Motif ID: Hoxa9_Hoxb9

Z-value: 0.580

Transcription factors associated with Hoxa9_Hoxb9:

Gene SymbolEntrez IDGene Name
Hoxa9 ENSMUSG00000038227.9 Hoxa9
Hoxb9 ENSMUSG00000020875.8 Hoxb9



Activity profile for motif Hoxa9_Hoxb9.

activity profile for motif Hoxa9_Hoxb9


Sorted Z-values histogram for motif Hoxa9_Hoxb9

Sorted Z-values for motif Hoxa9_Hoxb9



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa9_Hoxb9

PNG image of the network

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Top targets:


Showing 1 to 20 of 117 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91225550 1.756 ENSMUST00000035608.8
 Olig2
oligodendrocyte transcription factor 2
chr15_+_25773985 1.492 ENSMUST00000125667.1
 Myo10
myosin X
chr19_-_57197435 1.250 ENSMUST00000111550.1
 Ablim1
actin-binding LIM protein 1
chr3_+_108591279 1.236 ENSMUST00000051145.8
ENSMUST00000139626.1
 Wdr47

WD repeat domain 47

chr19_-_57197377 1.191 ENSMUST00000111546.1
 Ablim1
actin-binding LIM protein 1
chr19_-_7341848 1.112 ENSMUST00000171393.1
 Mark2
MAP/microtubule affinity-regulating kinase 2
chr6_+_49822710 0.963 ENSMUST00000031843.6
 Npy
neuropeptide Y
chr2_+_22622183 0.915 ENSMUST00000028123.3
 Gad2
glutamic acid decarboxylase 2
chr5_-_73191848 0.905 ENSMUST00000176910.1
 Fryl
furry homolog-like (Drosophila)
chr11_-_79504078 0.820 ENSMUST00000164465.2
 Omg
oligodendrocyte myelin glycoprotein
chr1_+_66386968 0.744 ENSMUST00000145419.1
 Map2
microtubule-associated protein 2
chr1_+_194619815 0.728 ENSMUST00000027952.5
 Plxna2
plexin A2
chr9_+_121366958 0.698 ENSMUST00000045903.6
 Trak1
trafficking protein, kinesin binding 1
chr7_+_56050135 0.679 ENSMUST00000076226.6
 Herc2
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2
chr19_+_44203265 0.663 ENSMUST00000026220.5
 Scd3
stearoyl-coenzyme A desaturase 3
chr14_+_20674311 0.638 ENSMUST00000048657.8
 Sec24c
Sec24 related gene family, member C (S. cerevisiae)
chr15_+_81936911 0.633 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr4_+_144893127 0.587 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr13_+_16014457 0.566 ENSMUST00000164993.1
 Inhba
inhibin beta-A
chr11_-_109298066 0.561 ENSMUST00000106706.1
 Rgs9
regulator of G-protein signaling 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 GO:0030032 lamellipodium assembly(GO:0030032)
0.6 1.8 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 1.2 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 1.0 GO:0032098 regulation of appetite(GO:0032098)
0.0 1.0 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.2 0.9 GO:0006538 glutamate catabolic process(GO:0006538)
0.1 0.9 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.9 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.8 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.2 0.7 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1 0.7 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.1 0.7 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.0 0.7 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 0.6 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.1 0.6 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.6 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.5 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.5 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.5 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.5 GO:0008299 isoprenoid biosynthetic process(GO:0008299)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 1.2 GO:0097427 microtubule bundle(GO:0097427)
0.0 1.1 GO:0016459 myosin complex(GO:0016459)
0.0 1.0 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 0.7 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.7 GO:1904115 axon cytoplasm(GO:1904115)
0.2 0.6 GO:0043512 inhibin A complex(GO:0043512)
0.0 0.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.6 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.4 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0097447 dendritic tree(GO:0097447)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.1 GO:0000798 nuclear cohesin complex(GO:0000798)
0.0 0.1 GO:0033269 internode region of axon(GO:0033269)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0030507 spectrin binding(GO:0030507)
0.1 1.2 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 1.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 1.0 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.9 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.2 0.7 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1 0.7 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.7 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.7 GO:0032183 SUMO binding(GO:0032183)
0.1 0.6 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.5 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.4 GO:0002135 CTP binding(GO:0002135)
0.1 0.4 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.4 GO:0004972 NMDA glutamate receptor activity(GO:0004972)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 1.0 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.8 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.6 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.2 PID_S1P_S1P4_PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 2.1 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 1.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 1.1 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.9 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 0.6 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.6 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.4 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.4 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.2 0.2 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 0.2 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.1 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.1 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade