Motif ID: Sp100

Z-value: 4.184


Transcription factors associated with Sp100:

Gene SymbolEntrez IDGene Name
Sp100 ENSMUSG00000026222.10 Sp100

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp100mm10_v2_chr1_+_85650008_85650020-0.214.0e-01Click!


Activity profile for motif Sp100.

activity profile for motif Sp100


Sorted Z-values histogram for motif Sp100

Sorted Z-values for motif Sp100



Network of associatons between targets according to the STRING database.



First level regulatory network of Sp100

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3023547 43.355 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3013140 43.106 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr14_-_19418930 38.942 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3025417 38.931 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3018753 36.474 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr9_+_3004457 36.340 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr2_-_98667264 33.177 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3017408 30.621 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3036877 27.431 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3000922 26.394 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3027439 26.102 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3015654 23.544 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr13_-_23762378 9.705 ENSMUST00000091701.2
 Hist1h3a
histone cluster 1, H3a
chr16_-_17125106 8.673 ENSMUST00000093336.6
 2610318N02Rik
RIKEN cDNA 2610318N02 gene
chr16_-_33380717 8.134 ENSMUST00000180923.1
 1700007L15Rik
RIKEN cDNA 1700007L15 gene
chr2_-_168767136 7.681 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr14_+_73237891 7.244 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr16_-_22161450 6.737 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr8_+_94179089 5.818 ENSMUST00000034215.6
 Mt1
metallothionein 1
chr8_-_4779513 5.790 ENSMUST00000022945.7
 Shcbp1
Shc SH2-domain binding protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 18.4 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.7 12.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 8.1 GO:0051028 mRNA transport(GO:0051028)
0.2 7.8 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.7 7.7 GO:0006228 UTP biosynthetic process(GO:0006228)
0.3 7.2 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.2 6.9 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.1 6.3 GO:0001578 microtubule bundle formation(GO:0001578)
0.8 5.8 GO:0010273 detoxification of copper ion(GO:0010273) cellular response to zinc ion(GO:0071294) stress response to copper ion(GO:1990169)
1.1 5.5 GO:0021764 amygdala development(GO:0021764)
0.9 5.3 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.0 5.2 GO:0007059 chromosome segregation(GO:0007059)
0.7 5.1 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.6 4.7 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.1 4.5 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.2 4.4 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.1 4.4 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.7 4.3 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.4 4.0 GO:0031441 negative regulation of mRNA 3'-end processing(GO:0031441)
0.3 3.9 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 18.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 6.7 GO:0000792 heterochromatin(GO:0000792)
0.2 5.7 GO:0001741 XY body(GO:0001741)
0.1 5.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.9 5.6 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.2 5.5 GO:0005721 pericentric heterochromatin(GO:0005721)
0.4 5.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 5.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 4.5 GO:0000794 condensed nuclear chromosome(GO:0000794) replication fork(GO:0005657)
0.5 4.3 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.2 4.1 GO:0035102 PRC1 complex(GO:0035102)
0.1 4.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.4 3.9 GO:0031595 nuclear proteasome complex(GO:0031595)
0.4 3.8 GO:0061574 ASAP complex(GO:0061574)
0.2 3.8 GO:0031527 filopodium membrane(GO:0031527)
0.4 3.7 GO:0097427 microtubule bundle(GO:0097427)
0.1 3.7 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.4 3.6 GO:0045298 tubulin complex(GO:0045298)
0.0 3.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 3.1 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 10.5 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 9.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 7.7 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
1.0 7.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 5.8 GO:0005507 copper ion binding(GO:0005507)
0.1 5.5 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 5.5 GO:0042393 histone binding(GO:0042393)
0.1 5.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.4 4.8 GO:0043522 leucine zipper domain binding(GO:0043522)
0.6 4.7 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.2 4.6 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
1.5 4.5 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 4.5 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.9 4.3 GO:0043515 kinetochore binding(GO:0043515)
0.6 3.9 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.2 3.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.7 3.4 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.3 3.3 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
1.0 3.1 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.0 PID_PLK1_PATHWAY PLK1 signaling events
0.1 7.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 5.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 5.3 NABA_COLLAGENS Genes encoding collagen proteins
0.1 5.0 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.5 4.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 4.4 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 3.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 2.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.2 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 1.9 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 1.8 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.1 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 1.1 PID_EPO_PATHWAY EPO signaling pathway
0.0 0.9 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.1 0.7 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.4 PID_AP1_PATHWAY AP-1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 20.3 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.8 7.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 6.1 REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway
0.1 5.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 5.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 5.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 5.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 5.2 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.4 4.5 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 4.4 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 4.2 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.1 3.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 3.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 3.1 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.4 2.9 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 2.9 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 2.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 2.6 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 2.6 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 2.5 REACTOME_PHOSPHORYLATION_OF_THE_APC_C Genes involved in Phosphorylation of the APC/C