Motif ID: SOX2.p2

Z-value: 1.203


Transcription factors associated with SOX2.p2:

Gene SymbolEntrez IDGene Name
SOX2 6657 SRY (sex determining region Y)-box 2



Activity profile for motif SOX2.p2.

activity profile for motif SOX2.p2


Sorted Z-values histogram for motif SOX2.p2

Sorted Z-values for motif SOX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_11246934 1.831 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr7_+_106292975 1.827 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr7_+_106292932 1.743 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr13_-_98757634 1.416 NM_004951
GPR183
G protein-coupled receptor 183
chr3_+_39484073 1.375 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr10_+_11247059 1.330 CELF2
CUGBP, Elav-like family member 2
chr17_-_46479127 1.265 SPAG9
sperm associated antigen 9
chr17_-_1195096 1.249 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chrX_-_11194015 1.172 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr7_+_106293112 1.129 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr1_+_22107137 1.126 RPL21
ribosomal protein L21
chr3_-_150533948 1.116 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr1_+_242283129 1.075 NM_006352
ZNF238
zinc finger protein 238
chr5_-_71838875 1.052 NM_152625
ZNF366
zinc finger protein 366
chr10_+_70517823 1.045 NM_002727
SRGN
serglycin
chr4_+_71806538 1.040 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr10_+_70517863 1.028 SRGN
serglycin
chr18_+_13601664 1.027 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr4_+_86918882 1.016 ARHGAP24
Rho GTPase activating protein 24
chr1_-_47468029 0.979 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr10_-_61570665 0.919 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr17_-_44006808 0.912 NM_002146
HOXB3
homeobox B3
chr1_-_7923464 0.910 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr3_-_143230124 0.889 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr18_+_3441589 0.887 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr3_-_3127057 0.883 NM_000564
NM_175724
NM_175725
NM_175726
NM_175727
NM_175728
IL5RA





interleukin 5 receptor, alpha





chr7_-_111633428 0.844 DOCK4
dedicator of cytokinesis 4
chr12_-_9804682 0.842 NM_001781
CD69
CD69 molecule
chr19_+_17923110 0.831 NM_002248
KCNN1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr5_-_88155360 0.830 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr7_+_128802719 0.824 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr4_-_74307637 0.807 ANKRD17
ankyrin repeat domain 17
chr7_+_116447499 0.791 ST7
suppression of tumorigenicity 7
chr7_-_111633620 0.774 NM_014705
DOCK4
dedicator of cytokinesis 4
chr11_+_129496792 0.761 APLP2
amyloid beta (A4) precursor-like protein 2
chr19_+_40824486 0.755 NM_014209
ETV2
ets variant 2
chr2_+_108637698 0.751 NM_001193485
LIMS1
LIM and senescent cell antigen-like domains 1
chr6_-_74284522 0.749 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr2_+_108637916 0.746 LIMS1
LIMS3
LIM and senescent cell antigen-like domains 1
LIM and senescent cell antigen-like domains 3
chr7_+_139175420 0.745 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr2_+_101874765 0.724 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr4_+_160408447 0.719 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr2_+_101874809 0.715 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chrX_+_86659370 0.711 NM_019117
NM_057162
KLHL4

kelch-like 4 (Drosophila)

chr3_+_190831909 0.706 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr17_-_59817575 0.702 PECAM1
platelet/endothelial cell adhesion molecule
chr17_-_59817722 0.692 NM_000442
PECAM1
platelet/endothelial cell adhesion molecule
chr22_-_25344037 0.685 CRYBB1
crystallin, beta B1
chr3_-_13032130 0.670


chr8_+_39890484 0.668 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr1_+_196874867 0.649 PTPRC
protein tyrosine phosphatase, receptor type, C
chr5_+_76470829 0.646


chr17_-_59817654 0.643 PECAM1
platelet/endothelial cell adhesion molecule
chr2_+_143603439 0.642 ARHGAP15
Rho GTPase activating protein 15
chr22_+_25383392 0.640 MIAT
myocardial infarction associated transcript (non-protein coding)
chr6_-_139654807 0.633 NM_153235
TXLNB
taxilin beta
chr9_+_100745531 0.633 NM_001855
COL15A1
collagen, type XV, alpha 1
chr1_+_242283906 0.632


chr1_+_84540921 0.629 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr10_-_11614279 0.629 NM_001080491
USP6NL
USP6 N-terminal like
chr22_-_25343959 0.621 NM_001887
CRYBB1
crystallin, beta B1
chr17_-_59817456 0.615 PECAM1
platelet/endothelial cell adhesion molecule
chr12_-_101115677 0.613 NM_002674
PMCH
pro-melanin-concentrating hormone
chr8_+_32623792 0.611 NM_013959
NRG1
neuregulin 1
chr2_-_110665188 0.611 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr7_+_102340579 0.605 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr7_+_111633878 0.604 NM_021994
ZNF277
zinc finger protein 277
chr6_+_105511615 0.602 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr1_-_51660328 0.597 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr5_+_143171918 0.597 NM_021182
HMHB1
histocompatibility (minor) HB-1
chr6_-_76259976 0.596 NM_015687
FILIP1
filamin A interacting protein 1
chr5_-_88004891 0.594 LOC645323
hypothetical LOC645323
chr11_-_85107569 0.593 NM_206929
SYTL2
synaptotagmin-like 2
chr13_-_32658215 0.588 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr17_-_59818033 0.584 PECAM1
platelet/endothelial cell adhesion molecule
chr14_+_76298693 0.583 VASH1
vasohibin 1
chr1_+_242281199 0.580 ZNF238
zinc finger protein 238
chr17_-_18890963 0.573 NM_006613
GRAP
GRB2-related adaptor protein
chr21_+_34112456 0.572 ITSN1
intersectin 1 (SH3 domain protein)
chr4_+_154397975 0.571 TRIM2
tripartite motif containing 2
chr17_-_44058612 0.569 NM_024017
HOXB9
homeobox B9
chr7_-_5533621 0.569 ACTB
actin, beta
chr1_+_165564904 0.559 NM_001198783
POU2F1
POU class 2 homeobox 1
chr19_+_39402167 0.558 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr3_+_44665220 0.554 NM_003420
ZNF35
zinc finger protein 35
chr2_+_143603368 0.554 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr11_-_85108030 0.554 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr9_+_126460511 0.552


chr2_+_110013297 0.551 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr2_-_198248828 0.550 NM_144629
RFTN2
raftlin family member 2
chrX_+_133952633 0.547 NM_001163438
LOC644538
hypothetical protein LOC644538
chr1_-_152431175 0.546 NM_152263
TPM3
tropomyosin 3
chr1_+_1062137 0.546 LOC254099
hypothetical protein LOC254099
chr1_+_165565006 0.545 POU2F1
POU class 2 homeobox 1
chr1_+_196874759 0.544 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr8_-_93144039 0.541


chr1_-_32574185 0.540 NM_023009
MARCKSL1
MARCKS-like 1
chr1_-_50661716 0.538 NM_032110
DMRTA2
DMRT-like family A2
chr3_+_148593911 0.537


chr13_+_110653407 0.535 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr10_-_25281510 0.533 NM_020200
PRTFDC1
phosphoribosyl transferase domain containing 1
chr17_+_53761293 0.528 LOC100506779
hypothetical LOC100506779
chr11_-_83071084 0.525 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr18_+_3439972 0.523 NM_173209
NM_173208
NM_003244
TGIF1


TGFB-induced factor homeobox 1


chr4_-_101658094 0.521 NM_001159694
NM_016242
EMCN

endomucin

chr16_+_55373241 0.519 NUP93
nucleoporin 93kDa
chr17_-_53761119 0.503 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr6_+_100161370 0.503 NM_021620
PRDM13
PR domain containing 13
chr3_-_158704056 0.498 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr10_+_11247243 0.491 CELF2
CUGBP, Elav-like family member 2
chr1_-_229058404 0.486 NM_001136495
C1orf198
chromosome 1 open reading frame 198
chr1_+_196874839 0.484 PTPRC
protein tyrosine phosphatase, receptor type, C
chr8_-_93176819 0.482 RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr5_+_140871107 0.479


chr3_+_186563529 0.474 NM_004721
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr5_+_140215778 0.474 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr19_-_53941835 0.472 NM_182575
IZUMO1
izumo sperm-egg fusion 1
chr13_+_45174446 0.471 NM_152719
SPERT
spermatid associated
chr5_-_178977441 0.469 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chrX_+_12903145 0.467 NM_021109
NM_183049
TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chr14_+_87541220 0.466 NM_003608
GPR65
G protein-coupled receptor 65
chr8_-_93176618 0.466 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr1_+_149395728 0.466 NM_024575
TNFAIP8L2
tumor necrosis factor, alpha-induced protein 8-like 2
chr11_-_72057755 0.465 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr8_-_6407882 0.464 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr10_+_11247449 0.462 CELF2
CUGBP, Elav-like family member 2
chr12_-_10464308 0.462 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr7_-_92693716 0.460 NM_001039372
HEPACAM2
HEPACAM family member 2
chr7_+_111633972 0.457 ZNF277
zinc finger protein 277
chr1_-_114215768 0.457 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr19_-_45016587 0.456 NM_004714
NM_006483
NM_006484
DYRK1B


dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B


chr9_+_124835608 0.456 RABGAP1
GPR21
RAB GTPase activating protein 1
G protein-coupled receptor 21
chr17_-_24491521 0.454 MYO18A
myosin XVIIIA
chr10_+_11247419 0.453 CELF2
CUGBP, Elav-like family member 2
chr15_+_21361546 0.453 NM_005664
MKRN3
makorin ring finger protein 3
chr10_+_11247467 0.451 CELF2
CUGBP, Elav-like family member 2
chr3_+_19164973 0.450 NM_144633
KCNH8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chrX_-_134013644 0.446 NM_001078172
NM_001134321
FAM127B

family with sequence similarity 127, member B

chr12_-_101396459 0.446 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr22_+_19601619 0.445 NM_005207
CRKL
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
chr8_-_108579270 0.444 NM_001146
ANGPT1
angiopoietin 1
chr5_+_176494690 0.442 NSD1
nuclear receptor binding SET domain protein 1
chr11_-_117600918 0.442 NM_001098526
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr7_-_26198673 0.434 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr8_+_67201684 0.434 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr7_-_112515035 0.426 GPR85
G protein-coupled receptor 85
chr4_-_176970407 0.421 GPM6A
glycoprotein M6A
chr5_-_150501393 0.419 NM_001193544
ANXA6
annexin A6
chr22_-_48865980 0.419 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr12_+_6915698 0.417


chr8_+_21833162 0.415 XPO7
exportin 7
chr12_-_47735373 0.415 NM_003482
MLL2
myeloid/lymphoid or mixed-lineage leukemia 2
chr22_-_48865864 0.414 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr1_+_181028016 0.414 NM_030769
NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr10_+_17310475 0.414 VIM
vimentin
chr22_+_19601723 0.411 CRKL
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
chr4_+_86918870 0.408 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr19_+_44886785 0.407 NM_020129
NM_203471
LGALS14

lectin, galactoside-binding, soluble, 14

chrX_-_19727775 0.405 SH3KBP1
SH3-domain kinase binding protein 1
chr22_+_19601721 0.404 CRKL
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
chr4_+_91035025 0.403 NM_007351
MMRN1
multimerin 1
chr10_-_61819493 0.397 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr2_-_207291364 0.397 NM_001093730
DYTN
dystrotelin
chr1_+_116727514 0.396 NM_001160234
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr18_-_27594696 0.396 NM_001034172
MCART2
mitochondrial carrier triple repeat 2
chr9_+_102275310 0.394 NM_003692
TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr7_-_112514990 0.393 GPR85
G protein-coupled receptor 85
chr17_+_71095733 0.391 MYO15B
myosin XVB pseudogene
chr19_-_11166186 0.391 NM_015493
KANK2
KN motif and ankyrin repeat domains 2
chrX_-_138114100 0.390 FGF13
fibroblast growth factor 13
chr22_-_48865907 0.389 NM_139202
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr7_+_50314801 0.389 NM_006060
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr12_-_107551783 0.388 NM_003006
SELPLG
selectin P ligand
chr15_-_75259714 0.387 PEAK1
NKF3 kinase family member
chr6_+_44295219 0.384 NM_001078174
NM_004955
SLC29A1

solute carrier family 29 (nucleoside transporters), member 1

chr6_-_111995213 0.383 NM_001164283
TRAF3IP2
TRAF3 interacting protein 2
chr7_-_112515068 0.383 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85

chr1_+_61642287 0.381 NFIA
nuclear factor I/A
chrX_-_19727828 0.380 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chrX_-_138114817 0.378 FGF13
fibroblast growth factor 13
chr22_-_40666168 0.376 NM_001110215
CENPM
centromere protein M
chr20_+_41976831 0.375 NM_001098797
TOX2
TOX high mobility group box family member 2
chr21_+_29593607 0.374 NM_206866
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr12_-_52939584 0.370 NM_001127322
CBX5
chromobox homolog 5
chr2_-_63518589 0.370 NM_001042692
WDPCP
WD repeat containing planar cell polarity effector
chr6_+_116939500 0.369 NM_153711
FAM26E
family with sequence similarity 26, member E
chr1_+_67404756 0.368 NM_144701
IL23R
interleukin 23 receptor
chr3_-_127303080 0.368 NM_001164475
SLC41A3
solute carrier family 41, member 3
chr10_+_97461525 0.365 NM_001098175
ENTPD1
ectonucleoside triphosphate diphosphohydrolase 1
chr12_-_107551744 0.363 SELPLG
selectin P ligand
chr6_-_46401363 0.363 NM_005822
RCAN2
regulator of calcineurin 2
chr4_-_83566045 0.363


chr4_-_83566246 0.363 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr11_-_6633427 0.362 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr12_-_101398503 0.362 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr17_-_60439764 0.361 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr22_-_20314366 0.361 YDJC
YdjC homolog (bacterial)
chr12_-_52939636 0.360 NM_001127321
CBX5
chromobox homolog 5
chr4_-_176970372 0.360 GPM6A
glycoprotein M6A
chr4_+_71713324 0.360 NM_031889
ENAM
enamelin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.17 1.54e-04 GO:0032501 multicellular organismal process
1.12 2.70e-03 GO:0050794 regulation of cellular process
1.10 1.15e-02 GO:0065007 biological regulation
1.11 1.55e-02 GO:0050789 regulation of biological process
1.12 1.98e-02 GO:0050896 response to stimulus
1.23 3.96e-02 GO:0048523 negative regulation of cellular process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.14 2.12e-04 GO:0005634 nucleus
3.85 2.84e-02 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
2.48 4.43e-02 GO:0035770 RNA granule

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.17 8.87e-03 GO:0003676 nucleic acid binding
1.33 1.96e-02 GO:0001071 nucleic acid binding transcription factor activity
1.33 1.96e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.20 3.01e-02 GO:0003677 DNA binding