Motif ID: Max_Mycn

Z-value: 3.277

Transcription factors associated with Max_Mycn:

Gene SymbolEntrez IDGene Name
Max ENSMUSG00000059436.6 Max
Mycn ENSMUSG00000037169.8 Mycn

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Maxmm10_v2_chr12_-_76962178_76962248-0.762.2e-04Click!
Mycnmm10_v2_chr12_-_12941827_12941914-0.494.1e-02Click!


Activity profile for motif Max_Mycn.

activity profile for motif Max_Mycn


Sorted Z-values histogram for motif Max_Mycn

Sorted Z-values for motif Max_Mycn



Network of associatons between targets according to the STRING database.



First level regulatory network of Max_Mycn

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_144896523 12.011 ENSMUST00000033389.5
 Fgf15
fibroblast growth factor 15
chr10_+_127063599 11.492 ENSMUST00000120226.1
ENSMUST00000133115.1
 Cdk4

cyclin-dependent kinase 4

chr9_-_119578981 10.867 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr10_+_127063527 10.851 ENSMUST00000006911.5
 Cdk4
cyclin-dependent kinase 4
chr5_-_135251209 9.307 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr5_+_139543889 8.976 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr10_-_77113676 8.645 ENSMUST00000072755.4
ENSMUST00000105409.1
 Col18a1

collagen, type XVIII, alpha 1

chr3_+_104638658 8.627 ENSMUST00000046212.1
 Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr17_+_46496753 8.527 ENSMUST00000046497.6
 Dnph1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
chr10_-_30842765 7.763 ENSMUST00000019924.8
 Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr9_-_114781986 7.655 ENSMUST00000035009.8
ENSMUST00000084867.7
 Cmtm7

CKLF-like MARVEL transmembrane domain containing 7

chr19_+_6975048 7.319 ENSMUST00000070850.6
 Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chrX_-_155338460 7.245 ENSMUST00000026328.4
 Prdx4
peroxiredoxin 4
chr2_+_156840966 7.207 ENSMUST00000109564.1
 Tgif2
TGFB-induced factor homeobox 2
chrX_-_134541847 7.196 ENSMUST00000054213.4
 Timm8a1
translocase of inner mitochondrial membrane 8A1
chr11_-_89302545 6.658 ENSMUST00000061728.3
 Nog
noggin
chr5_-_106458440 6.649 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr12_+_110279228 6.598 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III
chr5_+_129020069 6.569 ENSMUST00000031383.7
ENSMUST00000111343.1
 Ran

RAN, member RAS oncogene family

chr17_-_24960620 6.560 ENSMUST00000024981.7
 Hn1l
hematological and neurological expressed 1-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 678 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 22.6 GO:0006414 translational elongation(GO:0006414)
5.6 22.3 GO:0010288 response to lead ion(GO:0010288)
3.1 18.5 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
1.1 15.4 GO:0002192 IRES-dependent translational initiation(GO:0002192)
0.1 15.3 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.1 15.2 GO:0051028 mRNA transport(GO:0051028)
1.3 14.8 GO:0006228 UTP biosynthetic process(GO:0006228)
3.2 12.7 GO:0046073 dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073)
3.1 12.4 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
1.0 11.9 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
2.9 11.7 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
1.3 11.7 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.7 11.6 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
2.3 11.4 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.7 11.2 GO:0038092 nodal signaling pathway(GO:0038092)
3.6 10.9 GO:0086047 membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
1.0 10.5 GO:0018195 peptidyl-arginine modification(GO:0018195)
0.2 9.9 GO:0006413 translational initiation(GO:0006413)
3.2 9.5 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
1.9 9.5 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 302 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 105.0 GO:0005739 mitochondrion(GO:0005739)
0.0 40.9 GO:0005576 extracellular region(GO:0005576)
0.6 31.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 26.1 GO:0022626 cytosolic ribosome(GO:0022626)
5.6 22.3 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
1.7 19.0 GO:0005642 annulate lamellae(GO:0005642)
0.8 17.8 GO:0031527 filopodium membrane(GO:0031527)
0.2 17.0 GO:0005581 collagen trimer(GO:0005581)
2.7 16.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
1.0 14.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.3 14.5 GO:0000791 euchromatin(GO:0000791)
0.3 13.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 13.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 13.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 12.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.6 12.7 GO:0016580 Sin3 complex(GO:0016580)
1.1 12.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.4 12.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 11.6 GO:0015934 large ribosomal subunit(GO:0015934)
0.1 11.5 GO:0044452 nucleolar part(GO:0044452)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 430 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 51.9 GO:0003735 structural constituent of ribosome(GO:0003735)
1.7 40.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.7 32.1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 21.2 GO:0003723 RNA binding(GO:0003723)
0.4 19.2 GO:0016831 carboxy-lyase activity(GO:0016831)
0.5 18.2 GO:0045182 translation regulator activity(GO:0045182)
0.4 17.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.3 16.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.9 16.2 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.3 15.7 GO:0005158 insulin receptor binding(GO:0005158)
0.8 14.7 GO:0051920 peroxiredoxin activity(GO:0051920)
0.1 13.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 12.8 GO:0017025 TBP-class protein binding(GO:0017025)
3.9 11.7 GO:0035939 microsatellite binding(GO:0035939)
0.9 11.6 GO:0031386 protein tag(GO:0031386)
0.3 11.4 GO:0005109 frizzled binding(GO:0005109)
0.6 10.7 GO:0043121 neurotrophin binding(GO:0043121)
3.5 10.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 10.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.8 10.0 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 78.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
2.5 34.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.3 24.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.4 19.2 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.4 15.7 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.5 15.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.5 15.0 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.3 14.8 PID_IGF1_PATHWAY IGF1 pathway
0.2 14.2 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.3 11.3 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.2 11.0 PID_BMP_PATHWAY BMP receptor signaling
0.3 10.1 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.2 10.0 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.5 8.5 ST_STAT3_PATHWAY STAT3 Pathway
0.2 8.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 8.1 PID_INSULIN_PATHWAY Insulin Pathway
0.3 7.3 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 7.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.4 6.6 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 6.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 150 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 50.6 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
1.0 45.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.5 26.5 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.4 25.6 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 21.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 20.8 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.3 19.7 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
1.4 19.0 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.8 18.6 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.6 16.8 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.8 16.0 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.2 15.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.7 15.5 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
1.0 14.5 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.3 14.2 REACTOME_TRANSLATION Genes involved in Translation
0.6 12.5 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.1 10.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.4 10.5 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 10.5 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.5 10.4 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC