Motif ID: Tbx5
Z-value: 0.808
Transcription factors associated with Tbx5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tbx5 | ENSMUSG00000018263.8 | Tbx5 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tbx5 | mm10_v2_chr5_+_119834663_119834663 | -0.28 | 2.7e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.8 | GO:1900224 | positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224) |
| 0.6 | 1.8 | GO:0070634 | transepithelial ammonium transport(GO:0070634) |
| 0.6 | 1.7 | GO:0045014 | detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594) |
| 0.5 | 2.1 | GO:0030091 | protein repair(GO:0030091) |
| 0.5 | 1.5 | GO:0023016 | signal transduction by trans-phosphorylation(GO:0023016) regulation of rubidium ion transmembrane transporter activity(GO:2000686) |
| 0.5 | 1.5 | GO:0003104 | positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643) |
| 0.5 | 2.4 | GO:0035262 | gonad morphogenesis(GO:0035262) |
| 0.4 | 2.2 | GO:1903609 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 0.4 | 0.4 | GO:0003134 | BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) |
| 0.4 | 3.0 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
| 0.3 | 0.9 | GO:2000501 | natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501) |
| 0.3 | 2.6 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.3 | 0.8 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
| 0.3 | 3.1 | GO:0060272 | embryonic skeletal joint morphogenesis(GO:0060272) |
| 0.3 | 3.4 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.2 | 0.7 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.2 | 0.7 | GO:0070093 | negative regulation of glucagon secretion(GO:0070093) |
| 0.2 | 0.9 | GO:2000969 | positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969) |
| 0.2 | 0.6 | GO:0009446 | putrescine biosynthetic process(GO:0009446) |
| 0.2 | 0.6 | GO:2000373 | regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 0.2 | 1.4 | GO:0031508 | pericentric heterochromatin assembly(GO:0031508) |
| 0.2 | 1.0 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
| 0.2 | 1.0 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.2 | 0.8 | GO:0046013 | regulation of T cell homeostatic proliferation(GO:0046013) |
| 0.2 | 0.5 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
| 0.2 | 1.0 | GO:0060024 | rhythmic synaptic transmission(GO:0060024) |
| 0.2 | 0.6 | GO:1902608 | regulation of large conductance calcium-activated potassium channel activity(GO:1902606) positive regulation of large conductance calcium-activated potassium channel activity(GO:1902608) |
| 0.1 | 0.4 | GO:0034184 | positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184) |
| 0.1 | 1.0 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.1 | 0.4 | GO:1900060 | negative regulation of ceramide biosynthetic process(GO:1900060) |
| 0.1 | 0.6 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 0.1 | 0.5 | GO:1903760 | regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760) regulation of membrane repolarization during ventricular cardiac muscle cell action potential(GO:1905024) |
| 0.1 | 0.4 | GO:0070543 | response to linoleic acid(GO:0070543) |
| 0.1 | 0.4 | GO:0034473 | U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047) |
| 0.1 | 0.4 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 0.1 | 0.7 | GO:1901029 | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029) |
| 0.1 | 0.4 | GO:0007521 | muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596) |
| 0.1 | 0.4 | GO:0007181 | transforming growth factor beta receptor complex assembly(GO:0007181) chorionic trophoblast cell proliferation(GO:0097360) regulation of chorionic trophoblast cell proliferation(GO:1901382) |
| 0.1 | 1.1 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.1 | 0.7 | GO:0043415 | positive regulation of skeletal muscle tissue regeneration(GO:0043415) |
| 0.1 | 0.3 | GO:0060217 | hemangioblast cell differentiation(GO:0060217) |
| 0.1 | 1.8 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.1 | 0.9 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
| 0.1 | 0.3 | GO:0003245 | cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) |
| 0.1 | 0.3 | GO:0007621 | negative regulation of female receptivity(GO:0007621) |
| 0.1 | 0.5 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.1 | 1.5 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.1 | 0.6 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 0.1 | 0.9 | GO:1904153 | negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153) |
| 0.1 | 0.4 | GO:0035022 | positive regulation of Rac protein signal transduction(GO:0035022) |
| 0.1 | 0.6 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.1 | 0.3 | GO:0042823 | pyridoxal phosphate biosynthetic process(GO:0042823) |
| 0.1 | 0.2 | GO:0097089 | methyl-branched fatty acid metabolic process(GO:0097089) |
| 0.1 | 0.3 | GO:0098915 | membrane repolarization during ventricular cardiac muscle cell action potential(GO:0098915) |
| 0.1 | 0.4 | GO:0034162 | toll-like receptor 9 signaling pathway(GO:0034162) |
| 0.1 | 0.5 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
| 0.1 | 1.0 | GO:0061436 | establishment of skin barrier(GO:0061436) |
| 0.1 | 0.6 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
| 0.1 | 0.1 | GO:0003241 | growth involved in heart morphogenesis(GO:0003241) |
| 0.1 | 0.6 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.1 | 0.8 | GO:0036159 | outer dynein arm assembly(GO:0036158) inner dynein arm assembly(GO:0036159) |
| 0.1 | 0.4 | GO:0060385 | axonogenesis involved in innervation(GO:0060385) |
| 0.1 | 0.3 | GO:1901837 | negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837) |
| 0.1 | 0.2 | GO:0098974 | postsynaptic actin cytoskeleton organization(GO:0098974) |
| 0.1 | 0.7 | GO:0071318 | cellular response to ATP(GO:0071318) |
| 0.1 | 0.3 | GO:0002339 | B cell selection(GO:0002339) |
| 0.1 | 0.8 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.1 | 0.2 | GO:0035624 | receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625) |
| 0.1 | 0.5 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.1 | 0.3 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.1 | 0.4 | GO:0036506 | maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) |
| 0.0 | 0.3 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.0 | 0.4 | GO:0016264 | gap junction assembly(GO:0016264) |
| 0.0 | 0.1 | GO:0051890 | regulation of cardioblast differentiation(GO:0051890) |
| 0.0 | 0.6 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
| 0.0 | 0.3 | GO:0034393 | positive regulation of smooth muscle cell apoptotic process(GO:0034393) |
| 0.0 | 0.6 | GO:0060481 | lobar bronchus epithelium development(GO:0060481) |
| 0.0 | 1.0 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.0 | 0.4 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.0 | 0.3 | GO:0098903 | regulation of membrane repolarization during action potential(GO:0098903) |
| 0.0 | 0.1 | GO:2001187 | positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
| 0.0 | 0.3 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.0 | 0.1 | GO:2000193 | regulation of fatty acid transport(GO:2000191) positive regulation of fatty acid transport(GO:2000193) |
| 0.0 | 0.5 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 0.0 | 0.1 | GO:0006106 | fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401) |
| 0.0 | 0.2 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.0 | 0.3 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.0 | 1.0 | GO:0031116 | positive regulation of microtubule polymerization(GO:0031116) |
| 0.0 | 1.1 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.0 | 0.2 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.0 | 0.1 | GO:0009174 | UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049) |
| 0.0 | 0.1 | GO:0071544 | diphosphoinositol polyphosphate catabolic process(GO:0071544) |
| 0.0 | 2.2 | GO:0008543 | fibroblast growth factor receptor signaling pathway(GO:0008543) |
| 0.0 | 0.4 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
| 0.0 | 1.3 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.0 | 0.5 | GO:0001916 | positive regulation of T cell mediated cytotoxicity(GO:0001916) |
| 0.0 | 0.7 | GO:0046596 | regulation of viral entry into host cell(GO:0046596) |
| 0.0 | 0.2 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 0.0 | 0.6 | GO:0035036 | binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) |
| 0.0 | 0.4 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.0 | 0.8 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.0 | 1.5 | GO:0051893 | regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109) |
| 0.0 | 0.1 | GO:0006669 | sphinganine-1-phosphate biosynthetic process(GO:0006669) |
| 0.0 | 0.3 | GO:0006857 | oligopeptide transport(GO:0006857) |
| 0.0 | 0.2 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.0 | 0.3 | GO:0006833 | water transport(GO:0006833) |
| 0.0 | 0.4 | GO:0030970 | retrograde protein transport, ER to cytosol(GO:0030970) |
| 0.0 | 1.4 | GO:0006406 | mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427) |
| 0.0 | 0.4 | GO:0045103 | intermediate filament-based process(GO:0045103) |
| 0.0 | 0.4 | GO:0032465 | regulation of cytokinesis(GO:0032465) |
| 0.0 | 0.2 | GO:0000022 | mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256) |
| 0.0 | 0.3 | GO:0032366 | intracellular sterol transport(GO:0032366) intracellular cholesterol transport(GO:0032367) |
| 0.0 | 0.5 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.0 | 0.1 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 0.0 | 0.7 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 0.0 | 0.3 | GO:0042711 | maternal behavior(GO:0042711) |
| 0.0 | 0.4 | GO:0045604 | regulation of epidermal cell differentiation(GO:0045604) |
| 0.0 | 0.6 | GO:1901998 | toxin transport(GO:1901998) |
| 0.0 | 0.1 | GO:1902951 | negative regulation of dendritic spine maintenance(GO:1902951) |
| 0.0 | 0.2 | GO:0045792 | negative regulation of cell size(GO:0045792) |
| 0.0 | 0.6 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
| 0.0 | 0.5 | GO:0032292 | myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292) |
| 0.0 | 0.2 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.0 | 0.1 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
| 0.0 | 0.9 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.0 | 0.7 | GO:0043666 | regulation of phosphoprotein phosphatase activity(GO:0043666) |
| 0.0 | 0.3 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 0.2 | GO:0003417 | growth plate cartilage development(GO:0003417) |
| 0.0 | 0.2 | GO:2000637 | positive regulation of gene silencing by miRNA(GO:2000637) |
| 0.0 | 0.9 | GO:2001022 | positive regulation of response to DNA damage stimulus(GO:2001022) |
| 0.0 | 0.5 | GO:0000266 | mitochondrial fission(GO:0000266) |
| 0.0 | 0.1 | GO:0030539 | male genitalia development(GO:0030539) |
| 0.0 | 0.6 | GO:0034766 | negative regulation of ion transmembrane transport(GO:0034766) |
| 0.0 | 0.3 | GO:0007340 | acrosome reaction(GO:0007340) |
| 0.0 | 0.5 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.0 | 0.1 | GO:0001575 | globoside metabolic process(GO:0001575) |
| 0.0 | 0.1 | GO:0043383 | negative T cell selection(GO:0043383) negative thymic T cell selection(GO:0045060) |
| 0.0 | 0.1 | GO:0071340 | skeletal muscle acetylcholine-gated channel clustering(GO:0071340) |
| 0.0 | 0.4 | GO:0015909 | long-chain fatty acid transport(GO:0015909) |
| 0.0 | 0.3 | GO:0009409 | response to cold(GO:0009409) |
| 0.0 | 0.8 | GO:0006096 | glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757) |
| 0.0 | 0.3 | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.5 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.3 | 2.6 | GO:0002177 | manchette(GO:0002177) |
| 0.2 | 0.9 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
| 0.2 | 0.8 | GO:0032127 | dense core granule membrane(GO:0032127) |
| 0.2 | 1.3 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
| 0.2 | 2.2 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.2 | 1.5 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.1 | 0.7 | GO:0071817 | MMXD complex(GO:0071817) |
| 0.1 | 0.4 | GO:0048179 | activin receptor complex(GO:0048179) |
| 0.1 | 0.3 | GO:0033193 | Lsd1/2 complex(GO:0033193) |
| 0.1 | 0.6 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.1 | 0.6 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.1 | 0.3 | GO:0098592 | cytoplasmic side of apical plasma membrane(GO:0098592) |
| 0.1 | 0.4 | GO:0035339 | SPOTS complex(GO:0035339) |
| 0.1 | 0.6 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.1 | 0.8 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 0.4 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.1 | 0.7 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.1 | 0.3 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 0.1 | 0.5 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.1 | 0.3 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.1 | 0.3 | GO:0031983 | vesicle lumen(GO:0031983) |
| 0.1 | 0.2 | GO:0005594 | collagen type IX trimer(GO:0005594) |
| 0.1 | 0.4 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.1 | 0.4 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.1 | 0.3 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
| 0.1 | 0.7 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 2.1 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 1.0 | GO:0000346 | transcription export complex(GO:0000346) |
| 0.0 | 0.6 | GO:0016589 | NURF complex(GO:0016589) |
| 0.0 | 2.7 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 0.6 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 0.5 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 0.6 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.0 | 1.0 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 0.4 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.0 | 0.3 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.0 | 1.8 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.2 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.0 | 0.8 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 0.4 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.0 | 1.1 | GO:0034704 | calcium channel complex(GO:0034704) |
| 0.0 | 0.4 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 0.7 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 0.5 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 0.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 0.2 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.0 | 0.4 | GO:0046540 | U4/U6 x U5 tri-snRNP complex(GO:0046540) |
| 0.0 | 0.1 | GO:1990590 | ATF1-ATF4 transcription factor complex(GO:1990590) |
| 0.0 | 0.3 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 4.3 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 0.9 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.1 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 0.0 | 0.5 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 0.2 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.0 | 0.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 0.8 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 1.8 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.0 | 0.2 | GO:0002102 | podosome(GO:0002102) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.5 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
| 0.6 | 3.1 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.4 | 2.2 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 0.4 | 1.5 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763) |
| 0.4 | 2.1 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
| 0.3 | 0.8 | GO:0003953 | NAD+ nucleosidase activity(GO:0003953) |
| 0.2 | 0.9 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
| 0.2 | 0.6 | GO:0046592 | polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901) |
| 0.2 | 2.0 | GO:0002151 | G-quadruplex RNA binding(GO:0002151) |
| 0.2 | 0.8 | GO:0015166 | polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168) |
| 0.2 | 0.8 | GO:0050265 | RNA uridylyltransferase activity(GO:0050265) |
| 0.2 | 0.6 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.2 | 0.6 | GO:0004966 | galanin receptor activity(GO:0004966) |
| 0.1 | 0.6 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.1 | 0.9 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 0.1 | 1.1 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.1 | 0.4 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.1 | 0.6 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.1 | 0.6 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.1 | 1.0 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.1 | 1.0 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.1 | 0.5 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416) |
| 0.1 | 0.3 | GO:0031752 | D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752) |
| 0.1 | 0.8 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.1 | 0.5 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.1 | 4.2 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.1 | 0.4 | GO:0016361 | activin receptor activity, type I(GO:0016361) |
| 0.1 | 0.3 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159) |
| 0.1 | 0.5 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.1 | 0.7 | GO:0046790 | virion binding(GO:0046790) |
| 0.1 | 0.4 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
| 0.1 | 0.8 | GO:0050733 | RS domain binding(GO:0050733) |
| 0.1 | 0.5 | GO:0023029 | MHC class Ib protein binding(GO:0023029) |
| 0.1 | 1.5 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.1 | 0.9 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 0.7 | GO:0015217 | ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217) |
| 0.1 | 3.4 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.1 | 0.6 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.1 | 0.5 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.1 | 0.3 | GO:1902282 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282) |
| 0.1 | 0.2 | GO:0098973 | structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973) |
| 0.1 | 2.2 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 0.5 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.1 | 0.4 | GO:0031432 | titin binding(GO:0031432) |
| 0.1 | 0.4 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.1 | 1.1 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.1 | 0.3 | GO:0015250 | water channel activity(GO:0015250) |
| 0.1 | 0.3 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.1 | 1.3 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.0 | 0.3 | GO:0015198 | oligopeptide transporter activity(GO:0015198) |
| 0.0 | 0.4 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.0 | 0.5 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.0 | 0.4 | GO:0097027 | ubiquitin-protein transferase activator activity(GO:0097027) |
| 0.0 | 0.6 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.0 | 0.3 | GO:0043559 | insulin binding(GO:0043559) |
| 0.0 | 1.8 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.0 | 0.5 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 0.0 | 0.7 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 0.5 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.0 | 0.2 | GO:0034235 | GPI anchor binding(GO:0034235) |
| 0.0 | 0.1 | GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) |
| 0.0 | 0.5 | GO:0015464 | acetylcholine receptor activity(GO:0015464) |
| 0.0 | 0.5 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.9 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.0 | 0.3 | GO:0003993 | acid phosphatase activity(GO:0003993) |
| 0.0 | 0.2 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.0 | 0.3 | GO:0016004 | phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229) |
| 0.0 | 1.0 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 0.7 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.0 | 0.9 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 0.4 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.0 | 0.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.3 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.0 | 0.9 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.0 | 0.6 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 0.3 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 0.8 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 0.3 | GO:0010181 | FMN binding(GO:0010181) |
| 0.0 | 1.7 | GO:0046332 | SMAD binding(GO:0046332) |
| 0.0 | 0.1 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.0 | 0.3 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 0.5 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 0.1 | GO:0051765 | inositol tetrakisphosphate kinase activity(GO:0051765) |
| 0.0 | 0.5 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 1.8 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.0 | 0.1 | GO:0000298 | endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) |
| 0.0 | 0.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.1 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 0.0 | 0.2 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 0.0 | 1.2 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.6 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 0.1 | GO:0001094 | TFIID-class transcription factor binding(GO:0001094) |
| 0.0 | 0.2 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.0 | 0.1 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 0.0 | 0.2 | GO:0031418 | L-ascorbic acid binding(GO:0031418) |
| 0.0 | 0.1 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.0 | 0.6 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.0 | 1.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 1.8 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 1.1 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 0.0 | GO:0005119 | smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158) |
| 0.0 | 0.2 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.0 | 0.1 | GO:0034713 | type I transforming growth factor beta receptor binding(GO:0034713) |
| 0.0 | 0.7 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 2.2 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 0.5 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 2.6 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 1.5 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.6 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 2.1 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.0 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 1.7 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 2.2 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.0 | 0.3 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.6 | PID_PI3K_PLC_TRK_PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 1.6 | PID_TCR_PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.0 | 0.6 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.4 | PID_BCR_5PATHWAY | BCR signaling pathway |
| 0.0 | 0.3 | PID_S1P_S1P1_PATHWAY | S1P1 pathway |
| 0.0 | 0.4 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.7 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.0 | 1.5 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 2.1 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.1 | PID_PS1_PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 0.2 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.2 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.4 | ST_ADRENERGIC | Adrenergic Pathway |
| 0.0 | 0.3 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.6 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 0.4 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.0 | 0.6 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.0 | 0.4 | PID_AP1_PATHWAY | AP-1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.5 | REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.2 | 1.8 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
| 0.1 | 1.1 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 2.2 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 3.7 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 2.4 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 0.7 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.1 | 0.7 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 1.7 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 1.0 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 0.9 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.7 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.8 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 1.8 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.0 | 1.5 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 0.9 | REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.0 | 0.4 | REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.0 | 0.5 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.5 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 0.9 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.8 | REACTOME_IL_RECEPTOR_SHC_SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 0.5 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.0 | 0.8 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.9 | REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |
| 0.0 | 5.2 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.4 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.7 | REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.0 | 1.0 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 0.4 | REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.0 | 0.2 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 0.2 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.2 | REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 0.4 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.1 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 1.3 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 0.6 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 0.9 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 0.4 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
