ISMARA results

ISMARA - Integrated System for Motif Actitivity Response Analysis is a free online tool that recognizes most important transcription factors that are changing their activity in a set of samples.

All motifs sorted by activity significance

Motif name Z-value Associated genes Profile Logo
Hdx 8.725 Hdx
Nfatc1 7.300 Nfatc1
Ybx1_Nfya_Nfyb_Nfyc_Cebpz 7.218 Ybx1
Nfya
Nfyb
Nfyc
Cebpz
E2f1 5.236 E2f1
Irf2_Irf1_Irf8_Irf9_Irf7 5.008 Irf2
Irf1
Irf8
Irf9
Irf7
Hoxb7 4.531 Hoxb7
Yy1_Yy2 4.461 Yy1
Yy2
Tgif1_Meis3 4.395 Tgif1
Meis3
Sp100 4.184 Sp100
Chd1_Pml 4.018 Chd1
Pml
E2f2_E2f5 3.815 E2f2
E2f5
Rest 3.598 Rest
Zfp110 3.471 Zfp110
Gtf2i_Gtf2f1 3.295 Gtf2i
Gtf2f1
Max_Mycn 3.277 Max
Mycn
Tbp 3.255 Tbp
Egr1 3.182 Egr1
Wrnip1_Mta3_Rcor1 3.002 Wrnip1
Mta3
Rcor1
Stat2 2.943 Stat2
Elf1_Elf2_Etv2_Elf4 2.931 Elf1
Elf2
Etv2
Elf4
Klf1 2.899 Klf1
Zfx_Zfp711 2.879 Zfx
Zfp711
Mecp2 2.793 Mecp2
Foxi1_Foxo1 2.498 Foxi1
Foxo1
E2f4 2.472 E2f4
Hsf2 2.414 Hsf2
Tfdp1_Wt1_Egr2 2.412 Tfdp1
Wt1
Egr2
Ppara 2.347 Ppara
Nfil3_Tef 2.305 Nfil3
Tef
Tcf4_Mesp1 2.247 Tcf4
Mesp1
Creb1 2.245 Creb1
Nrf1 2.244 Nrf1
Sp1 2.224 Sp1
Ezh2_Atf2_Ikzf1 2.221 Ezh2
Atf2
Ikzf1
Pitx2_Otx2 2.205 Pitx2
Otx2
Scrt1 2.192 Scrt1
Taf1 2.189 Taf1
Epas1_Bcl3 2.152 Epas1
Bcl3
Tead3_Tead4 2.151 Tead3
Tead4
Zbtb14 2.128 Zbtb14
Tfcp2 2.113 Tfcp2
Hic1 2.088 Hic1
Foxp1_Foxj2 2.062 Foxp1
Foxj2
Myb 2.051 Myb
Rfx3_Rfx1_Rfx4 1.982 Rfx3
Rfx1
Rfx4
Ahr 1.971 Ahr
Gcm2 1.917 Gcm2
Nkx2-2 1.911 Nkx2-2
Nr1i3 1.898 Nr1i3
Pou5f1 1.898 Pou5f1
Etv1_Etv5_Gabpa 1.878 Etv1
Etv5
Gabpa
Foxd1 1.866 Foxd1
Sox2 1.802 Sox2
Hic2 1.799 Hic2
Klf15 1.774 Klf15
Ar 1.766 Ar
Snai1_Zeb1_Snai2 1.762 Snai1
Zeb1
Snai2
Hcfc1_Six5_Smarcc2_Zfp143 1.752 Hcfc1
Six5
Smarcc2
Zfp143
Mafa 1.741 Mafa
Gli3_Zic1 1.707 Gli3
Zic1
E2f7 1.707 E2f7
Zbtb33_Chd2 1.695 Zbtb33
Chd2
Tfap2a 1.694 Tfap2a
Nfia 1.656 Nfia
Klf4_Sp3 1.655 Klf4
Sp3
E2f8 1.649 E2f8
Nfatc2 1.631 Nfatc2
Hinfp 1.622 Hinfp
Mybl2 1.606 Mybl2
Erg 1.598 Erg
Hes1 1.580 Hes1
Cpeb1 1.567 Cpeb1
Nr2f1_Nr4a1 1.565 Nr2f1
Nr4a1
Tfap4 1.565 Tfap4
Atf7_E4f1 1.561 Atf7
Atf7
E4f1
Sox3_Sox10 1.551 Sox3
Sox10
Meis2 1.547 Meis2
Mybl1 1.542 Mybl1
Zbtb16 1.542 Zbtb16
Myf6 1.520 Myf6
Ets2 1.488 Ets2
Srf 1.487 Srf
Klf16_Sp8 1.487 Klf16
Sp8
Cenpb 1.481 Cenpb
Fli1 1.476 Fli1
Gfi1_Gfi1b 1.439 Gfi1
Gfi1b
Ebf1 1.424 Ebf1
Ebf1
Junb_Jund 1.420 Junb
Jund
Sin3a 1.418 Sin3a
Scrt2 1.415 Scrt2
Foxa2_Foxa1 1.404 Foxa2
Foxa1
Maz_Zfp281 1.394 Maz
Zfp281
Zfp148 1.388 Zfp148
Pou2f2_Pou3f1 1.385 Pou2f2
Pou3f1
Pax5 1.382 Pax5
Hoxa11_Hoxc12 1.357 Hoxa11
Hoxc12
Nr2c2 1.329 Nr2c2
Tbx4 1.314 Tbx4
E2f6 1.310 E2f6
Pbx1_Pbx3 1.307 Pbx1
Pbx3
Smad4 1.302 Smad4
Zscan4c 1.292 Zscan4c
Rela_Rel_Nfkb1 1.289 Rela
Rel
Nfkb1
Ebf3 1.288 Ebf3
Sox5_Sry 1.282 Sox5
Sry
Trp53 1.276 Trp53
Vsx2_Dlx3 1.274 Vsx2
Dlx3
Nfic_Nfib 1.267 Nfic
Nfib
Twist1 1.245 Twist1
Hmga2 1.242 Hmga2
Esrrb_Esrra 1.242 Esrrb
Esrra
Nfatc3 1.241 Nfatc3
Foxd2 1.236 Foxd2
Nr2e3 1.232 Nr2e3
Atf6 1.231 Atf6
Nfix 1.224 Nfix
Klf6_Patz1 1.212 Klf6
Patz1
Zfp219_Zfp740 1.208 Zfp219
Zfp740
Mef2d_Mef2a 1.206 Mef2d
Mef2a
Foxc1 1.202 Foxc1
Nkx2-3 1.198 Nkx2-3
Hnf4g 1.174 Hnf4g
Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 1.169 Tfeb
Usf1
Srebf1
Usf2
Bhlhe41
Srebf2
Fosl2_Bach2 1.161 Fosl2
Bach2
Hes5_Hes7 1.158 Hes5
Hes7
Etv3_Erf_Fev_Elk4_Elk1_Elk3 1.157 Etv3
Erf
Fev
Elk4
Elk1
Elk3
Tcf21_Msc 1.156 Tcf21
Msc
Zbtb7c 1.155 Zbtb7c
Rreb1 1.153 Rreb1
Hoxa2 1.153 Hoxa2
Tcf7l1 1.139 Tcf7l1
Tbx21 1.138 Tbx21
Cdc5l 1.136 Cdc5l
Zfp384 1.135 Zfp384
Nr1h2 1.128 Nr1h2
Rora 1.117 Rora
Ctcfl_Ctcf 1.113 Ctcfl
Ctcf
Id4 1.111 Id4
Irx6_Irx2_Irx3 1.105 Irx6
Irx2
Irx3
Gata5 1.104 Gata5
Lef1 1.102 Lef1
Runx1 1.100 Runx1
Mnx1_Lhx6_Lmx1a 1.099 Mnx1
Lhx6
Lmx1a
Glis2 1.096 Glis2
Smad1 1.091 Smad1
Bcl6 1.082 Bcl6
Hmbox1 1.075 Hmbox1
Nfe2l1_Mafg 1.072 Nfe2l1
Mafg
Mafg
Elf3 1.071 Elf3
Pparg_Rxrg 1.071 Pparg
Rxrg
Dlx1 1.065 Dlx1
Hoxb5 1.061 Hoxb5
Stat4_Stat3_Stat5b 1.055 Stat4
Stat3
Stat5b
Foxq1 1.054 Foxq1
Dbp 1.049 Dbp
Rfx5 1.047 Rfx5
Tbx15 1.039 Tbx15
Tbr1 1.035 Tbr1
Rarg 1.035 Rarg
Hbp1 1.030 Hbp1
Zbtb7b 1.029 Zbtb7b
Cebpe 1.028 Cebpe
Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec 1.027 Arntl
Tfe3
Mlx
Mitf
Mlxipl
Tfec
Atf4 1.026 Atf4
Osr2_Osr1 1.024 Osr2
Osr1
Meox2 1.019 Meox2
Hoxc13_Hoxd13 1.018
Klf8 1.015 Klf8
Dlx5_Dlx4 1.007 Dlx5
Dlx4
Mef2c 1.003 Mef2c
Hand1 1.002 Hand1
Foxo4 0.998 Foxo4
Vdr 0.997 Vdr
Pou4f1_Pou6f1 0.993 Pou4f1
Pou6f1
Nfat5 0.991 Nfat5
Hmga1 0.987 Hmga1
Fos 0.987 Fos
Runx2_Bcl11a 0.987 Runx2
Bcl11a
Stat5a 0.985 Stat5a
Rfx2_Rfx7 0.981 Rfx2
Rfx7
Vsx1_Uncx_Prrx2_Shox2_Noto 0.980 Vsx1
Uncx
Prrx2
Shox2
Noto
Hoxb3 0.979 Hoxb3
Nhlh1 0.979 Nhlh1
Nfe2_Bach1_Mafk 0.976 Nfe2
Bach1
Mafk
Rxra 0.969 Rxra
Pitx3 0.967 Pitx3
Foxo3 0.967 Foxo3
Nkx2-5 0.963 Nkx2-5
Tcf3 0.960 Tcf3
Hsf4 0.956 Hsf4
Foxa3 0.955 Foxa3
Atf1_Creb5 0.951 Atf1
Creb5
Hsfy2 0.946 Hsfy2
Foxk1_Foxj1 0.946 Foxk1
Foxj1
Aire 0.943 Aire
Spi1 0.940 Spi1
Etv6 0.940 Etv6
Nr0b1 0.940 Nr0b1
Zfp784 0.933 Zfp784
Onecut1_Cux2 0.932 Onecut1
Cux2
Cux2
Zfhx3 0.932 Zfhx3
Hey1_Myc_Mxi1 0.931 Hey1
Myc
Mxi1
Tcf7_Tcf7l2 0.931 Tcf7
Tcf7l2
Hnf1b 0.930 Hnf1b
Hoxc10 0.928 Hoxc10
Hoxd12 0.925 Hoxd12
Trp73 0.923 Trp73
Sox14 0.920 Sox14
Meis1 0.919 Meis1
Bptf 0.919 Bptf
Esr2 0.916 Esr2
Msx2_Hoxd4 0.912 Msx2
Irf3 0.906 Irf3
Hif1a 0.902 Hif1a
Zfp652 0.894 Zfp652
Zic3 0.891 Zic3
Ddit3 0.889 Ddit3
Tbx1_Eomes 0.888 Tbx1
Eomes
Nr3c2 0.888 Nr3c2
Foxj3_Tbl1xr1 0.876 Foxj3
Tbl1xr1
Lhx4 0.870 Lhx4
Elf5 0.870 Elf5
Atf5 0.870 Atf5
E2f3 0.864 E2f3
Hoxa4 0.863 Hoxa4
Pou2f3 0.861 Pou2f3
Pou2f1 0.856 Pou2f1
Rara 0.855 Rara
Gata3 0.854 Gata3
Stat6 0.854 Stat6
Hoxb13 0.848 Hoxb13
Prdm1 0.845 Prdm1
T 0.842 T
Arnt 0.839 Arnt
Creb3 0.837 Creb3
Hnf4a 0.836 Hnf4a
Nfatc4 0.828 Nfatc4
Sox6_Sox9 0.828 Sox6
Sox9
Hoxa1 0.826 Hoxa1
Six3_Six1_Six2 0.822 Six3
Six1
Six2
Rad21_Smc3 0.820 Rad21
Smc3
Pax6 0.817 Pax6
Tfap2e 0.816 Tfap2e
Zfp524 0.812 Zfp524
Foxf2 0.812 Foxf2
Mnt 0.812 Mnt
Tlx2 0.811 Tlx2
Tbx5 0.808 Tbx5
Nr1i2 0.803 Nr1i2
Fubp1 0.802 Fubp1
En1 0.800 En1
Hivep1 0.798 Hivep1
Atf3 0.798 Atf3
Egr4 0.796 Egr4
Smad3 0.795 Smad3
Zbtb18 0.793 Zbtb18
Lhx8 0.792 Lhx8
Rbpj 0.791 Rbpj
Evx2 0.791 Evx2
Mafb 0.790 Mafb
Homez 0.789 Homez
Tfap2b 0.788 Tfap2b
Sp2 0.787 Sp2
Hoxa13 0.783 Hoxa13
Gsx2_Hoxd3_Vax1 0.779 Gsx2
Hoxd3
Vax1
Mef2b 0.778 Mef2b
Olig2_Olig3 0.777 Olig2
Olig3
Pbx2 0.777 Pbx2
Mbd2 0.777 Mbd2
Trp63 0.769 Trp63
Prop1 0.768 Prop1
Cux1 0.768 Cux1
Hoxa10 0.764 Hoxa10
Hoxa6 0.763 Hoxa6
Hmx1 0.761 Hmx1
Thra 0.760 Thra
Ascl2 0.757 Ascl2
Smarcc1_Fosl1 0.757 Smarcc1
Fosl1
Pax2 0.755 Pax2
Stat1 0.754 Stat1
Mtf1 0.752 Mtf1
Tfap2d 0.752 Tfap2d
Pknox2_Pknox1 0.751 Pknox2
Pknox1
Hoxb1 0.747 Hoxb1
Tgif2_Tgif2lx1_Tgif2lx2 0.745 Tgif2
Tgif2lx1
Tgif2lx2
Bsx 0.745 Bsx
Neurod1 0.736 Neurod1
Spib 0.734 Spib
Hoxa5 0.730 Hoxa5
Emx1_Emx2 0.726 Emx1
Emx2
Smad2 0.725 Smad2
Hlf 0.725 Hlf
Mecom 0.725 Mecom
Tfcp2l1 0.724 Tfcp2l1
Neurod2_Bhlha15_Bhlhe22_Olig1 0.724 Neurod2
Bhlha15
Bhlhe22
Olig1
Xbp1_Creb3l1 0.719 Xbp1
Creb3l1
Nkx3-2 0.719 Nkx3-2
Nfe2l2 0.718 Nfe2l2
Rxrb 0.716 Rxrb
Insm1 0.715 Insm1
Hoxd1 0.714 Hoxd1
Obox6_Obox5 0.713 Obox6
Obox5
Hoxa3 0.707 Hoxa3
Nr1h4 0.706 Nr1h4
Prox1 0.704 Prox1
Lhx5_Lmx1b_Lhx1 0.703 Lhx5
Lmx1b
Lhx1
Foxb1 0.698 Foxb1
Crem_Jdp2 0.696 Crem
Jdp2
Pax3 0.696 Pax3
Nr2c1 0.694 Nr2c1
Foxm1 0.693 Foxm1
Ets1 0.691 Ets1
Spic 0.690 Spic
Hoxc9 0.688 Hoxc9
Onecut2_Onecut3 0.676 Onecut2
Onecut3
Tbx19 0.676 Tbx19
Figla 0.674 Figla
Foxd3 0.673 Foxd3
Dmc1 0.672 Dmc1
Nr2f6 0.670 Nr2f6
Foxf1 0.668 Foxf1
Tfap2c 0.668 Tfap2c
Nr6a1 0.667 Nr6a1
Hoxd11_Cdx1_Hoxc11 0.667 Hoxd11
Cdx1
Hoxc11
Nfkb2 0.666 Nfkb2
Myog_Tcf12 0.665 Myog
Tcf12
Pgr_Nr3c1 0.663 Pgr
Nr3c1
Zic4 0.662 Zic4
Nkx6-1_Evx1_Hesx1 0.661 Nkx6-1
Evx1
Hesx1
Meox1 0.660 Meox1
Sox18_Sox12 0.654 Sox18
Sox12
Rhox4e_Rhox6_Vax2 0.653 Rhox4e
Rhox6
Vax2
Hoxb8_Pdx1 0.649 Hoxb8
Pdx1
Zkscan1 0.647 Zkscan1
Zfp263 0.642 Zfp263
Plag1 0.642 Plag1
Isl2 0.641 Isl2
Relb 0.641 Relb
Gsx1_Alx1_Mixl1_Lbx2 0.640 Gsx1
Alx1
Mixl1
Lbx2
Nkx2-1 0.640 Nkx2-1
Klf13 0.640 Klf13
Otx1 0.639 Otx1
Foxp2_Foxp3 0.639 Foxp2
Foxp3
Rorc_Nr1d1 0.639 Rorc
Nr1d1
Creb3l2 0.639 Creb3l2
Zfp282 0.638 Zfp282
Hoxd8 0.636 Hoxd8
Gata4 0.636 Gata4
Foxo6 0.635 Foxo6
Ikzf2 0.635 Ikzf2
Runx3 0.634 Runx3
Zbtb7a 0.631 Zbtb7a
Etv4 0.630 Etv4
Hsf1 0.629 Hsf1
Gcm1 0.628 Gcm1
Hoxb2_Dlx2 0.627 Hoxb2
Dlx2
Zbtb4 0.625 Zbtb4
Nr2f2 0.624 Nr2f2
Hoxd9 0.623 Hoxd9
Ppard 0.618 Ppard
Nanog 0.613 Nanog
Prrx1_Isx_Prrxl1 0.612 Prrx1
Isx
Prrxl1
Tal1 0.609 Tal1
Bhlhe40 0.607 Bhlhe40
Pou1f1 0.607 Pou1f1
Zic2 0.605 Zic2
Nkx2-9 0.603 Nkx2-9
Nkx3-1 0.603 Nkx3-1
Ep300 0.603 Ep300
Ubp1 0.601 Ubp1
Gbx1_Nobox_Alx3 0.601 Gbx1
Nobox
Alx3
Tlx1 0.600 Tlx1
Irf5_Irf6 0.599 Irf5
Irf6
Esr1 0.599 Esr1
Jun 0.598 Jun
Bcl6b 0.595 Bcl6b
Mzf1 0.594 Mzf1
Zbtb6 0.593 Zbtb6
Nr4a2 0.588 Nr4a2
Phox2a 0.586 Phox2a
Klf12_Klf14_Sp4 0.586 Klf12
Klf14
Sp4
Egr3 0.585 Egr3
Irf4 0.584 Irf4
Obox1 0.581 Obox1
Hoxa9_Hoxb9 0.580 Hoxa9
Hoxb9
Klf7 0.578 Klf7
Foxl1 0.578 Foxl1
Foxl1
Zbtb3 0.575 Zbtb3
Maf_Nrl 0.572 Maf
Nrl
Lhx2_Hoxc5 0.572 Lhx2
Hoxc5
Nr4a3 0.570 Nr4a3
Cebpb 0.570 Cebpb
Crx_Gsc 0.566 Crx
Gsc
Arid3a 0.562 Arid3a
Sox17 0.558 Sox17
Cxxc1 0.548 Cxxc1
Grhl1 0.548 Grhl1
Gata2_Gata1 0.548 Gata2
Gata1
Gli2 0.547 Gli2
Pitx1 0.545 Pitx1
Cebpa_Cebpg 0.545 Cebpa
Cebpg
Nkx6-2 0.544 Nkx6-2
Foxg1 0.543 Foxg1
Hnf1a 0.542 Hnf1a
Gata6 0.541 Gata6
Pou3f2 0.539 Pou3f2
Tbx2 0.536 Tbx2
Pou6f2_Pou4f2 0.534 Pou6f2
Pou4f2
Gli1 0.534 Gli1
Nkx2-4 0.532 Nkx2-4
Maff 0.532 Maff
Zbtb12 0.531 Zbtb12
Alx4 0.530 Alx4
Obox3 0.527 Obox3
Pou3f4 0.525 Pou3f4
Six6 0.525 Six6
Msx3 0.524 Msx3
Irx5 0.521 Irx5
Cbfb 0.520 Cbfb
Plagl1 0.517 Plagl1
Gmeb1 0.516 Gmeb1
Barhl2 0.516 Barhl2
Gbx2 0.516 Gbx2
Sox21 0.513 Sox21
Six4 0.511 Six4
Zbtb49 0.511 Zbtb49
Ptf1a 0.506 Ptf1a
Zfp691 0.505 Zfp691
Brca1 0.505 Brca1
Tead1 0.502 Tead1
Pou4f3 0.502 Pou4f3
Gsc2_Dmbx1 0.501 Gsc2
Dmbx1
Lhx3 0.497 Lhx3
Cdx2 0.491 Cdx2
Cebpd 0.490 Cebpd
Glis3 0.487 Glis3
Glis3
Sox4 0.487 Sox4
Hey2 0.478 Hey2
Hoxd10 0.477 Hoxd10
Zfp423 0.477 Zfp423
Barhl1 0.475 Barhl1
Sox8 0.470 Sox8
Pax4 0.466 Pax4
Rhox11 0.465 Rhox11
Nkx6-3_Dbx2_Barx2 0.462 Nkx6-3
Dbx2
Barx2
Foxn1 0.457 Foxn1
Pax8 0.456 Pax8
Myod1 0.454 Myod1
Nr5a2 0.450 Nr5a2
Sox15 0.449 Sox15
Esrrg 0.449 Esrrg
Gmeb2 0.447 Gmeb2
Batf 0.433 Batf
Gzf1 0.430 Gzf1
Spdef 0.429 Spdef
Hoxa7_Hoxc8 0.429 Hoxa7
Hoxc8
En2 0.429 En2
Clock 0.420 Clock
Msx1_Lhx9_Barx1_Rax_Dlx6 0.413 Msx1
Lhx9
Barx1
Rax
Dlx6
Arid5b 0.407 Arid5b
Sox7 0.404 Sox7
Neurog2 0.401 Neurog2
Tbx3 0.394 Tbx3
Klf3 0.390 Klf3
Atoh1_Bhlhe23 0.390 Atoh1
Bhlhe23
Batf3 0.389 Batf3
Nkx1-1_Nkx1-2 0.386 Nkx1-1
Nkx1-2
Nr2e1 0.386 Nr2e1
Sox13 0.382 Sox13
Hmx2 0.380 Hmx2
Hoxb4 0.376 Hoxb4
Prdm4 0.372 Prdm4
Hoxc4_Arx_Otp_Esx1_Phox2b 0.371 Hoxc4
Arx
Otp
Esx1
Phox2b
Rarb 0.369 Rarb
Zfp410 0.367 Zfp410
Foxc2 0.366 Foxc2
Sox30 0.363 Sox30
Isl1 0.351 Isl1
Pax7 0.344 Pax7
Bbx 0.343 Bbx
Sox1 0.339 Sox1
Sox11 0.337 Sox11
Fosb 0.327 Fosb
Arnt2 0.319 Arnt2
Hlx 0.305 Hlx
Mga 0.302 Mga
Pax1_Pax9 0.301 Pax1
Pax9
Prdm14 0.301 Prdm14
Hoxc6 0.301 Hoxc6
Zkscan3 0.295 Zkscan3
Tbx20 0.293 Tbx20
Zfp128 0.280 Zfp128
Zfp105 0.272 Zfp105
Irx4 0.268 Irx4
Thrb 0.265 Thrb
Ovol1 0.257 Ovol1
Arid5a 0.249 Arid5a
Hmx3 0.241 Hmx3
Hoxb6 0.236 Hoxb6
Nkx2-6 0.225 Nkx2-6
Pou3f3 0.218 Pou3f3
Ehf 0.193 Ehf
Glis1 0.113 Glis1

All samples sorted alphabetically


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Sample name Condition Replicate/Batch
E125_NSC_WT_1
E125_NSC_WT_2
E125_NSC_WT_3
E135_NSC_WT_1
E135_NSC_WT_2
E135_NSC_WT_3
E135_NSC_WT_4
E145_NSC_WT_1
E145_NSC_WT_2
E145_NSC_WT_3
E155_NSC_WT_1
E155_NSC_WT_2
E155_NSC_WT_3
E155_NSC_WT_4
E165_NSC_WT_1
E165_NSC_WT_2
E165_NSC_WT_3
E165_NSC_WT_4