Motif ID: Lef1

Z-value: 1.102


Transcription factors associated with Lef1:

Gene SymbolEntrez IDGene Name
Lef1 ENSMUSG00000027985.8 Lef1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lef1mm10_v2_chr3_+_131110350_1311104710.513.1e-02Click!


Activity profile for motif Lef1.

activity profile for motif Lef1


Sorted Z-values histogram for motif Lef1

Sorted Z-values for motif Lef1



Network of associatons between targets according to the STRING database.



First level regulatory network of Lef1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_148392810 3.525 ENSMUST00000138257.1
 Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr14_-_98169542 3.461 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr2_+_70474923 3.007 ENSMUST00000100043.2
 Sp5
trans-acting transcription factor 5
chr11_+_108920800 2.660 ENSMUST00000140821.1
 Axin2
axin2
chr7_-_115824699 2.589 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr17_-_70851189 2.472 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr7_-_37772868 2.338 ENSMUST00000176205.1
 Zfp536
zinc finger protein 536
chr14_-_48662740 2.099 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr12_+_76072016 2.029 ENSMUST00000131480.1
 Syne2
spectrin repeat containing, nuclear envelope 2
chr10_-_92165159 1.988 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr14_+_25607797 1.978 ENSMUST00000160229.1
 Zmiz1
zinc finger, MIZ-type containing 1
chr3_+_102010138 1.958 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr3_+_131110350 1.919 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr7_-_144939823 1.830 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr1_-_138842429 1.786 ENSMUST00000112026.2
ENSMUST00000019374.7
 Lhx9

LIM homeobox protein 9

chr9_+_22454290 1.767 ENSMUST00000168332.1
 Gm17545
predicted gene, 17545
chr3_-_57575907 1.730 ENSMUST00000120977.1
 Wwtr1
WW domain containing transcription regulator 1
chr3_-_57575760 1.630 ENSMUST00000029380.7
 Wwtr1
WW domain containing transcription regulator 1
chr18_-_62756275 1.627 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr6_-_72788952 1.549 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 156 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.8 5.3 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.3 3.6 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
1.2 3.5 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.2 3.5 GO:0015809 arginine transport(GO:0015809)
0.5 3.4 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.8 3.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1 3.2 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.1 3.0 GO:0035329 hippo signaling(GO:0035329)
1.0 2.9 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.4 2.6 GO:0007296 vitellogenesis(GO:0007296)
0.5 2.5 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.1 2.4 GO:0009409 response to cold(GO:0009409)
0.1 2.2 GO:0001967 suckling behavior(GO:0001967)
0.2 2.1 GO:1990845 adaptive thermogenesis(GO:1990845)
0.0 2.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.7 2.0 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.2 2.0 GO:0060539 diaphragm development(GO:0060539)
0.1 2.0 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.4 1.8 GO:0035262 gonad morphogenesis(GO:0035262)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.4 GO:0005667 transcription factor complex(GO:0005667)
0.1 4.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.3 3.1 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.3 2.5 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 2.1 GO:0005871 kinesin complex(GO:0005871)
0.3 1.9 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 1.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.7 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 1.5 GO:0016580 Sin3 complex(GO:0016580)
0.1 1.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.3 GO:1990391 DNA repair complex(GO:1990391)
0.3 1.2 GO:0008623 CHRAC(GO:0008623)
0.1 1.0 GO:0005833 hemoglobin complex(GO:0005833)
0.1 1.0 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.9 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.1 0.9 GO:0042555 MCM complex(GO:0042555)
0.3 0.8 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.1 0.8 GO:0031105 septin complex(GO:0031105)
0.0 0.8 GO:0071564 npBAF complex(GO:0071564)
0.0 0.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.8 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.0 7.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 5.5 GO:0070411 I-SMAD binding(GO:0070411)
0.2 3.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.4 3.5 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.4 3.5 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 3.2 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 3.2 GO:0051015 actin filament binding(GO:0051015)
0.0 2.8 GO:0000975 regulatory region DNA binding(GO:0000975) transcription regulatory region DNA binding(GO:0044212)
0.0 2.7 GO:0003777 microtubule motor activity(GO:0003777)
0.1 2.5 GO:0070410 co-SMAD binding(GO:0070410)
0.1 2.4 GO:0033613 activating transcription factor binding(GO:0033613)
0.5 2.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.0 2.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.3 1.9 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 1.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 1.7 GO:0048495 Roundabout binding(GO:0048495)
0.1 1.5 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 1.4 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 1.4 GO:0070064 proline-rich region binding(GO:0070064)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 5.2 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 3.7 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 2.3 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 2.2 PID_BMP_PATHWAY BMP receptor signaling
0.0 2.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 1.9 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 1.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 1.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.6 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.2 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.1 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.1 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 1.0 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.8 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.7 PID_SHP2_PATHWAY SHP2 signaling
0.1 0.6 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.6 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 3.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 2.8 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 2.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 2.5 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 2.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 1.7 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 1.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 1.6 REACTOME_KINESINS Genes involved in Kinesins
0.1 1.5 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.3 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.1 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.0 1.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 0.9 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.9 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling