Motif ID: Six3_Six1_Six2

Z-value: 0.822

Transcription factors associated with Six3_Six1_Six2:

Gene SymbolEntrez IDGene Name
Six1 ENSMUSG00000051367.8 Six1
Six2 ENSMUSG00000024134.10 Six2
Six3 ENSMUSG00000038805.9 Six3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six3mm10_v2_chr17_+_85613432_85613608-0.351.6e-01Click!
Six1mm10_v2_chr12_-_73047179_730471790.223.7e-01Click!
Six2mm10_v2_chr17_-_85688252_856882750.204.4e-01Click!


Activity profile for motif Six3_Six1_Six2.

activity profile for motif Six3_Six1_Six2


Sorted Z-values histogram for motif Six3_Six1_Six2

Sorted Z-values for motif Six3_Six1_Six2



Network of associatons between targets according to the STRING database.



First level regulatory network of Six3_Six1_Six2

PNG image of the network

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Top targets:


Showing 1 to 20 of 76 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_142966709 2.791 ENSMUST00000041317.2
 Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr6_-_23248264 2.072 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr9_+_98422961 1.979 ENSMUST00000052068.9
 Rbp1
retinol binding protein 1, cellular
chr7_-_80115294 1.839 ENSMUST00000107384.3
 Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr15_+_98571004 1.642 ENSMUST00000023728.6
 4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr10_-_128180265 1.589 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr3_+_130068390 1.547 ENSMUST00000076703.6
 Gm9396
predicted gene 9396
chr3_-_37724321 1.319 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
 Gm5148


predicted gene 5148


chr15_-_82244716 1.253 ENSMUST00000089155.4
ENSMUST00000089157.3
 Cenpm

centromere protein M

chr7_+_30232310 1.024 ENSMUST00000108193.1
ENSMUST00000108192.1
 Polr2i

polymerase (RNA) II (DNA directed) polypeptide I

chr8_-_4275886 0.988 ENSMUST00000003029.7
 Timm44
translocase of inner mitochondrial membrane 44
chr18_+_56432116 0.981 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr2_+_106693185 0.961 ENSMUST00000111063.1
 Mpped2
metallophosphoesterase domain containing 2
chr15_-_75894474 0.938 ENSMUST00000023237.6
 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr17_-_53539411 0.928 ENSMUST00000056198.3
 Pp2d1
protein phosphatase 2C-like domain containing 1
chr7_+_30231884 0.916 ENSMUST00000019882.9
 Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chrX_-_74373260 0.897 ENSMUST00000073067.4
ENSMUST00000037967.5
 Slc10a3

solute carrier family 10 (sodium/bile acid cotransporter family), member 3

chr5_+_140607334 0.858 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr9_+_65141154 0.749 ENSMUST00000034961.4
 Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chrX_+_169685191 0.719 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.5 2.0 GO:0006776 vitamin A metabolic process(GO:0006776)
0.6 1.9 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.6 1.8 GO:0006097 glyoxylate cycle(GO:0006097) negative regulation of glial cell migration(GO:1903976)
0.0 1.3 GO:0032526 response to retinoic acid(GO:0032526)
0.1 1.0 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.2 0.9 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.9 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.1 0.7 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 0.7 GO:0051923 sulfation(GO:0051923)
0.1 0.6 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.6 GO:0007320 insemination(GO:0007320)
0.1 0.5 GO:0048539 bone marrow development(GO:0048539)
0.1 0.5 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 0.5 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.1 0.4 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.1 0.4 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.3 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.1 0.3 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.0 0.3 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 1.8 GO:0000776 kinetochore(GO:0000776)
0.0 1.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.9 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 0.8 GO:0061574 ASAP complex(GO:0061574)
0.1 0.6 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.5 GO:0001741 XY body(GO:0001741)
0.0 0.4 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.1 0.2 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 0.2 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.2 GO:0071564 npBAF complex(GO:0071564)
0.0 0.1 GO:0042405 nuclear inclusion body(GO:0042405)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 2.0 GO:0019841 retinol binding(GO:0019841)
0.0 1.9 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.6 1.8 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.3 1.3 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.3 0.9 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.2 0.9 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 0.7 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.2 0.5 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.1 0.4 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.0 0.4 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.3 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.2 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.2 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 0.1 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.3 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 1.8 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.0 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.9 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 0.7 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.3 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.2 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.2 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters