Motif ID: Foxd3

Z-value: 0.673


Transcription factors associated with Foxd3:

Gene SymbolEntrez IDGene Name
Foxd3 ENSMUSG00000067261.3 Foxd3



Activity profile for motif Foxd3.

activity profile for motif Foxd3


Sorted Z-values histogram for motif Foxd3

Sorted Z-values for motif Foxd3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxd3

PNG image of the network

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Top targets:


Showing 1 to 20 of 65 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_102010138 2.629 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr17_+_29090969 2.233 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr8_-_87959560 1.635 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr6_-_3494587 1.558 ENSMUST00000049985.8
 Hepacam2
HEPACAM family member 2
chr4_-_137785371 1.412 ENSMUST00000133473.1
 Alpl
alkaline phosphatase, liver/bone/kidney
chr17_+_93199348 1.242 ENSMUST00000064775.6
 Adcyap1
adenylate cyclase activating polypeptide 1
chr11_+_98798653 1.207 ENSMUST00000037930.6
 Msl1
male-specific lethal 1 homolog (Drosophila)
chr10_+_11609256 1.177 ENSMUST00000052902.7
 Gm9797
predicted pseudogene 9797
chr12_+_111971545 1.134 ENSMUST00000079009.5
 Tdrd9
tudor domain containing 9
chr1_+_6734827 1.112 ENSMUST00000139838.1
 St18
suppression of tumorigenicity 18
chr6_-_144209471 1.099 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr7_+_67655414 1.037 ENSMUST00000107470.1
 Ttc23
tetratricopeptide repeat domain 23
chr6_-_144209558 1.034 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr6_+_38918969 0.981 ENSMUST00000003017.6
 Tbxas1
thromboxane A synthase 1, platelet
chr4_-_82850721 0.948 ENSMUST00000139401.1
 Zdhhc21
zinc finger, DHHC domain containing 21
chr17_+_28691419 0.936 ENSMUST00000124886.1
 Mapk14
mitogen-activated protein kinase 14
chr2_+_181767040 0.927 ENSMUST00000108756.1
 Myt1
myelin transcription factor 1
chr4_-_36056726 0.868 ENSMUST00000108124.3
 Lingo2
leucine rich repeat and Ig domain containing 2
chr2_+_181767283 0.859 ENSMUST00000108757.2
 Myt1
myelin transcription factor 1
chr10_-_127030789 0.850 ENSMUST00000120547.1
ENSMUST00000152054.1
 Tsfm

Ts translation elongation factor, mitochondrial


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.2 2.2 GO:0071493 cellular response to UV-B(GO:0071493)
0.3 2.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.2 1.8 GO:0060539 diaphragm development(GO:0060539)
0.4 1.7 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.4 1.6 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.0 1.6 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 1.6 GO:0007098 centrosome cycle(GO:0007098)
0.0 1.4 GO:0046677 response to antibiotic(GO:0046677)
0.4 1.2 GO:0071649 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) regulation of chemokine (C-C motif) ligand 5 production(GO:0071649) positive regulation of somatostatin secretion(GO:0090274)
0.1 1.2 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.2 1.1 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 1.1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.2 1.0 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 0.9 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.2 0.8 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.8 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.1 0.7 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0 0.7 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 0.6 GO:0030242 pexophagy(GO:0030242)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.2 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 2.1 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 1.6 GO:0000922 spindle pole(GO:0000922)
0.0 1.6 GO:0030496 midbody(GO:0030496)
0.1 1.4 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.2 1.2 GO:0072487 MSL complex(GO:0072487)
0.2 1.1 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 0.8 GO:0005859 muscle myosin complex(GO:0005859)
0.2 0.6 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.4 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.7 2.2 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0 1.8 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 1.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.3 1.6 GO:0051525 NFAT protein binding(GO:0051525)
0.4 1.4 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 1.2 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 1.1 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 1.0 GO:0016860 monooxygenase activity(GO:0004497) intramolecular oxidoreductase activity(GO:0016860)
0.0 0.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 0.8 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.5 GO:0001515 opioid peptide activity(GO:0001515)
0.1 0.4 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.1 0.4 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0050265 RNA uridylyltransferase activity(GO:0050265)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.6 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.4 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 1.6 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 1.2 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.1 1.0 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.9 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.8 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.7 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.4 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.4 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.2 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha