Motif ID: Klf15
Z-value: 1.774
Transcription factors associated with Klf15:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Klf15 | ENSMUSG00000030087.5 | Klf15 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Klf15 | mm10_v2_chr6_+_90465287_90465304 | 0.63 | 5.4e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 5.8 | GO:1901492 | positive regulation of lymphangiogenesis(GO:1901492) |
| 1.1 | 4.6 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
| 1.0 | 7.2 | GO:0016480 | negative regulation of transcription from RNA polymerase III promoter(GO:0016480) |
| 1.0 | 2.0 | GO:0038091 | VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091) |
| 0.9 | 13.8 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.9 | 5.1 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.7 | 5.5 | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus(GO:0002862) |
| 0.7 | 2.1 | GO:1904742 | regulation of telomeric DNA binding(GO:1904742) |
| 0.6 | 3.7 | GO:0019695 | choline metabolic process(GO:0019695) |
| 0.6 | 1.9 | GO:0098928 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 0.6 | 1.8 | GO:0071544 | diphosphoinositol polyphosphate catabolic process(GO:0071544) |
| 0.6 | 2.3 | GO:0010808 | positive regulation of synaptic vesicle priming(GO:0010808) |
| 0.6 | 1.7 | GO:1902460 | transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462) |
| 0.5 | 4.3 | GO:0061368 | maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
| 0.5 | 3.0 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.5 | 1.5 | GO:1902277 | negative regulation of pancreatic amylase secretion(GO:1902277) |
| 0.5 | 2.5 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.5 | 2.0 | GO:0043974 | histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674) |
| 0.5 | 2.3 | GO:0070305 | response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321) |
| 0.5 | 3.2 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 0.5 | 1.4 | GO:0061075 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871) |
| 0.4 | 2.2 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.4 | 2.6 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) |
| 0.4 | 1.7 | GO:0021764 | amygdala development(GO:0021764) |
| 0.4 | 1.7 | GO:0021773 | striatal medium spiny neuron differentiation(GO:0021773) |
| 0.4 | 2.5 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.4 | 2.9 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.4 | 4.3 | GO:1903818 | positive regulation of voltage-gated potassium channel activity(GO:1903818) |
| 0.3 | 2.8 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.3 | 2.4 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.3 | 1.0 | GO:0061303 | noradrenergic neuron differentiation(GO:0003357) soft palate development(GO:0060023) cornea development in camera-type eye(GO:0061303) |
| 0.3 | 5.2 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.3 | 0.9 | GO:0060596 | mammary placode formation(GO:0060596) |
| 0.3 | 1.2 | GO:1900122 | positive regulation of receptor binding(GO:1900122) |
| 0.3 | 0.9 | GO:1905051 | regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053) |
| 0.3 | 1.1 | GO:0033140 | negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140) |
| 0.3 | 1.3 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.3 | 1.8 | GO:0032811 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811) |
| 0.3 | 1.0 | GO:0090472 | dibasic protein processing(GO:0090472) |
| 0.2 | 1.2 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 0.2 | 4.9 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.2 | 1.8 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.2 | 1.1 | GO:0006041 | glucosamine metabolic process(GO:0006041) |
| 0.2 | 2.1 | GO:0043383 | negative T cell selection(GO:0043383) negative thymic T cell selection(GO:0045060) |
| 0.2 | 2.2 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.2 | 1.3 | GO:0098964 | dendritic transport of ribonucleoprotein complex(GO:0098961) dendritic transport of messenger ribonucleoprotein complex(GO:0098963) anterograde dendritic transport of messenger ribonucleoprotein complex(GO:0098964) |
| 0.2 | 0.6 | GO:0007621 | negative regulation of female receptivity(GO:0007621) |
| 0.2 | 2.1 | GO:2000303 | regulation of ceramide biosynthetic process(GO:2000303) |
| 0.2 | 2.6 | GO:0035635 | entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535) |
| 0.2 | 5.1 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.2 | 0.6 | GO:0018094 | protein polyglycylation(GO:0018094) |
| 0.2 | 0.8 | GO:0003430 | growth plate cartilage chondrocyte growth(GO:0003430) |
| 0.2 | 1.9 | GO:1903025 | regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025) |
| 0.2 | 0.5 | GO:0071579 | phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) regulation of zinc ion transport(GO:0071579) |
| 0.2 | 1.8 | GO:0006691 | leukotriene metabolic process(GO:0006691) |
| 0.2 | 0.7 | GO:0018076 | N-terminal peptidyl-lysine acetylation(GO:0018076) negative regulation of interferon-beta biosynthetic process(GO:0045358) |
| 0.2 | 1.0 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.2 | 0.9 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
| 0.2 | 1.7 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.2 | 5.9 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
| 0.2 | 0.7 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
| 0.2 | 0.7 | GO:1905077 | negative regulation of interleukin-17 secretion(GO:1905077) |
| 0.2 | 1.3 | GO:0017145 | stem cell division(GO:0017145) |
| 0.2 | 2.7 | GO:2000272 | negative regulation of receptor activity(GO:2000272) |
| 0.1 | 2.3 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.1 | 0.4 | GO:0019085 | early viral transcription(GO:0019085) |
| 0.1 | 2.0 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.1 | 4.0 | GO:0061099 | negative regulation of protein tyrosine kinase activity(GO:0061099) |
| 0.1 | 0.6 | GO:0021914 | negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914) |
| 0.1 | 0.4 | GO:2001184 | regulation of interleukin-12 secretion(GO:2001182) positive regulation of interleukin-12 secretion(GO:2001184) |
| 0.1 | 1.1 | GO:0006560 | proline metabolic process(GO:0006560) |
| 0.1 | 1.1 | GO:0035507 | regulation of myosin-light-chain-phosphatase activity(GO:0035507) |
| 0.1 | 1.0 | GO:0035280 | miRNA loading onto RISC involved in gene silencing by miRNA(GO:0035280) |
| 0.1 | 0.8 | GO:0045200 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) |
| 0.1 | 0.5 | GO:0010726 | positive regulation of hydrogen peroxide metabolic process(GO:0010726) |
| 0.1 | 0.9 | GO:0051534 | negative regulation of NFAT protein import into nucleus(GO:0051534) |
| 0.1 | 0.9 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.1 | 0.4 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 0.1 | 0.2 | GO:0061209 | cell proliferation involved in mesonephros development(GO:0061209) nephric duct formation(GO:0072179) |
| 0.1 | 0.6 | GO:0051964 | negative regulation of synapse assembly(GO:0051964) |
| 0.1 | 2.9 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.1 | 0.4 | GO:0007217 | tachykinin receptor signaling pathway(GO:0007217) |
| 0.1 | 2.3 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030) |
| 0.1 | 0.7 | GO:1903351 | response to dopamine(GO:1903350) cellular response to dopamine(GO:1903351) |
| 0.1 | 0.5 | GO:0035616 | histone H2B conserved C-terminal lysine deubiquitination(GO:0035616) |
| 0.1 | 1.4 | GO:0035020 | regulation of Rac protein signal transduction(GO:0035020) |
| 0.1 | 0.7 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
| 0.1 | 1.7 | GO:0030325 | adrenal gland development(GO:0030325) |
| 0.1 | 0.2 | GO:0035106 | operant conditioning(GO:0035106) |
| 0.1 | 1.4 | GO:0042297 | vocal learning(GO:0042297) imitative learning(GO:0098596) observational learning(GO:0098597) |
| 0.1 | 0.3 | GO:0046947 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 0.1 | 1.6 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 0.1 | 2.0 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.1 | 0.4 | GO:0042045 | epithelial fluid transport(GO:0042045) |
| 0.1 | 0.3 | GO:0035405 | histone-threonine phosphorylation(GO:0035405) |
| 0.1 | 0.6 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 0.1 | 1.0 | GO:0043931 | ossification involved in bone maturation(GO:0043931) |
| 0.1 | 0.7 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.1 | 0.4 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.1 | 0.7 | GO:0043982 | histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982) |
| 0.1 | 1.0 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.1 | 0.5 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.1 | 0.3 | GO:2000628 | regulation of miRNA metabolic process(GO:2000628) |
| 0.1 | 1.8 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.1 | 1.7 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.1 | 3.0 | GO:0090307 | mitotic spindle assembly(GO:0090307) |
| 0.1 | 1.1 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.0 | 0.2 | GO:0070197 | meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240) |
| 0.0 | 1.7 | GO:0051926 | negative regulation of calcium ion transport(GO:0051926) |
| 0.0 | 0.1 | GO:0072236 | metanephric loop of Henle development(GO:0072236) |
| 0.0 | 0.7 | GO:1900452 | regulation of long term synaptic depression(GO:1900452) |
| 0.0 | 2.4 | GO:0042035 | regulation of cytokine biosynthetic process(GO:0042035) |
| 0.0 | 0.7 | GO:0006044 | N-acetylglucosamine metabolic process(GO:0006044) |
| 0.0 | 0.2 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.0 | 0.2 | GO:0000415 | negative regulation of histone H3-K36 methylation(GO:0000415) |
| 0.0 | 2.1 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
| 0.0 | 0.2 | GO:1903527 | regulation of membrane tubulation(GO:1903525) positive regulation of membrane tubulation(GO:1903527) |
| 0.0 | 3.1 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.0 | 1.1 | GO:0060351 | cartilage development involved in endochondral bone morphogenesis(GO:0060351) |
| 0.0 | 1.4 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
| 0.0 | 0.2 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
| 0.0 | 0.1 | GO:0061339 | establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339) |
| 0.0 | 0.3 | GO:2000291 | regulation of myoblast proliferation(GO:2000291) |
| 0.0 | 0.7 | GO:0095500 | acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 0.0 | 0.3 | GO:0097186 | amelogenesis(GO:0097186) |
| 0.0 | 0.6 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.0 | 1.1 | GO:0046329 | negative regulation of JNK cascade(GO:0046329) |
| 0.0 | 0.1 | GO:0031034 | myosin filament assembly(GO:0031034) |
| 0.0 | 1.1 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.0 | 1.3 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 0.1 | GO:0098903 | regulation of membrane repolarization during action potential(GO:0098903) |
| 0.0 | 0.4 | GO:0061036 | positive regulation of cartilage development(GO:0061036) |
| 0.0 | 0.5 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.0 | 1.0 | GO:0046888 | negative regulation of hormone secretion(GO:0046888) |
| 0.0 | 0.1 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.0 | 0.2 | GO:2001223 | negative regulation of neuron migration(GO:2001223) |
| 0.0 | 0.3 | GO:0045948 | positive regulation of translational initiation(GO:0045948) |
| 0.0 | 0.3 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.0 | 0.1 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 0.0 | 0.6 | GO:0006006 | glucose metabolic process(GO:0006006) |
| 0.0 | 0.7 | GO:0048286 | lung alveolus development(GO:0048286) |
| 0.0 | 1.7 | GO:0006402 | mRNA catabolic process(GO:0006402) |
| 0.0 | 1.2 | GO:0007631 | feeding behavior(GO:0007631) |
| 0.0 | 0.7 | GO:1902653 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
| 0.0 | 0.5 | GO:0006826 | iron ion transport(GO:0006826) |
| 0.0 | 0.3 | GO:0009411 | response to UV(GO:0009411) |
| 0.0 | 0.1 | GO:0021942 | radial glia guided migration of Purkinje cell(GO:0021942) |
| 0.0 | 0.1 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.0 | 0.5 | GO:0043631 | mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631) |
| 0.0 | 0.8 | GO:0030010 | establishment of cell polarity(GO:0030010) |
| 0.0 | 0.6 | GO:0008156 | negative regulation of DNA replication(GO:0008156) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.9 | GO:0030934 | collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934) |
| 0.8 | 4.2 | GO:0098831 | presynaptic active zone cytoplasmic component(GO:0098831) |
| 0.8 | 2.3 | GO:0098855 | HCN channel complex(GO:0098855) |
| 0.5 | 3.0 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.4 | 2.5 | GO:0008091 | spectrin(GO:0008091) |
| 0.4 | 1.8 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.2 | 3.7 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.2 | 2.6 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.1 | 3.0 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.1 | 1.4 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.1 | 0.7 | GO:1990246 | uniplex complex(GO:1990246) |
| 0.1 | 4.3 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 1.0 | GO:0070578 | RISC-loading complex(GO:0070578) |
| 0.1 | 1.7 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.1 | 2.1 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.1 | 11.0 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 0.4 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.1 | 1.0 | GO:0046930 | pore complex(GO:0046930) |
| 0.1 | 2.6 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.1 | 4.9 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 1.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 0.8 | GO:0042599 | lamellar body(GO:0042599) |
| 0.1 | 4.6 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.1 | 1.3 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 1.0 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.1 | 0.5 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.1 | 2.0 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.1 | 3.1 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.1 | 2.8 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 0.7 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 2.6 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 0.9 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 0.7 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.0 | 2.0 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 0.1 | GO:0031251 | PAN complex(GO:0031251) |
| 0.0 | 1.7 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.0 | 1.7 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 1.3 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 1.4 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.3 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.0 | 0.6 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 1.2 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 1.1 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 0.3 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 3.0 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 1.6 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 0.7 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 2.1 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 4.4 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 0.5 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.0 | 0.8 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 1.6 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 2.8 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.0 | 2.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 1.4 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 1.9 | GO:0005930 | axoneme(GO:0005930) |
| 0.0 | 0.2 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 0.2 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 4.2 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 0.1 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.0 | 0.7 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
| 0.0 | 0.1 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.0 | 1.4 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 1.2 | GO:0031514 | motile cilium(GO:0031514) |
| 0.0 | 5.4 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 1.4 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 1.6 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 0.7 | GO:0005811 | lipid particle(GO:0005811) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 3.7 | GO:0004104 | cholinesterase activity(GO:0004104) choline binding(GO:0033265) |
| 0.6 | 2.3 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.5 | 4.6 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.5 | 2.0 | GO:0045322 | unmethylated CpG binding(GO:0045322) |
| 0.4 | 1.7 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.4 | 1.7 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.4 | 2.0 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 0.3 | 8.6 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.3 | 2.7 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.3 | 1.7 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.3 | 2.0 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.3 | 1.8 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.3 | 1.2 | GO:0046920 | alpha-(1->3)-fucosyltransferase activity(GO:0046920) |
| 0.3 | 1.8 | GO:0000298 | endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) |
| 0.3 | 1.3 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.2 | 4.3 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.2 | 1.8 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.2 | 0.6 | GO:0031752 | D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752) |
| 0.2 | 2.2 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.2 | 0.6 | GO:0070736 | protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) |
| 0.2 | 7.3 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.2 | 8.5 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.2 | 1.0 | GO:0019841 | retinol binding(GO:0019841) |
| 0.2 | 2.0 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.2 | 5.1 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.2 | 2.3 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.1 | 4.7 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 1.0 | GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) |
| 0.1 | 4.3 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 2.9 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 0.7 | GO:0043426 | MRF binding(GO:0043426) |
| 0.1 | 0.3 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.1 | 3.0 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 1.2 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.1 | 0.6 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.1 | 2.5 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.1 | 1.9 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.1 | 1.5 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.1 | 1.1 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.1 | 0.3 | GO:0046964 | 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964) |
| 0.1 | 0.4 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
| 0.1 | 2.0 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.1 | 1.0 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.1 | 5.8 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 0.4 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
| 0.1 | 1.7 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 0.7 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.1 | 0.8 | GO:0047499 | calcium-independent phospholipase A2 activity(GO:0047499) |
| 0.1 | 0.6 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.1 | 0.7 | GO:0043995 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
| 0.1 | 4.7 | GO:0019213 | deacetylase activity(GO:0019213) |
| 0.1 | 0.3 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) |
| 0.1 | 0.5 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.1 | 0.3 | GO:0035184 | histone threonine kinase activity(GO:0035184) |
| 0.1 | 0.4 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.1 | 0.2 | GO:0008417 | fucosyltransferase activity(GO:0008417) |
| 0.1 | 0.6 | GO:0015093 | ferrous iron transmembrane transporter activity(GO:0015093) |
| 0.1 | 1.0 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.1 | 0.3 | GO:0022821 | potassium ion antiporter activity(GO:0022821) |
| 0.1 | 1.1 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.1 | 1.1 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.1 | 0.5 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.1 | 2.5 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.0 | 3.1 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 0.7 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.0 | 0.5 | GO:0000182 | rDNA binding(GO:0000182) |
| 0.0 | 0.2 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.0 | 3.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.8 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.0 | 1.7 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.0 | 1.3 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.0 | 0.5 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.0 | 1.0 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 1.1 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.0 | 2.9 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 1.3 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 0.0 | 1.3 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.9 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 0.7 | GO:0016866 | intramolecular transferase activity(GO:0016866) |
| 0.0 | 0.6 | GO:0008171 | O-methyltransferase activity(GO:0008171) |
| 0.0 | 0.8 | GO:0008235 | metalloexopeptidase activity(GO:0008235) |
| 0.0 | 1.1 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 1.3 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.0 | 1.9 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.0 | 0.8 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 3.8 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.1 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.0 | 0.4 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 1.8 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.0 | 0.9 | GO:0008378 | galactosyltransferase activity(GO:0008378) |
| 0.0 | 0.4 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 5.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 1.0 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 0.4 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.0 | 0.8 | GO:0043621 | protein self-association(GO:0043621) |
| 0.0 | 0.1 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.0 | 2.5 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 2.6 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 0.1 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.0 | 0.2 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.0 | 0.1 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.0 | 0.7 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.0 | 0.6 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 0.3 | GO:0004385 | guanylate kinase activity(GO:0004385) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.2 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.3 | 2.0 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.2 | 4.0 | PID_S1P_S1P1_PATHWAY | S1P1 pathway |
| 0.2 | 4.3 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.2 | 9.0 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 1.4 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 0.5 | PID_AVB3_INTEGRIN_PATHWAY | Integrins in angiogenesis |
| 0.1 | 4.1 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
| 0.1 | 0.9 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.1 | 1.7 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.3 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 2.1 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.8 | PID_ERBB2_ERBB3_PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 2.2 | PID_INSULIN_PATHWAY | Insulin Pathway |
| 0.0 | 2.6 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 6.6 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 2.1 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 0.1 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
| 0.0 | 1.7 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 1.1 | PID_MET_PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 1.2 | PID_CERAMIDE_PATHWAY | Ceramide signaling pathway |
| 0.0 | 0.8 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.7 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.4 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.0 | 1.0 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.1 | ST_STAT3_PATHWAY | STAT3 Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 5.5 | REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |
| 0.7 | 2.0 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.3 | 2.2 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.2 | 2.3 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.2 | 2.6 | REACTOME_DSCAM_INTERACTIONS | Genes involved in DSCAM interactions |
| 0.2 | 6.8 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.2 | 3.7 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
| 0.1 | 1.8 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 2.3 | REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.1 | 1.0 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 1.0 | REACTOME_COMPLEMENT_CASCADE | Genes involved in Complement cascade |
| 0.1 | 2.3 | REACTOME_POTASSIUM_CHANNELS | Genes involved in Potassium Channels |
| 0.1 | 6.1 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 2.5 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 3.9 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.1 | 2.0 | REACTOME_G_PROTEIN_ACTIVATION | Genes involved in G-protein activation |
| 0.1 | 0.8 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PC | Genes involved in Acyl chain remodelling of PC |
| 0.1 | 0.9 | REACTOME_KERATAN_SULFATE_BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.0 | 0.5 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 1.0 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.0 | 2.4 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 0.7 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 1.0 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.0 | 1.1 | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 1.8 | REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS | Genes involved in Post NMDA receptor activation events |
| 0.0 | 0.3 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA | Genes involved in G beta:gamma signalling through PI3Kgamma |
| 0.0 | 0.7 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.3 | REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.0 | 0.4 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 0.6 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 2.1 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.1 | REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.0 | 0.7 | REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.0 | 0.5 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 0.4 | REACTOME_ELONGATION_ARREST_AND_RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.0 | 0.3 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.0 | 0.8 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.1 | REACTOME_DNA_REPAIR | Genes involved in DNA Repair |
| 0.0 | 0.7 | REACTOME_SIGNALING_BY_PDGF | Genes involved in Signaling by PDGF |
