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ENCODE cell lines, expression (Ernst 2011)
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Results for MAFF_MAFG
Z-value: 1.66
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Transcription factors associated with MAFF_MAFG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MAFF | hg19_v2_chr22_+_38609538_38609547, hg19_v2_chr22_+_38597889_38598021 | 0.48 | 5.7e-02 | Click! |
| MAFG | hg19_v2_chr17_-_79881408_79881423, hg19_v2_chr17_-_79885576_79885624 | 0.26 | 3.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAFF_MAFG
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrY_+_2709527 | 19.89 |
ENST00000250784.8 |
RPS4Y1 |
ribosomal protein S4, Y-linked 1 |
| chrY_+_2709906 | 7.15 |
ENST00000430575.1 |
RPS4Y1 |
ribosomal protein S4, Y-linked 1 |
| chr3_-_99594948 | 4.83 |
ENST00000471562.1 ENST00000495625.2 |
FILIP1L |
filamin A interacting protein 1-like |
| chr3_-_99595037 | 4.51 |
ENST00000383694.2 |
FILIP1L |
filamin A interacting protein 1-like |
| chr22_+_21133469 | 4.40 |
ENST00000406799.1 |
SERPIND1 |
serpin peptidase inhibitor, clade D (heparin cofactor), member 1 |
| chr16_+_30211181 | 2.62 |
ENST00000395138.2 |
SULT1A3 |
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 |
| chr1_-_110283138 | 2.55 |
ENST00000256594.3 |
GSTM3 |
glutathione S-transferase mu 3 (brain) |
| chr5_-_42811986 | 2.23 |
ENST00000511224.1 ENST00000507920.1 ENST00000510965.1 |
SEPP1 |
selenoprotein P, plasma, 1 |
| chr4_+_74275057 | 2.22 |
ENST00000511370.1 |
ALB |
albumin |
| chr10_-_90751038 | 2.18 |
ENST00000458159.1 ENST00000415557.1 ENST00000458208.1 |
ACTA2 |
actin, alpha 2, smooth muscle, aorta |
Gene Ontology Analysis
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 2.2 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 2.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.4 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.2 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 1.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.1 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 1.0 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 26.2 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.0 | 4.0 | GO:0005518 | collagen binding(GO:0005518) |
| 0.2 | 3.0 | GO:0043295 | glutathione binding(GO:0043295) |
| 0.4 | 2.6 | GO:0047685 | amine sulfotransferase activity(GO:0047685) |
| 0.1 | 2.6 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 2.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 2.2 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.5 | 2.1 | GO:0047006 | 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) |
| 0.1 | 2.1 | GO:0008603 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 0.1 | 2.1 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 26.8 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.2 | 3.6 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.1 | 3.4 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 2.8 | REACTOME EXTRACELLULAR MATRIX ORGANIZATION | Genes involved in Extracellular matrix organization |
| 0.1 | 2.2 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 2.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 2.1 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 2.1 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 1.7 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 1.3 | REACTOME MUSCLE CONTRACTION | Genes involved in Muscle contraction |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 26.6 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.6 | 4.4 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.1 | 2.8 | GO:0097120 | receptor localization to synapse(GO:0097120) |
| 0.4 | 2.6 | GO:0098989 | NMDA selective glutamate receptor signaling pathway(GO:0098989) |
| 0.5 | 2.5 | GO:0008065 | establishment of blood-nerve barrier(GO:0008065) |
| 0.7 | 2.2 | GO:0019836 | hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331) |
| 0.4 | 2.2 | GO:0090131 | mesangial cell development(GO:0072143) glomerular mesangial cell development(GO:0072144) mesenchyme migration(GO:0090131) |
| 0.1 | 2.2 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 0.5 | 2.1 | GO:1903224 | regulation of endodermal cell differentiation(GO:1903224) |
| 0.4 | 2.1 | GO:0032487 | regulation of Rap protein signal transduction(GO:0032487) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 26.2 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 7.0 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 4.0 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.2 | 2.8 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.2 | 2.5 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.5 | 2.2 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.1 | 2.1 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 2.1 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 1.8 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.1 | 1.6 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |