Motif ID: Hoxa7_Hoxc8

Z-value: 0.429

Transcription factors associated with Hoxa7_Hoxc8:

Gene SymbolEntrez IDGene Name
Hoxa7 ENSMUSG00000038236.6 Hoxa7
Hoxc8 ENSMUSG00000001657.6 Hoxc8






Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa7_Hoxc8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_80000292 2.035 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chrX_-_143933089 1.984 ENSMUST00000087313.3
Dcx
doublecortin
chr15_-_8710409 1.552 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr14_-_100149764 1.096 ENSMUST00000097079.4
Klf12
Kruppel-like factor 12
chr5_-_62766153 1.090 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_-_143933204 0.938 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chr15_-_8710734 0.934 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr9_-_55919605 0.913 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr1_+_72284367 0.838 ENSMUST00000027380.5
ENSMUST00000141783.1
Tmem169

transmembrane protein 169

chr2_+_69897255 0.801 ENSMUST00000131553.1
Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr3_+_5218516 0.682 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr1_-_134955847 0.631 ENSMUST00000168381.1
Ppp1r12b
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr11_+_29373618 0.610 ENSMUST00000040182.6
ENSMUST00000109477.1
Ccdc88a

coiled coil domain containing 88A

chr12_-_87775755 0.574 ENSMUST00000164517.2
Gm21319
predicted gene, 21319
chr4_+_102589687 0.515 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b

phosphodiesterase 4B, cAMP specific

chr6_-_118479237 0.509 ENSMUST00000161170.1
Zfp9
zinc finger protein 9
chr1_-_134955908 0.490 ENSMUST00000045665.6
ENSMUST00000086444.4
ENSMUST00000112163.1
Ppp1r12b


protein phosphatase 1, regulatory (inhibitor) subunit 12B


chr13_+_42681513 0.488 ENSMUST00000149235.1
Phactr1
phosphatase and actin regulator 1
chr18_+_23753708 0.486 ENSMUST00000115830.1
Mapre2
microtubule-associated protein, RP/EB family, member 2
chr3_-_66296807 0.461 ENSMUST00000029419.7
Veph1
ventricular zone expressed PH domain-containing 1
chr4_-_14621805 0.444 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr17_-_45659312 0.443 ENSMUST00000120717.1
Capn11
calpain 11
chr2_+_69897220 0.443 ENSMUST00000055758.9
ENSMUST00000112251.2
Ubr3

ubiquitin protein ligase E3 component n-recognin 3

chr15_-_67113909 0.442 ENSMUST00000092640.5
St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr14_-_36919314 0.435 ENSMUST00000182797.1
Ccser2
coiled-coil serine rich 2
chr19_-_50678642 0.434 ENSMUST00000072685.6
ENSMUST00000164039.2
Sorcs1

VPS10 domain receptor protein SORCS 1

chr3_+_55461758 0.430 ENSMUST00000070418.4
Dclk1
doublecortin-like kinase 1
chr5_+_66968559 0.428 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr15_+_25773985 0.407 ENSMUST00000125667.1
Myo10
myosin X
chr10_-_117148474 0.398 ENSMUST00000020381.3
Frs2
fibroblast growth factor receptor substrate 2
chr2_-_177267036 0.388 ENSMUST00000108963.1
Gm14409
predicted gene 14409
chr9_+_113812547 0.359 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
Clasp2


CLIP associating protein 2


chr15_-_37458523 0.357 ENSMUST00000116445.2
Ncald
neurocalcin delta
chr13_+_83732438 0.335 ENSMUST00000182701.1
C130071C03Rik
RIKEN cDNA C130071C03 gene
chr18_+_32067729 0.321 ENSMUST00000025243.3
Iws1
IWS1 homolog (S. cerevisiae)
chr5_+_29195983 0.319 ENSMUST00000160888.1
ENSMUST00000159272.1
ENSMUST00000001247.5
ENSMUST00000161398.1
ENSMUST00000160246.1
Rnf32




ring finger protein 32




chr9_-_90255927 0.299 ENSMUST00000144646.1
Tbc1d2b
TBC1 domain family, member 2B
chr4_+_108719649 0.293 ENSMUST00000178992.1
3110021N24Rik
RIKEN cDNA 3110021N24 gene
chr2_+_110597298 0.286 ENSMUST00000045972.6
ENSMUST00000111026.2
Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chrM_+_9870 0.269 ENSMUST00000084013.1
mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr3_+_5218589 0.268 ENSMUST00000177488.1
Zfhx4
zinc finger homeodomain 4
chr17_+_88440711 0.252 ENSMUST00000112238.2
ENSMUST00000155640.1
Foxn2

forkhead box N2

chr18_+_37518341 0.250 ENSMUST00000097609.1
Pcdhb22
protocadherin beta 22
chr7_+_103550368 0.222 ENSMUST00000106888.1
Olfr613
olfactory receptor 613
chr2_-_45117349 0.220 ENSMUST00000176438.2
Zeb2
zinc finger E-box binding homeobox 2
chr9_-_103228420 0.214 ENSMUST00000126359.1
Trf
transferrin
chr2_+_23069210 0.205 ENSMUST00000155602.1
Acbd5
acyl-Coenzyme A binding domain containing 5
chr14_-_108914237 0.205 ENSMUST00000100322.2
Slitrk1
SLIT and NTRK-like family, member 1
chr7_+_35802593 0.202 ENSMUST00000052454.2
E130304I02Rik
RIKEN cDNA E130304I02 gene
chr17_-_36032682 0.196 ENSMUST00000102678.4
H2-T23
histocompatibility 2, T region locus 23
chr3_+_5218546 0.186 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chr5_+_66968416 0.166 ENSMUST00000038188.7
Limch1
LIM and calponin homology domains 1
chr7_+_126950687 0.163 ENSMUST00000106333.1
Sez6l2
seizure related 6 homolog like 2
chr10_-_86011833 0.149 ENSMUST00000105304.1
ENSMUST00000061699.5
Bpifc

BPI fold containing family C

chr10_+_23894688 0.146 ENSMUST00000041416.7
Vnn1
vanin 1
chr19_-_32196393 0.136 ENSMUST00000151822.1
Sgms1
sphingomyelin synthase 1
chr16_-_50330987 0.133 ENSMUST00000114488.1
Bbx
bobby sox homolog (Drosophila)
chr2_-_121235689 0.122 ENSMUST00000142400.1
Trp53bp1
transformation related protein 53 binding protein 1
chr6_+_145934113 0.120 ENSMUST00000032383.7
Sspn
sarcospan
chr4_-_14621494 0.113 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr17_-_29007925 0.106 ENSMUST00000009138.5
ENSMUST00000119274.1
Stk38

serine/threonine kinase 38

chr6_+_37870786 0.103 ENSMUST00000120428.1
ENSMUST00000031859.7
Trim24

tripartite motif-containing 24

chr1_-_24612700 0.102 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chrX_+_16619698 0.088 ENSMUST00000026013.5
Maoa
monoamine oxidase A
chr4_+_145585166 0.083 ENSMUST00000105739.1
ENSMUST00000119718.1
Gm13212

predicted gene 13212

chr13_+_43785107 0.078 ENSMUST00000015540.2
Cd83
CD83 antigen
chr10_-_76110956 0.078 ENSMUST00000120757.1
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr18_+_55057557 0.076 ENSMUST00000181765.1
Gm4221
predicted gene 4221
chr5_-_62765618 0.076 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_+_82316452 0.068 ENSMUST00000027322.7
Rhbdd1
rhomboid domain containing 1
chr8_+_94152607 0.064 ENSMUST00000034211.8
Mt3
metallothionein 3
chr1_-_132367879 0.064 ENSMUST00000142609.1
Tmcc2
transmembrane and coiled-coil domains 2
chr2_-_116067391 0.062 ENSMUST00000140185.1
2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr15_-_75905349 0.062 ENSMUST00000127550.1
Eef1d
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
chr8_-_109251698 0.060 ENSMUST00000079189.3
4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr18_-_10706688 0.058 ENSMUST00000002549.7
ENSMUST00000117726.1
ENSMUST00000117828.1
Abhd3


abhydrolase domain containing 3


chr12_+_71170589 0.057 ENSMUST00000129376.1
2700049A03Rik
RIKEN cDNA 2700049A03 gene
chr18_+_4920509 0.049 ENSMUST00000126977.1
Svil
supervillin
chr4_+_100478806 0.049 ENSMUST00000133493.2
ENSMUST00000092730.3
ENSMUST00000106979.3
Ube2u


ubiquitin-conjugating enzyme E2U (putative)


chr4_-_82850721 0.048 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr4_-_115133977 0.044 ENSMUST00000051400.7
Cyp4x1
cytochrome P450, family 4, subfamily x, polypeptide 1
chr7_-_83550258 0.040 ENSMUST00000177929.1
Gm10610
predicted gene 10610
chr2_-_164171113 0.039 ENSMUST00000045196.3
Kcns1
K+ voltage-gated channel, subfamily S, 1
chr10_+_75037066 0.029 ENSMUST00000147802.1
ENSMUST00000020391.5
Rab36

RAB36, member RAS oncogene family

chr3_-_86548268 0.026 ENSMUST00000077524.3
Mab21l2
mab-21-like 2 (C. elegans)
chr6_+_63255971 0.020 ENSMUST00000159561.1
ENSMUST00000095852.3
Grid2

glutamate receptor, ionotropic, delta 2

chr9_+_110052016 0.014 ENSMUST00000164930.1
ENSMUST00000163979.1
Map4

microtubule-associated protein 4

chr11_-_82890541 0.011 ENSMUST00000092844.6
ENSMUST00000021033.9
ENSMUST00000018985.8
Rad51d


RAD51 homolog D


chr2_+_109917639 0.008 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr2_+_116067213 0.007 ENSMUST00000152412.1
G630016G05Rik
RIKEN cDNA G630016G05 gene

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.3 1.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.2 2.9 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.6 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.1 0.4 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.1 0.5 GO:0019532 oxalate transport(GO:0019532)
0.1 0.2 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 0.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.3 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.0 2.0 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.2 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.2 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 0.1 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.0 0.1 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.1 GO:0097212 lysosomal membrane organization(GO:0097212)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.1 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.0 0.1 GO:1904659 glucose transmembrane transport(GO:1904659)
0.0 0.1 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.1 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0 0.1 GO:0043407 negative regulation of MAP kinase activity(GO:0043407)
0.0 0.4 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 GO:0042581 specific granule(GO:0042581)
0.1 0.4 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.2 GO:0097433 dense body(GO:0097433)
0.0 1.1 GO:0031672 A band(GO:0031672)
0.0 0.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.5 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 2.5 GO:0043197 dendritic spine(GO:0043197)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 0.4 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.5 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 0.1 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.1 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.6 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 1.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.1 GO:0051378 primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378)
0.0 0.1 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.1 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 3.9 GO:0008017 microtubule binding(GO:0008017)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.2 PID_ARF6_PATHWAY Arf6 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.8 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.4 REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS Genes involved in Prolonged ERK activation events
0.0 2.7 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 0.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides