Motif ID: Ikzf2

Z-value: 0.635


Transcription factors associated with Ikzf2:

Gene SymbolEntrez IDGene Name
Ikzf2 ENSMUSG00000025997.7 Ikzf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ikzf2mm10_v2_chr1_-_69685937_69685966-0.058.4e-01Click!


Activity profile for motif Ikzf2.

activity profile for motif Ikzf2


Sorted Z-values histogram for motif Ikzf2

Sorted Z-values for motif Ikzf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Ikzf2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_103422010 3.414 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr6_-_23248264 3.373 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr5_-_123141067 1.307 ENSMUST00000162697.1
ENSMUST00000160321.1
ENSMUST00000159637.1
 AI480526


expressed sequence AI480526


chr1_+_45311538 1.088 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr6_+_15185203 0.856 ENSMUST00000154448.1
 Foxp2
forkhead box P2
chr8_-_89147247 0.575 ENSMUST00000177870.1
 Gm6625
predicted gene 6625
chr1_-_45503282 0.573 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr1_+_107511489 0.557 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr5_-_123140135 0.553 ENSMUST00000160099.1
 AI480526
expressed sequence AI480526
chr14_+_64589802 0.517 ENSMUST00000180610.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chrX_+_106920618 0.496 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr3_-_154330543 0.492 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chr5_+_30913398 0.482 ENSMUST00000031055.5
 Emilin1
elastin microfibril interfacer 1
chr6_+_4003926 0.445 ENSMUST00000031670.8
 Gng11
guanine nucleotide binding protein (G protein), gamma 11
chr9_-_13446753 0.441 ENSMUST00000167906.2
 Gm17571
predicted gene, 17571
chr3_+_88214474 0.439 ENSMUST00000181356.1
ENSMUST00000181396.1
 Gm3764

predicted gene 3764

chr2_+_103970115 0.436 ENSMUST00000111143.1
ENSMUST00000138815.1
 Lmo2

LIM domain only 2

chr2_+_103970221 0.412 ENSMUST00000111140.2
ENSMUST00000111139.2
 Lmo2

LIM domain only 2

chr13_-_103764502 0.401 ENSMUST00000074616.5
 Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr17_-_56571438 0.379 ENSMUST00000131056.1
 Safb2
scaffold attachment factor B2
chr19_+_55894508 0.357 ENSMUST00000142291.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr1_-_87394721 0.350 ENSMUST00000113212.3
 Kcnj13
potassium inwardly-rectifying channel, subfamily J, member 13
chr3_-_106001474 0.335 ENSMUST00000066319.6
 Pifo
primary cilia formation
chr8_-_80739497 0.316 ENSMUST00000043359.8
 Smarca5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr10_+_25359798 0.284 ENSMUST00000053748.8
 Epb4.1l2
erythrocyte protein band 4.1-like 2
chr11_+_23020464 0.281 ENSMUST00000094363.3
ENSMUST00000151877.1
 Fam161a

family with sequence similarity 161, member A

chr13_+_89540636 0.274 ENSMUST00000022108.7
 Hapln1
hyaluronan and proteoglycan link protein 1
chr4_+_105157339 0.269 ENSMUST00000064139.7
 Ppap2b
phosphatidic acid phosphatase type 2B
chr5_+_92897981 0.262 ENSMUST00000113051.2
 Shroom3
shroom family member 3
chr7_-_139582790 0.250 ENSMUST00000106095.2
 Nkx6-2
NK6 homeobox 2
chr13_-_54590047 0.208 ENSMUST00000148222.1
ENSMUST00000026987.5
 Nop16

NOP16 nucleolar protein

chr17_-_46440099 0.205 ENSMUST00000166852.1
 Gm5093
predicted gene 5093
chr4_+_57637816 0.199 ENSMUST00000150412.1
 Gm20459
predicted gene 20459
chr3_-_95995662 0.198 ENSMUST00000123006.1
 Plekho1
pleckstrin homology domain containing, family O member 1
chr5_+_110330697 0.197 ENSMUST00000112481.1
 Pole
polymerase (DNA directed), epsilon
chr14_+_47663756 0.195 ENSMUST00000022391.7
 Ktn1
kinectin 1
chr2_-_72980402 0.192 ENSMUST00000066003.6
ENSMUST00000102689.3
 Sp3

trans-acting transcription factor 3

chrX_+_71556874 0.185 ENSMUST00000123100.1
 Hmgb3
high mobility group box 3
chr16_+_90727490 0.184 ENSMUST00000181232.1
 Gm17518
predicted gene, 17518
chr3_-_95995999 0.181 ENSMUST00000015889.3
 Plekho1
pleckstrin homology domain containing, family O member 1
chr4_-_92191749 0.175 ENSMUST00000123179.1
 Gm12666
predicted gene 12666
chr3_-_95995835 0.170 ENSMUST00000143485.1
 Plekho1
pleckstrin homology domain containing, family O member 1
chr9_-_42944479 0.168 ENSMUST00000114865.1
 Grik4
glutamate receptor, ionotropic, kainate 4
chr8_-_61591130 0.164 ENSMUST00000135439.1
ENSMUST00000121200.1
 Palld

palladin, cytoskeletal associated protein

chr11_-_55419898 0.162 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr14_+_11227511 0.158 ENSMUST00000080237.3
 Rpl21-ps4
ribosomal protein L21, pseudogene 4
chr17_-_55915870 0.156 ENSMUST00000074828.4
 Rpl21-ps6
ribosomal protein L21, pseudogene 6
chr11_-_84525514 0.156 ENSMUST00000018842.7
 Lhx1
LIM homeobox protein 1
chr16_-_90727329 0.152 ENSMUST00000099554.4
 Mis18a
MIS18 kinetochore protein homolog A (S. pombe)
chr3_-_33844255 0.143 ENSMUST00000029222.5
 Ccdc39
coiled-coil domain containing 39
chr9_+_70207342 0.142 ENSMUST00000034745.7
 Myo1e
myosin IE
chr10_+_58394381 0.139 ENSMUST00000105468.1
 Lims1
LIM and senescent cell antigen-like domains 1
chr5_-_88527841 0.138 ENSMUST00000087033.3
 Igj
immunoglobulin joining chain
chr13_-_56895737 0.132 ENSMUST00000022023.6
ENSMUST00000109871.1
 Trpc7

transient receptor potential cation channel, subfamily C, member 7

chr11_-_115491796 0.131 ENSMUST00000106530.1
ENSMUST00000021082.6
 Nt5c

5',3'-nucleotidase, cytosolic

chr3_-_95995698 0.131 ENSMUST00000130043.1
 Plekho1
pleckstrin homology domain containing, family O member 1
chr7_-_4778141 0.129 ENSMUST00000094892.5
 Il11
interleukin 11
chr19_+_5689131 0.128 ENSMUST00000004156.8
 Map3k11
mitogen-activated protein kinase kinase kinase 11
chr8_+_45627709 0.121 ENSMUST00000134321.1
ENSMUST00000135336.1
 Sorbs2

sorbin and SH3 domain containing 2

chr16_+_30065333 0.118 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chrX_+_109095359 0.114 ENSMUST00000033598.8
 Sh3bgrl
SH3-binding domain glutamic acid-rich protein like
chr3_+_159839729 0.112 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr11_+_29463735 0.106 ENSMUST00000155854.1
 Ccdc88a
coiled coil domain containing 88A
chr12_-_54999102 0.102 ENSMUST00000173529.1
 Baz1a
bromodomain adjacent to zinc finger domain 1A
chr13_+_44731265 0.102 ENSMUST00000173246.1
 Jarid2
jumonji, AT rich interactive domain 2
chr9_-_52168111 0.096 ENSMUST00000165519.1
 Zc3h12c
zinc finger CCCH type containing 12C
chrX_-_134600976 0.094 ENSMUST00000033621.6
 Gla
galactosidase, alpha
chr5_+_42067960 0.091 ENSMUST00000087332.4
 Gm16223
predicted gene 16223
chr8_-_67818218 0.087 ENSMUST00000059374.4
 Psd3
pleckstrin and Sec7 domain containing 3
chr2_-_77170592 0.086 ENSMUST00000164114.2
ENSMUST00000049544.7
 Ccdc141

