Motif ID: Sp2

Z-value: 0.787


Transcription factors associated with Sp2:

Gene SymbolEntrez IDGene Name
Sp2 ENSMUSG00000018678.6 Sp2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp2mm10_v2_chr11_-_96977660_96977711-0.048.8e-01Click!


Activity profile for motif Sp2.

activity profile for motif Sp2


Sorted Z-values histogram for motif Sp2

Sorted Z-values for motif Sp2



Network of associatons between targets according to the STRING database.



First level regulatory network of Sp2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_87948666 5.068 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr7_-_110061319 2.804 ENSMUST00000098110.2
 AA474408
expressed sequence AA474408
chr12_+_112644828 2.435 ENSMUST00000021728.4
ENSMUST00000109755.3
 Siva1

SIVA1, apoptosis-inducing factor

chr1_+_72824482 2.038 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr1_+_184034381 1.762 ENSMUST00000048655.7
 Dusp10
dual specificity phosphatase 10
chr1_-_184033998 1.555 ENSMUST00000050306.5
 1700056E22Rik
RIKEN cDNA 1700056E22 gene
chrX_-_48034842 1.468 ENSMUST00000039026.7
 Apln
apelin
chr12_+_112678803 1.423 ENSMUST00000174780.1
ENSMUST00000169593.1
ENSMUST00000173942.1
 Zbtb42


zinc finger and BTB domain containing 42


chrX_-_133688978 1.363 ENSMUST00000149154.1
ENSMUST00000167944.1
 Pcdh19

protocadherin 19

chr7_-_17062384 1.346 ENSMUST00000153833.1
ENSMUST00000108492.2
 Hif3a

hypoxia inducible factor 3, alpha subunit

chr4_+_46450892 1.291 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr4_+_3938888 1.279 ENSMUST00000121110.1
ENSMUST00000108386.1
ENSMUST00000149544.1
 Chchd7


coiled-coil-helix-coiled-coil-helix domain containing 7


chr17_-_70851189 1.219 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr15_-_82212796 1.217 ENSMUST00000179269.1
 AI848285
expressed sequence AI848285
chr6_+_85187438 1.177 ENSMUST00000045942.8
 Emx1
empty spiracles homeobox 1
chr8_-_57653023 1.118 ENSMUST00000034021.5
 Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr2_+_38339258 1.092 ENSMUST00000143783.2
 Lhx2
LIM homeobox protein 2
chr5_+_99979061 1.060 ENSMUST00000046721.1
 4930524J08Rik
RIKEN cDNA 4930524J08 gene
chr19_-_23652780 1.046 ENSMUST00000035849.3
 1700028P14Rik
RIKEN cDNA 1700028P14 gene
chr4_+_108579445 1.039 ENSMUST00000102744.3
 Orc1
origin recognition complex, subunit 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 197 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.1 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.1 2.6 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.2 1.9 GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901030)
0.0 1.9 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.4 1.8 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1 1.7 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 1.6 GO:0002227 innate immune response in mucosa(GO:0002227)
0.5 1.5 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.2 1.5 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.5 1.4 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.0 1.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.3 GO:0060019 radial glial cell differentiation(GO:0060019)
0.1 1.3 GO:0043486 histone exchange(GO:0043486)
0.4 1.2 GO:0061300 cerebellum vasculature development(GO:0061300)
0.2 1.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.2 1.2 GO:0045989 positive regulation of striated muscle contraction(GO:0045989)
0.1 1.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 1.1 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.0 1.1 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.3 1.0 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 GO:0016607 nuclear speck(GO:0016607)
0.0 2.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.3 GO:0072562 blood microparticle(GO:0072562)
0.0 2.1 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 1.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.3 1.8 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 1.7 GO:0045120 pronucleus(GO:0045120)
0.4 1.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 1.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 1.0 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 1.0 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.9 GO:0002102 podosome(GO:0002102)
0.0 0.9 GO:0030684 preribosome(GO:0030684)
0.2 0.7 GO:0090537 CERF complex(GO:0090537)
0.1 0.7 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 0.7 GO:0061617 MICOS complex(GO:0061617)
0.0 0.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.7 GO:0005680 anaphase-promoting complex(GO:0005680)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.8 5.1 GO:0019841 retinol binding(GO:0019841)
0.0 3.0 GO:0008236 serine-type peptidase activity(GO:0008236)
0.3 2.0 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 2.0 GO:0001618 virus receptor activity(GO:0001618)
0.1 2.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 1.9 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.1 1.8 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.3 1.6 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.2 1.5 GO:1990715 mRNA CDS binding(GO:1990715)
0.1 1.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 1.4 GO:0001848 complement binding(GO:0001848)
0.1 1.4 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 1.2 GO:0008432 JUN kinase binding(GO:0008432)
0.1 1.0 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 1.0 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 1.0 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 1.0 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 0.9 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.9 GO:0035497 cAMP response element binding(GO:0035497)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.8 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 1.7 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.2 PID_E2F_PATHWAY E2F transcription factor network
0.1 1.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.1 ST_STAT3_PATHWAY STAT3 Pathway
0.0 1.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.0 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.9 PID_P73PATHWAY p73 transcription factor network
0.0 0.8 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 0.7 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.6 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.5 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.5 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.2 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.2 PID_EPO_PATHWAY EPO signaling pathway
0.0 0.1 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.7 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 2.6 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 2.5 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 2.0 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 2.0 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 1.9 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 1.7 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 1.7 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 1.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.6 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.1 1.4 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 1.3 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 1.3 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 1.3 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.2 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.0 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.0 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.1 0.8 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 0.8 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.8 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation