Motif ID: Aire

Z-value: 0.943


Transcription factors associated with Aire:

Gene SymbolEntrez IDGene Name
Aire ENSMUSG00000000731.9 Aire



Activity profile for motif Aire.

activity profile for motif Aire


Sorted Z-values histogram for motif Aire

Sorted Z-values for motif Aire



Network of associatons between targets according to the STRING database.



First level regulatory network of Aire

PNG image of the network

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Top targets:


Showing 1 to 20 of 91 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_61185558 18.216 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr10_+_123264076 3.159 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr13_-_110280103 2.678 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr12_-_78983476 1.973 ENSMUST00000070174.7
 Tmem229b
transmembrane protein 229B
chr16_+_36875119 1.828 ENSMUST00000135406.1
ENSMUST00000114812.1
ENSMUST00000134616.1
ENSMUST00000023534.6
 Golgb1


Golgb1
golgi autoantigen, golgin subfamily b, macrogolgin 1


golgi autoantigen, golgin subfamily b, macrogolgin 1
chr19_-_28963863 1.789 ENSMUST00000161813.1
 4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr10_+_86021961 1.721 ENSMUST00000130320.1
 Fbxo7
F-box protein 7
chr3_-_116968969 1.586 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr8_+_69808672 1.371 ENSMUST00000036074.8
ENSMUST00000123453.1
 Gmip

Gem-interacting protein

chr7_-_14562171 1.186 ENSMUST00000181796.1
 Vmn1r90
vomeronasal 1 receptor 90
chr14_+_76476913 1.137 ENSMUST00000140251.2
 Tsc22d1
TSC22 domain family, member 1
chr18_+_37400845 1.117 ENSMUST00000057228.1
 Pcdhb9
protocadherin beta 9
chr8_+_64947177 1.096 ENSMUST00000079896.7
ENSMUST00000026595.5
 Tmem192

transmembrane protein 192

chr9_-_97111117 1.080 ENSMUST00000085206.4
 Slc25a36
solute carrier family 25, member 36
chr2_+_55435918 0.991 ENSMUST00000067101.3
 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr19_+_34217588 0.975 ENSMUST00000119603.1
 Stambpl1
STAM binding protein like 1
chr5_-_84417359 0.966 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr4_-_46566432 0.937 ENSMUST00000030021.7
ENSMUST00000107757.1
 Coro2a

coronin, actin binding protein 2A

chr2_+_164948219 0.932 ENSMUST00000017881.2
 Mmp9
matrix metallopeptidase 9
chr2_-_134644079 0.825 ENSMUST00000110119.1
 Tmx4
thioredoxin-related transmembrane protein 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.3 GO:0019882 antigen processing and presentation(GO:0019882)
0.2 1.7 GO:1903207 neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
0.0 1.3 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.3 1.1 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.1 1.0 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.1 1.0 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.2 0.9 GO:2001268 positive regulation of receptor binding(GO:1900122) negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.0 0.9 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 0.8 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.2 0.6 GO:0030974 thiamine pyrophosphate transport(GO:0030974)
0.2 0.6 GO:0006550 isoleucine catabolic process(GO:0006550) acetyl-CoA catabolic process(GO:0046356) ketone body catabolic process(GO:0046952)
0.2 0.6 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.2 0.6 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.1 0.6 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.1 0.6 GO:0090669 telomerase RNA stabilization(GO:0090669)
0.1 0.6 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 0.6 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.6 GO:0032288 myelin assembly(GO:0032288)
0.2 0.5 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.2 0.5 GO:0042726 flavin-containing compound metabolic process(GO:0042726)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0008021 synaptic vesicle(GO:0008021)
0.0 1.8 GO:0005801 cis-Golgi network(GO:0005801)
0.3 1.7 GO:1990037 Lewy body core(GO:1990037)
0.0 1.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.7 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.7 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.6 GO:0036038 MKS complex(GO:0036038)
0.0 0.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.5 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.4 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.4 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.3 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.1 GO:0090543 Flemming body(GO:0090543)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:0031489 myosin V binding(GO:0031489)
0.0 1.7 GO:0043130 ubiquitin binding(GO:0043130)
0.0 1.7 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 1.1 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 1.1 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.2 1.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.0 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.9 GO:0001968 fibronectin binding(GO:0001968)
0.1 0.7 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.6 GO:0015234 thiamine transmembrane transporter activity(GO:0015234)
0.1 0.6 GO:0016453 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.1 0.6 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.1 0.6 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.6 GO:0048038 quinone binding(GO:0048038)
0.0 0.6 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.6 GO:0019789 SUMO transferase activity(GO:0019789)
0.2 0.5 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.0 0.5 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.0 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.9 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.6 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 0.9 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.7 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 0.6 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.6 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.6 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.5 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.5 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling