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ENCODE cell lines, expression (Ernst 2011)
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Results for HNF4A
Z-value: 2.25
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Transcription factors associated with HNF4A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HNF4A | hg19_v2_chr20_+_43029911_43029941 | 0.36 | 1.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HNF4A
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_31949801 | 10.25 |
ENST00000428956.2 ENST00000498271.1 |
C4A |
complement component 4A (Rodgers blood group) |
| chr6_+_31982539 | 10.01 |
ENST00000435363.2 ENST00000425700.2 |
C4B |
complement component 4B (Chido blood group) |
| chr5_-_42812143 | 9.94 |
ENST00000514985.1 |
SEPP1 |
selenoprotein P, plasma, 1 |
| chr5_-_42811986 | 9.86 |
ENST00000511224.1 ENST00000507920.1 ENST00000510965.1 |
SEPP1 |
selenoprotein P, plasma, 1 |
| chr17_-_7082668 | 9.73 |
ENST00000573083.1 ENST00000574388.1 |
ASGR1 |
asialoglycoprotein receptor 1 |
| chr2_-_21266935 | 9.72 |
ENST00000233242.1 |
APOB |
apolipoprotein B |
| chr17_+_27369918 | 9.12 |
ENST00000323372.4 |
PIPOX |
pipecolic acid oxidase |
| chr17_-_7082861 | 8.94 |
ENST00000269299.3 |
ASGR1 |
asialoglycoprotein receptor 1 |
| chr1_-_161193349 | 8.78 |
ENST00000469730.2 ENST00000463273.1 ENST00000464492.1 ENST00000367990.3 ENST00000470459.2 ENST00000468465.1 ENST00000463812.1 |
APOA2 |
apolipoprotein A-II |
| chr19_+_45449228 | 8.47 |
ENST00000252490.4 |
APOC2 |
apolipoprotein C-II |
Gene Ontology Analysis
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 25.2 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 2.3 | 18.7 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 1.3 | 14.2 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.4 | 10.5 | GO:0001848 | complement binding(GO:0001848) |
| 1.3 | 10.3 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 2.4 | 9.7 | GO:0035473 | lipase binding(GO:0035473) |
| 1.5 | 9.1 | GO:0016647 | oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647) |
| 2.2 | 8.8 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.0 | 7.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.7 | 6.9 | GO:0035650 | AP-1 adaptor complex binding(GO:0035650) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 43.7 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.5 | 14.2 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.5 | 9.7 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.6 | 7.9 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.5 | 6.8 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.2 | 6.5 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.2 | 5.9 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.1 | 5.2 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 4.8 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.1 | 4.7 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 28.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 9.7 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.2 | 7.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 6.2 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 3.9 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 3.4 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 1.3 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.1 | 1.2 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.0 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 0.9 | PID CONE PATHWAY | Visual signal transduction: Cones |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 34.9 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.1 | 24.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 21.9 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.1 | 18.3 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.8 | 8.8 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.3 | 7.9 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.1 | 7.2 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 6.7 | GO:0005770 | late endosome(GO:0005770) |
| 0.7 | 5.9 | GO:0097425 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
| 0.0 | 5.9 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.4 | 25.2 | GO:0010902 | positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902) |
| 1.6 | 20.3 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.3 | 18.7 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.4 | 14.2 | GO:0036499 | PERK-mediated unfolded protein response(GO:0036499) |
| 3.5 | 10.4 | GO:1901253 | negative regulation of intracellular transport of viral material(GO:1901253) |
| 1.9 | 9.5 | GO:0034371 | chylomicron remodeling(GO:0034371) |
| 3.0 | 9.1 | GO:0019477 | L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440) |
| 2.9 | 8.8 | GO:0060621 | regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910) |
| 1.0 | 7.9 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
| 0.6 | 7.9 | GO:0034435 | steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435) |