Motif ID: Tbx5

Z-value: 0.808


Transcription factors associated with Tbx5:

Gene SymbolEntrez IDGene Name
Tbx5 ENSMUSG00000018263.8 Tbx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbx5mm10_v2_chr5_+_119834663_119834663-0.282.7e-01Click!


Activity profile for motif Tbx5.

activity profile for motif Tbx5


Sorted Z-values histogram for motif Tbx5

Sorted Z-values for motif Tbx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 2.897 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr14_+_122475397 2.833 ENSMUST00000075888.5
 Zic2
zinc finger protein of the cerebellum 2
chr2_-_54085542 2.547 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr14_-_70642268 2.491 ENSMUST00000022697.5
 Fgf17
fibroblast growth factor 17
chr1_-_138848576 2.412 ENSMUST00000112030.2
 Lhx9
LIM homeobox protein 9
chr4_-_41517326 2.155 ENSMUST00000030152.6
ENSMUST00000095126.4
 1110017D15Rik

RIKEN cDNA 1110017D15 gene

chr10_-_120899067 2.140 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr9_-_43239816 2.032 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr7_-_79594924 1.844 ENSMUST00000172788.1
 Rhcg
Rhesus blood group-associated C glycoprotein
chr4_-_134018829 1.829 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr2_+_103970221 1.698 ENSMUST00000111140.2
ENSMUST00000111139.2
 Lmo2

LIM domain only 2

chr2_+_103970115 1.666 ENSMUST00000111143.1
ENSMUST00000138815.1
 Lmo2

LIM domain only 2

chr15_-_98004695 1.654 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr10_+_79682304 1.549 ENSMUST00000166603.1
 Cdc34
cell division cycle 34
chr10_+_79682169 1.493 ENSMUST00000020550.5
 Cdc34
cell division cycle 34
chr2_-_68472138 1.492 ENSMUST00000102715.3
 Stk39
serine/threonine kinase 39
chr17_-_70851189 1.488 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr10_+_56377300 1.462 ENSMUST00000068581.7
 Gja1
gap junction protein, alpha 1
chr15_-_98004634 1.426 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr19_-_4439388 1.269 ENSMUST00000117462.1
ENSMUST00000048197.3
 Rhod

ras homolog gene family, member D


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.4 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.3 3.1 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.4 3.0 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.7 2.8 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.3 2.6 GO:0010587 miRNA catabolic process(GO:0010587)
0.5 2.4 GO:0035262 gonad morphogenesis(GO:0035262)
0.4 2.2 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.0 2.2 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.5 2.1 GO:0030091 protein repair(GO:0030091)
0.6 1.8 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.1 1.8 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.6 1.7 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.5 1.5 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016) regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.5 1.5 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
0.1 1.5 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 1.5 GO:0051893 regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109)
0.2 1.4 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.0 1.4 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 1.3 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 1.1 GO:0090527 actin filament reorganization(GO:0090527)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.3 3.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 2.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.3 2.6 GO:0002177 manchette(GO:0002177)
0.2 2.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 2.1 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.8 GO:0005681 spliceosomal complex(GO:0005681)
0.2 1.5 GO:0005916 fascia adherens(GO:0005916)
0.2 1.3 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 1.1 GO:0034704 calcium channel complex(GO:0034704)
0.0 1.0 GO:0000346 transcription export complex(GO:0000346)
0.0 1.0 GO:0005721 pericentric heterochromatin(GO:0005721)
0.2 0.9 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 0.8 GO:0032127 dense core granule membrane(GO:0032127)
0.1 0.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.8 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.8 GO:0005871 kinesin complex(GO:0005871)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 3.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.6 3.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.8 2.5 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.4 2.2 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.1 2.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.4 2.1 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.2 2.0 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 1.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 1.8 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.8 GO:0004386 helicase activity(GO:0004386)
0.0 1.7 GO:0046332 SMAD binding(GO:0046332)
0.4 1.5 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.1 1.5 GO:0070410 co-SMAD binding(GO:0070410)
0.1 1.3 GO:0030506 ankyrin binding(GO:0030506)
0.0 1.2 GO:0003777 microtubule motor activity(GO:0003777)
0.1 1.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 1.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 1.1 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 1.0 GO:0008420 CTD phosphatase activity(GO:0008420)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 NABA_COLLAGENS Genes encoding collagen proteins
0.1 2.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 2.2 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 2.2 PID_FGF_PATHWAY FGF signaling pathway
0.0 2.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.6 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 1.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.0 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.7 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.6 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.6 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.6 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.6 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 0.6 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 0.5 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.4 PID_BCR_5PATHWAY BCR signaling pathway
0.0 0.4 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 3.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.3 2.5 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 2.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 2.2 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 1.8 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 1.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 1.7 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.5 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.3 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 1.1 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.0 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 1.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 0.9 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.9 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.9 REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 0.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.8 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling