ENCODE cell lines, expression (Ernst 2011)

• Motif significance table
• Sample table
• Mean activities
• All promoters sorted by FOV

• Activity table
• Activity delta table
• Regulatory interactions
• Motifs sorted by significance
• Download the whole report

Gene Symbol	Gene ID	Gene Info
HNF4A Links Ensembl NCBI GeneCards UniProt	ENSG00000101076.12	HNF4A

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HNF4A	hg19_v2_chr20_+_43029911_43029941	0.36	1.7e-01	Click!

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Promoter	Score	Transcript	Gene	Gene Info
chr6_+_31949801	10.25	ENST00000428956.2 ENST00000498271.1	C4A	complement component 4A (Rodgers blood group)
chr6_+_31982539	10.01	ENST00000435363.2 ENST00000425700.2	C4B	complement component 4B (Chido blood group)
chr5_-_42812143	9.94	ENST00000514985.1	SEPP1	selenoprotein P, plasma, 1
chr5_-_42811986	9.86	ENST00000511224.1 ENST00000507920.1 ENST00000510965.1	SEPP1	selenoprotein P, plasma, 1
chr17_-_7082668	9.73	ENST00000573083.1 ENST00000574388.1	ASGR1	asialoglycoprotein receptor 1
chr2_-_21266935	9.72	ENST00000233242.1	APOB	apolipoprotein B
chr17_+_27369918	9.12	ENST00000323372.4	PIPOX	pipecolic acid oxidase
chr17_-_7082861	8.94	ENST00000269299.3	ASGR1	asialoglycoprotein receptor 1
chr1_-_161193349	8.78	ENST00000469730.2 ENST00000463273.1 ENST00000464492.1 ENST00000367990.3 ENST00000470459.2 ENST00000468465.1 ENST00000463812.1	APOA2	apolipoprotein A-II
chr19_+_45449228	8.47	ENST00000252490.4	APOC2	apolipoprotein C-II
chr19_+_45449301	8.47	ENST00000591597.1	APOC2	apolipoprotein C-II
chr19_+_45449266	8.25	ENST00000592257.1	APOC2	apolipoprotein C-II
chr6_+_30130969	8.08	ENST00000376694.4	TRIM15	tripartite motif containing 15
chr12_+_53497263	7.91	ENST00000551896.1 ENST00000301466.3	SOAT2	sterol O-acyltransferase 2
chr13_+_113777105	7.87	ENST00000409306.1 ENST00000375551.3 ENST00000375559.3	F10	coagulation factor X
chr17_+_4675175	7.23	ENST00000270560.3	TM4SF5	transmembrane 4 L six family member 5
chr7_+_45927956	7.18	ENST00000275525.3 ENST00000457280.1	IGFBP1	insulin-like growth factor binding protein 1
chr7_+_45928079	6.99	ENST00000468955.1	IGFBP1	insulin-like growth factor binding protein 1
chr20_+_56136136	6.84	ENST00000319441.4 ENST00000543666.1	PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)
chr19_+_18496957	6.50	ENST00000252809.3	GDF15	growth differentiation factor 15
chr16_-_16317321	5.69	ENST00000205557.7 ENST00000575728.1	ABCC6	ATP-binding cassette, sub-family C (CFTR/MRP), member 6
chr1_+_145727681	5.63	ENST00000417171.1 ENST00000451928.2	PDZK1	PDZ domain containing 1
chr16_+_8768422	5.20	ENST00000268251.8 ENST00000564714.1	ABAT	4-aminobutyrate aminotransferase
chr17_+_41052808	4.78	ENST00000592383.1 ENST00000253801.2 ENST00000585489.1	G6PC	glucose-6-phosphatase, catalytic subunit
chr1_+_78511586	4.14	ENST00000370759.3	GIPC2	GIPC PDZ domain containing family, member 2
chr17_+_1646130	4.03	ENST00000453066.1 ENST00000324015.3 ENST00000450523.2 ENST00000453723.1 ENST00000382061.4	SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr4_+_113152978	3.70	ENST00000309703.6	AP1AR	adaptor-related protein complex 1 associated regulatory protein
chr3_-_194072019	3.64	ENST00000429275.1 ENST00000323830.3	CPN2	carboxypeptidase N, polypeptide 2
chr13_+_76334567	3.64	ENST00000321797.8	LMO7	LIM domain 7
chr13_+_76334795	3.48	ENST00000526202.1 ENST00000465261.2	LMO7	LIM domain 7
chr2_+_241544834	3.47	ENST00000319838.5 ENST00000403859.1 ENST00000438013.2	GPR35	G protein-coupled receptor 35
chr16_+_29690358	3.44	ENST00000395384.4 ENST00000562473.1	QPRT	quinolinate phosphoribosyltransferase
chr4_+_113152881	3.22	ENST00000274000.5	AP1AR	adaptor-related protein complex 1 associated regulatory protein
chr14_-_39572279	2.96	ENST00000536508.1	SEC23A	Sec23 homolog A (S. cerevisiae)
chr19_+_35629702	2.93	ENST00000351325.4	FXYD1	FXYD domain containing ion transport regulator 1
chr19_+_35630022	2.92	ENST00000589209.1	FXYD1	FXYD domain containing ion transport regulator 1
chr12_-_51422017	2.91	ENST00000394904.3	SLC11A2	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr14_-_39572345	2.90	ENST00000548032.2 ENST00000556092.1 ENST00000557280.1 ENST00000545328.2 ENST00000553970.1	SEC23A	Sec23 homolog A (S. cerevisiae)
chr16_-_87970122	2.77	ENST00000309893.2	CA5A	carbonic anhydrase VA, mitochondrial
chr6_-_32145861	2.51	ENST00000336984.6	AGPAT1	1-acylglycerol-3-phosphate O-acyltransferase 1
chr6_+_32146131	2.39	ENST00000375094.3	RNF5	ring finger protein 5, E3 ubiquitin protein ligase
chr4_-_10023095	2.38	ENST00000264784.3	SLC2A9	solute carrier family 2 (facilitated glucose transporter), member 9
chr6_-_86099898	2.32	ENST00000455071.1	RP11-30P6.6	RP11-30P6.6
chr19_-_36304201	2.30	ENST00000301175.3	PRODH2	proline dehydrogenase (oxidase) 2
chr6_+_30131318	2.30	ENST00000376688.1	TRIM15	tripartite motif containing 15
chr3_+_124303539	2.26	ENST00000428018.2	KALRN	kalirin, RhoGEF kinase
chr19_-_10687948	2.18	ENST00000592285.1	AP1M2	adaptor-related protein complex 1, mu 2 subunit
chr12_+_121416489	2.17	ENST00000541395.1 ENST00000544413.1	HNF1A	HNF1 homeobox A
chr10_+_104404218	2.14	ENST00000302424.7	TRIM8	tripartite motif containing 8
chr22_+_25003626	2.05	ENST00000451366.1 ENST00000406383.2 ENST00000428855.1	GGT1	gamma-glutamyltransferase 1
chr1_-_60392452	1.94	ENST00000371204.3	CYP2J2	cytochrome P450, family 2, subfamily J, polypeptide 2
chr3_+_123813543	1.81	ENST00000360013.3	KALRN	kalirin, RhoGEF kinase
chr17_-_27503770	1.65	ENST00000533112.1	MYO18A	myosin XVIIIA
chr19_-_10687983	1.63	ENST00000587069.1	AP1M2	adaptor-related protein complex 1, mu 2 subunit
chr2_+_159313452	1.63	ENST00000389757.3 ENST00000389759.3	PKP4	plakophilin 4
chr3_-_125775629	1.61	ENST00000383598.2	SLC41A3	solute carrier family 41, member 3
chr10_-_116444371	1.49	ENST00000533213.2 ENST00000369252.4	ABLIM1	actin binding LIM protein 1
chr19_-_41256207	1.47	ENST00000598485.2 ENST00000470681.1 ENST00000339153.3 ENST00000598729.1	C19orf54	chromosome 19 open reading frame 54
chr2_-_219134822	1.34	ENST00000444053.1 ENST00000248450.4	AAMP	angio-associated, migratory cell protein
chr2_-_219134343	1.29	ENST00000447885.1 ENST00000420660.1	AAMP	angio-associated, migratory cell protein
chr2_-_39348137	1.28	ENST00000426016.1	SOS1	son of sevenless homolog 1 (Drosophila)
chr19_+_11546093	1.24	ENST00000591462.1	PRKCSH	protein kinase C substrate 80K-H
chr17_-_38256973	1.21	ENST00000246672.3	NR1D1	nuclear receptor subfamily 1, group D, member 1
chr8_+_22436635	1.20	ENST00000452226.1 ENST00000397760.4 ENST00000339162.7 ENST00000397761.2	PDLIM2	PDZ and LIM domain 2 (mystique)
chr12_+_121416340	1.10	ENST00000257555.6 ENST00000400024.2	HNF1A	HNF1 homeobox A
chr2_+_73441350	1.09	ENST00000389501.4	SMYD5	SMYD family member 5
chr19_+_11546153	1.08	ENST00000591946.1 ENST00000252455.2 ENST00000412601.1	PRKCSH	protein kinase C substrate 80K-H
chr6_+_43739697	1.03	ENST00000230480.6	VEGFA	vascular endothelial growth factor A
chr14_+_23790655	1.02	ENST00000397276.2	PABPN1	poly(A) binding protein, nuclear 1
chr12_-_6665200	1.00	ENST00000336604.4 ENST00000396840.2 ENST00000356896.4	IFFO1	intermediate filament family orphan 1
chr11_-_65381643	0.97	ENST00000309100.3 ENST00000529839.1 ENST00000526293.1	MAP3K11	mitogen-activated protein kinase kinase kinase 11
chr22_-_31063782	0.96	ENST00000404885.1 ENST00000403268.1 ENST00000407308.1 ENST00000342474.4 ENST00000334679.3	DUSP18	dual specificity phosphatase 18
chr14_+_39735411	0.95	ENST00000603904.1	RP11-407N17.3	cTAGE family member 5 isoform 4
chr6_+_143999072	0.91	ENST00000440869.2 ENST00000367582.3 ENST00000451827.2	PHACTR2	phosphatase and actin regulator 2
chr11_-_63536113	0.89	ENST00000433688.1 ENST00000546282.2	C11orf95 RP11-466C23.4	chromosome 11 open reading frame 95 RP11-466C23.4
chr17_-_2614927	0.89	ENST00000435359.1	CLUH	clustered mitochondria (cluA/CLU1) homolog
chr3_+_63897605	0.85	ENST00000487717.1	ATXN7	ataxin 7
chr19_+_11546440	0.85	ENST00000589126.1 ENST00000588269.1 ENST00000587509.1 ENST00000592741.1 ENST00000593101.1 ENST00000587327.1	PRKCSH	protein kinase C substrate 80K-H
chr17_+_44039704	0.83	ENST00000420682.2 ENST00000415613.2 ENST00000571987.1 ENST00000574436.1 ENST00000431008.3	MAPT	microtubule-associated protein tau
chr17_-_44896047	0.77	ENST00000225512.5	WNT3	wingless-type MMTV integration site family, member 3
chr3_+_37284824	0.70	ENST00000431105.1	GOLGA4	golgin A4
chr3_+_63898275	0.67	ENST00000538065.1	ATXN7	ataxin 7
chr16_-_47007545	0.65	ENST00000317089.5	DNAJA2	DnaJ (Hsp40) homolog, subfamily A, member 2
chr1_+_94884023	0.65	ENST00000315713.5	ABCD3	ATP-binding cassette, sub-family D (ALD), member 3
chr1_+_180601139	0.65	ENST00000367590.4 ENST00000367589.3	XPR1	xenotropic and polytropic retrovirus receptor 1
chr19_-_10687907	0.61	ENST00000589348.1	AP1M2	adaptor-related protein complex 1, mu 2 subunit
chr7_-_15601595	0.61	ENST00000342526.3	AGMO	alkylglycerol monooxygenase
chrX_+_65382381	0.58	ENST00000519389.1	HEPH	hephaestin
chr2_-_28113217	0.55	ENST00000444339.2	RBKS	ribokinase
chr14_+_100485712	0.55	ENST00000544450.2	EVL	Enah/Vasp-like
chr19_+_39881951	0.53	ENST00000315588.5 ENST00000594368.1 ENST00000599213.2 ENST00000596297.1	MED29	mediator complex subunit 29
chr5_-_32444828	0.53	ENST00000265069.8	ZFR	zinc finger RNA binding protein
chr12_-_54121261	0.49	ENST00000549784.1 ENST00000262059.4	CALCOCO1	calcium binding and coiled-coil domain 1
chr12_+_56114189	0.48	ENST00000548082.1	RDH5	retinol dehydrogenase 5 (11-cis/9-cis)
chr12_+_56114151	0.46	ENST00000547072.1 ENST00000552930.1 ENST00000257895.5	RDH5	retinol dehydrogenase 5 (11-cis/9-cis)
chr1_+_110163202	0.45	ENST00000531203.1 ENST00000256578.3	AMPD2	adenosine monophosphate deaminase 2
chr15_-_63448973	0.43	ENST00000462430.1	RPS27L	ribosomal protein S27-like
chr10_+_96698406	0.41	ENST00000260682.6	CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9
chr12_-_54121212	0.40	ENST00000548263.1 ENST00000430117.2 ENST00000550804.1 ENST00000549173.1 ENST00000551900.1 ENST00000546619.1 ENST00000548177.1 ENST00000549349.1	CALCOCO1	calcium binding and coiled-coil domain 1
chr3_+_37284668	0.40	ENST00000361924.2 ENST00000444882.1 ENST00000356847.4 ENST00000450863.2 ENST00000429018.1	GOLGA4	golgin A4
chr19_+_4639514	0.40	ENST00000327473.4	TNFAIP8L1	tumor necrosis factor, alpha-induced protein 8-like 1
chr7_+_33765593	0.38	ENST00000311067.3	RP11-89N17.1	HCG1643653; Uncharacterized protein
chr10_+_102106829	0.37	ENST00000370355.2	SCD	stearoyl-CoA desaturase (delta-9-desaturase)
chr1_-_15911510	0.34	ENST00000375826.3	AGMAT	agmatine ureohydrolase (agmatinase)
chr2_-_43019698	0.33	ENST00000431905.1 ENST00000294973.6	HAAO	3-hydroxyanthranilate 3,4-dioxygenase
chr14_+_23790690	0.30	ENST00000556821.1	PABPN1	poly(A) binding protein, nuclear 1
chr11_+_119056178	0.30	ENST00000525131.1 ENST00000531114.1 ENST00000355547.5 ENST00000322712.4	PDZD3	PDZ domain containing 3
chr9_+_139839686	0.26	ENST00000371634.2	C8G	complement component 8, gamma polypeptide
chr4_+_109541772	0.25	ENST00000506397.1 ENST00000394668.2	RPL34	ribosomal protein L34
chr20_+_62694461	0.24	ENST00000343484.5 ENST00000395053.3	TCEA2	transcription elongation factor A (SII), 2
chr12_+_109273806	0.24	ENST00000228476.3 ENST00000547768.1	DAO	D-amino-acid oxidase
chr20_-_36661826	0.23	ENST00000373448.2 ENST00000373447.3	TTI1	TELO2 interacting protein 1
chr15_+_50716576	0.23	ENST00000560297.1 ENST00000307179.4 ENST00000396444.3 ENST00000433963.1 ENST00000425032.3	USP8	ubiquitin specific peptidase 8
chr9_+_139839711	0.23	ENST00000224181.3	C8G	complement component 8, gamma polypeptide
chr19_-_49339080	0.20	ENST00000595764.1	HSD17B14	hydroxysteroid (17-beta) dehydrogenase 14
chrX_-_77041685	0.19	ENST00000373344.5 ENST00000395603.3	ATRX	alpha thalassemia/mental retardation syndrome X-linked
chr13_+_52586517	0.18	ENST00000523764.1 ENST00000521508.1	ALG11	ALG11, alpha-1,2-mannosyltransferase
chr6_-_33385854	0.18	ENST00000488478.1	CUTA	cutA divalent cation tolerance homolog (E. coli)
chr6_-_33385655	0.18	ENST00000440279.3 ENST00000607266.1	CUTA	cutA divalent cation tolerance homolog (E. coli)
chr6_+_43265992	0.18	ENST00000449231.1 ENST00000372589.3 ENST00000372585.5	SLC22A7	solute carrier family 22 (organic anion transporter), member 7
chr19_+_1205740	0.17	ENST00000326873.7	STK11	serine/threonine kinase 11
chr1_-_167059830	0.16	ENST00000367868.3	GPA33	glycoprotein A33 (transmembrane)
chr1_+_94883991	0.15	ENST00000370214.4	ABCD3	ATP-binding cassette, sub-family D (ALD), member 3
chr6_+_43266063	0.15	ENST00000372574.3	SLC22A7	solute carrier family 22 (organic anion transporter), member 7
chr6_-_33385823	0.15	ENST00000494751.1 ENST00000374496.3	CUTA	cutA divalent cation tolerance homolog (E. coli)
chr2_-_62733476	0.14	ENST00000335390.5	TMEM17	transmembrane protein 17
chr17_+_48423453	0.12	ENST00000017003.2 ENST00000509778.1 ENST00000507602.1	XYLT2	xylosyltransferase II
chr12_+_121163538	0.12	ENST00000242592.4	ACADS	acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr6_+_46761118	0.10	ENST00000230588.4	MEP1A	meprin A, alpha (PABA peptide hydrolase)
chr6_+_31926857	0.10	ENST00000375394.2 ENST00000544581.1	SKIV2L	superkiller viralicidic activity 2-like (S. cerevisiae)
chrX_+_118108601	0.10	ENST00000371628.3	LONRF3	LON peptidase N-terminal domain and ring finger 3
chr1_-_155271213	0.09	ENST00000342741.4	PKLR	pyruvate kinase, liver and RBC
chr6_-_31864977	0.09	ENST00000395728.3 ENST00000375528.4	EHMT2	euchromatic histone-lysine N-methyltransferase 2
chr7_-_37956409	0.08	ENST00000436072.2	SFRP4	secreted frizzled-related protein 4
chr1_+_43855560	0.07	ENST00000562955.1	SZT2	seizure threshold 2 homolog (mouse)
chr1_-_43855444	0.07	ENST00000372455.4	MED8	mediator complex subunit 8
chrX_+_118108571	0.07	ENST00000304778.7	LONRF3	LON peptidase N-terminal domain and ring finger 3
chr2_-_228244013	0.04	ENST00000304568.3	TM4SF20	transmembrane 4 L six family member 20
chr11_+_74870818	0.02	ENST00000525845.1 ENST00000534186.1 ENST00000428359.2	SLCO2B1	solute carrier organic anion transporter family, member 2B1
chr3_-_187009646	0.02	ENST00000296280.6 ENST00000392470.2 ENST00000169293.6 ENST00000439271.1 ENST00000392472.2 ENST00000392475.2	MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
chr15_-_41120896	0.01	ENST00000299174.5 ENST00000427255.2	PPP1R14D	protein phosphatase 1, regulatory (inhibitor) subunit 14D
chr4_+_109541740	0.01	ENST00000394665.1	RPL34	ribosomal protein L34
chr1_+_94883931	0.00	ENST00000394233.2 ENST00000454898.2 ENST00000536817.1	ABCD3	ATP-binding cassette, sub-family D (ALD), member 3
chr13_+_50656307	0.00	ENST00000378180.4	DLEU1	deleted in lymphocytic leukemia 1 (non-protein coding)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
5.0	25.2	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
2.4	9.7	GO:0035473	lipase binding(GO:0035473)
2.3	18.7	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
2.3	6.8	GO:0004611	phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
2.2	8.8	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
1.7	6.9	GO:0035650	AP-1 adaptor complex binding(GO:0035650)
1.5	9.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
1.4	5.6	GO:0005124	scavenger receptor binding(GO:0005124)
1.3	5.2	GO:0032145	4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
1.3	14.2	GO:0031995	insulin-like growth factor II binding(GO:0031995)
1.3	10.3	GO:0001849	complement component C1q binding(GO:0001849)
1.2	4.8	GO:0050309	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
1.1	3.4	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.6	2.9	GO:0015639	cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.6	2.3	GO:0004657	proline dehydrogenase activity(GO:0004657)
0.5	5.7	GO:0043225	anion transmembrane-transporting ATPase activity(GO:0043225)
0.4	10.5	GO:0001848	complement binding(GO:0001848)
0.3	3.5	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.2	1.0	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.2	2.3	GO:0015143	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.2	5.4	GO:0000062	fatty-acyl-CoA binding(GO:0000062)
0.2	0.8	GO:0099609	microtubule lateral binding(GO:0099609)
0.2	2.4	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.2	1.0	GO:0043183	vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.2	2.8	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.2	0.6	GO:0000822	inositol hexakisphosphate binding(GO:0000822)
0.1	2.1	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.1	3.4	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1	0.4	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.1	3.6	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.1	0.8	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.1	5.8	GO:0017080	sodium channel regulator activity(GO:0017080)
0.1	6.1	GO:0005160	transforming growth factor beta receptor binding(GO:0005160)
0.1	0.6	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.1	1.2	GO:0001222	transcription corepressor binding(GO:0001222)
0.1	1.4	GO:0042171	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.1	1.0	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1	0.2	GO:0015616	DNA translocase activity(GO:0015616)
0.1	0.2	GO:0000026	alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1	0.9	GO:0004745	retinol dehydrogenase activity(GO:0004745)
0.0	2.9	GO:0005080	protein kinase C binding(GO:0005080)
0.0	0.9	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.1	GO:0030158	protein xylosyltransferase activity(GO:0030158)
0.0	0.2	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0	0.3	GO:0030249	guanylate cyclase regulator activity(GO:0030249)
0.0	4.0	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	0.5	GO:0070330	aromatase activity(GO:0070330)
0.0	0.6	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0034875	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0	1.7	GO:0043531	ADP binding(GO:0043531)
0.0	7.3	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	0.4	GO:0008656	translation activator activity(GO:0008494) cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0	3.3	GO:0051082	unfolded protein binding(GO:0051082)
0.0	0.3	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.4	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.9	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.0	1.8	GO:0101005	thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	1.1	GO:0070063	RNA polymerase binding(GO:0070063)
0.0	0.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	1.3	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	0.6	GO:0019200	carbohydrate kinase activity(GO:0019200)
0.0	6.9	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.0	0.2	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0	0.3	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0	0.3	GO:0005452	inorganic anion exchanger activity(GO:0005452)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.0	43.7	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.6	7.9	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.5	14.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.5	6.8	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.5	9.7	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.3	4.4	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.3	3.2	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.2	5.9	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2	2.8	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.2	6.5	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.1	5.2	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.1	2.4	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.1	4.8	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.1	2.5	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.1	4.7	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	2.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.1	1.3	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.1	2.1	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.1	1.0	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	1.5	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	1.2	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	1.7	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	3.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	0.8	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.3	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	0.5	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.0	0.3	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.7	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	0.6	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	28.0	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.2	9.7	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.2	7.9	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.1	3.4	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.1	3.9	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.1	6.2	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	1.3	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1	1.2	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	0.8	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	0.9	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	0.8	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	1.0	PID REELIN PATHWAY	Reelin signaling pathway

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
4.4	34.9	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
1.3	5.2	GO:0032144	4-aminobutyrate transaminase complex(GO:0032144)
0.8	8.8	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.7	5.9	GO:0097425	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.6	2.9	GO:0070826	paraferritin complex(GO:0070826)
0.3	7.9	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.3	4.0	GO:0005577	fibrinogen complex(GO:0005577)
0.3	5.8	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2	2.4	GO:0036513	Derlin-1 retrotranslocation complex(GO:0036513)
0.2	0.2	GO:0031931	TORC1 complex(GO:0031931)
0.2	5.6	GO:0031528	microvillus membrane(GO:0031528)
0.2	0.8	GO:0045298	tubulin complex(GO:0045298)
0.1	7.2	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1	24.2	GO:0072562	blood microparticle(GO:0072562)
0.1	4.4	GO:0030131	clathrin adaptor complex(GO:0030131)
0.1	1.3	GO:0042405	nuclear inclusion body(GO:0042405)
0.1	2.6	GO:0030687	preribosome, large subunit precursor(GO:0030687)
0.1	0.8	GO:1990909	Wnt signalosome(GO:1990909)
0.1	0.2	GO:0036398	TCR signalosome(GO:0036398)
0.1	18.3	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.1	1.6	GO:0051233	spindle midzone(GO:0051233)
0.0	0.2	GO:0031313	extrinsic component of endosome membrane(GO:0031313)
0.0	0.9	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	4.2	GO:0005903	brush border(GO:0005903)
0.0	4.8	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.0	6.7	GO:0005770	late endosome(GO:0005770)
0.0	0.1	GO:0055087	Ski complex(GO:0055087)
0.0	1.7	GO:0016459	myosin complex(GO:0016459)
0.0	4.4	GO:0014069	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0	5.9	GO:0000151	ubiquitin ligase complex(GO:0000151)
0.0	5.1	GO:0016323	basolateral plasma membrane(GO:0016323)
0.0	2.3	GO:0016605	PML body(GO:0016605)
0.0	0.4	GO:0016592	mediator complex(GO:0016592)
0.0	0.4	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.0	1.5	GO:0016363	nuclear matrix(GO:0016363)
0.0	0.1	GO:1990130	Iml1 complex(GO:1990130)
0.0	21.9	GO:0005887	integral component of plasma membrane(GO:0005887)
0.0	0.1	GO:0036038	MKS complex(GO:0036038)
0.0	1.0	GO:0005882	intermediate filament(GO:0005882)

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
8.4	25.2	GO:0010902	positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902)
3.5	10.4	GO:1901253	negative regulation of intracellular transport of viral material(GO:1901253)
3.0	9.1	GO:0019477	L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
2.9	8.8	GO:0060621	regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910)
2.3	6.9	GO:0048203	vesicle targeting, trans-Golgi to endosome(GO:0048203)
1.9	9.5	GO:0034371	chylomicron remodeling(GO:0034371)
1.7	6.8	GO:0006114	glycerol biosynthetic process(GO:0006114) response to methionine(GO:1904640)
1.6	20.3	GO:2000427	positive regulation of apoptotic cell clearance(GO:2000427)
1.3	5.2	GO:0014053	negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
1.0	4.0	GO:0002034	regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072)
1.0	7.9	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
1.0	5.8	GO:0010732	protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.8	2.4	GO:0035565	regulation of pronephros size(GO:0035565) renal glucose absorption(GO:0035623)
0.7	3.4	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.7	3.4	GO:0060125	negative regulation of growth hormone secretion(GO:0060125)
0.7	4.8	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.6	7.9	GO:0034435	steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
0.6	2.9	GO:0015692	lead ion transport(GO:0015692)
0.6	3.5	GO:0051970	negative regulation of transmission of nerve impulse(GO:0051970)
0.6	1.7	GO:1903028	positive regulation of opsonization(GO:1903028)
0.4	1.3	GO:1904247	positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.4	14.2	GO:0036499	PERK-mediated unfolded protein response(GO:0036499)
0.4	1.2	GO:0060086	circadian temperature homeostasis(GO:0060086)
0.4	2.3	GO:0010133	proline catabolic process to glutamate(GO:0010133)
0.3	1.0	GO:1903572	regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.3	18.7	GO:0018279	protein N-linked glycosylation via asparagine(GO:0018279)
0.3	5.9	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.3	2.1	GO:0019344	cysteine biosynthetic process(GO:0019344)
0.3	0.8	GO:0044339	canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339) Spemann organizer formation(GO:0060061)
0.3	1.3	GO:1904693	midbrain morphogenesis(GO:1904693)
0.2	5.6	GO:0015879	carnitine transport(GO:0015879)
0.2	0.2	GO:0006562	proline catabolic process(GO:0006562)
0.2	5.4	GO:1901741	positive regulation of myoblast fusion(GO:1901741)
0.2	2.4	GO:0046415	urate metabolic process(GO:0046415)
0.2	0.8	GO:0090258	negative regulation of mitochondrial fission(GO:0090258)
0.2	0.8	GO:0015910	peroxisomal long-chain fatty acid import(GO:0015910)
0.2	0.6	GO:0006014	D-ribose metabolic process(GO:0006014)
0.2	2.4	GO:0071712	ER-associated misfolded protein catabolic process(GO:0071712)
0.2	2.5	GO:0016024	CDP-diacylglycerol biosynthetic process(GO:0016024)
0.1	0.9	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.1	1.5	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1	1.0	GO:0007256	activation of JNKK activity(GO:0007256)
0.1	2.1	GO:1902187	negative regulation of viral release from host cell(GO:1902187)
0.1	3.2	GO:0006491	N-glycan processing(GO:0006491)
0.1	1.9	GO:0043651	linoleic acid metabolic process(GO:0043651)
0.1	4.4	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.1	0.6	GO:0046485	ether lipid metabolic process(GO:0046485)
0.1	0.3	GO:1901162	primary amino compound biosynthetic process(GO:1901162)
0.1	1.0	GO:0035970	peptidyl-threonine dephosphorylation(GO:0035970)
0.0	2.8	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.2	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.0	0.3	GO:0030643	cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0	0.6	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
0.0	1.1	GO:0000042	protein targeting to Golgi(GO:0000042)
0.0	0.1	GO:2000118	regulation of sodium-dependent phosphate transport(GO:2000118)
0.0	1.6	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.2	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.0	2.6	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
0.0	7.1	GO:0007601	visual perception(GO:0007601)
0.0	4.1	GO:0030449	regulation of complement activation(GO:0030449)
0.0	0.3	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.0	0.3	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.2	GO:0032784	regulation of DNA-templated transcription, elongation(GO:0032784)
0.0	6.6	GO:0000209	protein polyubiquitination(GO:0000209)
0.0	0.4	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.0	0.7	GO:0042026	protein refolding(GO:0042026)
0.0	0.2	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.4	GO:0032007	negative regulation of TOR signaling(GO:0032007)
0.0	0.1	GO:0070989	oxidative demethylation(GO:0070989)
0.0	0.4	GO:0046949	fatty-acyl-CoA biosynthetic process(GO:0046949)
0.0	0.1	GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.0	0.2	GO:0006490	oligosaccharide-lipid intermediate biosynthetic process(GO:0006490) mannosylation(GO:0097502)
0.0	0.1	GO:0030202	heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)