coiled-coil domain containing 141

chr4_+_141239499 0.085 ENSMUST00000141834.2
 Arhgef19
Rho guanine nucleotide exchange factor (GEF) 19
chr5_-_51567717 0.085 ENSMUST00000127135.1
ENSMUST00000151104.1
 Ppargc1a

peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

chr7_+_46847128 0.083 ENSMUST00000005051.4
 Ldha
lactate dehydrogenase A
chr11_+_49609263 0.080 ENSMUST00000020617.2
 Flt4
FMS-like tyrosine kinase 4
chr2_+_174330006 0.080 ENSMUST00000109085.1
ENSMUST00000109087.1
ENSMUST00000109084.1
 Gnas


GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus


chr13_+_44731281 0.075 ENSMUST00000174086.1
 Jarid2
jumonji, AT rich interactive domain 2
chr2_-_71546745 0.073 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr12_+_76324905 0.070 ENSMUST00000172992.1
 Akap5
A kinase (PRKA) anchor protein 5
chr12_+_75308308 0.068 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
 Rhoj


ras homolog gene family, member J


chr5_+_107437908 0.062 ENSMUST00000094541.2
 Btbd8
BTB (POZ) domain containing 8
chr14_-_72709534 0.061 ENSMUST00000162478.1
 Fndc3a
fibronectin type III domain containing 3A
chr3_+_84925476 0.061 ENSMUST00000107675.1
 Fbxw7
F-box and WD-40 domain protein 7
chr8_-_67818284 0.057 ENSMUST00000120071.1
 Psd3
pleckstrin and Sec7 domain containing 3
chr7_-_84679346 0.057 ENSMUST00000069537.2
ENSMUST00000178385.1
 Zfand6

zinc finger, AN1-type domain 6

chr1_-_69685937 0.054 ENSMUST00000027146.2
 Ikzf2
IKAROS family zinc finger 2
chrX_-_153037549 0.052 ENSMUST00000051484.3
 Mageh1
melanoma antigen, family H, 1
chr19_+_41593363 0.048 ENSMUST00000099454.3
 AI606181
expressed sequence AI606181
chr4_-_129578535 0.047 ENSMUST00000052835.8
 Fam167b
family with sequence similarity 167, member B
chr11_-_110251736 0.047 ENSMUST00000044003.7
 Abca6
ATP-binding cassette, sub-family A (ABC1), member 6
chr12_+_76324860 0.043 ENSMUST00000095610.2
ENSMUST00000154078.2
 Akap5

A kinase (PRKA) anchor protein 5

chr2_-_26409161 0.042 ENSMUST00000145701.1
 Inpp5e
inositol polyphosphate-5-phosphatase E
chr10_+_58394361 0.041 ENSMUST00000020077.4
 Lims1
LIM and senescent cell antigen-like domains 1
chr19_-_29812952 0.039 ENSMUST00000099525.3
 Ranbp6
RAN binding protein 6
chrX_+_134601179 0.038 ENSMUST00000074950.4
ENSMUST00000113203.1
ENSMUST00000113202.1
 Hnrnph2


heterogeneous nuclear ribonucleoprotein H2


chr15_+_10952332 0.037 ENSMUST00000022853.8
ENSMUST00000110523.1
 C1qtnf3

C1q and tumor necrosis factor related protein 3

chr8_+_45627946 0.037 ENSMUST00000145458.1
 Sorbs2
sorbin and SH3 domain containing 2
chr8_+_45628176 0.034 ENSMUST00000130850.1
 Sorbs2
sorbin and SH3 domain containing 2
chrX_-_88115632 0.032 ENSMUST00000113966.1
ENSMUST00000113964.1
 Il1rapl1

interleukin 1 receptor accessory protein-like 1

chr12_+_64965742 0.031 ENSMUST00000066296.7
 Fam179b
family with sequence similarity 179, member B
chr13_+_54590204 0.021 ENSMUST00000026986.6
 Higd2a
HIG1 domain family, member 2A
chr11_-_78183551 0.019 ENSMUST00000102483.4
 Rpl23a
ribosomal protein L23A
chr13_+_23738804 0.011 ENSMUST00000040914.1
 Hist1h1c
histone cluster 1, H1c
chr19_-_42202150 0.010 ENSMUST00000018966.7
 Sfrp5
secreted frizzled-related sequence protein 5
chr14_-_54605908 0.007 ENSMUST00000022786.4
 4931414P19Rik
RIKEN cDNA 4931414P19 gene
chr6_+_145934113 0.004 ENSMUST00000032383.7
 Sspn
sarcospan
chr3_-_65529355 0.003 ENSMUST00000099076.3
 4931440P22Rik
RIKEN cDNA 4931440P22 gene
chr9_+_53537021 0.002 ENSMUST00000035850.7
 Npat
nuclear protein in the AT region
chr15_-_97020322 0.001 ENSMUST00000166223.1
 Slc38a4
solute carrier family 38, member 4
chr19_-_59943000 0.000 ENSMUST00000170819.1
 Rab11fip2
RAB11 family interacting protein 2 (class I)
chr14_-_54409469 0.000 ENSMUST00000000984.4
 Slc7a7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 1.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.2 0.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.9 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 0.9 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 0.2 GO:0045004 DNA replication proofreading(GO:0045004)
0.1 0.2 GO:0072284 cervix development(GO:0060067) metanephric S-shaped body morphogenesis(GO:0072284) anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744)
0.0 0.3 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.4 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:2000977 oculomotor nerve development(GO:0021557) cell-cell signaling involved in cell fate commitment(GO:0045168) comma-shaped body morphogenesis(GO:0072049) regulation of forebrain neuron differentiation(GO:2000977)
0.0 0.7 GO:0051451 myoblast migration(GO:0051451)
0.0 0.1 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.0 0.2 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.0 0.2 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.0 0.3 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.1 GO:0006244 pyrimidine nucleotide catabolic process(GO:0006244) pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.0 0.2 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.2 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.1 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.0 0.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.1 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
0.0 0.5 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.1 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.1 GO:0036394 amylase secretion(GO:0036394)
0.0 0.5 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.1 GO:0019659 fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.0 0.1 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.4 GO:0060008 Sertoli cell differentiation(GO:0060008)
0.0 0.2 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.1 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 0.4 GO:0010107 potassium ion import(GO:0010107)
0.0 0.2 GO:0003334 keratinocyte development(GO:0003334)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0005588 collagen type V trimer(GO:0005588)
0.1 1.1 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.7 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 0.5 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.4 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.2 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.1 GO:0032437 cuticular plate(GO:0032437)
0.0 0.2 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.1 GO:0008623 CHRAC(GO:0008623)
0.0 0.3 GO:0016589 NURF complex(GO:0016589)
0.0 0.4 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.1 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634)
0.1 1.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.5 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.2 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0 0.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 4.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.8 GO:0043425 bHLH transcription factor binding(GO:0043425) E-box binding(GO:0070888)
0.0 0.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.2 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.4 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.4 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0016936 galactoside binding(GO:0016936)
0.0 0.1 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0015279 store-operated calcium channel activity(GO:0015279)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 1.7 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.5 PID_LPA4_PATHWAY LPA4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.1 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.5 REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.1 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.2 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.1 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions