Motif ID: Hoxa7_Hoxc8

Z-value: 0.429

Transcription factors associated with Hoxa7_Hoxc8:

Gene SymbolEntrez IDGene Name
Hoxa7 ENSMUSG00000038236.6 Hoxa7
Hoxc8 ENSMUSG00000001657.6 Hoxc8



Activity profile for motif Hoxa7_Hoxc8.

activity profile for motif Hoxa7_Hoxc8


Sorted Z-values histogram for motif Hoxa7_Hoxc8

Sorted Z-values for motif Hoxa7_Hoxc8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa7_Hoxc8

PNG image of the network

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Top targets:


Showing 1 to 20 of 90 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_80000292 2.035 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chrX_-_143933089 1.984 ENSMUST00000087313.3
 Dcx
doublecortin
chr15_-_8710409 1.552 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr14_-_100149764 1.096 ENSMUST00000097079.4
 Klf12
Kruppel-like factor 12
chr5_-_62766153 1.090 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_-_143933204 0.938 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr15_-_8710734 0.934 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr9_-_55919605 0.913 ENSMUST00000037408.8
 Scaper
S phase cyclin A-associated protein in the ER
chr1_+_72284367 0.838 ENSMUST00000027380.5
ENSMUST00000141783.1
 Tmem169

transmembrane protein 169

chr2_+_69897255 0.801 ENSMUST00000131553.1
 Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr3_+_5218516 0.682 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr1_-_134955847 0.631 ENSMUST00000168381.1
 Ppp1r12b
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr11_+_29373618 0.610 ENSMUST00000040182.6
ENSMUST00000109477.1
 Ccdc88a

coiled coil domain containing 88A

chr12_-_87775755 0.574 ENSMUST00000164517.2
 Gm21319
predicted gene, 21319
chr4_+_102589687 0.515 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr6_-_118479237 0.509 ENSMUST00000161170.1
 Zfp9
zinc finger protein 9
chr1_-_134955908 0.490 ENSMUST00000045665.6
ENSMUST00000086444.4
ENSMUST00000112163.1
 Ppp1r12b


protein phosphatase 1, regulatory (inhibitor) subunit 12B


chr13_+_42681513 0.488 ENSMUST00000149235.1
 Phactr1
phosphatase and actin regulator 1
chr18_+_23753708 0.486 ENSMUST00000115830.1
 Mapre2
microtubule-associated protein, RP/EB family, member 2
chr3_-_66296807 0.461 ENSMUST00000029419.7
 Veph1
ventricular zone expressed PH domain-containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.9 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.6 2.5 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 2.0 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.3 1.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.6 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.1 0.5 GO:0019532 oxalate transport(GO:0019532)
0.0 0.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.4 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.1 0.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.4 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.3 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.1 0.2 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.0 0.2 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.2 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 0.1 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.0 0.1 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.1 GO:0097212 lysosomal membrane organization(GO:0097212)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.1 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0043197 dendritic spine(GO:0043197)
0.1 2.0 GO:0042581 specific granule(GO:0042581)
0.0 1.1 GO:0031672 A band(GO:0031672)
0.0 0.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.5 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.4 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.2 GO:0097433 dense body(GO:0097433)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 GO:0008017 microtubule binding(GO:0008017)
0.4 2.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 1.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.6 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.5 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.4 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 0.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.1 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.1 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.1 GO:0051378 primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378)
0.0 0.1 GO:0061649 ubiquitinated histone binding(GO:0061649)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.2 PID_ARF6_PATHWAY Arf6 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 1.8 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.4 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.4 REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS Genes involved in Prolonged ERK activation events