Motif ID: Tead3_Tead4

Z-value: 2.151

Transcription factors associated with Tead3_Tead4:

Gene SymbolEntrez IDGene Name
Tead3 ENSMUSG00000002249.11 Tead3
Tead4 ENSMUSG00000030353.9 Tead4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tead3mm10_v2_chr17_-_28350600_283506810.361.4e-01Click!


Activity profile for motif Tead3_Tead4.

activity profile for motif Tead3_Tead4


Sorted Z-values histogram for motif Tead3_Tead4

Sorted Z-values for motif Tead3_Tead4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tead3_Tead4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_35702297 6.943 ENSMUST00000135078.1
 Ddr1
discoidin domain receptor family, member 1
chr14_-_54577578 6.887 ENSMUST00000054487.8
 Ajuba
ajuba LIM protein
chr8_-_61760067 6.560 ENSMUST00000121493.1
 Palld
palladin, cytoskeletal associated protein
chr4_-_43558386 6.557 ENSMUST00000130353.1
 Tln1
talin 1
chr17_-_35701937 6.149 ENSMUST00000155628.1
 Ddr1
discoidin domain receptor family, member 1
chr17_-_35702040 5.398 ENSMUST00000166980.2
ENSMUST00000145900.1
 Ddr1

discoidin domain receptor family, member 1

chr2_+_20519776 4.932 ENSMUST00000114604.2
ENSMUST00000066509.3
 Etl4

enhancer trap locus 4

chr15_+_6386598 4.442 ENSMUST00000080880.5
ENSMUST00000110664.2
ENSMUST00000110663.2
ENSMUST00000161812.1
ENSMUST00000160134.1
 Dab2




disabled 2, mitogen-responsive phosphoprotein




chr5_-_137314175 4.376 ENSMUST00000024119.9
 Trip6
thyroid hormone receptor interactor 6
chr10_+_24595623 4.208 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr11_+_98412461 4.208 ENSMUST00000058295.5
 Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr12_-_80112998 3.789 ENSMUST00000165114.1
ENSMUST00000021552.1
 Zfp36l1

zinc finger protein 36, C3H type-like 1

chr6_+_17306335 3.658 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
 Cav1



caveolin 1, caveolae protein



chr7_-_132813715 3.603 ENSMUST00000134946.1
 Fam53b
family with sequence similarity 53, member B
chr7_-_132813799 3.004 ENSMUST00000097998.2
 Fam53b
family with sequence similarity 53, member B
chr11_+_112782182 3.003 ENSMUST00000000579.2
 Sox9
SRY-box containing gene 9
chr10_+_4710119 2.935 ENSMUST00000105588.1
ENSMUST00000105589.1
 Esr1

estrogen receptor 1 (alpha)

chr10_-_78591945 2.710 ENSMUST00000040580.6
 Syde1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr3_-_57575760 2.651 ENSMUST00000029380.7
 Wwtr1
WW domain containing transcription regulator 1
chr11_-_5381734 2.626 ENSMUST00000172492.1
 Znrf3
zinc and ring finger 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 161 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 20.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
1.7 8.5 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
1.2 8.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
1.0 8.1 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.3 6.6 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
0.1 4.8 GO:0032611 interleukin-1 beta production(GO:0032611)
0.6 4.5 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.1 4.5 GO:0035411 catenin import into nucleus(GO:0035411)
0.9 4.4 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.7 4.4 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 4.4 GO:0048706 embryonic skeletal system development(GO:0048706)
1.4 4.2 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
1.1 4.2 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
1.3 3.8 GO:1904580 regulation of intracellular mRNA localization(GO:1904580)
0.9 3.7 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.1 3.2 GO:0035329 hippo signaling(GO:0035329)
0.6 3.1 GO:0038018 Wnt receptor catabolic process(GO:0038018)
1.5 3.0 GO:0072190 ureter urothelium development(GO:0072190) ureter morphogenesis(GO:0072197)
1.0 2.9 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.1 2.9 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 21.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 11.6 GO:0005925 focal adhesion(GO:0005925)
0.1 10.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.6 8.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 6.6 GO:0002102 podosome(GO:0002102)
0.0 6.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 4.5 GO:0005801 cis-Golgi network(GO:0005801)
1.1 4.4 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 4.3 GO:0016459 myosin complex(GO:0016459)
0.3 4.2 GO:0043219 lateral loop(GO:0043219)
0.0 3.4 GO:0005667 transcription factor complex(GO:0005667)
0.4 2.9 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 2.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 2.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.7 GO:0005604 basement membrane(GO:0005604)
0.0 2.7 GO:0005923 bicellular tight junction(GO:0005923)
0.2 2.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 2.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.7 2.2 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.5 2.1 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 20.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.4 8.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
1.7 8.5 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.5 6.9 GO:0045294 alpha-catenin binding(GO:0045294)
0.7 6.6 GO:0030274 LIM domain binding(GO:0030274)
0.0 5.8 GO:0003774 motor activity(GO:0003774)
0.1 4.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 4.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3 4.4 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.3 4.4 GO:0005149 interleukin-1 receptor binding(GO:0005149)
1.4 4.2 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.3 3.9 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.3 3.8 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.4 3.7 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 3.3 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 3.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.3 3.0 GO:0097157 pre-mRNA intronic binding(GO:0097157)
1.0 2.9 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.3 2.9 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 2.9 GO:0005109 frizzled binding(GO:0005109)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.5 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.1 9.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.3 8.9 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 8.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.3 5.3 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 4.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.4 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.1 3.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.5 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.1 3.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.1 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 2.9 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 2.6 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 2.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 2.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.3 2.1 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 2.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 2.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.0 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.7 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.4 8.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.5 6.6 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.4 5.3 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.3 4.2 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.2 4.2 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 3.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 3.8 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1 3.4 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 3.1 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 2.9 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 2.8 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.3 2.6 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 2.6 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.2 2.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 2.4 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.4 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 2.3 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 2.3 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 2.1 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs