Motif ID: SREBF1,2.p2

Z-value: 1.172


Transcription factors associated with SREBF1,2.p2:

Gene SymbolEntrez IDGene Name
SREBF1 6720 sterol regulatory element binding transcription factor 1
SREBF2 6721 sterol regulatory element binding transcription factor 2



Activity profile for motif SREBF1,2.p2.

activity profile for motif SREBF1,2.p2


Sorted Z-values histogram for motif SREBF1,2.p2

Sorted Z-values for motif SREBF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_73638430 2.828 NM_152468
TMC8
transmembrane channel-like 8
chr22_+_34107087 2.617 HMOX1
heme oxygenase (decycling) 1
chr22_+_34107051 2.028 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr14_-_93512818 1.974 ASB2
ankyrin repeat and SOCS box containing 2
chr9_-_37566248 1.573 NM_012166
FBXO10
F-box protein 10
chr12_-_47604930 1.536 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr20_-_4743768 1.529 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr19_+_55614006 1.444 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr17_-_7078446 1.352 NM_004422
DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr19_-_15436333 1.333 NM_022904
RASAL3
RAS protein activator like 3
chr12_-_57600564 1.287 LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr2_+_143603439 1.226 ARHGAP15
Rho GTPase activating protein 15
chrX_+_128741578 1.187 SASH3
SAM and SH3 domain containing 3
chr8_+_11599119 1.185 NM_002052
GATA4
GATA binding protein 4
chrX_+_128741562 1.163 NM_018990
SASH3
SAM and SH3 domain containing 3
chr16_-_66827449 1.162 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr3_-_126414252 1.117 NM_024628
SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr13_+_48582389 1.086 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr12_+_56284867 1.086 NM_178502
DTX3
deltex homolog 3 (Drosophila)
chr17_+_75851984 1.074


chr17_-_7078399 1.074 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr17_+_69781980 1.042 NM_001172810
NM_023036
DNAI2

dynein, axonemal, intermediate chain 2

chr22_+_23153529 1.010 NM_000675
ADORA2A
adenosine A2a receptor
chr9_-_133574928 1.010 NM_198679
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr13_-_31900218 0.991 NM_001079691
NM_052818
N4BP2L1

NEDD4 binding protein 2-like 1

chr13_+_112999538 0.981 LAMP1
lysosomal-associated membrane protein 1
chr14_-_93512647 0.974 ASB2
ankyrin repeat and SOCS box containing 2
chr2_-_227372574 0.968 IRS1
insulin receptor substrate 1
chr16_-_66075216 0.965 NM_001138
AGRP
agouti related protein homolog (mouse)
chr12_-_57600336 0.961 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr16_-_5023934 0.947 NM_016256
NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr16_-_5023914 0.940 NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr22_+_40724674 0.938 NM_152613
WBP2NL
WBP2 N-terminal like
chr14_-_23752507 0.923 CHMP4A
chromatin modifying protein 4A
chr6_-_80713589 0.919 NM_022726
ELOVL4
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chr13_-_49057629 0.919 RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr17_-_7078304 0.917 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr13_-_20533629 0.912 LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr14_-_23752498 0.899 CHMP4A
chromatin modifying protein 4A
chr14_-_19999475 0.887 NM_001100814
NM_144568
TMEM55B

transmembrane protein 55B

chr5_+_244625 0.886 NM_001080478
LRRC14B
leucine rich repeat containing 14B
chr1_-_24386324 0.874 NM_170743
NM_173064
NM_173065
IL28RA


interleukin 28 receptor, alpha (interferon, lambda receptor)


chr12_-_107551783 0.866 NM_003006
SELPLG
selectin P ligand
chr13_-_32757835 0.861 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr15_+_86983038 0.859 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr7_+_101861007 0.856 ORAI2
ORAI calcium release-activated calcium modulator 2
chr5_-_133734616 0.844 CDKL3
cyclin-dependent kinase-like 3
chr12_-_107551744 0.831 SELPLG
selectin P ligand
chr19_+_7493436 0.831 NM_020533
MCOLN1
mucolipin 1
chr11_+_59979857 0.827 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr19_+_1018536 0.822 HMHA1
histocompatibility (minor) HA-1
chr13_-_49057707 0.821 NM_018191
RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr14_-_23752476 0.816 CHMP4A
chromatin modifying protein 4A
chr20_+_43953428 0.811 CTSA
cathepsin A
chr12_-_107551694 0.810 SELPLG
selectin P ligand
chr17_+_75689985 0.805 GAA
glucosidase, alpha; acid
chr3_-_49370755 0.801 NM_000581
NM_201397
GPX1

glutathione peroxidase 1

chr22_-_37966852 0.799 NM_033016
PDGFB
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
chr16_+_88512769 0.791 MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr1_+_111544469 0.787


chr20_+_43953331 0.785 CTSA
cathepsin A
chr9_-_139564656 0.783 NM_001098537
NM_152286
PNPLA7

patatin-like phospholipase domain containing 7

chr12_-_101835183 0.780 PAH
phenylalanine hydroxylase
chr2_+_219751207 0.779 FAM134A
family with sequence similarity 134, member A
chr6_+_35852369 0.779 NM_207409
C6orf126
chromosome 6 open reading frame 126
chr11_-_60475558 0.778 NM_016582
SLC15A3
solute carrier family 15, member 3
chr3_+_44878380 0.778 NM_144638
TMEM42
transmembrane protein 42
chr19_+_1018293 0.776 HMHA1
histocompatibility (minor) HA-1
chr12_+_120840829 0.767 NM_001178003
NM_144668
WDR66

WD repeat domain 66

chr16_-_87570716 0.766 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr7_+_17304707 0.762 NM_001621
AHR
aryl hydrocarbon receptor
chr10_-_98021144 0.758 NM_001114094
NM_013314
BLNK

B-cell linker

chr22_-_35232979 0.750 FOXRED2
FAD-dependent oxidoreductase domain containing 2
chr8_+_75066117 0.748 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr17_+_45527507 0.747 NM_002611
PDK2
pyruvate dehydrogenase kinase, isozyme 2
chr14_+_102458745 0.742 NM_030943
AMN
amnionless homolog (mouse)
chr12_+_52713098 0.739 NM_018953
HOXC5
homeobox C5
chr17_-_73636386 0.737 NM_001127198
TMC6
transmembrane channel-like 6
chr16_+_639278 0.734 NM_145294
WDR90
WD repeat domain 90
chr17_-_3407780 0.731 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr16_-_4528380 0.715 NM_001199054
C16orf5
chromosome 16 open reading frame 5
chr3_-_49370682 0.712 GPX1
glutathione peroxidase 1
chr2_+_219751192 0.712 FAM134A
family with sequence similarity 134, member A
chr12_-_54409107 0.707 NM_001040034
NM_001780
CD63

CD63 molecule

chr5_-_172130766 0.705 NM_004417
DUSP1
dual specificity phosphatase 1
chr11_+_120828058 0.691 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr1_-_159459999 0.686 NM_001643
APOA2
apolipoprotein A-II
chr2_+_46779553 0.685 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr2_+_208284484 0.675 NM_001142300
NM_152523
CCNYL1

cyclin Y-like 1

chr1_-_153477673 0.673 NM_001171812
NM_000157
GBA

glucosidase, beta, acid

chr16_+_68353738 0.673 NM_007014
NM_199423
WWP2

WW domain containing E3 ubiquitin protein ligase 2

chr16_+_68353662 0.666 WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr7_+_27102508 0.661


chr19_+_54149843 0.660 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chr17_-_73636362 0.660 TMC6
transmembrane channel-like 6
chr16_+_5023672 0.656 LOC100507589
hypothetical LOC100507589
chr20_-_2769120 0.650 FAM113A
family with sequence similarity 113, member A
chr16_-_5023562 0.643 NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr19_-_5789740 0.643 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr20_+_43953372 0.640 CTSA
cathepsin A
chr12_-_54409015 0.632 CD63
CD63 molecule
chr22_-_35233032 0.629 NM_024955
NM_001102371
FOXRED2

FAD-dependent oxidoreductase domain containing 2

chr19_+_54149963 0.623 BAX
BCL2-associated X protein
chr11_+_9642182 0.623 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr16_+_70217564 0.622 NM_001017967
NM_052858
MARVELD3

MARVEL domain containing 3

chr7_+_101860958 0.621 NM_001126340
NM_032831
ORAI2

ORAI calcium release-activated calcium modulator 2

chr14_-_20922264 0.619 NM_007192
SUPT16H
suppressor of Ty 16 homolog (S. cerevisiae)
chr2_-_172675873 0.611 DLX2
distal-less homeobox 2
chr20_+_43952997 0.610 NM_000308
NM_001127695
NM_001167594
CTSA


cathepsin A


chr17_-_37586716 0.610 NM_012285
KCNH4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr6_-_33493792 0.608 CUTA
cutA divalent cation tolerance homolog (E. coli)
chr11_+_120828275 0.608 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr13_+_112999590 0.607 LAMP1
lysosomal-associated membrane protein 1
chr14_+_23711044 0.600 NM_001048205
NM_005132
REC8

REC8 homolog (yeast)

chr2_+_227898163 0.600 MFF
mitochondrial fission factor
chr20_-_39199936 0.594


chr12_+_115660468 0.594 NM_001109903
NM_032814
RNFT2

ring finger protein, transmembrane 2

chr5_+_133734768 0.592 NM_003337
UBE2B
ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr2_+_219751230 0.590 FAM134A
family with sequence similarity 134, member A
chr14_-_93919305 0.590 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr7_-_29995809 0.588 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr12_-_54409059 0.584 CD63
CD63 molecule
chr19_+_54149941 0.577 BAX
BCL2-associated X protein
chr1_-_153477511 0.574 GBA
glucosidase, beta, acid
chr2_+_219751145 0.572 NM_024293
FAM134A
family with sequence similarity 134, member A
chr14_-_63830830 0.570 NM_001040275
NM_001437
ESR2

estrogen receptor 2 (ER beta)

chr17_+_75689955 0.569 GAA
glucosidase, alpha; acid
chr2_+_208284691 0.564 CCNYL1
cyclin Y-like 1
chr9_-_21984414 0.563 NM_058195
CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr4_-_647424 0.562


chr20_-_2769245 0.560 NM_022760
FAM113A
family with sequence similarity 113, member A
chr14_-_20921925 0.558 SUPT16H
suppressor of Ty 16 homolog (S. cerevisiae)
chr2_-_25328452 0.557 NM_153759
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr11_+_9642226 0.556 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr11_+_9642200 0.555 NM_015055
SWAP70
SWAP switching B-cell complex 70kDa subunit
chr17_+_75689894 0.552 NM_000152
NM_001079803
NM_001079804
GAA


glucosidase, alpha; acid


chr1_-_197173159 0.551 LOC100131234
familial acute myelogenous leukemia related factor
chr8_+_21937533 0.551 NPM2
nucleophosmin/nucleoplasmin 2
chr5_+_68746694 0.540 NM_001038603
MARVELD2
MARVEL domain containing 2
chr9_-_116732403 0.538 NM_001244
TNFSF8
tumor necrosis factor (ligand) superfamily, member 8
chr1_-_40555511 0.535 NM_001852
COL9A2
collagen, type IX, alpha 2
chr16_-_4528739 0.534 NM_001199055
NM_001199056
NM_013399
C16orf5


chromosome 16 open reading frame 5


chr1_+_20385164 0.533 NM_152376
UBXN10
UBX domain protein 10
chr11_+_67532592 0.532 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr2_+_208284610 0.531 CCNYL1
cyclin Y-like 1
chr9_-_21984329 0.526 CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr20_+_39199542 0.523 NM_002660
NM_182811
PLCG1

phospholipase C, gamma 1

chr12_+_52733927 0.520 NM_153633
HOXC4
HOXC6
homeobox C4
homeobox C6
chr2_-_219750975 0.519 C2orf24
chromosome 2 open reading frame 24
chr14_+_75114692 0.519 NM_017791
FLVCR2
feline leukemia virus subgroup C cellular receptor family, member 2
chr16_-_65742323 0.516 NM_033309
B3GNT9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr2_+_26249463 0.515 NM_001168241
FAM59B
family with sequence similarity 59, member B
chr20_+_33823318 0.510 NM_016436
PHF20
PHD finger protein 20
chr14_-_20922001 0.507 SUPT16H
suppressor of Ty 16 homolog (S. cerevisiae)
chr1_-_40555413 0.507 COL9A2
collagen, type IX, alpha 2
chr7_+_27102197 0.507


chr4_+_91267706 0.506 NM_001145065
FAM190A
family with sequence similarity 190, member A
chr4_+_37131946 0.505 NM_001104629
C4orf19
chromosome 4 open reading frame 19
chr22_-_36907638 0.503 NM_001004426
NM_003560
PLA2G6

phospholipase A2, group VI (cytosolic, calcium-independent)

chr9_-_21984379 0.503 CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr12_-_101835026 0.501 PAH
phenylalanine hydroxylase
chr11_+_9642229 0.498 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr7_-_29996429 0.496 NM_001145514
SCRN1
secernin 1
chr9_+_115151632 0.496 NM_017688
BSPRY
B-box and SPRY domain containing
chr14_-_34660902 0.487 PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr13_-_20533703 0.486 NM_014572
LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr19_+_14405100 0.484 NM_002741
PKN1
protein kinase N1
chr15_-_77170135 0.482 NM_001145648
NM_002891
RASGRF1

Ras protein-specific guanine nucleotide-releasing factor 1

chr19_-_17236522 0.482 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr17_-_7138620 0.481 YBX2
Y box binding protein 2
chr6_-_90178685 0.480 NM_021244
RRAGD
Ras-related GTP binding D
chr14_+_23710924 0.480 REC8
REC8 homolog (yeast)
chr14_-_23981493 0.478 NM_020195
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr11_-_16992524 0.477 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr14_-_19999324 0.474 TMEM55B
transmembrane protein 55B
chrX_-_154342781 0.461 NM_001017991
NM_001017990
NM_080720
H2AFB2
H2AFB1
H2AFB3
H2A histone family, member B2
H2A histone family, member B1
H2A histone family, member B3
chr6_+_32090516 0.459 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr3_-_113763425 0.453 ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chr14_-_34661190 0.450 NM_017917
PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr8_+_109525010 0.448 NM_014673
TTC35
tetratricopeptide repeat domain 35
chrX_+_154263553 0.448 NM_001017991
NM_001017990
NM_080720
H2AFB2
H2AFB1
H2AFB3
H2A histone family, member B2
H2A histone family, member B1
H2A histone family, member B3
chr14_+_34661497 0.446 NM_014672
KIAA0391
KIAA0391
chr13_-_78075683 0.445 NM_006237
POU4F1
POU class 4 homeobox 1
chr8_+_109525050 0.445 TTC35
tetratricopeptide repeat domain 35
chr6_+_64403631 0.442 PHF3
PHD finger protein 3
chr5_+_150807380 0.440 SLC36A1
solute carrier family 36 (proton/amino acid symporter), member 1
chr16_+_55580910 0.435 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr6_-_18230829 0.434 NM_198586
NHLRC1
NHL repeat containing 1
chr11_-_8849485 0.433 ST5
suppression of tumorigenicity 5
chr1_+_1157485 0.433 NM_080605
B3GALT6
UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6
chr6_-_33493898 0.433 CUTA
cutA divalent cation tolerance homolog (E. coli)
chrX_-_114703273 0.431


chr1_+_181871830 0.430 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr20_-_43953036 0.428 NM_080749
NEURL2
neuralized homolog 2 (Drosophila)
chrX_+_10084984 0.427 NM_001830
CLCN4
chloride channel 4
chr1_-_210939929 0.424 NM_018664
BATF3
basic leucine zipper transcription factor, ATF-like 3
chr12_+_70434920 0.423 NM_014999
RAB21
RAB21, member RAS oncogene family
chr5_-_150517499 0.422 ANXA6
annexin A6
chr1_-_224253678 0.421 NM_152608
C1orf55
chromosome 1 open reading frame 55
chr2_-_210744158 0.421 NM_152519
C2orf67
chromosome 2 open reading frame 67

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.23 3.49e-05 GO:0044237 cellular metabolic process
1.12 6.75e-05 GO:0009987 cellular process
1.19 3.84e-04 GO:0008152 metabolic process
1.31 1.64e-03 GO:0006807 nitrogen compound metabolic process
1.20 1.93e-03 GO:0044238 primary metabolic process
1.30 5.41e-03 GO:0034641 cellular nitrogen compound metabolic process
1.33 7.63e-03 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.17 8.02e-13 GO:0044424 intracellular part
1.16 1.41e-12 GO:0005622 intracellular
2.58 2.01e-08 GO:0005773 vacuole
1.19 1.04e-07 GO:0005737 cytoplasm
1.18 4.06e-07 GO:0043227 membrane-bounded organelle
1.18 4.66e-07 GO:0043231 intracellular membrane-bounded organelle
1.15 7.90e-07 GO:0043226 organelle
1.24 1.05e-06 GO:0044444 cytoplasmic part
1.15 1.10e-06 GO:0043229 intracellular organelle
1.25 1.84e-06 GO:0044446 intracellular organelle part
1.25 2.30e-06 GO:0044422 organelle part
2.50 3.03e-06 GO:0000323 lytic vacuole
2.50 3.03e-06 GO:0005764 lysosome
1.23 2.93e-05 GO:0005634 nucleus
2.81 5.71e-05 GO:0044437 vacuolar part
1.39 1.25e-04 GO:0031974 membrane-enclosed lumen
1.39 1.34e-04 GO:0043233 organelle lumen
1.54 1.50e-04 GO:0005654 nucleoplasm
1.40 1.58e-04 GO:0044428 nuclear part
2.75 2.27e-04 GO:0005774 vacuolar membrane
1.38 4.01e-04 GO:0070013 intracellular organelle lumen
1.38 9.96e-04 GO:0005829 cytosol
2.85 1.81e-03 GO:0005765 lysosomal membrane
1.40 1.87e-03 GO:0031981 nuclear lumen
7.77 1.65e-02 GO:0005732 small nucleolar ribonucleoprotein complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.18 1.92e-04 GO:0005515 protein binding
1.09 1.51e-03 GO:0005488 binding