Motif ID: Hoxa9_Hoxb9
Z-value: 0.580
Transcription factors associated with Hoxa9_Hoxb9:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Hoxa9 | ENSMUSG00000038227.9 | Hoxa9 |
Hoxb9 | ENSMUSG00000020875.8 | Hoxb9 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 1.8 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
0.2 | 0.9 | GO:0006538 | glutamate catabolic process(GO:0006538) |
0.2 | 0.7 | GO:1903966 | monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966) |
0.1 | 0.4 | GO:0097278 | transforming growth factor beta activation(GO:0036363) complement-dependent cytotoxicity(GO:0097278) |
0.1 | 0.6 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
0.1 | 0.9 | GO:0090527 | actin filament reorganization(GO:0090527) |
0.1 | 0.7 | GO:0021785 | branchiomotor neuron axon guidance(GO:0021785) |
0.1 | 0.7 | GO:0019896 | axonal transport of mitochondrion(GO:0019896) |
0.1 | 0.5 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
0.1 | 0.5 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
0.1 | 1.0 | GO:0032098 | regulation of appetite(GO:0032098) |
0.1 | 0.4 | GO:0032264 | IMP salvage(GO:0032264) |
0.1 | 0.6 | GO:0042572 | retinol metabolic process(GO:0042572) |
0.1 | 0.4 | GO:0017121 | phospholipid scrambling(GO:0017121) |
0.0 | 0.1 | GO:0046104 | thymidine metabolic process(GO:0046104) |
0.0 | 0.4 | GO:0031848 | protection from non-homologous end joining at telomere(GO:0031848) |
0.0 | 0.2 | GO:2000821 | regulation of grooming behavior(GO:2000821) |
0.0 | 0.6 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
0.0 | 0.5 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
0.0 | 3.6 | GO:0030032 | lamellipodium assembly(GO:0030032) |
0.0 | 0.1 | GO:1990414 | replication-born double-strand break repair via sister chromatid exchange(GO:1990414) |
0.0 | 0.2 | GO:0032489 | regulation of Cdc42 protein signal transduction(GO:0032489) |
0.0 | 0.1 | GO:0010891 | negative regulation of sequestering of triglyceride(GO:0010891) positive regulation of triglyceride catabolic process(GO:0010898) |
0.0 | 0.8 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
0.0 | 0.1 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
0.0 | 0.1 | GO:0038032 | termination of G-protein coupled receptor signaling pathway(GO:0038032) |
0.0 | 1.2 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
0.0 | 0.4 | GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain(GO:0050966) |
0.0 | 0.1 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
0.0 | 0.1 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
0.0 | 0.5 | GO:0008299 | isoprenoid biosynthetic process(GO:0008299) |
0.0 | 1.0 | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197) |
0.0 | 0.1 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
0.0 | 0.7 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
0.0 | 0.1 | GO:0043313 | regulation of neutrophil degranulation(GO:0043313) |
0.0 | 0.0 | GO:0044208 | 'de novo' AMP biosynthetic process(GO:0044208) |
0.0 | 0.9 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
0.0 | 0.1 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
0.0 | 0.2 | GO:0016246 | RNA interference(GO:0016246) |
0.0 | 0.5 | GO:0046677 | response to antibiotic(GO:0046677) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 0.6 | GO:0043512 | inhibin A complex(GO:0043512) |
0.1 | 1.2 | GO:0097427 | microtubule bundle(GO:0097427) |
0.1 | 0.7 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
0.1 | 0.4 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
0.0 | 0.2 | GO:0097447 | dendritic tree(GO:0097447) |
0.0 | 0.6 | GO:0030127 | COPII vesicle coat(GO:0030127) |
0.0 | 0.7 | GO:1904115 | axon cytoplasm(GO:1904115) |
0.0 | 0.1 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
0.0 | 0.4 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
0.0 | 0.1 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
0.0 | 1.0 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
0.0 | 2.7 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
0.0 | 1.1 | GO:0016459 | myosin complex(GO:0016459) |
0.0 | 0.2 | GO:0031209 | SCAR complex(GO:0031209) |
0.0 | 0.2 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
0.0 | 0.6 | GO:0060077 | inhibitory synapse(GO:0060077) |
0.0 | 0.1 | GO:0000798 | nuclear cohesin complex(GO:0000798) |
0.0 | 0.1 | GO:0033269 | internode region of axon(GO:0033269) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 0.7 | GO:0032896 | palmitoyl-CoA 9-desaturase activity(GO:0032896) |
0.1 | 0.9 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
0.1 | 0.6 | GO:0070699 | type II activin receptor binding(GO:0070699) |
0.1 | 0.7 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
0.1 | 0.3 | GO:0004609 | phosphatidylserine decarboxylase activity(GO:0004609) |
0.1 | 0.6 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
0.1 | 0.5 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
0.1 | 0.2 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
0.1 | 0.4 | GO:0002135 | CTP binding(GO:0002135) |
0.1 | 1.2 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
0.1 | 1.2 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
0.1 | 0.4 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
0.1 | 0.7 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
0.1 | 0.2 | GO:0016160 | alpha-amylase activity(GO:0004556) amylase activity(GO:0016160) |
0.0 | 0.2 | GO:0051377 | mannose-ethanolamine phosphotransferase activity(GO:0051377) |
0.0 | 0.5 | GO:0015093 | ferrous iron transmembrane transporter activity(GO:0015093) |
0.0 | 0.4 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
0.0 | 0.4 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
0.0 | 0.7 | GO:0050811 | GABA receptor binding(GO:0050811) |
0.0 | 1.0 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.0 | 1.5 | GO:0030507 | spectrin binding(GO:0030507) |
0.0 | 0.1 | GO:0002054 | nucleobase binding(GO:0002054) |
0.0 | 0.4 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
0.0 | 0.1 | GO:0009378 | four-way junction helicase activity(GO:0009378) |
0.0 | 0.7 | GO:0032183 | SUMO binding(GO:0032183) |
0.0 | 0.1 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
0.0 | 0.6 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
0.0 | 0.1 | GO:0050816 | phosphothreonine binding(GO:0050816) |
0.0 | 0.1 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
0.0 | 0.1 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
0.0 | 0.2 | GO:0008308 | voltage-gated anion channel activity(GO:0008308) |
0.0 | 0.5 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.0 | 0.3 | GO:0015026 | coreceptor activity(GO:0015026) |
0.0 | 0.1 | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308) |
0.0 | 0.1 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
0.0 | 0.1 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
0.0 | 0.4 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
0.0 | 0.9 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.0 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
0.0 | 0.2 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
0.0 | 1.6 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
0.0 | 1.9 | PID_LKB1_PATHWAY | LKB1 signaling events |
0.0 | 0.6 | PID_ALK1_PATHWAY | ALK1 signaling events |
0.0 | 0.8 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 0.2 | REACTOME_G_PROTEIN_ACTIVATION | Genes involved in G-protein activation |
0.1 | 0.6 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
0.1 | 3.3 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
0.1 | 1.1 | REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
0.1 | 1.8 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
0.0 | 0.9 | REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
0.0 | 0.6 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
0.0 | 0.4 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
0.0 | 0.4 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
0.0 | 0.1 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
0.0 | 0.1 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
0.0 | 2.1 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
0.0 | 0.2 | REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN | Genes involved in Signalling to p38 via RIT and RIN |