Motif ID: Lhx5_Lmx1b_Lhx1

Z-value: 0.703

Transcription factors associated with Lhx5_Lmx1b_Lhx1:

Gene SymbolEntrez IDGene Name
Lhx1 ENSMUSG00000018698.9 Lhx1
Lhx5 ENSMUSG00000029595.7 Lhx5
Lmx1b ENSMUSG00000038765.7 Lmx1b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx5mm10_v2_chr5_+_120431770_120431905-0.223.8e-01Click!
Lhx1mm10_v2_chr11_-_84525514_84525542-0.175.0e-01Click!
Lmx1bmm10_v2_chr2_-_33640480_336405110.009.9e-01Click!


Activity profile for motif Lhx5_Lmx1b_Lhx1.

activity profile for motif Lhx5_Lmx1b_Lhx1


Sorted Z-values histogram for motif Lhx5_Lmx1b_Lhx1

Sorted Z-values for motif Lhx5_Lmx1b_Lhx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx5_Lmx1b_Lhx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_67833235 1.937 ENSMUST00000060609.7
 Gm10037
predicted gene 10037
chr4_+_102589687 1.686 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr1_-_158356258 1.329 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr7_+_66365905 1.329 ENSMUST00000107486.1
 Gm10974
predicted gene 10974
chr3_+_121953213 1.311 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr11_-_87359011 1.273 ENSMUST00000055438.4
 Ppm1e
protein phosphatase 1E (PP2C domain containing)
chrX_-_143933089 1.199 ENSMUST00000087313.3
 Dcx
doublecortin
chr15_-_93595877 1.156 ENSMUST00000048982.4
 Prickle1
prickle homolog 1 (Drosophila)
chr18_-_66860458 1.130 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr19_-_5802640 1.129 ENSMUST00000173523.1
ENSMUST00000173499.1
ENSMUST00000172812.2
 Malat1


metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)


chr14_+_80000292 1.106 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr18_+_57468478 1.089 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr8_+_34054622 1.023 ENSMUST00000149618.1
 Gm9951
predicted gene 9951
chr16_+_11406618 0.951 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr5_+_13398688 0.893 ENSMUST00000125629.1
 Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr5_-_118244861 0.845 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
 Rnft2



ring finger protein, transmembrane 2



chrX_-_143933204 0.811 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr13_+_77135513 0.757 ENSMUST00000168779.1
 2210408I21Rik
RIKEN cDNA 2210408I21 gene
chr4_-_14621805 0.713 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr11_+_51261719 0.672 ENSMUST00000130641.1
 Clk4
CDC like kinase 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.6 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 2.0 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 1.4 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 1.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.4 1.2 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.2 1.1 GO:0002024 diet induced thermogenesis(GO:0002024)
0.2 1.1 GO:0035063 nuclear speck organization(GO:0035063)
0.0 1.1 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 1.0 GO:0019532 oxalate transport(GO:0019532)
0.2 0.9 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.3 0.8 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.1 0.6 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.6 GO:1902741 type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
0.1 0.6 GO:0036159 inner dynein arm assembly(GO:0036159)
0.1 0.6 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.0 0.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.6 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.2 0.5 GO:0046110 xanthine metabolic process(GO:0046110)
0.1 0.5 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.1 0.5 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.1 GO:0042581 specific granule(GO:0042581)
0.0 0.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.3 GO:0090543 Flemming body(GO:0090543)
0.0 0.3 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.3 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.3 GO:0000346 transcription export complex(GO:0000346)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.2 GO:0036156 inner dynein arm(GO:0036156)
0.1 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.2 GO:0071439 clathrin complex(GO:0071439)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.2 GO:0031143 pseudopodium(GO:0031143)
0.0 0.1 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.7 GO:0030165 PDZ domain binding(GO:0030165)
0.4 1.1 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 1.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 1.0 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 0.9 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.8 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.7 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 0.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.2 0.6 GO:0016160 alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.1 0.6 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.5 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 0.5 GO:0030151 molybdenum ion binding(GO:0030151)
0.1 0.5 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.5 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.4 GO:0008384 IkappaB kinase activity(GO:0008384)
0.1 0.4 GO:0051378 primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378)
0.0 0.4 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.8 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.8 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.6 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.0 0.5 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.3 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.3 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.3 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.1 PID_S1P_S1P4_PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 2.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 1.0 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 0.6 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.4 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.4 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.4 REACTOME_ARMS_MEDIATED_ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.3 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.3 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation