Motif ID: Rad21_Smc3

Z-value: 0.820

Transcription factors associated with Rad21_Smc3:

Gene SymbolEntrez IDGene Name
Rad21 ENSMUSG00000022314.9 Rad21
Smc3 ENSMUSG00000024974.10 Smc3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rad21mm10_v2_chr15_-_51991679_51991760-0.371.3e-01Click!
Smc3mm10_v2_chr19_+_53600377_53600435-0.068.2e-01Click!


Activity profile for motif Rad21_Smc3.

activity profile for motif Rad21_Smc3


Sorted Z-values histogram for motif Rad21_Smc3

Sorted Z-values for motif Rad21_Smc3



Network of associatons between targets according to the STRING database.



First level regulatory network of Rad21_Smc3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_53286052 3.317 ENSMUST00000021918.8
 Ror2
receptor tyrosine kinase-like orphan receptor 2
chr7_-_79594924 3.189 ENSMUST00000172788.1
 Rhcg
Rhesus blood group-associated C glycoprotein
chr19_+_60144682 3.119 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr2_-_54085542 3.043 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr8_+_87473116 2.695 ENSMUST00000182650.1
ENSMUST00000182758.1
ENSMUST00000181898.1
 Gm2694


predicted gene 2694


chr13_-_113046357 2.507 ENSMUST00000022282.3
 Gpx8
glutathione peroxidase 8 (putative)
chr2_-_117342709 2.415 ENSMUST00000173541.1
ENSMUST00000172901.1
ENSMUST00000173252.1
 Rasgrp1


RAS guanyl releasing protein 1


chr7_+_16891755 2.407 ENSMUST00000078182.4
 Gng8
guanine nucleotide binding protein (G protein), gamma 8
chr9_-_108452377 2.274 ENSMUST00000035232.7
 Klhdc8b
kelch domain containing 8B
chr8_+_87472805 2.207 ENSMUST00000180700.2
ENSMUST00000182174.1
ENSMUST00000181159.1
 Gm2694


predicted gene 2694


chr4_+_63215402 2.152 ENSMUST00000036300.6
 Col27a1
collagen, type XXVII, alpha 1
chr7_-_127026479 2.125 ENSMUST00000032916.4
 Maz
MYC-associated zinc finger protein (purine-binding transcription factor)
chr18_+_74442500 2.025 ENSMUST00000074157.6
 Myo5b
myosin VB
chr9_-_96889381 1.984 ENSMUST00000112951.2
ENSMUST00000126411.1
ENSMUST00000078478.1
ENSMUST00000119141.1
ENSMUST00000120101.1
 Acpl2




acid phosphatase-like 2




chr8_+_119446719 1.981 ENSMUST00000098363.3
 Necab2
N-terminal EF-hand calcium binding protein 2
chr18_+_74442551 1.963 ENSMUST00000121875.1
 Myo5b
myosin VB
chr10_+_121033960 1.906 ENSMUST00000020439.4
ENSMUST00000175867.1
 Wif1

Wnt inhibitory factor 1

chr2_-_166155272 1.888 ENSMUST00000088086.3
 Sulf2
sulfatase 2
chr6_+_85154992 1.849 ENSMUST00000089584.5
 Spr-ps1
sepiapterin reductase pseudogene 1
chr11_-_114795888 1.821 ENSMUST00000000206.3
 Btbd17
BTB (POZ) domain containing 17

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 177 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 4.0 GO:0032439 endosome localization(GO:0032439)
1.3 3.9 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.7 3.3 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
1.1 3.2 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.1 3.2 GO:0051290 protein heterotetramerization(GO:0051290)
0.8 2.5 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.6 2.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.6 2.4 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.5 2.4 GO:0019236 response to pheromone(GO:0019236)
0.3 2.4 GO:0032825 positive regulation of natural killer cell differentiation(GO:0032825) positive regulation of interferon-gamma secretion(GO:1902715)
0.1 2.4 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.4 2.2 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.7 2.1 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630) positive regulation of aminoacyl-tRNA ligase activity(GO:1903632) regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.3 2.1 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.7 2.0 GO:0060167 regulation of adenosine receptor signaling pathway(GO:0060167) regulation of G-protein coupled receptor internalization(GO:1904020)
0.6 1.7 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.6 1.7 GO:0009814 defense response, incompatible interaction(GO:0009814)
0.3 1.7 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 1.7 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 1.7 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.8 4.9 GO:0045179 apical cortex(GO:0045179)
0.0 4.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 4.0 GO:0005838 proteasome regulatory particle(GO:0005838)
0.1 3.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 3.4 GO:0009925 basal plasma membrane(GO:0009925)
0.0 3.2 GO:0005844 polysome(GO:0005844)
0.0 2.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 2.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 2.2 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 2.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 2.0 GO:0005840 ribosome(GO:0005840)
0.0 2.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 1.9 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 1.8 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 1.7 GO:0000242 pericentriolar material(GO:0000242)
0.0 1.7 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.5 1.4 GO:0000814 ESCRT II complex(GO:0000814)
0.1 1.4 GO:0005921 gap junction(GO:0005921)
0.2 1.3 GO:0097452 GAIT complex(GO:0097452)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 125 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 6.2 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 5.8 GO:0001047 core promoter binding(GO:0001047)
0.0 4.1 GO:0003774 motor activity(GO:0003774)
1.3 3.9 GO:0004454 ketohexokinase activity(GO:0004454)
0.2 3.2 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.3 2.8 GO:0019992 diacylglycerol binding(GO:0019992)
0.5 2.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.3 2.5 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.1 2.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.4 2.4 GO:0043199 Ran guanyl-nucleotide exchange factor activity(GO:0005087) sulfate binding(GO:0043199)
0.1 2.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 2.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 2.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 2.1 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 2.1 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.5 2.0 GO:0031687 A2A adenosine receptor binding(GO:0031687)
0.6 1.7 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.2 1.7 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 1.6 GO:0003743 translation initiation factor activity(GO:0003743)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 3.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.4 NABA_COLLAGENS Genes encoding collagen proteins
0.0 2.2 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 2.1 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 2.1 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.8 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 1.5 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.2 1.4 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 1.4 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 1.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 1.3 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 1.3 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.1 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.8 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.8 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.8 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 0.8 PID_ENDOTHELIN_PATHWAY Endothelins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.8 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 6.4 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.1 4.1 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.2 3.2 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 2.7 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 2.4 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS Genes involved in Host Interactions of HIV factors
0.0 2.3 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.0 2.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 2.0 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.9 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 1.8 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 1.8 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 1.8 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.2 1.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.4 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.3 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 1.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.1 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis