Motif ID: Nr1i3

Z-value: 1.898


Transcription factors associated with Nr1i3:

Gene SymbolEntrez IDGene Name
Nr1i3 ENSMUSG00000005677.8 Nr1i3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr1i3mm10_v2_chr1_+_171213969_171214007-0.272.8e-01Click!


Activity profile for motif Nr1i3.

activity profile for motif Nr1i3


Sorted Z-values histogram for motif Nr1i3

Sorted Z-values for motif Nr1i3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1i3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_110061319 6.725 ENSMUST00000098110.2
 AA474408
expressed sequence AA474408
chr1_+_166254095 6.098 ENSMUST00000111416.1
 Ildr2
immunoglobulin-like domain containing receptor 2
chr7_-_30973464 5.827 ENSMUST00000001279.8
 Lsr
lipolysis stimulated lipoprotein receptor
chr7_-_30973367 5.566 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor
chr1_+_87264345 5.399 ENSMUST00000118687.1
ENSMUST00000027472.6
 Efhd1

EF hand domain containing 1

chr4_-_154097105 5.216 ENSMUST00000105643.1
ENSMUST00000133533.1
ENSMUST00000097762.4
 Trp73


transformation related protein 73


chr2_+_165655237 5.037 ENSMUST00000063433.7
 Eya2
eyes absent 2 homolog (Drosophila)
chr1_+_72824482 4.993 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr7_-_30973399 4.700 ENSMUST00000098553.4
ENSMUST00000147431.1
 Lsr

lipolysis stimulated lipoprotein receptor

chr2_+_136057927 4.584 ENSMUST00000057503.6
 Lamp5
lysosomal-associated membrane protein family, member 5
chr7_+_29289300 4.571 ENSMUST00000048187.4
 Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr1_-_163289214 4.542 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr5_-_116422858 4.430 ENSMUST00000036991.4
 Hspb8
heat shock protein 8
chr17_+_29093763 4.028 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr9_-_27155418 3.956 ENSMUST00000167074.1
ENSMUST00000034472.8
 Jam3

junction adhesion molecule 3

chr14_-_48667508 3.953 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr10_-_120899067 3.924 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr5_-_53707532 3.827 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr17_+_43952999 3.796 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr2_+_30078584 3.748 ENSMUST00000045246.7
 Pkn3
protein kinase N3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 616 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.4 16.1 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.4 12.5 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.3 9.9 GO:0042775 mitochondrial ATP synthesis coupled electron transport(GO:0042775)
1.0 8.8 GO:0071493 cellular response to UV-B(GO:0071493)
0.5 8.4 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.5 8.1 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.4 7.5 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.4 6.5 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.4 6.5 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.2 6.5 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.1 6.3 GO:0032543 mitochondrial translation(GO:0032543)
0.3 6.0 GO:0038092 nodal signaling pathway(GO:0038092)
0.7 5.5 GO:0006004 fucose metabolic process(GO:0006004)
0.5 5.4 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.3 5.2 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.6 5.2 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.3 5.2 GO:0051451 myoblast migration(GO:0051451)
1.7 5.1 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.6 5.0 GO:0016576 histone dephosphorylation(GO:0016576)
0.8 4.9 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 256 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 22.7 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
2.7 16.1 GO:0061689 tricellular tight junction(GO:0061689)
0.1 15.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 13.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 13.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 13.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 9.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 8.9 GO:0005667 transcription factor complex(GO:0005667)
0.4 8.4 GO:0070469 respiratory chain(GO:0070469)
0.1 8.0 GO:0000922 spindle pole(GO:0000922)
0.1 7.7 GO:0044391 ribosomal subunit(GO:0044391)
0.5 7.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 7.3 GO:0005657 replication fork(GO:0005657)
0.2 7.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
2.2 6.5 GO:0070557 PCNA-p21 complex(GO:0070557)
0.4 6.1 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 5.5 GO:0035371 microtubule plus-end(GO:0035371)
0.1 5.5 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.5 5.4 GO:0045275 respiratory chain complex III(GO:0045275)
0.7 5.1 GO:0097452 GAIT complex(GO:0097452)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 391 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 22.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.9 16.1 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.6 13.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.4 11.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 9.3 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.7 8.1 GO:0008430 selenium binding(GO:0008430)
0.5 7.3 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 6.6 GO:0051087 chaperone binding(GO:0051087)
2.2 6.5 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.1 6.5 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.3 6.5 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 6.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 5.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.7 5.8 GO:0031995 insulin-like growth factor II binding(GO:0031995)
1.4 5.7 GO:0042806 fucose binding(GO:0042806)
0.2 5.7 GO:0071837 HMG box domain binding(GO:0071837)
0.6 5.5 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 5.4 GO:0005518 collagen binding(GO:0005518)
0.1 5.4 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.6 5.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 23.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 11.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 11.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.1 9.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 6.8 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 6.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 6.4 PID_AURORA_A_PATHWAY Aurora A signaling
0.2 6.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 5.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 5.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 5.1 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 5.1 PID_PLK1_PATHWAY PLK1 signaling events
0.3 4.8 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 4.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 4.5 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 4.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 3.7 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 3.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 2.9 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 2.9 PID_IL4_2PATHWAY IL4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 38.6 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.4 18.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 12.4 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.1 12.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 9.1 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 8.2 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.1 7.8 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.5 7.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 7.2 REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway
0.3 6.8 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.2 6.7 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2 6.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.4 6.1 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 5.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.3 5.0 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.3 4.5 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.2 4.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 4.4 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 4.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 4.2 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing