Motif ID: Rxra

Z-value: 0.969


Transcription factors associated with Rxra:

Gene SymbolEntrez IDGene Name
Rxra ENSMUSG00000015846.8 Rxra

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rxramm10_v2_chr2_+_27677201_27677229-0.662.8e-03Click!


Activity profile for motif Rxra.

activity profile for motif Rxra


Sorted Z-values histogram for motif Rxra

Sorted Z-values for motif Rxra



Network of associatons between targets according to the STRING database.



First level regulatory network of Rxra

PNG image of the network

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Top targets:


Showing 1 to 20 of 144 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_112172540 2.335 ENSMUST00000132994.1
 Caps2
calcyphosphine 2
chr16_+_15317458 2.216 ENSMUST00000178312.1
 Gm21897
predicted gene, 21897
chr11_-_11627824 2.139 ENSMUST00000081896.4
 4930512M02Rik
RIKEN cDNA 4930512M02 gene
chr13_+_13590402 2.120 ENSMUST00000110559.1
 Lyst
lysosomal trafficking regulator
chr2_+_126215100 2.102 ENSMUST00000164042.2
 Gm17555
predicted gene, 17555
chr2_+_71117923 2.073 ENSMUST00000028403.2
 Cybrd1
cytochrome b reductase 1
chr7_-_14562171 1.995 ENSMUST00000181796.1
 Vmn1r90
vomeronasal 1 receptor 90
chr6_+_8259327 1.982 ENSMUST00000159378.1
 Gm16039
predicted gene 16039
chr7_+_30169861 1.873 ENSMUST00000085668.4
 Gm5113
predicted gene 5113
chr14_+_73661225 1.827 ENSMUST00000098874.3
 Gm21750
predicted gene, 21750
chr4_+_85205120 1.648 ENSMUST00000107188.3
 Sh3gl2
SH3-domain GRB2-like 2
chr5_-_143895025 1.626 ENSMUST00000079624.5
ENSMUST00000110717.2
 Ankrd61

ankyrin repeat domain 61

chr9_-_122862128 1.607 ENSMUST00000056467.7
 Zfp445
zinc finger protein 445
chr12_-_74316394 1.605 ENSMUST00000110441.1
 Gm11042
predicted gene 11042
chr13_+_18948344 1.602 ENSMUST00000003345.7
 Amph
amphiphysin
chr19_+_36554661 1.582 ENSMUST00000169036.2
ENSMUST00000047247.5
 Hectd2

HECT domain containing 2

chr11_+_75531690 1.579 ENSMUST00000149727.1
ENSMUST00000042561.7
ENSMUST00000108433.1
ENSMUST00000143035.1
 Slc43a2



solute carrier family 43, member 2



chr8_-_99416397 1.572 ENSMUST00000155527.1
ENSMUST00000142129.1
ENSMUST00000093249.4
ENSMUST00000142475.2
ENSMUST00000128860.1
 Cdh8




cadherin 8




chr8_+_12947935 1.560 ENSMUST00000110871.1
 Mcf2l
mcf.2 transforming sequence-like
chrX_-_41911877 1.523 ENSMUST00000047037.8
 Thoc2
THO complex 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.1 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.7 2.1 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 2.1 GO:0010039 response to iron ion(GO:0010039)
0.3 2.0 GO:0032264 IMP salvage(GO:0032264)
0.0 2.0 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.1 1.8 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.6 1.7 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.1 1.7 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 1.6 GO:0009409 response to cold(GO:0009409)
0.0 1.6 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 1.6 GO:0015807 L-amino acid transport(GO:0015807)
0.2 1.5 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.4 1.4 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 1.4 GO:0003341 cilium movement(GO:0003341)
0.1 1.2 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.0 1.2 GO:0006611 protein export from nucleus(GO:0006611)
0.0 1.2 GO:0046847 filopodium assembly(GO:0046847)
0.2 1.0 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.0 1.0 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.2 0.9 GO:0002175 protein localization to paranode region of axon(GO:0002175)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 GO:0060170 ciliary membrane(GO:0060170)
0.0 2.1 GO:0031526 brush border membrane(GO:0031526)
0.2 1.7 GO:0097427 microtubule bundle(GO:0097427)
0.1 1.6 GO:0043083 synaptic cleft(GO:0043083)
0.0 1.6 GO:0043195 terminal bouton(GO:0043195)
0.0 1.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 1.5 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.2 1.4 GO:0036157 outer dynein arm(GO:0036157)
0.0 1.4 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.3 GO:0043204 perikaryon(GO:0043204)
0.0 1.2 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.2 1.0 GO:1990130 Iml1 complex(GO:1990130)
0.2 0.9 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 0.9 GO:0005643 nuclear pore(GO:0005643)
0.1 0.8 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.8 GO:0045120 pronucleus(GO:0045120)
0.0 0.8 GO:0032420 stereocilium(GO:0032420)
0.2 0.7 GO:0045098 type III intermediate filament(GO:0045098)
0.1 0.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.7 GO:0035327 transcriptionally active chromatin(GO:0035327)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.4 2.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.3 2.0 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.3 1.7 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 1.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 1.6 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.2 1.4 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.1 1.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 1.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 1.1 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.2 0.9 GO:0004111 creatine kinase activity(GO:0004111)
0.2 0.9 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.2 0.9 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 0.9 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.3 0.8 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.1 0.8 GO:1990405 protein antigen binding(GO:1990405)
0.0 0.8 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 0.7 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.7 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.7 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.2 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.2 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.8 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.4 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 0.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.3 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.1 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 2.0 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 1.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.6 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.5 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.1 1.4 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 1.2 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.0 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.8 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.7 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.6 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.4 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.3 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.1 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases