SPN
sialophorin
chr14_-_23846993 3.050 CIDEB
cell death-inducing DFFA-like effector b
chr1_-_158815895 3.021 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr1_+_28134090 2.970 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr3_+_99733432 2.963 NM_005290
GPR15
G protein-coupled receptor 15
chr11_+_22652957 2.949 GAS2
growth arrest-specific 2
chr16_-_20495126 2.933 NM_001105069
NM_182617
ACSM2B

acyl-CoA synthetase medium-chain family member 2B

chr7_-_100630912 2.932 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr19_+_40224480 2.885 HPN
hepsin
chr19_-_56585603 2.854 NM_001193623
LOC147646
hypothetical protein LOC147646
chr11_+_89624017 2.854


chr11_+_22646229 2.841 NM_177553
GAS2
growth arrest-specific 2
chr2_-_25328452 2.833 NM_153759
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr19_+_41085221 2.825 NM_001007469
NM_014266
HCST

hematopoietic cell signal transducer

chr11_-_62753574 2.808 NM_199352
SLC22A25
solute carrier family 22, member 25
chr17_-_36346240 2.804 KRT23
keratin 23 (histone deacetylase inducible)
chr19_+_3659358 2.755 TJP3
tight junction protein 3 (zona occludens 3)
chr9_-_106705780 2.716 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr14_-_23846904 2.710 CIDEB
cell death-inducing DFFA-like effector b
chr11_+_2279932 2.696 TSPAN32
tetraspanin 32
chr20_-_48686832 2.684 NM_080829
FAM65C
family with sequence similarity 65, member C
chr14_-_106240998 2.677 IGHV1-69
IGHG1
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_+_75058518 2.650 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr1_-_158815850 2.531 CD84
CD84 molecule
chr11_+_2279812 2.524 NM_139022
TSPAN32
tetraspanin 32
chr11_-_2279642 2.506 NM_001142946
C11orf21
chromosome 11 open reading frame 21
chr19_-_56564068 2.498 NM_152353
CLDND2
claudin domain containing 2
chr14_+_75058591 2.478 BATF
basic leucine zipper transcription factor, ATF-like
chr16_-_20246309 2.475 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr1_+_159899528 2.439 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr5_-_149772469 2.401 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr7_+_99654806 2.395 NM_024070
PVRIG
poliovirus receptor related immunoglobulin domain containing
chr12_-_52016270 2.381 NM_001173467
SP7
Sp7 transcription factor
chr6_+_37081387 2.338 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr19_-_56582997 2.326 NM_001161748
NM_030657
LIM2

lens intrinsic membrane protein 2, 19kDa

chr6_+_64289585 2.323 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr11_+_118463906 2.314 NM_001024382
HMBS
hydroxymethylbilane synthase
chr11_+_62813947 2.300 NM_001039752
SLC22A10
solute carrier family 22, member 10
chr1_+_26517045 2.278 CD52
CD52 molecule
chr16_-_3089253 2.245 ZSCAN10
zinc finger and SCAN domain containing 10
chr2_+_218929822 2.242 NM_198559
C2orf62
chromosome 2 open reading frame 62
chr9_-_106705867 2.235 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr4_+_74500748 2.233 ALB
albumin
chr10_+_82287637 2.226 NM_207372
SH2D4B
SH2 domain containing 4B
chr1_-_26517342 2.205 NM_145345
UBXN11
UBX domain protein 11
chr16_+_20370359 2.196 NM_001010845
ACSM2A
acyl-CoA synthetase medium-chain family member 2A
chr1_+_159817752 2.186 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr10_-_76529253 2.184 NM_016364
DUSP13
dual specificity phosphatase 13
chr19_-_60360768 2.146 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr6_-_41823056 2.112 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr2_-_85490984 2.073 CAPG
capping protein (actin filament), gelsolin-like
chr2_+_218978375 2.056 CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr19_+_10404110 2.038 NM_001111309
PDE4A
phosphodiesterase 4A, cAMP-specific
chrX_+_128741562 2.034 NM_018990
SASH3
SAM and SH3 domain containing 3
chrX_+_128741578 2.017 SASH3
SAM and SH3 domain containing 3
chr17_+_35038276 1.995 NM_181505
PPP1R1B
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr19_-_63715135 1.969 NM_012254
SLC27A5
solute carrier family 27 (fatty acid transporter), member 5
chr14_-_106241445 1.965 IGHV4-31
IGHV1-69
IGHA1
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr19_+_61624 1.949 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr1_+_556968 1.946


chr16_+_21152516 1.944 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr1_+_205329206 1.944 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr12_-_55134692 1.924 NM_012064
MIP
major intrinsic protein of lens fiber
chr1_+_26516967 1.913 NM_001803
CD52
CD52 molecule
chr20_+_71230 1.858 NM_030931
DEFB126
defensin, beta 126
chr2_-_31293882 1.828 NM_001145122
CAPN14
calpain 14
chr11_-_64459910 1.825 NM_130769
GPHA2
glycoprotein hormone alpha 2
chr2_-_85490997 1.819 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr19_+_11510578 1.815 NM_001299
CNN1
calponin 1, basic, smooth muscle
chr16_-_29817841 1.814 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr17_-_76897590 1.813 NM_178519
C17orf55
chromosome 17 open reading frame 55
chr17_+_16259812 1.761 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr6_-_34632061 1.751 NM_012391
SPDEF
SAM pointed domain containing ets transcription factor
chr1_+_116455898 1.737 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr1_+_228949752 1.729 NM_006615
NM_016452
CAPN9

calpain 9

chr6_+_31016755 1.729 NM_080870
DPCR1
diffuse panbronchiolitis critical region 1
chr19_+_44886785 1.697 NM_020129
NM_203471
LGALS14

lectin, galactoside-binding, soluble, 14

chr22_+_40286957 1.696 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr12_-_55917134 1.667 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr14_+_87560646 1.664 LOC283587
hypothetical protein LOC283587
chr5_-_121842680 1.658


chr6_-_39180390 1.657 C6orf64
chromosome 6 open reading frame 64
chr2_-_127817143 1.620 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr3_+_51870684 1.609 NM_203424
IQCF2
IQ motif containing F2
chr16_+_29581783 1.599 NM_001030288
SPN
sialophorin
chr19_-_40996040 1.590 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr14_-_23847000 1.582 CIDEB
cell death-inducing DFFA-like effector b
chr1_+_557269 1.572


chr9_-_129707392 1.562 LOC100131355
ST6GALNAC6
hypothetical protein LOC100131355
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr11_-_64283945 1.560 PYGM
phosphorylase, glycogen, muscle
chr11_-_113082233 1.555 NM_030770
TMPRSS5
transmembrane protease, serine 5
chr11_-_60880799 1.540 NM_001161452
CYBASC3
cytochrome b, ascorbate dependent 3
chr11_+_66927955 1.527 TBC1D10C
TBC1 domain family, member 10C
chr19_-_10311262 1.519 NM_002162
ICAM3
intercellular adhesion molecule 3
chr22_+_39404940 1.506 NM_005297
MCHR1
melanin-concentrating hormone receptor 1
chr1_-_159099090 1.506 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr17_-_8711701 1.503 NM_001010855
PIK3R6
phosphoinositide-3-kinase, regulatory subunit 6
chr2_+_228386800 1.483 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr22_+_21393107 1.472 IGLJ3
immunoglobulin lambda joining 3
chr5_+_73145098 1.469 RGNEF
190 kDa guanine nucleotide exchange factor
chr12_+_102859354 1.469 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr22_-_34886727 1.467 NM_145640
APOL3
apolipoprotein L, 3
chr5_+_141326620 1.454 NM_183399
RNF14
ring finger protein 14
chr16_-_66590856 1.451 NM_022355
DPEP2
dipeptidase 2
chr2_+_74913289 1.443 NM_000189
HK2
hexokinase 2
chr17_-_35328368 1.440 NM_001042471
NM_001165958
NM_001165959
GSDMB


gasdermin B


chr8_-_30121741 1.439 NM_001100916
MBOAT4
membrane bound O-acyltransferase domain containing 4
chr10_-_5035967 1.432 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr19_-_53914768 1.422 NM_001130915
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr6_-_53121540 1.413 NM_003643
GCM1
glial cells missing homolog 1 (Drosophila)
chr13_-_45640679 1.393 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_+_60850765 1.386 NM_013301
CCDC106
coiled-coil domain containing 106
chr19_-_59542197 1.384 NM_012276
LILRA4
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
chr20_+_43764068 1.383 NM_172005
WFDC13
WAP four-disulfide core domain 13
chr11_+_71605466 1.376 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr5_+_59819761 1.343 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr4_+_22608252 1.329


chr7_-_100077072 1.325 NM_003227
TFR2
transferrin receptor 2
chr1_+_152560179 1.323 NM_080429
AQP10
aquaporin 10
chr14_-_88948486 1.316 FOXN3
forkhead box N3
chr21_-_45165204 1.316 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr1_-_158948176 1.309 NM_001778
CD48
CD48 molecule
chr11_+_45899747 1.306 NM_152312
GYLTL1B
glycosyltransferase-like 1B
chr5_-_176769094 1.290 F12
coagulation factor XII (Hageman factor)
chr6_+_88026338 1.287 ZNF292
zinc finger protein 292
chr2_+_169367345 1.280 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr17_+_16259636 1.279 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr10_-_121286034 1.277 NM_002925
RGS10
regulator of G-protein signaling 10
chr2_+_68815416 1.271 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr1_-_92724181 1.270 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr7_-_44547382 1.269 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr6_-_55848317 1.268 NM_021073
BMP5
bone morphogenetic protein 5
chr2_+_11600238 1.268 GREB1
growth regulation by estrogen in breast cancer 1
chr19_-_8548309 1.262 NM_012335
MYO1F
myosin IF
chr10_-_104201234 1.259 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr12_+_119617060 1.258


chr19_-_17819773 1.252 JAK3
Janus kinase 3
chr10_+_124135574 1.249 NM_001195608
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr11_-_117305277 1.249 NM_001077263
TMPRSS13
transmembrane protease, serine 13
chr11_+_359723 1.243 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr11_-_64520964 1.239 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr14_-_20694023 1.226 NM_001004731
OR5AU1
olfactory receptor, family 5, subfamily AU, member 1
chr6_-_53321545 1.224 ELOVL5
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
chr10_+_685887 1.220 C10orf108
chromosome 10 open reading frame 108
chr14_+_23492780 1.218 NM_021004
DHRS4
dehydrogenase/reductase (SDR family) member 4
chr12_+_121218218 1.211 NM_152759
LRRC43
leucine rich repeat containing 43
chr7_+_100037817 1.209 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr12_+_117067214 1.207 PEBP1
phosphatidylethanolamine binding protein 1
chr7_-_94791763 1.197 NM_000446
PON1
paraoxonase 1
chr6_-_135312899 1.193 NM_001193480
NM_022568
NM_170771
ALDH8A1


aldehyde dehydrogenase 8 family, member A1


chr19_-_8548337 1.191 MYO1F
myosin IF
chr14_-_105392671 1.190


chr9_+_135389698 1.189 NM_014694
ADAMTSL2
ADAMTS-like 2
chr10_+_4995453 1.179 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr16_-_67943157 1.176 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr19_+_56420181 1.174 CD33
CD33 molecule
chrX_-_105169370 1.164 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr2_-_73723001 1.154 NM_003960
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr12_+_99274987 1.145 NM_001145288
NM_139319
SLC17A8

solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8

chr17_+_16259573 1.143 NM_016113
TRPV2
transient receptor potential cation channel, subfamily V, member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.07 1.42e-03 GO:0050776 regulation of immune response
1.65 6.24e-03 GO:0006629 lipid metabolic process
1.96 7.59e-03 GO:0007606 sensory perception of chemical stimulus
1.97 1.85e-02 GO:0007608 sensory perception of smell
3.53 1.91e-02 GO:0007015 actin filament organization
2.29 4.40e-02 GO:0008202 steroid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.39 3.64e-09 GO:0071944 cell periphery
1.39 6.77e-09 GO:0005886 plasma membrane
1.50 8.15e-06 GO:0005576 extracellular region
1.78 9.80e-05 GO:0005615 extracellular space
1.24 1.00e-04 GO:0031224 intrinsic to membrane
1.18 1.86e-04 GO:0016020 membrane
1.23 2.67e-04 GO:0016021 integral to membrane
1.20 3.47e-04 GO:0044425 membrane part
1.60 1.31e-03 GO:0044421 extracellular region part
1.36 4.66e-03 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.68 1.00e-08 GO:0004872 receptor activity
1.53 1.23e-06 GO:0004871 signal transducer activity
1.53 1.23e-06 GO:0060089 molecular transducer activity
1.98 6.05e-03 GO:0004984 olfactory receptor activity
2.66 8.06e-03 GO:0004252 serine-type endopeptidase activity
1.48 1.53e-02 GO:0004888 transmembrane receptor activity
7.74 2.72e-02 GO:0016805 dipeptidase activity
13.42 3.08e-02 GO:0032052 bile acid binding
2.88 3.66e-02 GO:0005179 hormone activity
4.19 4.59e-02 GO:0003823 antigen binding