ISMARA results: Clock

Motif ID: Clock

Z-value: 0.420

Transcription factors associated with Clock:

Gene Symbol	Entrez ID	Gene Name
Clock	ENSMUSG00000029238.8	Clock

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Clock	mm10_v2_chr5_-_76304474_76304548	-0.49	3.8e-02	Click!

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Top targets:

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Showing 1 to 20 of 145 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr14_-_20181773	1.340	ENSMUST00000024011.8	Kcnk5	potassium channel, subfamily K, member 5
chr7_-_144939823	1.132	ENSMUST00000093962.4	Ccnd1	cyclin D1
chr5_-_22344690	0.892	ENSMUST00000062372.7 ENSMUST00000161356.1	Reln	reelin
chrX_+_56786527	0.853	ENSMUST00000144600.1	Fhl1	four and a half LIM domains 1
chr10_+_22158566	0.743	ENSMUST00000181645.1 ENSMUST00000105522.2	Raet1e H60b	retinoic acid early transcript 1E histocompatibility 60b
chr11_+_101316917	0.724	ENSMUST00000151385.1	Psme3	proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)
chr2_+_164769892	0.677	ENSMUST00000088248.6 ENSMUST00000001439.6	Ube2c	ubiquitin-conjugating enzyme E2C
chr17_-_35000848	0.605	ENSMUST00000166828.3	D17H6S56E-5	DNA segment, Chr 17, human D6S56E 5
chr6_+_108660616	0.594	ENSMUST00000032194.4	Bhlhe40	basic helix-loop-helix family, member e40
chr17_-_35000746	0.546	ENSMUST00000163360.1	D17H6S56E-5	DNA segment, Chr 17, human D6S56E 5
chr9_-_106891401	0.526	ENSMUST00000069036.7	Manf	mesencephalic astrocyte-derived neurotrophic factor
chr4_-_97778042	0.516	ENSMUST00000146447.1	E130114P18Rik	RIKEN cDNA E130114P18 gene
chr15_+_39076885	0.505	ENSMUST00000067072.3	Cthrc1	collagen triple helix repeat containing 1
chr7_-_25250720	0.501	ENSMUST00000116343.2 ENSMUST00000045847.8	Erf	Ets2 repressor factor
chr9_-_114781986	0.487	ENSMUST00000035009.8 ENSMUST00000084867.7	Cmtm7	CKLF-like MARVEL transmembrane domain containing 7
chr5_+_93093428	0.482	ENSMUST00000074733.7	Sept11	septin 11
chr5_+_139543889	0.482	ENSMUST00000174792.1 ENSMUST00000031523.8	Uncx	UNC homeobox
chr1_-_82291370	0.479	ENSMUST00000069799.2	Irs1	insulin receptor substrate 1
chr5_-_76951560	0.476	ENSMUST00000140076.1	Ppat	phosphoribosyl pyrophosphate amidotransferase
chr18_+_35553401	0.474	ENSMUST00000181664.1	Snhg4	small nucleolar RNA host gene 4 (non-protein coding)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 49 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.3	GO:0030322	stabilization of membrane potential(GO:0030322)
0.2	1.1	GO:0000320	re-entry into mitotic cell cycle(GO:0000320)
0.2	0.9	GO:0097477	lateral motor column neuron migration(GO:0097477)
0.0	0.9	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.2	0.7	GO:1903334	positive regulation of protein folding(GO:1903334)
0.1	0.7	GO:0010993	regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.0	0.7	GO:0001913	T cell mediated cytotoxicity(GO:0001913)
0.0	0.7	GO:0032933	response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.7	GO:0043153	entrainment of circadian clock by photoperiod(GO:0043153)
0.2	0.6	GO:0002014	vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.1	0.6	GO:0006438	valyl-tRNA aminoacylation(GO:0006438)
0.1	0.6	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.1	0.6	GO:0010745	negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.1	0.5	GO:0002337	B-1a B cell differentiation(GO:0002337)
0.1	0.5	GO:0060535	trachea cartilage morphogenesis(GO:0060535)
0.1	0.5	GO:0031581	hemidesmosome assembly(GO:0031581)
0.1	0.5	GO:0046864	retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
0.1	0.5	GO:0010668	ectodermal cell differentiation(GO:0010668)
0.1	0.5	GO:0061073	ciliary body morphogenesis(GO:0061073)
0.1	0.5	GO:0090273	regulation of somatostatin secretion(GO:0090273)

Gene overrepresentation in cellular_component category:

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Showing 1 to 19 of 19 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.1	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2	1.0	GO:0008537	proteasome activator complex(GO:0008537)
0.2	0.7	GO:0089717	spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0	0.7	GO:0005680	anaphase-promoting complex(GO:0005680)
0.2	0.5	GO:0005899	insulin receptor complex(GO:0005899)
0.2	0.5	GO:0031088	platelet dense granule membrane(GO:0031088)
0.1	0.5	GO:0043259	laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.1	0.5	GO:0000125	PCAF complex(GO:0000125)
0.0	0.4	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	0.4	GO:0032797	SMN complex(GO:0032797)
0.0	0.4	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.1	0.3	GO:0031074	nucleocytoplasmic shuttling complex(GO:0031074)
0.1	0.3	GO:0043202	lysosomal lumen(GO:0043202)
0.1	0.2	GO:0070552	BRISC complex(GO:0070552)
0.0	0.2	GO:0034751	aryl hydrocarbon receptor complex(GO:0034751)
0.0	0.2	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0	0.2	GO:0061689	tricellular tight junction(GO:0061689)
0.0	0.2	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0	0.1	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 36 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.3	GO:0022841	potassium ion leak channel activity(GO:0022841)
0.0	1.1	GO:0016831	carboxy-lyase activity(GO:0016831)
0.2	1.0	GO:0043426	MRF binding(GO:0043426)
0.1	1.0	GO:0061133	endopeptidase activator activity(GO:0061133)
0.1	0.9	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0	0.9	GO:0070064	proline-rich region binding(GO:0070064)
0.1	0.8	GO:0015037	peptide disulfide oxidoreductase activity(GO:0015037)
0.1	0.7	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)
0.0	0.7	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.1	0.6	GO:0004832	valine-tRNA ligase activity(GO:0004832)
0.1	0.5	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.5	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.5	GO:0015245	fatty acid transporter activity(GO:0015245)
0.0	0.5	GO:0051183	vitamin transporter activity(GO:0051183)
0.0	0.5	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.5	GO:0017147	Wnt-protein binding(GO:0017147)
0.0	0.5	GO:0017025	TBP-class protein binding(GO:0017025)
0.0	0.5	GO:0016763	transferase activity, transferring pentosyl groups(GO:0016763)
0.1	0.4	GO:0004998	transferrin receptor activity(GO:0004998)
0.0	0.4	GO:0000175	3'-5'-exoribonuclease activity(GO:0000175)

Gene overrepresentation in C2:CP category:

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Showing 1 to 8 of 8 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.5	NABA_ECM_GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	1.1	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	1.1	PID_MYC_PATHWAY	C-MYC pathway
0.0	0.7	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1	0.5	PID_INTEGRIN4_PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	0.5	PID_CIRCADIAN_PATHWAY	Circadian rhythm pathway
0.0	0.5	PID_S1P_S1P2_PATHWAY	S1P2 pathway
0.0	0.2	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 16 of 16 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	1.1	REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.7	REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.7	REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.6	REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	0.5	REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.5	REACTOME_SOS_MEDIATED_SIGNALLING	Genes involved in SOS-mediated signalling
0.0	0.5	REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.0	0.5	REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.4	REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.0	0.3	REACTOME_INTRINSIC_PATHWAY	Genes involved in Intrinsic Pathway
0.0	0.3	REACTOME_SYNTHESIS_OF_PE	Genes involved in Synthesis of PE
0.0	0.3	REACTOME_PYRIMIDINE_METABOLISM	Genes involved in Pyrimidine metabolism
0.0	0.3	REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	0.2	REACTOME_THE_NLRP3_INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.1	REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)