Motif ID: Lef1
Z-value: 1.102
Transcription factors associated with Lef1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Lef1 | ENSMUSG00000027985.8 | Lef1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Lef1 | mm10_v2_chr3_+_131110350_131110471 | 0.51 | 3.1e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 5.3 | GO:0061181 | regulation of chondrocyte development(GO:0061181) |
| 1.2 | 3.5 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 1.0 | 2.9 | GO:0046022 | regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022) |
| 0.8 | 3.2 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
| 0.7 | 2.0 | GO:0061153 | trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) |
| 0.6 | 1.7 | GO:0021972 | corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260) |
| 0.5 | 1.6 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
| 0.5 | 2.5 | GO:0031022 | nuclear migration along microfilament(GO:0031022) |
| 0.5 | 1.5 | GO:0061537 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
| 0.5 | 3.4 | GO:0072257 | metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307) |
| 0.4 | 6.8 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.4 | 0.8 | GO:0098528 | skeletal muscle fiber differentiation(GO:0098528) |
| 0.4 | 2.6 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.4 | 1.8 | GO:0035262 | gonad morphogenesis(GO:0035262) |
| 0.3 | 1.3 | GO:0014834 | skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834) regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384) |
| 0.3 | 3.6 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 0.3 | 0.6 | GO:0060242 | contact inhibition(GO:0060242) |
| 0.3 | 0.9 | GO:2000739 | regulation of mesenchymal stem cell differentiation(GO:2000739) |
| 0.3 | 1.1 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.3 | 1.1 | GO:1904565 | response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566) |
| 0.3 | 1.3 | GO:0060849 | regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849) |
| 0.3 | 1.8 | GO:0000320 | re-entry into mitotic cell cycle(GO:0000320) |
| 0.3 | 0.8 | GO:0048687 | positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) |
| 0.2 | 0.7 | GO:0019405 | alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166) |
| 0.2 | 3.5 | GO:0015809 | arginine transport(GO:0015809) |
| 0.2 | 2.1 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
| 0.2 | 0.7 | GO:0097401 | synaptic vesicle lumen acidification(GO:0097401) |
| 0.2 | 0.7 | GO:0045004 | DNA replication proofreading(GO:0045004) |
| 0.2 | 1.0 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.2 | 0.8 | GO:0051866 | general adaptation syndrome(GO:0051866) |
| 0.2 | 0.6 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 0.2 | 2.0 | GO:0060539 | diaphragm development(GO:0060539) |
| 0.2 | 0.5 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
| 0.2 | 0.5 | GO:0061075 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871) |
| 0.2 | 0.3 | GO:1900377 | negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) |
| 0.2 | 1.2 | GO:0033184 | positive regulation of histone ubiquitination(GO:0033184) |
| 0.2 | 0.8 | GO:0035616 | histone H2B conserved C-terminal lysine deubiquitination(GO:0035616) |
| 0.1 | 0.6 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.1 | 0.4 | GO:1990927 | negative regulation of membrane invagination(GO:1905154) calcium ion regulated lysosome exocytosis(GO:1990927) |
| 0.1 | 1.1 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 0.1 | 1.0 | GO:0070314 | G1 to G0 transition(GO:0070314) |
| 0.1 | 0.6 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 0.1 | 0.4 | GO:1904020 | regulation of G-protein coupled receptor internalization(GO:1904020) |
| 0.1 | 1.5 | GO:1901250 | regulation of lung goblet cell differentiation(GO:1901249) negative regulation of lung goblet cell differentiation(GO:1901250) |
| 0.1 | 1.5 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
| 0.1 | 0.7 | GO:0070345 | negative regulation of fat cell proliferation(GO:0070345) |
| 0.1 | 3.2 | GO:0036342 | post-anal tail morphogenesis(GO:0036342) |
| 0.1 | 0.4 | GO:0072720 | response to sorbitol(GO:0072708) response to dithiothreitol(GO:0072720) |
| 0.1 | 0.5 | GO:0007056 | spindle assembly involved in female meiosis(GO:0007056) |
| 0.1 | 0.5 | GO:0060028 | convergent extension involved in axis elongation(GO:0060028) |
| 0.1 | 0.3 | GO:2000686 | regulation of rubidium ion transmembrane transporter activity(GO:2000686) |
| 0.1 | 1.4 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.1 | 0.3 | GO:0060023 | soft palate development(GO:0060023) |
| 0.1 | 1.0 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.1 | 0.6 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
| 0.1 | 2.2 | GO:0001967 | suckling behavior(GO:0001967) |
| 0.1 | 1.7 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 0.1 | 0.3 | GO:1904207 | chemokine (C-C motif) ligand 2 secretion(GO:0035926) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 0.1 | 1.1 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.1 | 0.3 | GO:1902256 | endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) atrial septum primum morphogenesis(GO:0003289) positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) |
| 0.1 | 0.6 | GO:0010992 | ubiquitin homeostasis(GO:0010992) |
| 0.1 | 1.0 | GO:0048853 | forebrain morphogenesis(GO:0048853) |
| 0.1 | 0.9 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 0.3 | GO:1900149 | positive regulation of Schwann cell migration(GO:1900149) |
| 0.1 | 0.4 | GO:0031133 | regulation of axon diameter(GO:0031133) |
| 0.1 | 0.6 | GO:0060836 | lymphatic endothelial cell differentiation(GO:0060836) |
| 0.1 | 3.0 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.1 | 1.5 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
| 0.1 | 2.0 | GO:0007617 | mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705) |
| 0.1 | 0.7 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
| 0.1 | 0.8 | GO:1900121 | negative regulation of receptor binding(GO:1900121) |
| 0.1 | 0.6 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
| 0.1 | 0.6 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.1 | 2.4 | GO:0009409 | response to cold(GO:0009409) |
| 0.1 | 0.6 | GO:0035280 | miRNA loading onto RISC involved in gene silencing by miRNA(GO:0035280) |
| 0.1 | 0.2 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
| 0.1 | 0.2 | GO:2000313 | fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314) |
| 0.1 | 0.3 | GO:0007352 | zygotic specification of dorsal/ventral axis(GO:0007352) positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224) positive regulation of mesoderm development(GO:2000382) |
| 0.1 | 0.3 | GO:0018076 | N-terminal peptidyl-lysine acetylation(GO:0018076) |
| 0.1 | 0.3 | GO:2000182 | regulation of progesterone biosynthetic process(GO:2000182) |
| 0.1 | 0.2 | GO:0035089 | establishment of apical/basal cell polarity(GO:0035089) |
| 0.1 | 0.9 | GO:0001573 | ganglioside metabolic process(GO:0001573) |
| 0.1 | 0.5 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.1 | 0.8 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 0.1 | 0.5 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 0.1 | 0.3 | GO:0035547 | interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549) CRD-mediated mRNA stabilization(GO:0070934) |
| 0.1 | 0.8 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
| 0.1 | 0.5 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 0.1 | 0.2 | GO:0007217 | tachykinin receptor signaling pathway(GO:0007217) |
| 0.0 | 0.2 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
| 0.0 | 0.1 | GO:0021764 | amygdala development(GO:0021764) |
| 0.0 | 0.2 | GO:0010792 | blastocyst hatching(GO:0001835) DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) hatching(GO:0035188) organism emergence from protective structure(GO:0071684) |
| 0.0 | 1.2 | GO:0010763 | positive regulation of fibroblast migration(GO:0010763) |
| 0.0 | 0.8 | GO:0021819 | layer formation in cerebral cortex(GO:0021819) |
| 0.0 | 2.1 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.0 | 0.3 | GO:0070561 | vitamin D receptor signaling pathway(GO:0070561) positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138) |
| 0.0 | 0.4 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.0 | 0.6 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.0 | 0.2 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.0 | 0.3 | GO:0061304 | retinal blood vessel morphogenesis(GO:0061304) |
| 0.0 | 0.4 | GO:0048664 | neuron fate determination(GO:0048664) |
| 0.0 | 0.6 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 0.5 | GO:0034390 | smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391) |
| 0.0 | 0.2 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 0.0 | 0.6 | GO:0051292 | nuclear pore complex assembly(GO:0051292) |
| 0.0 | 0.2 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.0 | 1.4 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.0 | 0.2 | GO:0051151 | negative regulation of smooth muscle cell differentiation(GO:0051151) |
| 0.0 | 0.5 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.0 | 0.8 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.0 | 0.3 | GO:0060712 | spongiotrophoblast layer development(GO:0060712) |
| 0.0 | 0.2 | GO:0007406 | negative regulation of neuroblast proliferation(GO:0007406) |
| 0.0 | 1.4 | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197) |
| 0.0 | 0.9 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.0 | 0.8 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.0 | 0.2 | GO:0051534 | negative regulation of NFAT protein import into nucleus(GO:0051534) |
| 0.0 | 0.1 | GO:0090365 | regulation of mRNA modification(GO:0090365) |
| 0.0 | 1.2 | GO:0021884 | forebrain neuron development(GO:0021884) |
| 0.0 | 0.1 | GO:1900122 | positive regulation of receptor binding(GO:1900122) |
| 0.0 | 0.6 | GO:0014912 | negative regulation of smooth muscle cell migration(GO:0014912) |
| 0.0 | 0.2 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 0.1 | GO:2000325 | nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327) |
| 0.0 | 0.2 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.0 | 0.1 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.0 | 0.2 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.0 | 0.5 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
| 0.0 | 0.1 | GO:0050904 | diapedesis(GO:0050904) |
| 0.0 | 0.2 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.0 | 0.1 | GO:0089700 | protein kinase D signaling(GO:0089700) |
| 0.0 | 0.1 | GO:0021555 | midbrain-hindbrain boundary morphogenesis(GO:0021555) initiation of neural tube closure(GO:0021993) |
| 0.0 | 0.2 | GO:0072600 | establishment of protein localization to Golgi(GO:0072600) |
| 0.0 | 0.1 | GO:0032511 | late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511) |
| 0.0 | 0.2 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.0 | 0.2 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.0 | 0.1 | GO:2000319 | negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320) |
| 0.0 | 0.8 | GO:1901998 | toxin transport(GO:1901998) |
| 0.0 | 0.7 | GO:0060612 | adipose tissue development(GO:0060612) |
| 0.0 | 0.2 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.0 | 0.4 | GO:0034453 | microtubule anchoring(GO:0034453) |
| 0.0 | 0.5 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.0 | 0.4 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 0.0 | 0.3 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.0 | 0.4 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.0 | 0.2 | GO:0080182 | histone H3-K4 trimethylation(GO:0080182) |
| 0.0 | 0.4 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.0 | 0.2 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.0 | 0.1 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
| 0.0 | 0.7 | GO:0016574 | histone ubiquitination(GO:0016574) |
| 0.0 | 0.1 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) |
| 0.0 | 0.1 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
| 0.0 | 0.0 | GO:0045578 | negative regulation of B cell differentiation(GO:0045578) |
| 0.0 | 0.1 | GO:0060371 | regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) |
| 0.0 | 0.5 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 0.1 | GO:0032308 | positive regulation of prostaglandin secretion(GO:0032308) |
| 0.0 | 0.4 | GO:2001222 | regulation of neuron migration(GO:2001222) |
| 0.0 | 0.1 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.9 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.3 | 2.5 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.3 | 1.2 | GO:0008623 | CHRAC(GO:0008623) |
| 0.3 | 3.1 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.3 | 0.8 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
| 0.1 | 0.7 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 0.1 | 1.0 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.1 | 0.6 | GO:0000235 | astral microtubule(GO:0000235) |
| 0.1 | 0.4 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.1 | 0.9 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.1 | 1.4 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 0.7 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.1 | 1.5 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.1 | 0.3 | GO:0032444 | activin responsive factor complex(GO:0032444) |
| 0.1 | 0.3 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.1 | 0.3 | GO:0005587 | collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651) |
| 0.1 | 0.9 | GO:0042555 | MCM complex(GO:0042555) |
| 0.1 | 1.0 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.1 | 0.6 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.1 | 4.1 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 0.8 | GO:0031105 | septin complex(GO:0031105) |
| 0.1 | 0.6 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.1 | 1.9 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 0.3 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.1 | 0.2 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.0 | 0.6 | GO:0031597 | cytosolic proteasome complex(GO:0031597) |
| 0.0 | 0.7 | GO:0042581 | specific granule(GO:0042581) |
| 0.0 | 0.5 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 0.4 | GO:0097413 | Lewy body(GO:0097413) |
| 0.0 | 0.8 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 0.4 | GO:0032009 | early phagosome(GO:0032009) |
| 0.0 | 16.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.1 | GO:0097629 | extrinsic component of omegasome membrane(GO:0097629) |
| 0.0 | 0.3 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 1.3 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.0 | 0.3 | GO:0060091 | kinocilium(GO:0060091) |
| 0.0 | 0.3 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 2.1 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 0.8 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 0.6 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 0.6 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.0 | 0.4 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 0.3 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.0 | 0.3 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 0.2 | GO:0071437 | invadopodium(GO:0071437) |
| 0.0 | 0.1 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.0 | 0.2 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.0 | 0.5 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.0 | GO:0070436 | Grb2-EGFR complex(GO:0070436) |
| 0.0 | 0.0 | GO:0030289 | protein phosphatase 4 complex(GO:0030289) |
| 0.0 | 0.2 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 1.7 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 0.5 | GO:0043198 | dendritic shaft(GO:0043198) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.1 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.4 | 3.5 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
| 0.4 | 3.5 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.3 | 1.9 | GO:0030284 | estrogen receptor activity(GO:0030284) |
| 0.3 | 5.5 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.3 | 1.7 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.3 | 1.0 | GO:0031721 | hemoglobin alpha binding(GO:0031721) |
| 0.2 | 3.6 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.2 | 0.7 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 0.2 | 1.3 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.2 | 0.7 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) |
| 0.2 | 1.2 | GO:0045322 | unmethylated CpG binding(GO:0045322) |
| 0.2 | 1.1 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.2 | 0.7 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.2 | 0.6 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
| 0.2 | 1.1 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915) |
| 0.2 | 0.8 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
| 0.1 | 1.5 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.1 | 2.5 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.1 | 0.6 | GO:0005113 | patched binding(GO:0005113) |
| 0.1 | 0.6 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.1 | 1.0 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
| 0.1 | 0.5 | GO:0071987 | WD40-repeat domain binding(GO:0071987) |
| 0.1 | 0.6 | GO:0050265 | RNA uridylyltransferase activity(GO:0050265) |
| 0.1 | 0.5 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.1 | 1.4 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.1 | 0.4 | GO:0003844 | 1,4-alpha-glucan branching enzyme activity(GO:0003844) |
| 0.1 | 0.6 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.1 | 1.0 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.1 | 0.3 | GO:0033680 | ATP-dependent DNA/RNA helicase activity(GO:0033680) |
| 0.1 | 0.6 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 0.1 | 0.6 | GO:0048185 | activin binding(GO:0048185) |
| 0.1 | 2.4 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.1 | 0.3 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.1 | 0.3 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 0.1 | 0.7 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.1 | 0.5 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.1 | 1.1 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.1 | 0.8 | GO:0015197 | peptide transporter activity(GO:0015197) |
| 0.1 | 0.8 | GO:1990459 | transferrin receptor binding(GO:1990459) |
| 0.1 | 0.2 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
| 0.1 | 1.2 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.1 | 1.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 0.2 | GO:0035650 | AP-1 adaptor complex binding(GO:0035650) |
| 0.1 | 1.1 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.1 | 0.3 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.1 | 1.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 0.4 | GO:0043559 | insulin binding(GO:0043559) |
| 0.1 | 0.2 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
| 0.0 | 0.4 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.0 | 0.8 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
| 0.0 | 0.3 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.0 | 0.3 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.0 | 0.6 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
| 0.0 | 0.7 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 1.0 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 7.0 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 0.3 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 1.8 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.0 | 0.3 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 0.6 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.0 | 3.2 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.0 | 0.8 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.0 | 0.8 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.0 | 0.3 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.0 | 2.7 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.6 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.0 | 1.2 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 0.9 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 0.3 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.0 | 0.4 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 0.5 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 11.8 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) |
| 0.0 | 0.6 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 0.5 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 0.1 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
| 0.0 | 0.1 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.0 | 0.5 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 0.1 | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184) |
| 0.0 | 0.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.2 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.0 | 0.3 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.0 | 0.9 | GO:0042054 | histone methyltransferase activity(GO:0042054) |
| 0.0 | 0.8 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.3 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.0 | 0.1 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.0 | 0.3 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.0 | 0.0 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 0.0 | 2.1 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 3.2 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 1.2 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 1.1 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 2.8 | GO:0000975 | regulatory region DNA binding(GO:0000975) transcription regulatory region DNA binding(GO:0044212) |
| 0.0 | 0.2 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
| 0.0 | 0.1 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
| 0.0 | 0.8 | GO:0008186 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186) |
| 0.0 | 0.1 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.0 | 0.8 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.2 | PID_BETA_CATENIN_DEG_PATHWAY | Degradation of beta catenin |
| 0.1 | 1.8 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 8.1 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 2.3 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.1 | 0.6 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.1 | 1.9 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 1.9 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.0 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 2.2 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.0 | 2.1 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 1.9 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.6 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 3.7 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.2 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 0.5 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.0 | 0.5 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 0.5 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 1.6 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.0 | 0.3 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
| 0.0 | 0.3 | PID_IL5_PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.8 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.1 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 0.5 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 0.5 | PID_PS1_PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 0.7 | PID_SHP2_PATHWAY | SHP2 signaling |
| 0.0 | 0.2 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.8 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.4 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 1.1 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
| 0.0 | 0.3 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.6 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
| 0.0 | 0.4 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 0.2 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.6 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 1.5 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 1.6 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.1 | 2.8 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 3.0 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 2.7 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 1.7 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.1 | 0.4 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 1.6 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.1 | 0.9 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.4 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 0.9 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.6 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 0.7 | REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.0 | 0.3 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.8 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 1.3 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 2.5 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 2.1 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.6 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 0.6 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 2.1 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.0 | 1.3 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.6 | REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 0.2 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.0 | 0.5 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 0.7 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.4 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.2 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 1.4 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.3 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.2 | REACTOME_RAF_MAP_KINASE_CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.0 | 0.1 | REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 0.8 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 0.5 | REACTOME_CA_DEPENDENT_EVENTS | Genes involved in Ca-dependent events |
| 0.0 | 0.2 | REACTOME_MEIOSIS | Genes involved in Meiosis |
| 0.0 | 1.0 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 1.1 | REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS | Genes involved in G alpha (q) signalling events |
| 0.0 | 0.5 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.2 | REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.0 | 0.1 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
